The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution

Autores
Bovine Genome Sequencing and Analysis Consortium; Amadio, Ariel Fernando; Poli, Mario Andres
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
Fil: Bovine Genome Sequencing and Analysis Consortium. Bovine Genome Sequencing And Analysis Consortium; Estados Unidos
Fil: Amadio, Ariel Fernando. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Genética; Argentina
Materia
Bos taurus
Genome
Evolution
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/102238
Acceder
id CONICETDig_8ba657b2a46efdc4d21df4353fb09ffa
oai_identifier_str oai:ri.conicet.gov.ar:11336/102238
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and EvolutionBovine Genome Sequencing and Analysis ConsortiumAmadio, Ariel FernandoPoli, Mario AndresBos taurusGenomeEvolutionhttps://purl.org/becyt/ford/4.4https://purl.org/becyt/ford/4https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.Fil: Bovine Genome Sequencing and Analysis Consortium. Bovine Genome Sequencing And Analysis Consortium; Estados UnidosFil: Amadio, Ariel Fernando. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Genética; ArgentinaAmerican Association for the Advancement of Science2009-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/102238Bovine Genome Sequencing and Analysis Consortium ; Amadio, Ariel Fernando; Poli, Mario Andres; The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution; American Association for the Advancement of Science; Science; 324; 5926; 4-2009; 522-5280036-8075CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencemag.org/content/324/5926/522info:eu-repo/semantics/altIdentifier/doi/10.1126/science.1169588info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:36Zoai:ri.conicet.gov.ar:11336/102238instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:36.585CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution
title The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution
spellingShingle The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution
Bovine Genome Sequencing and Analysis Consortium
Bos taurus
Genome
Evolution
title_short The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution
title_full The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution
title_fullStr The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution
title_full_unstemmed The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution
title_sort The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution
dc.creator.none.fl_str_mv Bovine Genome Sequencing and Analysis Consortium
Amadio, Ariel Fernando
Poli, Mario Andres
author Bovine Genome Sequencing and Analysis Consortium
author_facet Bovine Genome Sequencing and Analysis Consortium
Amadio, Ariel Fernando
Poli, Mario Andres
author_role author
author2 Amadio, Ariel Fernando
Poli, Mario Andres
author2_role author
author
dc.subject.none.fl_str_mv Bos taurus
Genome
Evolution
topic Bos taurus
Genome
Evolution
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.4
https://purl.org/becyt/ford/4
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
Fil: Bovine Genome Sequencing and Analysis Consortium. Bovine Genome Sequencing And Analysis Consortium; Estados Unidos
Fil: Amadio, Ariel Fernando. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Genética; Argentina
description To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
publishDate 2009
dc.date.none.fl_str_mv 2009-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/102238
Bovine Genome Sequencing and Analysis Consortium ; Amadio, Ariel Fernando; Poli, Mario Andres; The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution; American Association for the Advancement of Science; Science; 324; 5926; 4-2009; 522-528
0036-8075
CONICET Digital
CONICET
url http://hdl.handle.net/11336/102238
identifier_str_mv Bovine Genome Sequencing and Analysis Consortium ; Amadio, Ariel Fernando; Poli, Mario Andres; The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution; American Association for the Advancement of Science; Science; 324; 5926; 4-2009; 522-528
0036-8075
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencemag.org/content/324/5926/522
info:eu-repo/semantics/altIdentifier/doi/10.1126/science.1169588
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for the Advancement of Science
publisher.none.fl_str_mv American Association for the Advancement of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269918877188096
score 13.13397

Publicaciones similares