Global Population Structure and Evolution of Bordetella pertussis and Their Relationship with Vaccination

• Autores: Bart, Marieke J.; Harris, Simon R.; Advani, Abdolreza; Arakawa, Yoshichika; Bottero, Daniela; Bouchez, Valérie; Cassiday, Pamela K.; Chiang, Chuen Sheue; Dalby, Tine; Fry, Norman K.; Gaillard, María Emilia; Van Gent, Marjolein; Guiso, Nicole; Hallander, Hans O.; Harvill, Eric T.; He, Qiushui; Van der Heide, Han G. J.; Heuvelman, Kees; Hozbor, Daniela Flavia; Kamachi, Kazunari; Karataev, Gennady I.; Lan, Ruiting; Lutynska, Anna; Maharjan, Ram P.; Mertsola, Jussi; Miyamura, Tatsuo; Octavia, Sophie; Preston, Andrew; Quail, Michael A.; Sintchenko, Vitali; Stefanelli, Paola; Tondella, M. Lucia; Tsang, Raymond S. W.; Xu, Yinghua; Yao, Shu-Man; Zhang, Shumin; Parkhill, Julian; Mooi, Frits R.
• Año de publicación: 2014
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: BORDETELLA PERTUSSIS; VACCINATION; POPULATION STRUCTURE; EVOLUTION
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Bordetella pertussis causes pertussis, a respiratory disease that is most severe for infants. Vaccination was introduced in the 1950s, and in recent years, a resurgence of disease was observed worldwide, with significant mortality in infants. Possible causes for this include the switch from whole-cell vaccines (WCVs) to less effective acellular vaccines (ACVs), waning immunity, and pathogen adaptation. Pathogen adaptation is suggested by antigenic divergence between vaccine strains and circulating strains and by the emergence of strains with increased pertussis toxin production. We applied comparative genomics to a worldwide collection of 343 B. pertussis strains isolated between 1920 and 2010. The global phylogeny showed two deep branches; the largest of these contained 98% of all strains, and its expansion correlated temporally with the first descriptions of pertussis outbreaks in Europe in the 16th century. We found little evidence of recent geographical clustering of the strains within this lineage, suggesting rapid strain flow between countries. We observed that changes in genes encoding proteins implicated in protective immunity that are included in ACVs occurred after the introduction of WCVs but before the switch to ACVs. Furthermore, our analyses consistently suggested that virulence-associated genes and genes coding for surface-exposed proteins were involved in adaptation. However, many of the putative adaptive loci identified have a physiological role, and further studies of these loci may reveal less obvious ways in which B. pertussis and the host interact. This work provides insight into ways in which pathogens may adapt to vaccination and suggests ways to improve pertussis vaccines.
Fil: Bart, Marieke J.. National Institute of Public Health and the Environment; Países Bajos. St. Radboud Hospital; Países Bajos
Fil: Harris, Simon R.. Wellcome Trust Genome Campus. Wellcome Trust Sanger Institute; Reino Unido
Fil: Advani, Abdolreza. Swedish Institute for Communicable Disease Control; Suiza
Fil: Arakawa, Yoshichika. National Institute of Infectious Diseases; Japón
Fil: Bottero, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Bouchez, Valérie. Molecular Prevention and Therapy of Human Infections. Institut Pasteur; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Cassiday, Pamela K.. Centers for Disease Control and Prevention; Estados Unidos
Fil: Chiang, Chuen Sheue. Centers for Disease Control; China
Fil: Dalby, Tine. Statens Serum Institut. Microbiology & Infection Control; Dinamarca
Fil: Fry, Norman K.. Public Health England-Respiratory and Vaccine Preventable Bacteria Reference Unit; Reino Unido
Fil: Gaillard, María Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Van Gent, Marjolein. National Institute of Public Health and the Environment; Países Bajos
Fil: Guiso, Nicole. Molecular Prevention and Therapy of Human Infections. Institut Pasteur; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Hallander, Hans O.. Swedish Institute for Communicable Disease Control; Suiza
Fil: Harvill, Eric T.. University Park. The Pennsylvania State University. Department of Veterinary and Biomedical Sciences; Estados Unidos
Fil: He, Qiushui. National Institute for Health and Welfare. Department of Infectious Disease Surveillance and Control; Finlandia
Fil: Van der Heide, Han G. J.. National Institute of Public Health and the Environment; Países Bajos
Fil: Heuvelman, Kees. National Institute of Public Health and the Environment; Países Bajos
Fil: Hozbor, Daniela Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Biotecnología y Biología Molecular. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Biotecnología y Biología Molecular; Argentina
Fil: Kamachi, Kazunari. National Institute of Infectious Diseases; Japón
Fil: Karataev, Gennady I.. Ministry of Health Russian Federation. Gamaleya Research Institute for Epidemiology and Microbiology; Rusia
Fil: Lan, Ruiting. University of New South Wales. School of Biotechnology and Biomolecular Sciences; Australia
Fil: Lutynska, Anna. National Institute of Hygiene. National Institute of Public Health; Polonia
Fil: Maharjan, Ram P.. University of New South Wales. School of Biotechnology and Biomolecular Sciences; Australia
Fil: Mertsola, Jussi. Turku University Hospital. Department of Pediatrics; Finlandia
Fil: Miyamura, Tatsuo. National Institute of Infectious Diseases; Japón
Fil: Octavia, Sophie. University of New South Wales. School of Biotechnology and Biomolecular Sciences; Australia
Fil: Preston, Andrew. University of Bath. Department of Biology and Biochemistry; Reino Unido
Fil: Quail, Michael A.. Wellcome Trust Genome Campus. Wellcome Trust Sanger Institute; Reino Unido
Fil: Sintchenko, Vitali. Westmead Hospital. Institute of Clinical Pathology and Medical Research. Centre for Infectious Diseases and Microbiology-Public Health; Australia. University of Sydney. Sydney Emerging Infectious Diseases and Biosecurity Institute; Australia
Fil: Stefanelli, Paola. Istituto Superiore di Sanita. Department of Infectious, Parasitic & Immune-Mediated Diseases; Italia
Fil: Tondella, M. Lucia. Centers for Disease Control and Prevention; Estados Unidos
Fil: Tsang, Raymond S. W.. Public Health Agency of Canada. National Microbiology Laboratory. Laboratory for Syphilis Diagnostics and Vaccine Preventable Bacterial Diseases; Canadá
Fil: Xu, Yinghua. National Institute for Food and Drug Control; China
Fil: Yao, Shu-Man. Centers for Disease Control; China
Fil: Zhang, Shumin. National Institute for Food and Drug Control; China
Fil: Parkhill, Julian. Wellcome Trust Sanger Institute. Wellcome Trust Genome Campus; Reino Unido
Fil: Mooi, Frits R.. National Institute of Public Health and the Environment; Países Bajos. St. Radboud Hospital; Países Bajos