In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease

Autores
Boiani, Lucia; Davies, Carolina; Arredondo, Carolina; Porcal, Williams; Merlino, Alicia; Gerpe, Alejandra; Boiani, Mariana; Pacheco, José Pedro; Basombrío, Miguel Ángel Manuel; Cerecetto, Hugo; González, Mercedes
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
5-Arylethenylbenzofuroxan derivatives with high in vitro anti-Trypanosoma cruzi activity were studied in vivo using acute murine models of Chagas' disease. The selected compounds, as pure isomeric forms, 1, 2, 3 and 4, or as equimolecular mixture of geometric isomers, 1:2, 3:4, 5:6 were studied against different T. cruzi strains. Consequently, Tulahuen 2 strain, Colombiana strain (resistant to Nifurtimox and Benznidazole), and two different wild strains, one isolated from the wild reservoir Didelphis marsupialis and another one from Uruguayan patients, were selected. No relevant signs of in vivo toxicity were observed with the benzofuroxans orally administered. Compound 1 and the mixture of isomers 1:2 were the best for treating infection against the four studied strains.
Fil: Boiani, Lucia. Universidad de la República; Uruguay
Fil: Davies, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Arredondo, Carolina. Universidad de la República; Uruguay
Fil: Porcal, Williams. Universidad de la República; Uruguay
Fil: Merlino, Alicia. Universidad de la República; Uruguay
Fil: Gerpe, Alejandra. Universidad de la República; Uruguay
Fil: Boiani, Mariana. Universidad de la República; Uruguay
Fil: Pacheco, José Pedro. Universidad de la República; Uruguay
Fil: Basombrío, Miguel Ángel Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Cerecetto, Hugo. Universidad de la República; Uruguay
Fil: González, Mercedes. Universidad de la República; Uruguay
Materia
Arylethenylbenzofuroxan
Chagas
In Vivo Studies
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/36728
Acceder
id CONICETDig_8c467265f0cff797ed0d323c3cae9875
oai_identifier_str oai:ri.conicet.gov.ar:11336/36728
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' diseaseBoiani, LuciaDavies, CarolinaArredondo, CarolinaPorcal, WilliamsMerlino, AliciaGerpe, AlejandraBoiani, MarianaPacheco, José PedroBasombrío, Miguel Ángel ManuelCerecetto, HugoGonzález, MercedesArylethenylbenzofuroxanChagasIn Vivo Studieshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/15-Arylethenylbenzofuroxan derivatives with high in vitro anti-Trypanosoma cruzi activity were studied in vivo using acute murine models of Chagas' disease. The selected compounds, as pure isomeric forms, 1, 2, 3 and 4, or as equimolecular mixture of geometric isomers, 1:2, 3:4, 5:6 were studied against different T. cruzi strains. Consequently, Tulahuen 2 strain, Colombiana strain (resistant to Nifurtimox and Benznidazole), and two different wild strains, one isolated from the wild reservoir Didelphis marsupialis and another one from Uruguayan patients, were selected. No relevant signs of in vivo toxicity were observed with the benzofuroxans orally administered. Compound 1 and the mixture of isomers 1:2 were the best for treating infection against the four studied strains.Fil: Boiani, Lucia. Universidad de la República; UruguayFil: Davies, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaFil: Arredondo, Carolina. Universidad de la República; UruguayFil: Porcal, Williams. Universidad de la República; UruguayFil: Merlino, Alicia. Universidad de la República; UruguayFil: Gerpe, Alejandra. Universidad de la República; UruguayFil: Boiani, Mariana. Universidad de la República; UruguayFil: Pacheco, José Pedro. Universidad de la República; UruguayFil: Basombrío, Miguel Ángel Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaFil: Cerecetto, Hugo. Universidad de la República; UruguayFil: González, Mercedes. Universidad de la República; UruguayElsevier2008-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/36728Boiani, Lucia; Davies, Carolina; Arredondo, Carolina; Porcal, Williams; Merlino, Alicia; et al.; In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease; Elsevier; European Journal of Medical Chemistry; 43; 10; 10-2008; 2229-22370223-5234CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejmech.2007.12.016info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0223523407004898info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:37Zoai:ri.conicet.gov.ar:11336/36728instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:38.042CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease
title In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease
