Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications
- Autores
- Capece, Bettencourt P. S.; Virkel, Guillermo Leon; Lanusse, Carlos Edmundo
- Año de publicación
- 2009
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Albendazole and fenbendazole are methylcarbamate benzimidazole anthelmintics extensively used to control gastrointestinal parasites in domestic animals. These parent compounds are metabolised to albendazole sulfoxide and fenbendazole sulfoxide (oxfendazole), respectively. Both sulfoxide derivatives are anthelmintically active and are manufactured for use in animals. They metabolites have an asymmetric centre on their chemical structures and two enantiomeric forms of each sulfoxide have been identified in plasma, tissues of parasite location and within target helminths. Both the flavin-monooxygenase and cytochrome P450 systems are involved in the enantioselective biotransformation of these anthelmintic compounds in ruminant species. A relevant progress on the understanding of the relationship among enantioselective metabolism and systemic availability of each enantiomeric form has been achieved. This article reviews the current knowledge on the pharmacological implications of the enantiomeric behaviour of albendazole sulfoxide and oxfendazole in domestic animals.
Fil: Capece, Bettencourt P. S.. Universidade Eduardo Mondlane; Mozambique
Fil: Virkel, Guillermo Leon. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina - Materia
-
ALBENDAZOLE SULFOXIDE
DOMESTIC ANIMALS
ENANTIOMERIC BEHAVIOUR
ENANTIOSELECTIVE BIOTRANSFORMATION
FENBENDAZOLE SULFOXIDE (OXFENDAZOLE) - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/95707
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
spelling |
Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implicationsCapece, Bettencourt P. S.Virkel, Guillermo LeonLanusse, Carlos EdmundoALBENDAZOLE SULFOXIDEDOMESTIC ANIMALSENANTIOMERIC BEHAVIOURENANTIOSELECTIVE BIOTRANSFORMATIONFENBENDAZOLE SULFOXIDE (OXFENDAZOLE)https://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Albendazole and fenbendazole are methylcarbamate benzimidazole anthelmintics extensively used to control gastrointestinal parasites in domestic animals. These parent compounds are metabolised to albendazole sulfoxide and fenbendazole sulfoxide (oxfendazole), respectively. Both sulfoxide derivatives are anthelmintically active and are manufactured for use in animals. They metabolites have an asymmetric centre on their chemical structures and two enantiomeric forms of each sulfoxide have been identified in plasma, tissues of parasite location and within target helminths. Both the flavin-monooxygenase and cytochrome P450 systems are involved in the enantioselective biotransformation of these anthelmintic compounds in ruminant species. A relevant progress on the understanding of the relationship among enantioselective metabolism and systemic availability of each enantiomeric form has been achieved. This article reviews the current knowledge on the pharmacological implications of the enantiomeric behaviour of albendazole sulfoxide and oxfendazole in domestic animals.Fil: Capece, Bettencourt P. S.. Universidade Eduardo Mondlane; MozambiqueFil: Virkel, Guillermo Leon. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaElsevier2009-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/95707Capece, Bettencourt P. S.; Virkel, Guillermo Leon; Lanusse, Carlos Edmundo; Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications; Elsevier; The Veterinary Journal; 181; 3; 9-2009; 241-2501090-0233CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1090023308004097info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tvjl.2008.11.010info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:25:54Zoai:ri.conicet.gov.ar:11336/95707instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:25:54.67CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications |
title |
Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications |
spellingShingle |
Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications Capece, Bettencourt P. S. ALBENDAZOLE SULFOXIDE DOMESTIC ANIMALS ENANTIOMERIC BEHAVIOUR ENANTIOSELECTIVE BIOTRANSFORMATION FENBENDAZOLE SULFOXIDE (OXFENDAZOLE) |
title_short |
Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications |
title_full |
Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications |
title_fullStr |
Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications |
title_full_unstemmed |
Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications |
title_sort |
Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications |
dc.creator.none.fl_str_mv |
Capece, Bettencourt P. S. Virkel, Guillermo Leon Lanusse, Carlos Edmundo |
author |
Capece, Bettencourt P. S. |
author_facet |
Capece, Bettencourt P. S. Virkel, Guillermo Leon Lanusse, Carlos Edmundo |
author_role |
author |
author2 |
Virkel, Guillermo Leon Lanusse, Carlos Edmundo |
author2_role |
author author |
dc.subject.none.fl_str_mv |
ALBENDAZOLE SULFOXIDE DOMESTIC ANIMALS ENANTIOMERIC BEHAVIOUR ENANTIOSELECTIVE BIOTRANSFORMATION FENBENDAZOLE SULFOXIDE (OXFENDAZOLE) |
topic |
ALBENDAZOLE SULFOXIDE DOMESTIC ANIMALS ENANTIOMERIC BEHAVIOUR ENANTIOSELECTIVE BIOTRANSFORMATION FENBENDAZOLE SULFOXIDE (OXFENDAZOLE) |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
Albendazole and fenbendazole are methylcarbamate benzimidazole anthelmintics extensively used to control gastrointestinal parasites in domestic animals. These parent compounds are metabolised to albendazole sulfoxide and fenbendazole sulfoxide (oxfendazole), respectively. Both sulfoxide derivatives are anthelmintically active and are manufactured for use in animals. They metabolites have an asymmetric centre on their chemical structures and two enantiomeric forms of each sulfoxide have been identified in plasma, tissues of parasite location and within target helminths. Both the flavin-monooxygenase and cytochrome P450 systems are involved in the enantioselective biotransformation of these anthelmintic compounds in ruminant species. A relevant progress on the understanding of the relationship among enantioselective metabolism and systemic availability of each enantiomeric form has been achieved. This article reviews the current knowledge on the pharmacological implications of the enantiomeric behaviour of albendazole sulfoxide and oxfendazole in domestic animals. Fil: Capece, Bettencourt P. S.. Universidade Eduardo Mondlane; Mozambique Fil: Virkel, Guillermo Leon. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina |
description |
Albendazole and fenbendazole are methylcarbamate benzimidazole anthelmintics extensively used to control gastrointestinal parasites in domestic animals. These parent compounds are metabolised to albendazole sulfoxide and fenbendazole sulfoxide (oxfendazole), respectively. Both sulfoxide derivatives are anthelmintically active and are manufactured for use in animals. They metabolites have an asymmetric centre on their chemical structures and two enantiomeric forms of each sulfoxide have been identified in plasma, tissues of parasite location and within target helminths. Both the flavin-monooxygenase and cytochrome P450 systems are involved in the enantioselective biotransformation of these anthelmintic compounds in ruminant species. A relevant progress on the understanding of the relationship among enantioselective metabolism and systemic availability of each enantiomeric form has been achieved. This article reviews the current knowledge on the pharmacological implications of the enantiomeric behaviour of albendazole sulfoxide and oxfendazole in domestic animals. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/95707 Capece, Bettencourt P. S.; Virkel, Guillermo Leon; Lanusse, Carlos Edmundo; Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications; Elsevier; The Veterinary Journal; 181; 3; 9-2009; 241-250 1090-0233 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/95707 |
identifier_str_mv |
Capece, Bettencourt P. S.; Virkel, Guillermo Leon; Lanusse, Carlos Edmundo; Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications; Elsevier; The Veterinary Journal; 181; 3; 9-2009; 241-250 1090-0233 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1090023308004097 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tvjl.2008.11.010 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614258797576192 |
score |
13.070432 |