Onset Age and Clinical Heterogeneity of Dementias: A Diagnostic and Therapeutic Approach

Autores
Serrano, Cecilia M.; Dillon, Carol; Heisecke Peralta, Silvina Lidia; Castro, Diego M.; Pérez Leguizamón, Patricio; Allegri, Ricardo Francisco; Taragano, Fernando Emilio
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Frontotemporal dementia (FTD) is the main differential diagnosis with early stages of Alzheimer’s disease (AD). Usually, differential diagnosis between a first depressive episode and the beginning of an early degenerative dementia with mood disorders, either AD or FTD, can be difficult. Objective: To evaluate the clinical characteristics of patients with senile and presenile onset dementia, to compare their neuropsychiatric and neuropsychological profiles according to onset age and to provide clinical approach. Methods: A two year prospective-retrospective study was conducted. All patients were evaluated with a complete neuropsychiatric and neuropsychological battery, laboratory tests and neuroimaging. Healthy control subjects were also studied. Results: Included 366 subjects were divided into over or under 65 years old, and then matched for educational level. AD was the most common cause of dementia in subjects over 65 years of age, followed by depression and FTD. Subjects younger than 65 years old, showed higher prevalence of depression followed by FTD, AD, and finally primary progressive aphasia (PPA). At younger ages, the highest severity of cognitive impairment, behavioral disorder and major depression were observed. Conclusion: Onset age of cognitive and/or behavioral impairment may be one of the variables influencing the clinical heterogeneity of dementias. Many of the young-onset dementias may be potentially reversible so, its early identification and pathophysiology understand, increase pharmacological intervention opportunities of halting the cascade of events that lead inexorably to dementia. In the new era of biomarkers, their help in identifying each clinical phenotype could encourage their best use in clinical practice and help selecting more accurate pharmacological treatment.
Fil: Serrano, Cecilia M.. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
Fil: Dillon, Carol. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Heisecke Peralta, Silvina Lidia. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Castro, Diego M.. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
Fil: Pérez Leguizamón, Patricio. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
Fil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Taragano, Fernando Emilio. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Alzheimer
Depression
Frontotemporal Dementia
Onset Age Primary Aphasia
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/35650
Acceder
id CONICETDig_8b90d4c156e9a13b87eee232fbf44a3f
oai_identifier_str oai:ri.conicet.gov.ar:11336/35650
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Onset Age and Clinical Heterogeneity of Dementias: A Diagnostic and Therapeutic ApproachSerrano, Cecilia M.Dillon, CarolHeisecke Peralta, Silvina LidiaCastro, Diego M.Pérez Leguizamón, PatricioAllegri, Ricardo FranciscoTaragano, Fernando EmilioAlzheimerDepressionFrontotemporal DementiaOnset Age Primary Aphasiahttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Frontotemporal dementia (FTD) is the main differential diagnosis with early stages of Alzheimer’s disease (AD). Usually, differential diagnosis between a first depressive episode and the beginning of an early degenerative dementia with mood disorders, either AD or FTD, can be difficult. Objective: To evaluate the clinical characteristics of patients with senile and presenile onset dementia, to compare their neuropsychiatric and neuropsychological profiles according to onset age and to provide clinical approach. Methods: A two year prospective-retrospective study was conducted. All patients were evaluated with a complete neuropsychiatric and neuropsychological battery, laboratory tests and neuroimaging. Healthy control subjects were also studied. Results: Included 366 subjects were divided into over or under 65 years old, and then matched for educational level. AD was the most common cause of dementia in subjects over 65 years of age, followed by depression and FTD. Subjects younger than 65 years old, showed higher prevalence of depression followed by FTD, AD, and finally primary progressive aphasia (PPA). At younger ages, the highest severity of cognitive impairment, behavioral disorder and major depression were observed. Conclusion: Onset age of cognitive and/or behavioral impairment may be one of the variables influencing the clinical heterogeneity of dementias. Many of the young-onset dementias may be potentially reversible so, its early identification and pathophysiology understand, increase pharmacological intervention opportunities of halting the cascade of events that lead inexorably to dementia. In the new era of biomarkers, their help in identifying each clinical phenotype could encourage their best use in clinical practice and help selecting more accurate pharmacological treatment.Fil: Serrano, Cecilia M.. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; ArgentinaFil: Dillon, Carol. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Heisecke Peralta, Silvina Lidia. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Castro, Diego M.. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; ArgentinaFil: Pérez Leguizamón, Patricio. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; ArgentinaFil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Taragano, Fernando Emilio. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaBentham Science2014-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/35650Serrano, Cecilia M.; Dillon, Carol; Heisecke Peralta, Silvina Lidia; Castro, Diego M.; Pérez Leguizamón, Patricio; et al.; Onset Age and Clinical Heterogeneity of Dementias: A Diagnostic and Therapeutic Approach; Bentham Science; Current Psychopharmocology; 3; 1; 6-2014; 2-172211-5579CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2174/2211556003666140703152048info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/123124/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:21:58Zoai:ri.conicet.gov.ar:11336/35650instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:21:58.605CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Onset Age and Clinical Heterogeneity of Dementias: A Diagnostic and Therapeutic Approach
title Onset Age and Clinical Heterogeneity of Dementias: A Diagnostic and Therapeutic Approach
spellingShingle Onset Age and Clinical Heterogeneity of Dementias: A Diagnostic and Therapeutic Approach
Serrano, Cecilia M.
