Microtubule-associated protein 1A/1B-light chain 3 (LC3) ‘decorates’ intracytoplasmic inclusions in a patient with chronic lymphocytic leukaemia

Autores
Bussi, Claudio; Iribarren, Pablo; Rodriguez, Cecilia M.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A 77-year-old woman, diagnosed nine years previously with chronic lymphocytic leukaemia (CLL) Rai stage I, was referred to our hospital with disease progression (night sweats, weight loss and organomegaly). Her peripheral blood count showed leucocytosis (WBC 104 9 9 109 /l; 94% lymphocytes), anaemia (haemoglobin concentration 105 g/l) and a normal platelet count (146 9 109 /l). The monoclonal B-cell immunophenotype had been determined previously as lambda light chain-restricted, CD19+ , CD20dim, CD5+ , CD200+ , CD22dim, CD79bdim, surface membrane immunoglobulin (sIg)Mdim, CD23, CD10 and FMC7. A May-Grunwald-Giemsa-stained blood film showed € mature lymphocytes with around 50% of the total lymphocytes containing intracytoplasmic inclusions, seen as rectangular crystalline structures (top). The patient was treated with chlorambucil (unfit patient), several times, obtaining partial remission.
Fil: Bussi, Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Iribarren, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Rodriguez, Cecilia M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Materia
Leukemia
autophagy
LC3
inclusions
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/85797
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/85797
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Microtubule-associated protein 1A/1B-light chain 3 (LC3) ‘decorates’ intracytoplasmic inclusions in a patient with chronic lymphocytic leukaemiaBussi, ClaudioIribarren, PabloRodriguez, Cecilia M.LeukemiaautophagyLC3inclusionshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3A 77-year-old woman, diagnosed nine years previously with chronic lymphocytic leukaemia (CLL) Rai stage I, was referred to our hospital with disease progression (night sweats, weight loss and organomegaly). Her peripheral blood count showed leucocytosis (WBC 104 9 9 109 /l; 94% lymphocytes), anaemia (haemoglobin concentration 105 g/l) and a normal platelet count (146 9 109 /l). The monoclonal B-cell immunophenotype had been determined previously as lambda light chain-restricted, CD19+ , CD20dim, CD5+ , CD200+ , CD22dim, CD79bdim, surface membrane immunoglobulin (sIg)Mdim, CD23, CD10 and FMC7. A May-Grunwald-Giemsa-stained blood film showed € mature lymphocytes with around 50% of the total lymphocytes containing intracytoplasmic inclusions, seen as rectangular crystalline structures (top). The patient was treated with chlorambucil (unfit patient), several times, obtaining partial remission.Fil: Bussi, Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Iribarren, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Rodriguez, Cecilia M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaWiley Blackwell Publishing, Inc2017-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/85797Bussi, Claudio; Iribarren, Pablo; Rodriguez, Cecilia M.; Microtubule-associated protein 1A/1B-light chain 3 (LC3) ‘decorates’ intracytoplasmic inclusions in a patient with chronic lymphocytic leukaemia; Wiley Blackwell Publishing, Inc; British Journal of Haematology; 179; 4; 11-2017; 10007-1048CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/bjh.14893info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.14893info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:25:09Zoai:ri.conicet.gov.ar:11336/85797instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:25:10.124CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Microtubule-associated protein 1A/1B-light chain 3 (LC3) ‘decorates’ intracytoplasmic inclusions in a patient with chronic lymphocytic leukaemia
title Microtubule-associated protein 1A/1B-light chain 3 (LC3) ‘decorates’ intracytoplasmic inclusions in a patient with chronic lymphocytic leukaemia
spellingShingle Microtubule-associated protein 1A/1B-light chain 3 (LC3) ‘decorates’ intracytoplasmic inclusions in a patient with chronic lymphocytic leukaemia
Bussi, Claudio
Leukemia
autophagy
LC3
inclusions
title_short Microtubule-associated protein 1A/1B-light chain 3 (LC3) ‘decorates’ intracytoplasmic inclusions in a patient with chronic lymphocytic leukaemia
title_full Microtubule-associated protein 1A/1B-light chain 3 (LC3) ‘decorates’ intracytoplasmic inclusions in a patient with chronic lymphocytic leukaemia
title_fullStr Microtubule-associated protein 1A/1B-light chain 3 (LC3) ‘decorates’ intracytoplasmic inclusions in a patient with chronic lymphocytic leukaemia
title_full_unstemmed Microtubule-associated protein 1A/1B-light chain 3 (LC3) ‘decorates’ intracytoplasmic inclusions in a patient with chronic lymphocytic leukaemia
title_sort Microtubule-associated protein 1A/1B-light chain 3 (LC3) ‘decorates’ intracytoplasmic inclusions in a patient with chronic lymphocytic leukaemia
dc.creator.none.fl_str_mv Bussi, Claudio
Iribarren, Pablo
Rodriguez, Cecilia M.
