Progression to degenerative dementia in mild cognitive impairment patients: a cohort study

Autores
Feldberg, Carolina; Feldberg, Carolina; Stefani, Dorina; Stefani, Dorina; Tartaglini, Maria Florencia; Tartaglini, Maria Florencia; Hermida, Paula Daniela; Hermida, Paula Daniela; Caruso, Diego; Caruso, Diego; Somale, María Verónica; Somale, María Verónica; Allegri, Ricardo Francisco; Allegri, Ricardo Francisco
Año de publicación
2019
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Background: Mild cognitive impairment (MCI) is a controversial clinical entity, conceptualized as a transitional zone between normal aging and dementia. Socio-demographic and genetic factors have been involved in the development of cognitive impairment and its progression to dementia. The aim of the present study is to describe the rate of conversion to dementia in a cohort of patients with mild cognitive impairment.Method: Design Prospective cohort. Setting: A cohort of subjects with MCI was assessed and followed for three years (2013-2015) in a private institution dedicated to neurology. Participants: Patients with cognitive complaints over 60 years old who consulted spontaneously and met the MCI criteria without commitment in activities of daily living, were included consecutively and followed up annually for 3 years. Variables: Dementia and MCI were defined according to DSM IV criteria. Statistical methods we describe conversion rate as a proportion with confidence interval (CI) 95%. Bivariate analysis was performed between dementia and sociodemographic predictors and Odds Ratio and CI was calculatedResults: We include 82 subjects with MCI (age: 76.6±6.9 years, 67% women, education: 11.5±3.7 years) 4 participants were lost to follow-up. The conversion rate to dementia was 14.1% (CI95% 7.7 to 23.2) In the bivariate analysis we compared the median baseline IQ of the patients who developed dementia (97; IQR 89-103) and those who did not (93; IQR 85-95) and we obtained a significant difference with a p = 0.040Conclusions: The conversion rate to dementia in this Latin American population is coincident with studies conducted in other populations. A larger sample size is required to establish the possible predictors of conversion to dementia.
Background: Mild cognitive impairment (MCI) is a controversial clinical entity, conceptualized as a transitional zone between normal aging and dementia. Socio-demographic and genetic factors have been involved in the development of cognitive impairment and its progression to dementia. The aim of the present study is to describe the rate of conversion to dementia in a cohort of patients with mild cognitive impairment.Method: Design Prospective cohort. Setting: A cohort of subjects with MCI was assessed and followed for three years (2013-2015) in a private institution dedicated to neurology. Participants: Patients with cognitive complaints over 60 years old who consulted spontaneously and met the MCI criteria without commitment in activities of daily living, were included consecutively and followed up annually for 3 years. Variables: Dementia and MCI were defined according to DSM IV criteria. Statistical methods we describe conversion rate as a proportion with confidence interval (CI) 95%. Bivariate analysis was performed between dementia and sociodemographic predictors and Odds Ratio and CI was calculatedResults: We include 82 subjects with MCI (age: 76.6±6.9 years, 67% women, education: 11.5±3.7 years) 4 participants were lost to follow-up. The conversion rate to dementia was 14.1% (CI95% 7.7 to 23.2) In the bivariate analysis we compared the median baseline IQ of the patients who developed dementia (97; IQR 89-103) and those who did not (93; IQR 85-95) and we obtained a significant difference with a p = 0.040Conclusions: The conversion rate to dementia in this Latin American population is coincident with studies conducted in other populations. A larger sample size is required to establish the possible predictors of conversion to dementia.
