New Insights in Immunotherapies for Food Allergies. A Path between the Mouse Model and the Allergic Patient

Autores
Smaldini, Paola Lorena; Docena, Guillermo H.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Allergic diseases are the most prevalent immunopathologies worldwide.Nowadays, allergen avoidance is the unique effective treatment for allergic patients. Pre-clinical studies and clinical trials have been successful to provethat immunotherapies may accomplish mucosal mechanisms of allergenspecifictolerance, which are able to revoke the allergic sensitization. Although more than 100 years have elapsed since the first reported procedure achieved in patients sensitive to pollen, the main obstacle in these therapies still remains adverse reactions induced during treatment. The need for further studies is required to explore safe and effective therapeutic protocols. More recently, immunotherapy appears to be an attractive option for patients with food allergy, although it is still experimental. Different strategies were proposed to overcome the concerning adverse effects that compromise safety, effectiveness and compliance with treatments. At this point, translational medicine is a flourish field in the arenas of basic science, applied science, and clinical research. The use of experimental animals may provide new insights to unravel mechanisms that play key roles in desensitization and tolerance induction, and to modify existing protocols or design new therapeutic approaches. The present reviews describes the different immunotherapies that are used in allergic patients, the promising immune interventions that are currently evaluated in clinical trials and the contributions that animal models may provide to improve the quality of treatments.
Fil: Smaldini, Paola Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
Fil: Docena, Guillermo H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
Materia
FOOD-ALLERGY
MOUSE-MODEL
IMMUNOTHERAPY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/54449
Acceder
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network_name_str CONICET Digital (CONICET)
spelling New Insights in Immunotherapies for Food Allergies. A Path between the Mouse Model and the Allergic PatientSmaldini, Paola LorenaDocena, Guillermo H.FOOD-ALLERGYMOUSE-MODELIMMUNOTHERAPYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Allergic diseases are the most prevalent immunopathologies worldwide.Nowadays, allergen avoidance is the unique effective treatment for allergic patients. Pre-clinical studies and clinical trials have been successful to provethat immunotherapies may accomplish mucosal mechanisms of allergenspecifictolerance, which are able to revoke the allergic sensitization. Although more than 100 years have elapsed since the first reported procedure achieved in patients sensitive to pollen, the main obstacle in these therapies still remains adverse reactions induced during treatment. The need for further studies is required to explore safe and effective therapeutic protocols. More recently, immunotherapy appears to be an attractive option for patients with food allergy, although it is still experimental. Different strategies were proposed to overcome the concerning adverse effects that compromise safety, effectiveness and compliance with treatments. At this point, translational medicine is a flourish field in the arenas of basic science, applied science, and clinical research. The use of experimental animals may provide new insights to unravel mechanisms that play key roles in desensitization and tolerance induction, and to modify existing protocols or design new therapeutic approaches. The present reviews describes the different immunotherapies that are used in allergic patients, the promising immune interventions that are currently evaluated in clinical trials and the contributions that animal models may provide to improve the quality of treatments.Fil: Smaldini, Paola Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaFil: Docena, Guillermo H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaAustin Publishing Group2015-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/54449Smaldini, Paola Lorena; Docena, Guillermo H.; New Insights in Immunotherapies for Food Allergies. A Path between the Mouse Model and the Allergic Patient; Austin Publishing Group; Austin Journal of Allergy; 2; 4-2015; 1-62378-6655CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://austinpublishinggroup.com/allergy/fulltext/aja-v2-id1016.phpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:00Zoai:ri.conicet.gov.ar:11336/54449instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:00.855CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv New Insights in Immunotherapies for Food Allergies. A Path between the Mouse Model and the Allergic Patient
title New Insights in Immunotherapies for Food Allergies. A Path between the Mouse Model and the Allergic Patient
spellingShingle New Insights in Immunotherapies for Food Allergies. A Path between the Mouse Model and the Allergic Patient
Smaldini, Paola Lorena
FOOD-ALLERGY
MOUSE-MODEL
IMMUNOTHERAPY
title_short New Insights in Immunotherapies for Food Allergies. A Path between the Mouse Model and the Allergic Patient
title_full New Insights in Immunotherapies for Food Allergies. A Path between the Mouse Model and the Allergic Patient
title_fullStr New Insights in Immunotherapies for Food Allergies. A Path between the Mouse Model and the Allergic Patient
title_full_unstemmed New Insights in Immunotherapies for Food Allergies. A Path between the Mouse Model and the Allergic Patient
title_sort New Insights in Immunotherapies for Food Allergies. A Path between the Mouse Model and the Allergic Patient
dc.creator.none.fl_str_mv Smaldini, Paola Lorena
Docena, Guillermo H.
