Histological evolution of the effects of bee venom on squamous cell carcinoma of the tongue

Autores
Zavala, Walther; Foscolo, Mabel Rosa
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bee venom (apitoxin) composition contains numerous biologically active peptides, including melittin (main component), apamin, peptide mast cell degranulation and enzymes and non-peptide components such as histamine. While the effect of bee venom, according to the literature, would be beneficial in rheumatic diseases, evidence of its action on tumor pathology is inconclusive. In this paper, the potential chemopreventive effect of apitoxin on tumor lesions of the tongue was studied. Materials and Methods: Two groups of rats were used. Both groups were subjected to the carcinogenic action of 4-NQO. One group served as a control, and the other group (experimental) received subcutaneous bee venom that was applied weekly. The incidence of dysplastic lesions and tongue squamous cell carcinoma (TSCC) in both groups was determined microscopically. In addition, peritumoral mast cell density was determined at 30 weeks of exposure to a carcinogen. Results: The results showed no significant reduction in the incidence of TSCC. The peritumoral mast cell density found in dysplastic lesions and TSCC was lower than in the normal tongue tissue. Conclusions: The findings of this study indicate poor action of bee venom as a preventive drug in the emergence of TSCC. The lack of recruitment of mast cells indicates that every tumor is influenced by its particular microenvironment.
Fil: Zavala, Walther. Universidad Nacional de Cuyo. Facultad de Odontología; Argentina
Fil: Foscolo, Mabel Rosa. Universidad Nacional de Cuyo. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Materia
Apitoxin
Tongue
Oral cancer
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/49394
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/49394
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Histological evolution of the effects of bee venom on squamous cell carcinoma of the tongueZavala, WaltherFoscolo, Mabel RosaApitoxinTongueOral cancerhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Bee venom (apitoxin) composition contains numerous biologically active peptides, including melittin (main component), apamin, peptide mast cell degranulation and enzymes and non-peptide components such as histamine. While the effect of bee venom, according to the literature, would be beneficial in rheumatic diseases, evidence of its action on tumor pathology is inconclusive. In this paper, the potential chemopreventive effect of apitoxin on tumor lesions of the tongue was studied. Materials and Methods: Two groups of rats were used. Both groups were subjected to the carcinogenic action of 4-NQO. One group served as a control, and the other group (experimental) received subcutaneous bee venom that was applied weekly. The incidence of dysplastic lesions and tongue squamous cell carcinoma (TSCC) in both groups was determined microscopically. In addition, peritumoral mast cell density was determined at 30 weeks of exposure to a carcinogen. Results: The results showed no significant reduction in the incidence of TSCC. The peritumoral mast cell density found in dysplastic lesions and TSCC was lower than in the normal tongue tissue. Conclusions: The findings of this study indicate poor action of bee venom as a preventive drug in the emergence of TSCC. The lack of recruitment of mast cells indicates that every tumor is influenced by its particular microenvironment.Fil: Zavala, Walther. Universidad Nacional de Cuyo. Facultad de Odontología; ArgentinaFil: Foscolo, Mabel Rosa. Universidad Nacional de Cuyo. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaHuman Journals2016-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/49394Zavala, Walther; Foscolo, Mabel Rosa; Histological evolution of the effects of bee venom on squamous cell carcinoma of the tongue; Human Journals; International Journal of Science and Research Methodology; 4; 1; 7-2016; 14-232454-2008CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://ijsrm.humanjournals.com/histological-evaluation-of-the-effect-of-bee-venom-on-squamous-cell-carcinoma-of-the-tongue/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:29:22Zoai:ri.conicet.gov.ar:11336/49394instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:29:22.969CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Histological evolution of the effects of bee venom on squamous cell carcinoma of the tongue
title Histological evolution of the effects of bee venom on squamous cell carcinoma of the tongue
spellingShingle Histological evolution of the effects of bee venom on squamous cell carcinoma of the tongue
Zavala, Walther
Apitoxin
Tongue
Oral cancer
