New Neurons in the Adult Mammalian Brain: Synaptogenesis and Functional Integration

Autores
Song, Hongjun; Kempermann, Gerd; Overstreet Wadiche, Linda; Zhao, Chunmei; Schinder, Alejandro Fabián; Bischofberger, Josef
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
New neurons are continuously added in the olfactory bulb and dentate gyrus of the hippocampus throughout adult life (Kem- permann and Gage, 1999; Temple and Alvarez-Buylla, 1999; Schinder and Gage, 2004; Lledo and Saghatelyan, 2005; Ming and Song, 2005). This adult form of neurogenesis represents a previ- ously unrecognized structural and functional plasticity in the ma- ture mammalian brain, including in humans. Now it is well es- tablished that adult-born dentate granule cells (DGCs) can functionally integrate into the existing circuitry (Carlen et al., 2002; van Praag et al., 2002; Jessberger and Kempermann, 2003; Schmidt-Hieber et al., 2004). However, little is known about how that occurs and what is the contribution of new DGCs to the overall hippocampal function. Accumulating evidence suggests that adult neurogenesis is involved in many physiological and pathological conditions, such as learning and memory, epilepsy, mental disorders, and degenerative neurological diseases (Ming and Song, 2005). The impact of new neurons on the adult neu- ronal circuitry is determined by their physiological properties and synaptic connectivity. This mini-symposium presented at the 2005 Society for Neuroscience Meeting will provide insight into how newly generated neurons become synaptically inte- grated into the existing circuitry of the adult brain, with emphasis on the physiological properties of newborn DGCs in the hippocampus.
Fil: Song, Hongjun. University Johns Hopkins; Estados Unidos
Fil: Kempermann, Gerd. Max Delbrück Center for Molecular Medicine Berlin Buch; Alemania
Fil: Overstreet Wadiche, Linda. University of Oregon; Estados Unidos
Fil: Zhao, Chunmei. Salk Institute for Biological Studies; Estados Unidos
Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Bischofberger, Josef. University of Freiburg; Alemania
Materia
Neurons
Brain
Synaptogenesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42703
Acceder
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network_name_str CONICET Digital (CONICET)
spelling New Neurons in the Adult Mammalian Brain: Synaptogenesis and Functional IntegrationSong, HongjunKempermann, GerdOverstreet Wadiche, LindaZhao, ChunmeiSchinder, Alejandro FabiánBischofberger, JosefNeuronsBrainSynaptogenesisNew neurons are continuously added in the olfactory bulb and dentate gyrus of the hippocampus throughout adult life (Kem- permann and Gage, 1999; Temple and Alvarez-Buylla, 1999; Schinder and Gage, 2004; Lledo and Saghatelyan, 2005; Ming and Song, 2005). This adult form of neurogenesis represents a previ- ously unrecognized structural and functional plasticity in the ma- ture mammalian brain, including in humans. Now it is well es- tablished that adult-born dentate granule cells (DGCs) can functionally integrate into the existing circuitry (Carlen et al., 2002; van Praag et al., 2002; Jessberger and Kempermann, 2003; Schmidt-Hieber et al., 2004). However, little is known about how that occurs and what is the contribution of new DGCs to the overall hippocampal function. Accumulating evidence suggests that adult neurogenesis is involved in many physiological and pathological conditions, such as learning and memory, epilepsy, mental disorders, and degenerative neurological diseases (Ming and Song, 2005). The impact of new neurons on the adult neu- ronal circuitry is determined by their physiological properties and synaptic connectivity. This mini-symposium presented at the 2005 Society for Neuroscience Meeting will provide insight into how newly generated neurons become synaptically inte- grated into the existing circuitry of the adult brain, with emphasis on the physiological properties of newborn DGCs in the hippocampus.Fil: Song, Hongjun. University Johns Hopkins; Estados UnidosFil: Kempermann, Gerd. Max Delbrück Center for Molecular Medicine Berlin Buch; AlemaniaFil: Overstreet Wadiche, Linda. University of Oregon; Estados UnidosFil: Zhao, Chunmei. Salk Institute for Biological Studies; Estados UnidosFil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Bischofberger, Josef. University of Freiburg; AlemaniaSociety for Neuroscience2005-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42703Song, Hongjun; Kempermann, Gerd; Overstreet Wadiche, Linda; Zhao, Chunmei; Schinder, Alejandro Fabián; et al.; New Neurons in the Adult Mammalian Brain: Synaptogenesis and Functional Integration; Society for Neuroscience; Journal of Neuroscience; 25; 45; 11-2005; 10366-103680270-64741529-2401CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/25/45/10366.longinfo:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.3452-05.2005info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:20Zoai:ri.conicet.gov.ar:11336/42703instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:21.129CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv New Neurons in the Adult Mammalian Brain: Synaptogenesis and Functional Integration
title New Neurons in the Adult Mammalian Brain: Synaptogenesis and Functional Integration
spellingShingle New Neurons in the Adult Mammalian Brain: Synaptogenesis and Functional Integration
Song, Hongjun
Neurons
Brain