spellingShingle In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease
Boiani, Lucia
Arylethenylbenzofuroxan
Chagas
In Vivo Studies
title_short In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease
title_full In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease
title_fullStr In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease
title_full_unstemmed In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease
title_sort In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease
dc.creator.none.fl_str_mv Boiani, Lucia
Davies, Carolina
Arredondo, Carolina
Porcal, Williams
Merlino, Alicia
Gerpe, Alejandra
Boiani, Mariana
Pacheco, José Pedro
Basombrío, Miguel Ángel Manuel
Cerecetto, Hugo
González, Mercedes
author Boiani, Lucia
author_facet Boiani, Lucia
Davies, Carolina
Arredondo, Carolina
Porcal, Williams
Merlino, Alicia
Gerpe, Alejandra
Boiani, Mariana
Pacheco, José Pedro
Basombrío, Miguel Ángel Manuel
Cerecetto, Hugo
González, Mercedes
author_role author
author2 Davies, Carolina
Arredondo, Carolina
Porcal, Williams
Merlino, Alicia
Gerpe, Alejandra
Boiani, Mariana
Pacheco, José Pedro
Basombrío, Miguel Ángel Manuel
Cerecetto, Hugo
González, Mercedes
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Arylethenylbenzofuroxan
Chagas
In Vivo Studies
topic Arylethenylbenzofuroxan
Chagas
In Vivo Studies
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv 5-Arylethenylbenzofuroxan derivatives with high in vitro anti-Trypanosoma cruzi activity were studied in vivo using acute murine models of Chagas' disease. The selected compounds, as pure isomeric forms, 1, 2, 3 and 4, or as equimolecular mixture of geometric isomers, 1:2, 3:4, 5:6 were studied against different T. cruzi strains. Consequently, Tulahuen 2 strain, Colombiana strain (resistant to Nifurtimox and Benznidazole), and two different wild strains, one isolated from the wild reservoir Didelphis marsupialis and another one from Uruguayan patients, were selected. No relevant signs of in vivo toxicity were observed with the benzofuroxans orally administered. Compound 1 and the mixture of isomers 1:2 were the best for treating infection against the four studied strains.
Fil: Boiani, Lucia. Universidad de la República; Uruguay
Fil: Davies, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Arredondo, Carolina. Universidad de la República; Uruguay
Fil: Porcal, Williams. Universidad de la República; Uruguay
Fil: Merlino, Alicia. Universidad de la República; Uruguay
Fil: Gerpe, Alejandra. Universidad de la República; Uruguay
Fil: Boiani, Mariana. Universidad de la República; Uruguay
Fil: Pacheco, José Pedro. Universidad de la República; Uruguay
Fil: Basombrío, Miguel Ángel Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Cerecetto, Hugo. Universidad de la República; Uruguay
Fil: González, Mercedes. Universidad de la República; Uruguay
description 5-Arylethenylbenzofuroxan derivatives with high in vitro anti-Trypanosoma cruzi activity were studied in vivo using acute murine models of Chagas' disease. The selected compounds, as pure isomeric forms, 1, 2, 3 and 4, or as equimolecular mixture of geometric isomers, 1:2, 3:4, 5:6 were studied against different T. cruzi strains. Consequently, Tulahuen 2 strain, Colombiana strain (resistant to Nifurtimox and Benznidazole), and two different wild strains, one isolated from the wild reservoir Didelphis marsupialis and another one from Uruguayan patients, were selected. No relevant signs of in vivo toxicity were observed with the benzofuroxans orally administered. Compound 1 and the mixture of isomers 1:2 were the best for treating infection against the four studied strains.
publishDate 2008
dc.date.none.fl_str_mv 2008-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/36728
Boiani, Lucia; Davies, Carolina; Arredondo, Carolina; Porcal, Williams; Merlino, Alicia; et al.; In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease; Elsevier; European Journal of Medical Chemistry; 43; 10; 10-2008; 2229-2237
0223-5234
CONICET Digital
CONICET
url http://hdl.handle.net/11336/36728
identifier_str_mv Boiani, Lucia; Davies, Carolina; Arredondo, Carolina; Porcal, Williams; Merlino, Alicia; et al.; In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease; Elsevier; European Journal of Medical Chemistry; 43; 10; 10-2008; 2229-2237
0223-5234
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejmech.2007.12.016
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0223523407004898
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613456434561024
score 13.070432

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