Waiting list registration and liver transplantation rates among patients with autoimmune liver disease: An 11-year trend analysis

Autores
Dirchwolf, Melisa; Marciano, Sebastian; Giunta, Diego Hernan; Ruf, Andres E.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: We aimed to analyze waiting list and liver transplantation trends for autoimmune liver disease in Argentina.Methods: We designed a population-based analysis of waitlisted or liver transplanted patients for autoimmune hepatitis, primary biliary cholangitis or primary sclerosing cholangitis between 2006-2017 in Argentina. Cumulative incidence rates of waiting list registration and liver transplantation were standardized for age and sex using the 2000 WHO standard population. Joinpoint regression analysis was used to identify changes in waiting list and liver transplantation trends.Results: Waiting list registrations for autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis represented 9.66%, 5.07% and 0.85%.Wait-listing rates for autoimmune hepatitis and primary biliary cholangitis increased significantly between 2006 and 2017, with an annual percentage change of 4.9% (95% CI 0.8 to 9; p=0.01) and 5.5% (95% CI 1 to 10.2; p=0.01) respectively. Patients with autoimmune hepatitis and primary biliary cholangitis aged 40-59 years showed the highest increase in waiting list registration rates. Waiting list registration trends for primary sclerosing cholangitis remained stable: annual percentagechange 1.4% (CI 95% -2.1 to 5; p=0.4). Liver transplantation for autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis represented 10.69%, 5.99% and 3.64%. Liver transplantation trends remained stable in all autoimmune liver diseases.Conclusion: Increasing trends of waiting list registration of autoimmune hepatitis and primary biliary cholangitis may respond to higher diagnosis and early referral rates to liver transplant units. Nevertheless, the growing waitlisting of patients with autoimmune end-stage liver disease underlines an unmet need for effective therapy.
Fil: Dirchwolf, Melisa. Hospital Privado de Rosario; Argentina
Fil: Marciano, Sebastian. Hospital Italiano. Departamento de Medicina.; Argentina
Fil: Giunta, Diego Hernan. Hospital Italiano. Departamento de Medicina.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ruf, Andres E.. Fundación para la Docencia e Investigación de las Enfermedades del Hígado; Argentina
Materia
AUTOIMMUNE LIVER DISEASE
WAITING LIST REGISTRATION
LIVER TRANSPLANTATION
TRENDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/165474
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/165474
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Waiting list registration and liver transplantation rates among patients with autoimmune liver disease: An 11-year trend analysisDirchwolf, MelisaMarciano, SebastianGiunta, Diego HernanRuf, Andres E.AUTOIMMUNE LIVER DISEASEWAITING LIST REGISTRATIONLIVER TRANSPLANTATIONTRENDShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objectives: We aimed to analyze waiting list and liver transplantation trends for autoimmune liver disease in Argentina.Methods: We designed a population-based analysis of waitlisted or liver transplanted patients for autoimmune hepatitis, primary biliary cholangitis or primary sclerosing cholangitis between 2006-2017 in Argentina. Cumulative incidence rates of waiting list registration and liver transplantation were standardized for age and sex using the 2000 WHO standard population. Joinpoint regression analysis was used to identify changes in waiting list and liver transplantation trends.Results: Waiting list registrations for autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis represented 9.66%, 5.07% and 0.85%.Wait-listing rates for autoimmune hepatitis and primary biliary cholangitis increased significantly between 2006 and 2017, with an annual percentage change of 4.9% (95% CI 0.8 to 9; p=0.01) and 5.5% (95% CI 1 to 10.2; p=0.01) respectively. Patients with autoimmune hepatitis and primary biliary cholangitis aged 40-59 years showed the highest increase in waiting list registration rates. Waiting list registration trends for primary sclerosing cholangitis remained stable: annual percentagechange 1.4% (CI 95% -2.1 to 5; p=0.4). Liver transplantation for autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis represented 10.69%, 5.99% and 3.64%. Liver transplantation trends remained stable in all autoimmune liver diseases.Conclusion: Increasing trends of waiting list registration of autoimmune hepatitis and primary biliary cholangitis may respond to higher diagnosis and early referral rates to liver transplant units. Nevertheless, the growing waitlisting of patients with autoimmune end-stage liver disease underlines an unmet need for effective therapy.Fil: Dirchwolf, Melisa. Hospital Privado de Rosario; ArgentinaFil: Marciano, Sebastian. Hospital Italiano. Departamento de Medicina.; ArgentinaFil: Giunta, Diego Hernan. Hospital Italiano. Departamento de Medicina.