title_short Histological evolution of the effects of bee venom on squamous cell carcinoma of the tongue
title_full Histological evolution of the effects of bee venom on squamous cell carcinoma of the tongue
title_fullStr Histological evolution of the effects of bee venom on squamous cell carcinoma of the tongue
title_full_unstemmed Histological evolution of the effects of bee venom on squamous cell carcinoma of the tongue
title_sort Histological evolution of the effects of bee venom on squamous cell carcinoma of the tongue
dc.creator.none.fl_str_mv Zavala, Walther
Foscolo, Mabel Rosa
author Zavala, Walther
author_facet Zavala, Walther
Foscolo, Mabel Rosa
author_role author
author2 Foscolo, Mabel Rosa
author2_role author
dc.subject.none.fl_str_mv Apitoxin
Tongue
Oral cancer
topic Apitoxin
Tongue
Oral cancer
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Bee venom (apitoxin) composition contains numerous biologically active peptides, including melittin (main component), apamin, peptide mast cell degranulation and enzymes and non-peptide components such as histamine. While the effect of bee venom, according to the literature, would be beneficial in rheumatic diseases, evidence of its action on tumor pathology is inconclusive. In this paper, the potential chemopreventive effect of apitoxin on tumor lesions of the tongue was studied. Materials and Methods: Two groups of rats were used. Both groups were subjected to the carcinogenic action of 4-NQO. One group served as a control, and the other group (experimental) received subcutaneous bee venom that was applied weekly. The incidence of dysplastic lesions and tongue squamous cell carcinoma (TSCC) in both groups was determined microscopically. In addition, peritumoral mast cell density was determined at 30 weeks of exposure to a carcinogen. Results: The results showed no significant reduction in the incidence of TSCC. The peritumoral mast cell density found in dysplastic lesions and TSCC was lower than in the normal tongue tissue. Conclusions: The findings of this study indicate poor action of bee venom as a preventive drug in the emergence of TSCC. The lack of recruitment of mast cells indicates that every tumor is influenced by its particular microenvironment.
Fil: Zavala, Walther. Universidad Nacional de Cuyo. Facultad de Odontología; Argentina
Fil: Foscolo, Mabel Rosa. Universidad Nacional de Cuyo. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
description Bee venom (apitoxin) composition contains numerous biologically active peptides, including melittin (main component), apamin, peptide mast cell degranulation and enzymes and non-peptide components such as histamine. While the effect of bee venom, according to the literature, would be beneficial in rheumatic diseases, evidence of its action on tumor pathology is inconclusive. In this paper, the potential chemopreventive effect of apitoxin on tumor lesions of the tongue was studied. Materials and Methods: Two groups of rats were used. Both groups were subjected to the carcinogenic action of 4-NQO. One group served as a control, and the other group (experimental) received subcutaneous bee venom that was applied weekly. The incidence of dysplastic lesions and tongue squamous cell carcinoma (TSCC) in both groups was determined microscopically. In addition, peritumoral mast cell density was determined at 30 weeks of exposure to a carcinogen. Results: The results showed no significant reduction in the incidence of TSCC. The peritumoral mast cell density found in dysplastic lesions and TSCC was lower than in the normal tongue tissue. Conclusions: The findings of this study indicate poor action of bee venom as a preventive drug in the emergence of TSCC. The lack of recruitment of mast cells indicates that every tumor is influenced by its particular microenvironment.
publishDate 2016
dc.date.none.fl_str_mv 2016-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/49394
Zavala, Walther; Foscolo, Mabel Rosa; Histological evolution of the effects of bee venom on squamous cell carcinoma of the tongue; Human Journals; International Journal of Science and Research Methodology; 4; 1; 7-2016; 14-23
2454-2008
CONICET Digital
CONICET
url http://hdl.handle.net/11336/49394
identifier_str_mv Zavala, Walther; Foscolo, Mabel Rosa; Histological evolution of the effects of bee venom on squamous cell carcinoma of the tongue; Human Journals; International Journal of Science and Research Methodology; 4; 1; 7-2016; 14-23
2454-2008
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://ijsrm.humanjournals.com/histological-evaluation-of-the-effect-of-bee-venom-on-squamous-cell-carcinoma-of-the-tongue/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Human Journals
publisher.none.fl_str_mv Human Journals
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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