Synaptogenesis
title_short New Neurons in the Adult Mammalian Brain: Synaptogenesis and Functional Integration
title_full New Neurons in the Adult Mammalian Brain: Synaptogenesis and Functional Integration
title_fullStr New Neurons in the Adult Mammalian Brain: Synaptogenesis and Functional Integration
title_full_unstemmed New Neurons in the Adult Mammalian Brain: Synaptogenesis and Functional Integration
title_sort New Neurons in the Adult Mammalian Brain: Synaptogenesis and Functional Integration
dc.creator.none.fl_str_mv Song, Hongjun
Kempermann, Gerd
Overstreet Wadiche, Linda
Zhao, Chunmei
Schinder, Alejandro Fabián
Bischofberger, Josef
author Song, Hongjun
author_facet Song, Hongjun
Kempermann, Gerd
Overstreet Wadiche, Linda
Zhao, Chunmei
Schinder, Alejandro Fabián
Bischofberger, Josef
author_role author
author2 Kempermann, Gerd
Overstreet Wadiche, Linda
Zhao, Chunmei
Schinder, Alejandro Fabián
Bischofberger, Josef
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Neurons
Brain
Synaptogenesis
topic Neurons
Brain
Synaptogenesis
dc.description.none.fl_txt_mv New neurons are continuously added in the olfactory bulb and dentate gyrus of the hippocampus throughout adult life (Kem- permann and Gage, 1999; Temple and Alvarez-Buylla, 1999; Schinder and Gage, 2004; Lledo and Saghatelyan, 2005; Ming and Song, 2005). This adult form of neurogenesis represents a previ- ously unrecognized structural and functional plasticity in the ma- ture mammalian brain, including in humans. Now it is well es- tablished that adult-born dentate granule cells (DGCs) can functionally integrate into the existing circuitry (Carlen et al., 2002; van Praag et al., 2002; Jessberger and Kempermann, 2003; Schmidt-Hieber et al., 2004). However, little is known about how that occurs and what is the contribution of new DGCs to the overall hippocampal function. Accumulating evidence suggests that adult neurogenesis is involved in many physiological and pathological conditions, such as learning and memory, epilepsy, mental disorders, and degenerative neurological diseases (Ming and Song, 2005). The impact of new neurons on the adult neu- ronal circuitry is determined by their physiological properties and synaptic connectivity. This mini-symposium presented at the 2005 Society for Neuroscience Meeting will provide insight into how newly generated neurons become synaptically inte- grated into the existing circuitry of the adult brain, with emphasis on the physiological properties of newborn DGCs in the hippocampus.
Fil: Song, Hongjun. University Johns Hopkins; Estados Unidos
Fil: Kempermann, Gerd. Max Delbrück Center for Molecular Medicine Berlin Buch; Alemania
Fil: Overstreet Wadiche, Linda. University of Oregon; Estados Unidos
Fil: Zhao, Chunmei. Salk Institute for Biological Studies; Estados Unidos
Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Bischofberger, Josef. University of Freiburg; Alemania
description New neurons are continuously added in the olfactory bulb and dentate gyrus of the hippocampus throughout adult life (Kem- permann and Gage, 1999; Temple and Alvarez-Buylla, 1999; Schinder and Gage, 2004; Lledo and Saghatelyan, 2005; Ming and Song, 2005). This adult form of neurogenesis represents a previ- ously unrecognized structural and functional plasticity in the ma- ture mammalian brain, including in humans. Now it is well es- tablished that adult-born dentate granule cells (DGCs) can functionally integrate into the existing circuitry (Carlen et al., 2002; van Praag et al., 2002; Jessberger and Kempermann, 2003; Schmidt-Hieber et al., 2004). However, little is known about how that occurs and what is the contribution of new DGCs to the overall hippocampal function. Accumulating evidence suggests that adult neurogenesis is involved in many physiological and pathological conditions, such as learning and memory, epilepsy, mental disorders, and degenerative neurological diseases (Ming and Song, 2005). The impact of new neurons on the adult neu- ronal circuitry is determined by their physiological properties and synaptic connectivity. This mini-symposium presented at the 2005 Society for Neuroscience Meeting will provide insight into how newly generated neurons become synaptically inte- grated into the existing circuitry of the adult brain, with emphasis on the physiological properties of newborn DGCs in the hippocampus.
publishDate 2005
dc.date.none.fl_str_mv 2005-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42703
Song, Hongjun; Kempermann, Gerd; Overstreet Wadiche, Linda; Zhao, Chunmei; Schinder, Alejandro Fabián; et al.; New Neurons in the Adult Mammalian Brain: Synaptogenesis and Functional Integration; Society for Neuroscience; Journal of Neuroscience; 25; 45; 11-2005; 10366-10368
0270-6474
1529-2401
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42703
identifier_str_mv Song, Hongjun; Kempermann, Gerd; Overstreet Wadiche, Linda; Zhao, Chunmei; Schinder, Alejandro Fabián; et al.; New Neurons in the Adult Mammalian Brain: Synaptogenesis and Functional Integration; Society for Neuroscience; Journal of Neuroscience; 25; 45; 11-2005; 10366-10368
0270-6474
1529-2401
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/25/45/10366.long
info:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.3452-05.2005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270154456563712
score 13.13397

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