Fil: Feldberg, Carolina. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Feldberg, Carolina. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Stefani, Dorina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Stefani, Dorina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Tartaglini, Maria Florencia. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tartaglini, Maria Florencia. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Hermida, Paula Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Hermida, Paula Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Caruso, Diego. Hospital General de Agudos Cesar Milstein; Argentina
Fil: Caruso, Diego. Hospital General de Agudos Cesar Milstein; Argentina
Fil: Somale, María Verónica. Instituto de Neurociencias Buenos Aires S. A.; Argentina
Fil: Somale, María Verónica. Instituto de Neurociencias Buenos Aires S. A.; Argentina
Fil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Alzheimer´s Association International Conference
Los Angeles
Estados Unidos
Alzheimer´s Association
Alzheimer´s Association
Materia
ACTIVITIES OF DAILY LIVING
ACTIVITIES OF DAILY LIVING
DEMENTIA
DEMENTIA
MILD COGNITIVE IMPAIRMENT
MILD COGNITIVE IMPAIRMENT
RISK FACTORS
RISK FACTORS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/130218
Acceder
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spelling Progression to degenerative dementia in mild cognitive impairment patients: a cohort studyProgression to degenerative dementia in mild cognitive impairment patients: a cohort studyFeldberg, CarolinaFeldberg, CarolinaStefani, DorinaStefani, DorinaTartaglini, Maria FlorenciaTartaglini, Maria FlorenciaHermida, Paula DanielaHermida, Paula DanielaCaruso, DiegoCaruso, DiegoSomale, María VerónicaSomale, María VerónicaAllegri, Ricardo FranciscoAllegri, Ricardo FranciscoACTIVITIES OF DAILY LIVINGACTIVITIES OF DAILY LIVINGDEMENTIADEMENTIAMILD COGNITIVE IMPAIRMENTMILD COGNITIVE IMPAIRMENTRISK FACTORSRISK FACTORShttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Background: Mild cognitive impairment (MCI) is a controversial clinical entity, conceptualized as a transitional zone between normal aging and dementia. Socio-demographic and genetic factors have been involved in the development of cognitive impairment and its progression to dementia. The aim of the present study is to describe the rate of conversion to dementia in a cohort of patients with mild cognitive impairment.Method: Design Prospective cohort. Setting: A cohort of subjects with MCI was assessed and followed for three years (2013-2015) in a private institution dedicated to neurology. Participants: Patients with cognitive complaints over 60 years old who consulted spontaneously and met the MCI criteria without commitment in activities of daily living, were included consecutively and followed up annually for 3 years. Variables: Dementia and MCI were defined according to DSM IV criteria. Statistical methods we describe conversion rate as a proportion with confidence interval (CI) 95%. Bivariate analysis was performed between dementia and sociodemographic predictors and Odds Ratio and CI was calculatedResults: We include 82 subjects with MCI (age: 76.6±6.9 years, 67% women, education: 11.5±3.7 years) 4 participants were lost to follow-up. The conversion rate to dementia was 14.1% (CI95% 7.7 to 23.2) In the bivariate analysis we compared the median baseline IQ of the patients who developed dementia (97; IQR 89-103) and those who did not (93; IQR 85-95) and we obtained a significant difference with a p = 0.040Conclusions: The conversion rate to dementia in this Latin American population is coincident with studies conducted in other populations. A larger sample size is required to establish the possible predictors of conversion to dementia.Background: Mild cognitive impairment (MCI) is a controversial clinical entity, conceptualized as a transitional zone between normal aging and dementia. Socio-demographic and genetic factors have been involved in the development of cognitive impairment and its progression to dementia. The aim of the present study is to describe the rate of conversion to dementia in a cohort of patients with mild cognitive impairment.Method: Design Prospective cohort. Setting: A cohort of subjects with MCI was assessed and followed for three years (2013-2015) in a private institution dedicated to neurology. Participants: Patients with cognitive complaints over 60 years old who consulted spontaneously and met the MCI criteria without commitment in activities of daily living, were included consecutively and followed up annually for 3 years. Variables: Dementia and MCI were defined according to DSM IV criteria. Statistical methods we describe conversion rate as a proportion with confidence interval (CI) 95%. Bivariate analysis was performed between dementia and sociodemographic predictors and Odds Ratio and CI was calculatedResults: We include 82 subjects with MCI (age: 76.6±6.9 years, 67% women, education: 11.5±3.7 years) 4 participants were lost to follow-up. The conversion rate to dementia was 14.1% (CI95% 7.7 to 23.2) In the bivariate analysis we compared the median baseline IQ of the patients who developed dementia (97; IQR 89-103) and those who did not (93; IQR 85-95) and we obtained a significant difference with a p = 0.040Conclusions: The conversion rate to dementia in this Latin American population is coincident with studies conducted in other populations. A larger sample size is required to establish the possible predictors of conversion to dementia.Fil: Feldberg, Carolina. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Feldberg, Carolina. