Folic acid flour fortification: Impact on the frequencies of 52 congenital anomaly types in three South American countries

Autores
López Camelo, Jorge Santiago; Castilla, Eduardo Enrique; Orioli, Ieda Maria
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the present investigation was to search for a reduction in birth prevalence estimates of 52 selected types of congenital anomalies, associated with folic acid fortification programs in Chile, Argentina, and Brazil. The material included 3,347,559 total births in 77 hospitals of the three countries during the 1982-2007 period: 596,704 births (17 hospitals) in Chile, 1,643,341 (41 hospitals) in Argentina, and 1,107,514 (19 hospitals) in Brazil. We compared pre- and post-fortification rates within each hospital and the resulting Prevalence Rate Ratios (PRRs) were pooled by country. Statistically significant reductions in birth prevalence estimates after fortification were observed for neural tube defects (NTDs), septal heart defects, transverse limb deficiencies, and subluxation of the hip. However, only the reduction of NTDs appeared to be associated with folic acid fortification and not due to other factors, because of its consistency among the three countries, as well as with previously published reports, and its strong statistical significance. Among the NTDs, the maximum prevalence reduction was observed for isolated cephalic (cervical-thoracic) spina bifida, followed by caudal (lumbo-sacral) spina bifida, anencephaly, and cephalocele. This observation suggests etiologic and pathogenetic heterogeneity among different levels of spina bifida, as well as among different NTD subtypes. We concluded that food fortification with folic acid prevents NTDs but not other types of congenital anomalies.
Fil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Instituto Oswaldo Cruz; Brasil. Fundación Oswaldo Cruz; Brasil
Fil: Orioli, Ieda Maria. Universidade Federal do Rio de Janeiro; Brasil
Materia
ANENCEPHALY
BIRTH DEFECTS MONITORING
CEPHALOCELE
CONGENITAL ANOMALIES
FOLIC ACID
FOOD FORTIFICATION
FORTIFIED FLOUR
NEURAL TUBE DEFECTS
NTD
SOUTH AMERICA
SPINA BIFIDA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/99940
Acceder
id CONICETDig_15225f8416dce49c993b8190bb72dfef
oai_identifier_str oai:ri.conicet.gov.ar:11336/99940
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Folic acid flour fortification: Impact on the frequencies of 52 congenital anomaly types in three South American countriesLópez Camelo, Jorge SantiagoCastilla, Eduardo EnriqueOrioli, Ieda MariaANENCEPHALYBIRTH DEFECTS MONITORINGCEPHALOCELECONGENITAL ANOMALIESFOLIC ACIDFOOD FORTIFICATIONFORTIFIED FLOURNEURAL TUBE DEFECTSNTDSOUTH AMERICASPINA BIFIDAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The aim of the present investigation was to search for a reduction in birth prevalence estimates of 52 selected types of congenital anomalies, associated with folic acid fortification programs in Chile, Argentina, and Brazil. The material included 3,347,559 total births in 77 hospitals of the three countries during the 1982-2007 period: 596,704 births (17 hospitals) in Chile, 1,643,341 (41 hospitals) in Argentina, and 1,107,514 (19 hospitals) in Brazil. We compared pre- and post-fortification rates within each hospital and the resulting Prevalence Rate Ratios (PRRs) were pooled by country. Statistically significant reductions in birth prevalence estimates after fortification were observed for neural tube defects (NTDs), septal heart defects, transverse limb deficiencies, and subluxation of the hip. However, only the reduction of NTDs appeared to be associated with folic acid fortification and not due to other factors, because of its consistency among the three countries, as well as with previously published reports, and its strong statistical significance. Among the NTDs, the maximum prevalence reduction was observed for isolated cephalic (cervical-thoracic) spina bifida, followed by caudal (lumbo-sacral) spina bifida, anencephaly, and cephalocele. This observation suggests etiologic and pathogenetic heterogeneity among different levels of spina bifida, as well as among different NTD subtypes. We concluded that food fortification with folic acid prevents NTDs but not other types of congenital anomalies.Fil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Instituto Oswaldo Cruz; Brasil. Fundación Oswaldo Cruz; BrasilFil: Orioli, Ieda Maria. Universidade Federal do Rio de Janeiro; BrasilWiley-liss, Div John Wiley & Sons Inc2010-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99940López Camelo, Jorge Santiago; Castilla, Eduardo Enrique; Orioli, Ieda Maria; Folic acid flour fortification: Impact on the frequencies of 52 congenital anomaly types in three South American countries; Wiley-liss, Div John Wiley & Sons Inc; American Journal of Medical Genetics Part A; 152 A; 10; 10-2010; 2444-24581552-4825CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.a.33479info:eu-repo/semantics/altIdentifier/doi/10.1002/ajmg.a.33479info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:12:58Zoai:ri.conicet.gov.ar:11336/99940instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:12:58.592CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Folic acid flour fortification: Impact on the frequencies of 52 congenital anomaly types in three South American countries
title Folic acid flour fortification: Impact on the frequencies of 52 congenital anomaly types in three South American countries
spellingShingle Folic acid flour fortification: Impact on the frequencies of 52 congenital anomaly types in three South American countries
López Camelo, Jorge Santiago
ANENCEPHALY
BIRTH DEFECTS MONITORING
CEPHALOCELE
CONGENITAL ANOMALIES
FOLIC ACID
FOOD FORTIFICATION
FORTIFIED FLOUR