author Smaldini, Paola Lorena
author_facet Smaldini, Paola Lorena
Docena, Guillermo H.
author_role author
author2 Docena, Guillermo H.
author2_role author
dc.subject.none.fl_str_mv FOOD-ALLERGY
MOUSE-MODEL
IMMUNOTHERAPY
topic FOOD-ALLERGY
MOUSE-MODEL
IMMUNOTHERAPY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Allergic diseases are the most prevalent immunopathologies worldwide.Nowadays, allergen avoidance is the unique effective treatment for allergic patients. Pre-clinical studies and clinical trials have been successful to provethat immunotherapies may accomplish mucosal mechanisms of allergenspecifictolerance, which are able to revoke the allergic sensitization. Although more than 100 years have elapsed since the first reported procedure achieved in patients sensitive to pollen, the main obstacle in these therapies still remains adverse reactions induced during treatment. The need for further studies is required to explore safe and effective therapeutic protocols. More recently, immunotherapy appears to be an attractive option for patients with food allergy, although it is still experimental. Different strategies were proposed to overcome the concerning adverse effects that compromise safety, effectiveness and compliance with treatments. At this point, translational medicine is a flourish field in the arenas of basic science, applied science, and clinical research. The use of experimental animals may provide new insights to unravel mechanisms that play key roles in desensitization and tolerance induction, and to modify existing protocols or design new therapeutic approaches. The present reviews describes the different immunotherapies that are used in allergic patients, the promising immune interventions that are currently evaluated in clinical trials and the contributions that animal models may provide to improve the quality of treatments.
Fil: Smaldini, Paola Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
Fil: Docena, Guillermo H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
description Allergic diseases are the most prevalent immunopathologies worldwide.Nowadays, allergen avoidance is the unique effective treatment for allergic patients. Pre-clinical studies and clinical trials have been successful to provethat immunotherapies may accomplish mucosal mechanisms of allergenspecifictolerance, which are able to revoke the allergic sensitization. Although more than 100 years have elapsed since the first reported procedure achieved in patients sensitive to pollen, the main obstacle in these therapies still remains adverse reactions induced during treatment. The need for further studies is required to explore safe and effective therapeutic protocols. More recently, immunotherapy appears to be an attractive option for patients with food allergy, although it is still experimental. Different strategies were proposed to overcome the concerning adverse effects that compromise safety, effectiveness and compliance with treatments. At this point, translational medicine is a flourish field in the arenas of basic science, applied science, and clinical research. The use of experimental animals may provide new insights to unravel mechanisms that play key roles in desensitization and tolerance induction, and to modify existing protocols or design new therapeutic approaches. The present reviews describes the different immunotherapies that are used in allergic patients, the promising immune interventions that are currently evaluated in clinical trials and the contributions that animal models may provide to improve the quality of treatments.
publishDate 2015
dc.date.none.fl_str_mv 2015-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/54449
Smaldini, Paola Lorena; Docena, Guillermo H.; New Insights in Immunotherapies for Food Allergies. A Path between the Mouse Model and the Allergic Patient; Austin Publishing Group; Austin Journal of Allergy; 2; 4-2015; 1-6
2378-6655
CONICET Digital
CONICET
url http://hdl.handle.net/11336/54449
identifier_str_mv Smaldini, Paola Lorena; Docena, Guillermo H.; New Insights in Immunotherapies for Food Allergies. A Path between the Mouse Model and the Allergic Patient; Austin Publishing Group; Austin Journal of Allergy; 2; 4-2015; 1-6
2378-6655
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://austinpublishinggroup.com/allergy/fulltext/aja-v2-id1016.php
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Austin Publishing Group
publisher.none.fl_str_mv Austin Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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