author Bussi, Claudio
author_facet Bussi, Claudio
Iribarren, Pablo
Rodriguez, Cecilia M.
author_role author
author2 Iribarren, Pablo
Rodriguez, Cecilia M.
author2_role author
author
dc.subject.none.fl_str_mv Leukemia
autophagy
LC3
inclusions
topic Leukemia
autophagy
LC3
inclusions
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A 77-year-old woman, diagnosed nine years previously with chronic lymphocytic leukaemia (CLL) Rai stage I, was referred to our hospital with disease progression (night sweats, weight loss and organomegaly). Her peripheral blood count showed leucocytosis (WBC 104 9 9 109 /l; 94% lymphocytes), anaemia (haemoglobin concentration 105 g/l) and a normal platelet count (146 9 109 /l). The monoclonal B-cell immunophenotype had been determined previously as lambda light chain-restricted, CD19+ , CD20dim, CD5+ , CD200+ , CD22dim, CD79bdim, surface membrane immunoglobulin (sIg)Mdim, CD23, CD10 and FMC7. A May-Grunwald-Giemsa-stained blood film showed € mature lymphocytes with around 50% of the total lymphocytes containing intracytoplasmic inclusions, seen as rectangular crystalline structures (top). The patient was treated with chlorambucil (unfit patient), several times, obtaining partial remission.
Fil: Bussi, Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Iribarren, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Rodriguez, Cecilia M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
description A 77-year-old woman, diagnosed nine years previously with chronic lymphocytic leukaemia (CLL) Rai stage I, was referred to our hospital with disease progression (night sweats, weight loss and organomegaly). Her peripheral blood count showed leucocytosis (WBC 104 9 9 109 /l; 94% lymphocytes), anaemia (haemoglobin concentration 105 g/l) and a normal platelet count (146 9 109 /l). The monoclonal B-cell immunophenotype had been determined previously as lambda light chain-restricted, CD19+ , CD20dim, CD5+ , CD200+ , CD22dim, CD79bdim, surface membrane immunoglobulin (sIg)Mdim, CD23, CD10 and FMC7. A May-Grunwald-Giemsa-stained blood film showed € mature lymphocytes with around 50% of the total lymphocytes containing intracytoplasmic inclusions, seen as rectangular crystalline structures (top). The patient was treated with chlorambucil (unfit patient), several times, obtaining partial remission.
publishDate 2017
dc.date.none.fl_str_mv 2017-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/85797
Bussi, Claudio; Iribarren, Pablo; Rodriguez, Cecilia M.; Microtubule-associated protein 1A/1B-light chain 3 (LC3) ‘decorates’ intracytoplasmic inclusions in a patient with chronic lymphocytic leukaemia; Wiley Blackwell Publishing, Inc; British Journal of Haematology; 179; 4; 11-2017; 1
0007-1048
CONICET Digital
CONICET
url http://hdl.handle.net/11336/85797
identifier_str_mv Bussi, Claudio; Iribarren, Pablo; Rodriguez, Cecilia M.; Microtubule-associated protein 1A/1B-light chain 3 (LC3) ‘decorates’ intracytoplasmic inclusions in a patient with chronic lymphocytic leukaemia; Wiley Blackwell Publishing, Inc; British Journal of Haematology; 179; 4; 11-2017; 1
0007-1048
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/bjh.14893
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.14893
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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