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ruf, Andres E.. Fundación para la Docencia e Investigación de las Enfermedades del Hígado; ArgentinaOat2021-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/165474Dirchwolf, Melisa; Marciano, Sebastian; Giunta, Diego Hernan; Ruf, Andres E. ; Waiting list registration and liver transplantation rates among patients with autoimmune liver disease: An 11-year trend analysis; Oat; Trends in Transplantation; 14; 4-2021; 1-71887-455XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.15761/TiT.1000298info:eu-repo/semantics/altIdentifier/url/https://www.oatext.com/waiting-list-registration-and-liver-transplantation-rates-among-patients-with-autoimmune-liver-disease-an-11-year-trend-analysis.phpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:41Zoai:ri.conicet.gov.ar:11336/165474instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:41.581CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Waiting list registration and liver transplantation rates among patients with autoimmune liver disease: An 11-year trend analysis
title Waiting list registration and liver transplantation rates among patients with autoimmune liver disease: An 11-year trend analysis
spellingShingle Waiting list registration and liver transplantation rates among patients with autoimmune liver disease: An 11-year trend analysis
Dirchwolf, Melisa
AUTOIMMUNE LIVER DISEASE
WAITING LIST REGISTRATION
LIVER TRANSPLANTATION
TRENDS
title_short Waiting list registration and liver transplantation rates among patients with autoimmune liver disease: An 11-year trend analysis
title_full Waiting list registration and liver transplantation rates among patients with autoimmune liver disease: An 11-year trend analysis
title_fullStr Waiting list registration and liver transplantation rates among patients with autoimmune liver disease: An 11-year trend analysis
title_full_unstemmed Waiting list registration and liver transplantation rates among patients with autoimmune liver disease: An 11-year trend analysis
title_sort Waiting list registration and liver transplantation rates among patients with autoimmune liver disease: An 11-year trend analysis
dc.creator.none.fl_str_mv Dirchwolf, Melisa
Marciano, Sebastian
Giunta, Diego Hernan
Ruf, Andres E.
author Dirchwolf, Melisa
author_facet Dirchwolf, Melisa
Marciano, Sebastian
Giunta, Diego Hernan
Ruf, Andres E.
author_role author
author2 Marciano, Sebastian
Giunta, Diego Hernan
Ruf, Andres E.
author2_role author
author
author
dc.subject.none.fl_str_mv AUTOIMMUNE LIVER DISEASE
WAITING LIST REGISTRATION
LIVER TRANSPLANTATION
TRENDS
topic AUTOIMMUNE LIVER DISEASE
WAITING LIST REGISTRATION
LIVER TRANSPLANTATION
TRENDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objectives: We aimed to analyze waiting list and liver transplantation trends for autoimmune liver disease in Argentina.Methods: We designed a population-based analysis of waitlisted or liver transplanted patients for autoimmune hepatitis, primary biliary cholangitis or primary sclerosing cholangitis between 2006-2017 in Argentina. Cumulative incidence rates of waiting list registration and liver transplantation were standardized for age and sex using the 2000 WHO standard population. Joinpoint regression analysis was used to identify changes in waiting list and liver transplantation trends.Results: Waiting list registrations for autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis represented 9.66%, 5.07% and 0.85%.Wait-listing rates for autoimmune hepatitis and primary biliary cholangitis increased significantly between 2006 and 2017, with an annual percentage change of 4.9% (95% CI 0.8 to 9; p=0.01) and 5.5% (95% CI 1 to 10.2; p=0.01) respectively. Patients with autoimmune hepatitis and primary biliary cholangitis aged 40-59 years showed the highest increase in waiting list registration rates. Waiting list registration trends for primary sclerosing cholangitis remained stable: annual percentagechange 1.4% (CI 95% -2.1 to 5; p=0.4). Liver transplantation for autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis represented 10.69%, 5.99% and 3.64%. Liver transplantation trends remained stable in all autoimmune liver diseases.Conclusion: Increasing trends of waiting list registration of autoimmune hepatitis and primary biliary cholangitis may respond to higher diagnosis and early referral rates to liver transplant units. Nevertheless, the growing waitlisting of patients with autoimmune end-stage liver disease underlines an unmet need for effective therapy.