NEURAL TUBE DEFECTS
NTD
SOUTH AMERICA
SPINA BIFIDA
title_short Folic acid flour fortification: Impact on the frequencies of 52 congenital anomaly types in three South American countries
title_full Folic acid flour fortification: Impact on the frequencies of 52 congenital anomaly types in three South American countries
title_fullStr Folic acid flour fortification: Impact on the frequencies of 52 congenital anomaly types in three South American countries
title_full_unstemmed Folic acid flour fortification: Impact on the frequencies of 52 congenital anomaly types in three South American countries
title_sort Folic acid flour fortification: Impact on the frequencies of 52 congenital anomaly types in three South American countries
dc.creator.none.fl_str_mv López Camelo, Jorge Santiago
Castilla, Eduardo Enrique
Orioli, Ieda Maria
author López Camelo, Jorge Santiago
author_facet López Camelo, Jorge Santiago
Castilla, Eduardo Enrique
Orioli, Ieda Maria
author_role author
author2 Castilla, Eduardo Enrique
Orioli, Ieda Maria
author2_role author
author
dc.subject.none.fl_str_mv ANENCEPHALY
BIRTH DEFECTS MONITORING
CEPHALOCELE
CONGENITAL ANOMALIES
FOLIC ACID
FOOD FORTIFICATION
FORTIFIED FLOUR
NEURAL TUBE DEFECTS
NTD
SOUTH AMERICA
SPINA BIFIDA
topic ANENCEPHALY
BIRTH DEFECTS MONITORING
CEPHALOCELE
CONGENITAL ANOMALIES
FOLIC ACID
FOOD FORTIFICATION
FORTIFIED FLOUR
NEURAL TUBE DEFECTS
NTD
SOUTH AMERICA
SPINA BIFIDA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of the present investigation was to search for a reduction in birth prevalence estimates of 52 selected types of congenital anomalies, associated with folic acid fortification programs in Chile, Argentina, and Brazil. The material included 3,347,559 total births in 77 hospitals of the three countries during the 1982-2007 period: 596,704 births (17 hospitals) in Chile, 1,643,341 (41 hospitals) in Argentina, and 1,107,514 (19 hospitals) in Brazil. We compared pre- and post-fortification rates within each hospital and the resulting Prevalence Rate Ratios (PRRs) were pooled by country. Statistically significant reductions in birth prevalence estimates after fortification were observed for neural tube defects (NTDs), septal heart defects, transverse limb deficiencies, and subluxation of the hip. However, only the reduction of NTDs appeared to be associated with folic acid fortification and not due to other factors, because of its consistency among the three countries, as well as with previously published reports, and its strong statistical significance. Among the NTDs, the maximum prevalence reduction was observed for isolated cephalic (cervical-thoracic) spina bifida, followed by caudal (lumbo-sacral) spina bifida, anencephaly, and cephalocele. This observation suggests etiologic and pathogenetic heterogeneity among different levels of spina bifida, as well as among different NTD subtypes. We concluded that food fortification with folic acid prevents NTDs but not other types of congenital anomalies.
Fil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina. Instituto Oswaldo Cruz; Brasil. Fundación Oswaldo Cruz; Brasil
Fil: Orioli, Ieda Maria. Universidade Federal do Rio de Janeiro; Brasil
description The aim of the present investigation was to search for a reduction in birth prevalence estimates of 52 selected types of congenital anomalies, associated with folic acid fortification programs in Chile, Argentina, and Brazil. The material included 3,347,559 total births in 77 hospitals of the three countries during the 1982-2007 period: 596,704 births (17 hospitals) in Chile, 1,643,341 (41 hospitals) in Argentina, and 1,107,514 (19 hospitals) in Brazil. We compared pre- and post-fortification rates within each hospital and the resulting Prevalence Rate Ratios (PRRs) were pooled by country. Statistically significant reductions in birth prevalence estimates after fortification were observed for neural tube defects (NTDs), septal heart defects, transverse limb deficiencies, and subluxation of the hip. However, only the reduction of NTDs appeared to be associated with folic acid fortification and not due to other factors, because of its consistency among the three countries, as well as with previously published reports, and its strong statistical significance. Among the NTDs, the maximum prevalence reduction was observed for isolated cephalic (cervical-thoracic) spina bifida, followed by caudal (lumbo-sacral) spina bifida, anencephaly, and cephalocele. This observation suggests etiologic and pathogenetic heterogeneity among different levels of spina bifida, as well as among different NTD subtypes. We concluded that food fortification with folic acid prevents NTDs but not other types of congenital anomalies.
publishDate 2010
dc.date.none.fl_str_mv 2010-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99940
López Camelo, Jorge Santiago; Castilla, Eduardo Enrique; Orioli, Ieda Maria; Folic acid flour fortification: Impact on the frequencies of 52 congenital anomaly types in three South American countries; Wiley-liss, Div John Wiley & Sons Inc; American Journal of Medical Genetics Part A; 152 A; 10; 10-2010; 2444-2458
1552-4825
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99940
identifier_str_mv López Camelo, Jorge Santiago; Castilla, Eduardo Enrique; Orioli, Ieda Maria; Folic acid flour fortification: Impact on the frequencies of 52 congenital anomaly types in three South American countries; Wiley-liss, Div John Wiley & Sons Inc; American Journal of Medical Genetics Part A; 152 A; 10; 10-2010; 2444-2458
1552-4825
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.a.33479
info:eu-repo/semantics/altIdentifier/doi/10.1002/ajmg.a.33479
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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