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Stefani, Dorina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Stefani, Dorina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Tartaglini, Maria Florencia. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tartaglini, Maria Florencia. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Hermida, Paula Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Hermida, Paula Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Caruso, Diego. Hospital General de Agudos Cesar Milstein; ArgentinaFil: Caruso, Diego. Hospital General de Agudos Cesar Milstein; ArgentinaFil: Somale, María Verónica. Instituto de Neurociencias Buenos Aires S. A.; ArgentinaFil: Somale, María Verónica. Instituto de Neurociencias Buenos Aires S. A.; ArgentinaFil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAlzheimer´s Association International ConferenceLos AngelesEstados UnidosAlzheimer´s AssociationAlzheimer´s AssociationWiley2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectConferenciaJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/130218Progression to degenerative dementia in mild cognitive impairment patients: a cohort study; Alzheimer´s Association International Conference; Los Angeles; Estados Unidos; 2019; P816-P8161552-5279CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://alz-journals.onlinelibrary.wiley.com/doi/10.1016/j.jalz.2019.06.2926info:eu-repo/semantics/altIdentifier/url/https://alz-journals.onlinelibrary.wiley.com/doi/10.1016/j.jalz.2019.06.2926info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1016/j.jalz.2019.06.2926info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1016/j.jalz.2019.06.2926Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:04Zoai:ri.conicet.gov.ar:11336/130218instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:04.821CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Progression to degenerative dementia in mild cognitive impairment patients: a cohort study
Progression to degenerative dementia in mild cognitive impairment patients: a cohort study
title Progression to degenerative dementia in mild cognitive impairment patients: a cohort study
spellingShingle Progression to degenerative dementia in mild cognitive impairment patients: a cohort study
Feldberg, Carolina
ACTIVITIES OF DAILY LIVING
ACTIVITIES OF DAILY LIVING
DEMENTIA
DEMENTIA
MILD COGNITIVE IMPAIRMENT
MILD COGNITIVE IMPAIRMENT
RISK FACTORS
RISK FACTORS
title_short Progression to degenerative dementia in mild cognitive impairment patients: a cohort study
title_full Progression to degenerative dementia in mild cognitive impairment patients: a cohort study
title_fullStr Progression to degenerative dementia in mild cognitive impairment patients: a cohort study
title_full_unstemmed Progression to degenerative dementia in mild cognitive impairment patients: a cohort study
title_sort Progression to degenerative dementia in mild cognitive impairment patients: a cohort study
dc.creator.none.fl_str_mv Feldberg, Carolina
Feldberg, Carolina
Stefani, Dorina
Stefani, Dorina
Tartaglini, Maria Florencia
Tartaglini, Maria Florencia
Hermida, Paula Daniela
Hermida, Paula Daniela
Caruso, Diego
Caruso, Diego
Somale, María Verónica
Somale, María Verónica
Allegri, Ricardo Francisco
Allegri, Ricardo Francisco
author Feldberg, Carolina
author_facet Feldberg, Carolina
Stefani, Dorina
Tartaglini, Maria Florencia
Hermida, Paula Daniela
Caruso, Diego
Somale, María Verónica
Allegri, Ricardo Francisco
author_role author
author2 Stefani, Dorina
Tartaglini, Maria Florencia
Hermida, Paula Daniela
Caruso, Diego
Somale, María Verónica
Allegri, Ricardo Francisco
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ACTIVITIES OF DAILY LIVING
ACTIVITIES OF DAILY LIVING
DEMENTIA
DEMENTIA
MILD COGNITIVE IMPAIRMENT
MILD COGNITIVE IMPAIRMENT
RISK FACTORS
RISK FACTORS
topic ACTIVITIES OF DAILY LIVING
ACTIVITIES OF DAILY LIVING
DEMENTIA
DEMENTIA
MILD COGNITIVE IMPAIRMENT
MILD COGNITIVE IMPAIRMENT
RISK FACTORS
RISK FACTORS
purl_subject.fl_str_mv https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Background: Mild cognitive impairment (MCI) is a controversial clinical entity, conceptualized as a transitional zone between normal aging and dementia. Socio-demographic and genetic factors have been involved in the development of cognitive impairment and its progression to dementia. The aim of the present study is to describe the rate of conversion to dementia in a cohort of patients with mild cognitive impairment.Method: Design Prospective cohort. Setting: A cohort of subjects with MCI was assessed and followed for three years (2013-2015) in a private institution dedicated to neurology. Participants: Patients with cognitive complaints over 60 years old who consulted spontaneously and met the MCI criteria without commitment in activities of daily living, were included consecutively and followed up annually for 3 years. Variables: Dementia and MCI were defined according to DSM IV criteria. Statistical methods we describe conversion rate as a proportion with confidence interval (CI) 95%. Bivariate analysis was performed between dementia and sociodemographic predictors and Odds Ratio and CI was calculatedResults: We include 82 subjects with MCI (age: 76.6±6.9 years, 67% women, education: 11.5±3.7 years) 4 participants were lost to follow-up. The conversion rate to dementia was 14.1% (CI95% 7.7 to 23.2) In the bivariate analysis we compared the median baseline IQ of the patients who developed dementia (97; IQR 89-103) and those who did not (93; IQR 85-95) and we obtained a significant difference with a p = 0.040Conclusions: The conversion rate to dementia in this Latin American population is coincident with studies conducted in other populations. A larger sample size is required to establish the possible predictors of conversion to dementia.