Alzheimer
Depression
Frontotemporal Dementia
Onset Age Primary Aphasia
title_short Onset Age and Clinical Heterogeneity of Dementias: A Diagnostic and Therapeutic Approach
title_full Onset Age and Clinical Heterogeneity of Dementias: A Diagnostic and Therapeutic Approach
title_fullStr Onset Age and Clinical Heterogeneity of Dementias: A Diagnostic and Therapeutic Approach
title_full_unstemmed Onset Age and Clinical Heterogeneity of Dementias: A Diagnostic and Therapeutic Approach
title_sort Onset Age and Clinical Heterogeneity of Dementias: A Diagnostic and Therapeutic Approach
dc.creator.none.fl_str_mv Serrano, Cecilia M.
Dillon, Carol
Heisecke Peralta, Silvina Lidia
Castro, Diego M.
Pérez Leguizamón, Patricio
Allegri, Ricardo Francisco
Taragano, Fernando Emilio
author Serrano, Cecilia M.
author_facet Serrano, Cecilia M.
Dillon, Carol
Heisecke Peralta, Silvina Lidia
Castro, Diego M.
Pérez Leguizamón, Patricio
Allegri, Ricardo Francisco
Taragano, Fernando Emilio
author_role author
author2 Dillon, Carol
Heisecke Peralta, Silvina Lidia
Castro, Diego M.
Pérez Leguizamón, Patricio
Allegri, Ricardo Francisco
Taragano, Fernando Emilio
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Alzheimer
Depression
Frontotemporal Dementia
Onset Age Primary Aphasia
topic Alzheimer
Depression
Frontotemporal Dementia
Onset Age Primary Aphasia
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Frontotemporal dementia (FTD) is the main differential diagnosis with early stages of Alzheimer’s disease (AD). Usually, differential diagnosis between a first depressive episode and the beginning of an early degenerative dementia with mood disorders, either AD or FTD, can be difficult. Objective: To evaluate the clinical characteristics of patients with senile and presenile onset dementia, to compare their neuropsychiatric and neuropsychological profiles according to onset age and to provide clinical approach. Methods: A two year prospective-retrospective study was conducted. All patients were evaluated with a complete neuropsychiatric and neuropsychological battery, laboratory tests and neuroimaging. Healthy control subjects were also studied. Results: Included 366 subjects were divided into over or under 65 years old, and then matched for educational level. AD was the most common cause of dementia in subjects over 65 years of age, followed by depression and FTD. Subjects younger than 65 years old, showed higher prevalence of depression followed by FTD, AD, and finally primary progressive aphasia (PPA). At younger ages, the highest severity of cognitive impairment, behavioral disorder and major depression were observed. Conclusion: Onset age of cognitive and/or behavioral impairment may be one of the variables influencing the clinical heterogeneity of dementias. Many of the young-onset dementias may be potentially reversible so, its early identification and pathophysiology understand, increase pharmacological intervention opportunities of halting the cascade of events that lead inexorably to dementia. In the new era of biomarkers, their help in identifying each clinical phenotype could encourage their best use in clinical practice and help selecting more accurate pharmacological treatment.
Fil: Serrano, Cecilia M.. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
Fil: Dillon, Carol. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Heisecke Peralta, Silvina Lidia. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Castro, Diego M.. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
Fil: Pérez Leguizamón, Patricio. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
Fil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Taragano, Fernando Emilio. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Frontotemporal dementia (FTD) is the main differential diagnosis with early stages of Alzheimer’s disease (AD). Usually, differential diagnosis between a first depressive episode and the beginning of an early degenerative dementia with mood disorders, either AD or FTD, can be difficult. Objective: To evaluate the clinical characteristics of patients with senile and presenile onset dementia, to compare their neuropsychiatric and neuropsychological profiles according to onset age and to provide clinical approach. Methods: A two year prospective-retrospective study was conducted. All patients were evaluated with a complete neuropsychiatric and neuropsychological battery, laboratory tests and neuroimaging. Healthy control subjects were also studied. Results: Included 366 subjects were divided into over or under 65 years old, and then matched for educational level. AD was the most common cause of dementia in subjects over 65 years of age, followed by depression and FTD. Subjects younger than 65 years old, showed higher prevalence of depression followed by FTD, AD, and finally primary progressive aphasia (PPA). At younger ages, the highest severity of cognitive impairment, behavioral disorder and major depression were observed. Conclusion: Onset age of cognitive and/or behavioral impairment may be one of the variables influencing the clinical heterogeneity of dementias. Many of the young-onset dementias may be potentially reversible so, its early identification and pathophysiology understand, increase pharmacological intervention opportunities of halting the cascade of events that lead inexorably to dementia. In the new era of biomarkers, their help in identifying each clinical phenotype could encourage their best use in clinical practice and help selecting more accurate pharmacological treatment.
publishDate 2014
dc.date.none.fl_str_mv 2014-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/35650
Serrano, Cecilia M.; Dillon, Carol; Heisecke Peralta, Silvina Lidia; Castro, Diego M.; Pérez Leguizamón, Patricio; et al.; Onset Age and Clinical Heterogeneity of Dementias: A Diagnostic and Therapeutic Approach; Bentham Science; Current Psychopharmocology; 3; 1; 6-2014; 2-17
2211-5579
CONICET Digital
CONICET
url http://hdl.handle.net/11336/35650
identifier_str_mv Serrano, Cecilia M.; Dillon, Carol; Heisecke Peralta, Silvina Lidia; Castro, Diego M.; Pérez Leguizamón, Patricio; et al.; Onset Age and Clinical Heterogeneity of Dementias: A Diagnostic and Therapeutic Approach; Bentham Science; Current Psychopharmocology; 3; 1; 6-2014; 2-17
2211-5579
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2174/2211556003666140703152048
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/123124/article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science
publisher.none.fl_str_mv Bentham Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981209049661440
score 12.48226

Publicaciones similares