Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges

Autores
Villena, Julio Cesar; Oliveira, María Leonor S.; Ferreira, Patricia D.; Salva, Maria Susana; Alvarez, Gladis Susana
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Lactic acid bacteria (LAB) are technologically and commercially important and have various beneficial effects on human health. Several studies have demonstrated that certain LAB strains can exert their beneficial effect on the host through their immunomudulatory activity. Although most research concerning LAB-mediated enhanced immune protection is focused on gastrointestinal tract pathogens, recent studies have centered on whether these immunobiotics might sufficiently stimulate the common mucosal immune system to provide protection to other mucosal sites as well. In this sense, LAB have been used for the development of probiotic foods with the ability to stimulate respiratory immunity, which would increase resistance to infections, even in immunocompromised hosts. On the other hand, the advances in the molecular biology of LAB have enabled the development of recombinant strains expressing antigens from respiratory pathogens that have proved effective to induce protective immunity. In this review we examine the current scientific literature concerning the use of LAB strains to prevent respiratory infections. In particular, we have focused on the works that deal with the capacity of probiotic and recombinant LAB to improve the immune response against Streptococcus pneumoniae. Research from the last decade demonstrates that LAB represent a promising resource for the development of prevention strategies against respiratory infections that could be effective tools for medical application.
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Oliveira, María Leonor S.. Instituto Butantan. Centro de Biotecnología; Brasil
Fil: Ferreira, Patricia D.. Instituto Butantan. Centro de Biotecnología; Brasil
Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Materia
Adjuvant
Immunocompromised Hosts
Lactic Acid Bacteria
Respiratory Infection
Streptococcus Pneumoniae
Vaccine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/52135

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network_name_str CONICET Digital (CONICET)
spelling Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challengesVillena, Julio CesarOliveira, María Leonor S.Ferreira, Patricia D.Salva, Maria SusanaAlvarez, Gladis SusanaAdjuvantImmunocompromised HostsLactic Acid BacteriaRespiratory InfectionStreptococcus PneumoniaeVaccinehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Lactic acid bacteria (LAB) are technologically and commercially important and have various beneficial effects on human health. Several studies have demonstrated that certain LAB strains can exert their beneficial effect on the host through their immunomudulatory activity. Although most research concerning LAB-mediated enhanced immune protection is focused on gastrointestinal tract pathogens, recent studies have centered on whether these immunobiotics might sufficiently stimulate the common mucosal immune system to provide protection to other mucosal sites as well. In this sense, LAB have been used for the development of probiotic foods with the ability to stimulate respiratory immunity, which would increase resistance to infections, even in immunocompromised hosts. On the other hand, the advances in the molecular biology of LAB have enabled the development of recombinant strains expressing antigens from respiratory pathogens that have proved effective to induce protective immunity. In this review we examine the current scientific literature concerning the use of LAB strains to prevent respiratory infections. In particular, we have focused on the works that deal with the capacity of probiotic and recombinant LAB to improve the immune response against Streptococcus pneumoniae. Research from the last decade demonstrates that LAB represent a promising resource for the development of prevention strategies against respiratory infections that could be effective tools for medical application.Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Oliveira, María Leonor S.. Instituto Butantan. Centro de Biotecnología; BrasilFil: Ferreira, Patricia D.. Instituto Butantan. Centro de Biotecnología; BrasilFil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaElsevier Science2011-11-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/52135Villena, Julio Cesar; Oliveira, María Leonor S.; Ferreira, Patricia D.; Salva, Maria Susana; Alvarez, Gladis Susana; Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges; Elsevier Science; International Immunopharmacology; 11; 11; 25-11-2011; 1633-16451567-57691878-1705CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.intimp.2011.06.004info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1567576911002530info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:24:53Zoai:ri.conicet.gov.ar:11336/52135instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:24:53.452CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges
title Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges
spellingShingle Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges
Villena, Julio Cesar
Adjuvant
Immunocompromised Hosts
Lactic Acid Bacteria
Respiratory Infection
Streptococcus Pneumoniae
Vaccine
title_short Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges
title_full Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges
title_fullStr Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges
title_full_unstemmed Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges
title_sort Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges
dc.creator.none.fl_str_mv Villena, Julio Cesar
Oliveira, María Leonor S.
