Effects of folic acid fortification on spina bifida prevalence in Brazil

Autores
Orioli, Ieda Maria; Lima do Nascimento, Ricardo; López Camelo, Jorge Santiago; Castilla, Eduardo Enrique
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: To assess spina bifida birth prevalence changes after folic acid fortification of wheat and maize flours began in Brazil in June 2004. METHODS: Cross-sectional study of Brazilian live births in 2004 and 2006. Spina bifida birth prevalence from the Live Births Information System (SINASC: Sistema de Informações sobre Nascidos Vivos) in a prefortified period was compared to a period fortified with folic acid in each state. Observed prevalence rates in 2004 were used to calculate the expected prevalence rates in 2006 under the null hypothesis that both were similar. The observed/expected (O/E) ratios were tested by two-tailed Z-test. To minimize ascertainment differences among states, the O/E ratio of each one of the 27 Brazilian states was adjusted for the number of births with the Mantel-Haenszel statistic. Results The reduction in spina bifida birth prevalence in 2006 was 39% (O/E = 0.61; 95% confidence interval [CI], 0.55-0.67), and 40% (O/E = 0.60; 95% CI, 0.53-0.68), after adjusting for state birth number. This reduction was significant (p < 0.0001), and heterogeneous among states (χ 2 = 72.96; p < 0.0001). Conclusions: Using SINASC data, there was a significant reduction in spina bifida birth prevalence in Brazil, probably related to the folic acid food fortification program.
Fil: Orioli, Ieda Maria. Universidade Federal do Rio de Janeiro; Brasil. Instituto Nacional de Ciência e Tecnologia Genética Médica Populacional; Brasil
Fil: Lima do Nascimento, Ricardo. Instituto Nacional de Ciência e Tecnologia Genética Médica Populacional; Brasil. Universidade Federal do Rio de Janeiro; Brasil
Fil: López Camelo, Jorge Santiago. Instituto Nacional de Ciência e Tecnologia Genética Médica Populacional; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Castilla, Eduardo Enrique. Fundación Oswaldo Cruz; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Instituto Nacional de Ciência e Tecnologia Genética Médica Populacional; Brasil
Materia
CONGENITAL DEFECT
FOLIC ACID
FOOD FORTIFICATION
NEURAL TUBE DEFECT
SINASC
SPINA BIFIDA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/95451
Acceder
id CONICETDig_8ab9ad339fa1a06468b44ad5210a8c10
oai_identifier_str oai:ri.conicet.gov.ar:11336/95451
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of folic acid fortification on spina bifida prevalence in BrazilOrioli, Ieda MariaLima do Nascimento, RicardoLópez Camelo, Jorge SantiagoCastilla, Eduardo EnriqueCONGENITAL DEFECTFOLIC ACIDFOOD FORTIFICATIONNEURAL TUBE DEFECTSINASCSPINA BIFIDAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: To assess spina bifida birth prevalence changes after folic acid fortification of wheat and maize flours began in Brazil in June 2004. METHODS: Cross-sectional study of Brazilian live births in 2004 and 2006. Spina bifida birth prevalence from the Live Births Information System (SINASC: Sistema de Informações sobre Nascidos Vivos) in a prefortified period was compared to a period fortified with folic acid in each state. Observed prevalence rates in 2004 were used to calculate the expected prevalence rates in 2006 under the null hypothesis that both were similar. The observed/expected (O/E) ratios were tested by two-tailed Z-test. To minimize ascertainment differences among states, the O/E ratio of each one of the 27 Brazilian states was adjusted for the number of births with the Mantel-Haenszel statistic. Results The reduction in spina bifida birth prevalence in 2006 was 39% (O/E = 0.61; 95% confidence interval [CI], 0.55-0.67), and 40% (O/E = 0.60; 95% CI, 0.53-0.68), after adjusting for state birth number. This reduction was significant (p < 0.0001), and heterogeneous among states (χ 2 = 72.96; p < 0.0001). Conclusions: Using SINASC data, there was a significant reduction in spina bifida birth prevalence in Brazil, probably related to the folic acid food fortification program.Fil: Orioli, Ieda Maria. Universidade Federal do Rio de Janeiro; Brasil. Instituto Nacional de Ciência e Tecnologia Genética Médica Populacional; BrasilFil: Lima do Nascimento, Ricardo. Instituto Nacional de Ciência e Tecnologia Genética Médica Populacional; Brasil. Universidade Federal do Rio de Janeiro; BrasilFil: López Camelo, Jorge Santiago. Instituto Nacional de Ciência e Tecnologia Genética Médica Populacional; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Castilla, Eduardo Enrique. Fundación Oswaldo Cruz; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Instituto Nacional de Ciência e Tecnologia Genética Médica Populacional; BrasilWiley-liss, Div John Wiley & Sons Inc2011-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/95451Orioli, Ieda Maria; Lima do Nascimento, Ricardo; López Camelo, Jorge Santiago; Castilla, Eduardo Enrique; Effects of folic acid fortification on spina bifida prevalence in Brazil; Wiley-liss, Div John Wiley & Sons Inc; Birth Defects Research Part A: Clinical and Molecular Teratology; 91; 9; 9-2011; 831-8351542-0752CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/bdra.20830info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/bdra.20830info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:14:25Zoai:ri.conicet.gov.ar:11336/95451instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:14:25.862CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of folic acid fortification on spina bifida prevalence in Brazil
title Effects of folic acid fortification on spina bifida prevalence in Brazil