Background: Mild cognitive impairment (MCI) is a controversial clinical entity, conceptualized as a transitional zone between normal aging and dementia. Socio-demographic and genetic factors have been involved in the development of cognitive impairment and its progression to dementia. The aim of the present study is to describe the rate of conversion to dementia in a cohort of patients with mild cognitive impairment.Method: Design Prospective cohort. Setting: A cohort of subjects with MCI was assessed and followed for three years (2013-2015) in a private institution dedicated to neurology. Participants: Patients with cognitive complaints over 60 years old who consulted spontaneously and met the MCI criteria without commitment in activities of daily living, were included consecutively and followed up annually for 3 years. Variables: Dementia and MCI were defined according to DSM IV criteria. Statistical methods we describe conversion rate as a proportion with confidence interval (CI) 95%. Bivariate analysis was performed between dementia and sociodemographic predictors and Odds Ratio and CI was calculatedResults: We include 82 subjects with MCI (age: 76.6±6.9 years, 67% women, education: 11.5±3.7 years) 4 participants were lost to follow-up. The conversion rate to dementia was 14.1% (CI95% 7.7 to 23.2) In the bivariate analysis we compared the median baseline IQ of the patients who developed dementia (97; IQR 89-103) and those who did not (93; IQR 85-95) and we obtained a significant difference with a p = 0.040Conclusions: The conversion rate to dementia in this Latin American population is coincident with studies conducted in other populations. A larger sample size is required to establish the possible predictors of conversion to dementia.
Fil: Feldberg, Carolina. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Feldberg, Carolina. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Stefani, Dorina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Stefani, Dorina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Tartaglini, Maria Florencia. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tartaglini, Maria Florencia. Instituto de Neurociencias Buenos Aires S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Hermida, Paula Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Hermida, Paula Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Caruso, Diego. Hospital General de Agudos Cesar Milstein; Argentina
Fil: Caruso, Diego. Hospital General de Agudos Cesar Milstein; Argentina
Fil: Somale, María Verónica. Instituto de Neurociencias Buenos Aires S. A.; Argentina
Fil: Somale, María Verónica. Instituto de Neurociencias Buenos Aires S. A.; Argentina
Fil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Allegri, Ricardo Francisco. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Alzheimer´s Association International Conference
Los Angeles
Estados Unidos
Alzheimer´s Association
Alzheimer´s Association
description Background: Mild cognitive impairment (MCI) is a controversial clinical entity, conceptualized as a transitional zone between normal aging and dementia. Socio-demographic and genetic factors have been involved in the development of cognitive impairment and its progression to dementia. The aim of the present study is to describe the rate of conversion to dementia in a cohort of patients with mild cognitive impairment.Method: Design Prospective cohort. Setting: A cohort of subjects with MCI was assessed and followed for three years (2013-2015) in a private institution dedicated to neurology. Participants: Patients with cognitive complaints over 60 years old who consulted spontaneously and met the MCI criteria without commitment in activities of daily living, were included consecutively and followed up annually for 3 years. Variables: Dementia and MCI were defined according to DSM IV criteria. Statistical methods we describe conversion rate as a proportion with confidence interval (CI) 95%. Bivariate analysis was performed between dementia and sociodemographic predictors and Odds Ratio and CI was calculatedResults: We include 82 subjects with MCI (age: 76.6±6.9 years, 67% women, education: 11.5±3.7 years) 4 participants were lost to follow-up. The conversion rate to dementia was 14.1% (CI95% 7.7 to 23.2) In the bivariate analysis we compared the median baseline IQ of the patients who developed dementia (97; IQR 89-103) and those who did not (93; IQR 85-95) and we obtained a significant difference with a p = 0.040Conclusions: The conversion rate to dementia in this Latin American population is coincident with studies conducted in other populations. A larger sample size is required to establish the possible predictors of conversion to dementia.
publishDate 2019
dc.date.none.fl_str_mv 2019
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http://purl.org/coar/resource_type/c_5794
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dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/130218
Progression to degenerative dementia in mild cognitive impairment patients: a cohort study; Alzheimer´s Association International Conference; Los Angeles; Estados Unidos; 2019; P816-P816
1552-5279
CONICET Digital
CONICET
url http://hdl.handle.net/11336/130218
identifier_str_mv Progression to degenerative dementia in mild cognitive impairment patients: a cohort study; Alzheimer´s Association International Conference; Los Angeles; Estados Unidos; 2019; P816-P816
1552-5279
CONICET Digital
CONICET
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language eng
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