Ferreira, Patricia D.
Salva, Maria Susana
Alvarez, Gladis Susana
author Villena, Julio Cesar
author_facet Villena, Julio Cesar
Oliveira, María Leonor S.
Ferreira, Patricia D.
Salva, Maria Susana
Alvarez, Gladis Susana
author_role author
author2 Oliveira, María Leonor S.
Ferreira, Patricia D.
Salva, Maria Susana
Alvarez, Gladis Susana
author2_role author
author
author
author
dc.subject.none.fl_str_mv Adjuvant
Immunocompromised Hosts
Lactic Acid Bacteria
Respiratory Infection
Streptococcus Pneumoniae
Vaccine
topic Adjuvant
Immunocompromised Hosts
Lactic Acid Bacteria
Respiratory Infection
Streptococcus Pneumoniae
Vaccine
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Lactic acid bacteria (LAB) are technologically and commercially important and have various beneficial effects on human health. Several studies have demonstrated that certain LAB strains can exert their beneficial effect on the host through their immunomudulatory activity. Although most research concerning LAB-mediated enhanced immune protection is focused on gastrointestinal tract pathogens, recent studies have centered on whether these immunobiotics might sufficiently stimulate the common mucosal immune system to provide protection to other mucosal sites as well. In this sense, LAB have been used for the development of probiotic foods with the ability to stimulate respiratory immunity, which would increase resistance to infections, even in immunocompromised hosts. On the other hand, the advances in the molecular biology of LAB have enabled the development of recombinant strains expressing antigens from respiratory pathogens that have proved effective to induce protective immunity. In this review we examine the current scientific literature concerning the use of LAB strains to prevent respiratory infections. In particular, we have focused on the works that deal with the capacity of probiotic and recombinant LAB to improve the immune response against Streptococcus pneumoniae. Research from the last decade demonstrates that LAB represent a promising resource for the development of prevention strategies against respiratory infections that could be effective tools for medical application.
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Oliveira, María Leonor S.. Instituto Butantan. Centro de Biotecnología; Brasil
Fil: Ferreira, Patricia D.. Instituto Butantan. Centro de Biotecnología; Brasil
Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
description Lactic acid bacteria (LAB) are technologically and commercially important and have various beneficial effects on human health. Several studies have demonstrated that certain LAB strains can exert their beneficial effect on the host through their immunomudulatory activity. Although most research concerning LAB-mediated enhanced immune protection is focused on gastrointestinal tract pathogens, recent studies have centered on whether these immunobiotics might sufficiently stimulate the common mucosal immune system to provide protection to other mucosal sites as well. In this sense, LAB have been used for the development of probiotic foods with the ability to stimulate respiratory immunity, which would increase resistance to infections, even in immunocompromised hosts. On the other hand, the advances in the molecular biology of LAB have enabled the development of recombinant strains expressing antigens from respiratory pathogens that have proved effective to induce protective immunity. In this review we examine the current scientific literature concerning the use of LAB strains to prevent respiratory infections. In particular, we have focused on the works that deal with the capacity of probiotic and recombinant LAB to improve the immune response against Streptococcus pneumoniae. Research from the last decade demonstrates that LAB represent a promising resource for the development of prevention strategies against respiratory infections that could be effective tools for medical application.
publishDate 2011
dc.date.none.fl_str_mv 2011-11-25
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/52135
Villena, Julio Cesar; Oliveira, María Leonor S.; Ferreira, Patricia D.; Salva, Maria Susana; Alvarez, Gladis Susana; Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges; Elsevier Science; International Immunopharmacology; 11; 11; 25-11-2011; 1633-1645
1567-5769
1878-1705
CONICET Digital
CONICET
url http://hdl.handle.net/11336/52135
identifier_str_mv Villena, Julio Cesar; Oliveira, María Leonor S.; Ferreira, Patricia D.; Salva, Maria Susana; Alvarez, Gladis Susana; Lactic acid bacteria in the prevention of pneumococcal respiratory infection: Future opportunities and challenges; Elsevier Science; International Immunopharmacology; 11; 11; 25-11-2011; 1633-1645
1567-5769
1878-1705
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.intimp.2011.06.004
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1567576911002530
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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