spellingShingle Effects of folic acid fortification on spina bifida prevalence in Brazil
Orioli, Ieda Maria
CONGENITAL DEFECT
FOLIC ACID
FOOD FORTIFICATION
NEURAL TUBE DEFECT
SINASC
SPINA BIFIDA
title_short Effects of folic acid fortification on spina bifida prevalence in Brazil
title_full Effects of folic acid fortification on spina bifida prevalence in Brazil
title_fullStr Effects of folic acid fortification on spina bifida prevalence in Brazil
title_full_unstemmed Effects of folic acid fortification on spina bifida prevalence in Brazil
title_sort Effects of folic acid fortification on spina bifida prevalence in Brazil
dc.creator.none.fl_str_mv Orioli, Ieda Maria
Lima do Nascimento, Ricardo
López Camelo, Jorge Santiago
Castilla, Eduardo Enrique
author Orioli, Ieda Maria
author_facet Orioli, Ieda Maria
Lima do Nascimento, Ricardo
López Camelo, Jorge Santiago
Castilla, Eduardo Enrique
author_role author
author2 Lima do Nascimento, Ricardo
López Camelo, Jorge Santiago
Castilla, Eduardo Enrique
author2_role author
author
author
dc.subject.none.fl_str_mv CONGENITAL DEFECT
FOLIC ACID
FOOD FORTIFICATION
NEURAL TUBE DEFECT
SINASC
SPINA BIFIDA
topic CONGENITAL DEFECT
FOLIC ACID
FOOD FORTIFICATION
NEURAL TUBE DEFECT
SINASC
SPINA BIFIDA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: To assess spina bifida birth prevalence changes after folic acid fortification of wheat and maize flours began in Brazil in June 2004. METHODS: Cross-sectional study of Brazilian live births in 2004 and 2006. Spina bifida birth prevalence from the Live Births Information System (SINASC: Sistema de Informações sobre Nascidos Vivos) in a prefortified period was compared to a period fortified with folic acid in each state. Observed prevalence rates in 2004 were used to calculate the expected prevalence rates in 2006 under the null hypothesis that both were similar. The observed/expected (O/E) ratios were tested by two-tailed Z-test. To minimize ascertainment differences among states, the O/E ratio of each one of the 27 Brazilian states was adjusted for the number of births with the Mantel-Haenszel statistic. Results The reduction in spina bifida birth prevalence in 2006 was 39% (O/E = 0.61; 95% confidence interval [CI], 0.55-0.67), and 40% (O/E = 0.60; 95% CI, 0.53-0.68), after adjusting for state birth number. This reduction was significant (p < 0.0001), and heterogeneous among states (χ 2 = 72.96; p < 0.0001). Conclusions: Using SINASC data, there was a significant reduction in spina bifida birth prevalence in Brazil, probably related to the folic acid food fortification program.
Fil: Orioli, Ieda Maria. Universidade Federal do Rio de Janeiro; Brasil. Instituto Nacional de Ciência e Tecnologia Genética Médica Populacional; Brasil
Fil: Lima do Nascimento, Ricardo. Instituto Nacional de Ciência e Tecnologia Genética Médica Populacional; Brasil. Universidade Federal do Rio de Janeiro; Brasil
Fil: López Camelo, Jorge Santiago. Instituto Nacional de Ciência e Tecnologia Genética Médica Populacional; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Castilla, Eduardo Enrique. Fundación Oswaldo Cruz; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Instituto Nacional de Ciência e Tecnologia Genética Médica Populacional; Brasil
description Background: To assess spina bifida birth prevalence changes after folic acid fortification of wheat and maize flours began in Brazil in June 2004. METHODS: Cross-sectional study of Brazilian live births in 2004 and 2006. Spina bifida birth prevalence from the Live Births Information System (SINASC: Sistema de Informações sobre Nascidos Vivos) in a prefortified period was compared to a period fortified with folic acid in each state. Observed prevalence rates in 2004 were used to calculate the expected prevalence rates in 2006 under the null hypothesis that both were similar. The observed/expected (O/E) ratios were tested by two-tailed Z-test. To minimize ascertainment differences among states, the O/E ratio of each one of the 27 Brazilian states was adjusted for the number of births with the Mantel-Haenszel statistic. Results The reduction in spina bifida birth prevalence in 2006 was 39% (O/E = 0.61; 95% confidence interval [CI], 0.55-0.67), and 40% (O/E = 0.60; 95% CI, 0.53-0.68), after adjusting for state birth number. This reduction was significant (p < 0.0001), and heterogeneous among states (χ 2 = 72.96; p < 0.0001). Conclusions: Using SINASC data, there was a significant reduction in spina bifida birth prevalence in Brazil, probably related to the folic acid food fortification program.
publishDate 2011
dc.date.none.fl_str_mv 2011-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/95451
Orioli, Ieda Maria; Lima do Nascimento, Ricardo; López Camelo, Jorge Santiago; Castilla, Eduardo Enrique; Effects of folic acid fortification on spina bifida prevalence in Brazil; Wiley-liss, Div John Wiley & Sons Inc; Birth Defects Research Part A: Clinical and Molecular Teratology; 91; 9; 9-2011; 831-835
1542-0752
CONICET Digital
CONICET
url http://hdl.handle.net/11336/95451
identifier_str_mv Orioli, Ieda Maria; Lima do Nascimento, Ricardo; López Camelo, Jorge Santiago; Castilla, Eduardo Enrique; Effects of folic acid fortification on spina bifida prevalence in Brazil; Wiley-liss, Div John Wiley & Sons Inc; Birth Defects Research Part A: Clinical and Molecular Teratology; 91; 9; 9-2011; 831-835
1542-0752
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/bdra.20830
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/bdra.20830
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614071676043264
score 13.070432

Publicaciones similares