Fil: Dirchwolf, Melisa. Hospital Privado de Rosario; Argentina
Fil: Marciano, Sebastian. Hospital Italiano. Departamento de Medicina.; Argentina
Fil: Giunta, Diego Hernan. Hospital Italiano. Departamento de Medicina.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ruf, Andres E.. Fundación para la Docencia e Investigación de las Enfermedades del Hígado; Argentina
description Objectives: We aimed to analyze waiting list and liver transplantation trends for autoimmune liver disease in Argentina.Methods: We designed a population-based analysis of waitlisted or liver transplanted patients for autoimmune hepatitis, primary biliary cholangitis or primary sclerosing cholangitis between 2006-2017 in Argentina. Cumulative incidence rates of waiting list registration and liver transplantation were standardized for age and sex using the 2000 WHO standard population. Joinpoint regression analysis was used to identify changes in waiting list and liver transplantation trends.Results: Waiting list registrations for autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis represented 9.66%, 5.07% and 0.85%.Wait-listing rates for autoimmune hepatitis and primary biliary cholangitis increased significantly between 2006 and 2017, with an annual percentage change of 4.9% (95% CI 0.8 to 9; p=0.01) and 5.5% (95% CI 1 to 10.2; p=0.01) respectively. Patients with autoimmune hepatitis and primary biliary cholangitis aged 40-59 years showed the highest increase in waiting list registration rates. Waiting list registration trends for primary sclerosing cholangitis remained stable: annual percentagechange 1.4% (CI 95% -2.1 to 5; p=0.4). Liver transplantation for autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis represented 10.69%, 5.99% and 3.64%. Liver transplantation trends remained stable in all autoimmune liver diseases.Conclusion: Increasing trends of waiting list registration of autoimmune hepatitis and primary biliary cholangitis may respond to higher diagnosis and early referral rates to liver transplant units. Nevertheless, the growing waitlisting of patients with autoimmune end-stage liver disease underlines an unmet need for effective therapy.
publishDate 2021
dc.date.none.fl_str_mv 2021-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/165474
Dirchwolf, Melisa; Marciano, Sebastian; Giunta, Diego Hernan; Ruf, Andres E. ; Waiting list registration and liver transplantation rates among patients with autoimmune liver disease: An 11-year trend analysis; Oat; Trends in Transplantation; 14; 4-2021; 1-7
1887-455X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/165474
identifier_str_mv Dirchwolf, Melisa; Marciano, Sebastian; Giunta, Diego Hernan; Ruf, Andres E. ; Waiting list registration and liver transplantation rates among patients with autoimmune liver disease: An 11-year trend analysis; Oat; Trends in Transplantation; 14; 4-2021; 1-7
1887-455X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.15761/TiT.1000298
info:eu-repo/semantics/altIdentifier/url/https://www.oatext.com/waiting-list-registration-and-liver-transplantation-rates-among-patients-with-autoimmune-liver-disease-an-11-year-trend-analysis.php
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oat
publisher.none.fl_str_mv Oat
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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