Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate

Autores
Palacios, María Gabriela; Cunnick, Joan E.; Winkler, David W.; Vleck, Carol M.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Understanding the relationships among immune components in free-living animals is a challenge in ecoimmunology, and it is important not only for selecting the immune assays to be used but also for more knowledgeable interpretation of results. In this study, we investigated the relationships among six immune defense indexes commonly used by ecoimmunologists and measured simultaneously in individual free-living tree swallows. Three main axes of variation in immune function were identified using a principal components analysis, representing variation in T-cell, B-cell, and innate immunity. Measures within each axis tended to be positively correlated among individuals, while measures in different axes were uncorrelated. A trade-off between T-cell function and B-cell function became apparent only when variation among individuals in body condition, age, and general quality was taken into account. Interestingly, the level of natural antibodies, a component of innate immunity, showed the strongest association with components of acquired B-cell function, possibly reflecting a common underlying genetic mechanism, as has been documented in poultry. Our results indicate that despite the complexity of the immune system, important insights can be gained by using the currently available assays but in a more comprehensive approach than has generally been used in the field of ecoimmunology.
Fil: Palacios, María Gabriela. Iowa State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cunnick, Joan E.. Iowa State University; Estados Unidos
Fil: Winkler, David W.. Cornell University; Estados Unidos
Fil: Vleck, Carol M.. Iowa State University; Estados Unidos
Materia
Complement
Ecological Immunology
Immunocompetence
Lymphocyte Proliferation
Natural Antibodies
Phytohemagglutinin
Tachycineta Bicolor
Trade-Off
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24363
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/24363
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebratePalacios, María GabrielaCunnick, Joan E.Winkler, David W.Vleck, Carol M.ComplementEcological ImmunologyImmunocompetenceLymphocyte ProliferationNatural AntibodiesPhytohemagglutininTachycineta BicolorTrade-Offhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Understanding the relationships among immune components in free-living animals is a challenge in ecoimmunology, and it is important not only for selecting the immune assays to be used but also for more knowledgeable interpretation of results. In this study, we investigated the relationships among six immune defense indexes commonly used by ecoimmunologists and measured simultaneously in individual free-living tree swallows. Three main axes of variation in immune function were identified using a principal components analysis, representing variation in T-cell, B-cell, and innate immunity. Measures within each axis tended to be positively correlated among individuals, while measures in different axes were uncorrelated. A trade-off between T-cell function and B-cell function became apparent only when variation among individuals in body condition, age, and general quality was taken into account. Interestingly, the level of natural antibodies, a component of innate immunity, showed the strongest association with components of acquired B-cell function, possibly reflecting a common underlying genetic mechanism, as has been documented in poultry. Our results indicate that despite the complexity of the immune system, important insights can be gained by using the currently available assays but in a more comprehensive approach than has generally been used in the field of ecoimmunology.Fil: Palacios, María Gabriela. Iowa State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cunnick, Joan E.. Iowa State University; Estados UnidosFil: Winkler, David W.. Cornell University; Estados UnidosFil: Vleck, Carol M.. Iowa State University; Estados UnidosUniversity of Chicago Press2011-12-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24363Palacios, María Gabriela; Cunnick, Joan E.; Winkler, David W.; Vleck, Carol M.; Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate; University of Chicago Press; Physiological and Biochemical Zoology; 85; 1; 12-12-2011; 1-101522-2152CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.journals.uchicago.edu/doi/10.1086/663311info:eu-repo/semantics/altIdentifier/doi/10.1086/663311info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:17:27Zoai:ri.conicet.gov.ar:11336/24363instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:17:27.458CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate
title Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate
spellingShingle Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate
Palacios, María Gabriela
Complement
Ecological Immunology
Immunocompetence
Lymphocyte Proliferation
Natural Antibodies
Phytohemagglutinin
Tachycineta Bicolor
Trade-Off
title_short Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate
title_full Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate
title_fullStr Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate
title_full_unstemmed Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate
title_sort Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate
dc.creator.none.fl_str_mv Palacios, María Gabriela
Cunnick, Joan E.
Winkler, David W.
Vleck, Carol M.
author Palacios, María Gabriela
author_facet Palacios, María Gabriela
Cunnick, Joan E.
Winkler, David W.
Vleck, Carol M.
author_role author
author2 Cunnick, Joan E.
Winkler, David W.
Vleck, Carol M.
author2_role author
author
author
dc.subject.none.fl_str_mv Complement
Ecological Immunology
Immunocompetence
Lymphocyte Proliferation
Natural Antibodies
Phytohemagglutinin
Tachycineta Bicolor
Trade-Off
topic Complement
Ecological Immunology
Immunocompetence
Lymphocyte Proliferation
Natural Antibodies
Phytohemagglutinin
Tachycineta Bicolor
Trade-Off
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Understanding the relationships among immune components in free-living animals is a challenge in ecoimmunology, and it is important not only for selecting the immune assays to be used but also for more knowledgeable interpretation of results. In this study, we investigated the relationships among six immune defense indexes commonly used by ecoimmunologists and measured simultaneously in individual free-living tree swallows. Three main axes of variation in immune function were identified using a principal components analysis, representing variation in T-cell, B-cell, and innate immunity. Measures within each axis tended to be positively correlated among individuals, while measures in different axes were uncorrelated. A trade-off between T-cell function and B-cell function became apparent only when variation among individuals in body condition, age, and general quality was taken into account. Interestingly, the level of natural antibodies, a component of innate immunity, showed the strongest association with components of acquired B-cell function, possibly reflecting a common underlying genetic mechanism, as has been documented in poultry. Our results indicate that despite the complexity of the immune system, important insights can be gained by using the currently available assays but in a more comprehensive approach than has generally been used in the field of ecoimmunology.
Fil: Palacios, María Gabriela. Iowa State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cunnick, Joan E.. Iowa State University; Estados Unidos
Fil: Winkler, David W.. Cornell University; Estados Unidos
Fil: Vleck, Carol M.. Iowa State University; Estados Unidos
description Understanding the relationships among immune components in free-living animals is a challenge in ecoimmunology, and it is important not only for selecting the immune assays to be used but also for more knowledgeable interpretation of results. In this study, we investigated the relationships among six immune defense indexes commonly used by ecoimmunologists and measured simultaneously in individual free-living tree swallows. Three main axes of variation in immune function were identified using a principal components analysis, representing variation in T-cell, B-cell, and innate immunity. Measures within each axis tended to be positively correlated among individuals, while measures in different axes were uncorrelated. A trade-off between T-cell function and B-cell function became apparent only when variation among individuals in body condition, age, and general quality was taken into account. Interestingly, the level of natural antibodies, a component of innate immunity, showed the strongest association with components of acquired B-cell function, possibly reflecting a common underlying genetic mechanism, as has been documented in poultry. Our results indicate that despite the complexity of the immune system, important insights can be gained by using the currently available assays but in a more comprehensive approach than has generally been used in the field of ecoimmunology.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24363
Palacios, María Gabriela; Cunnick, Joan E.; Winkler, David W.; Vleck, Carol M.; Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate; University of Chicago Press; Physiological and Biochemical Zoology; 85; 1; 12-12-2011; 1-10
1522-2152
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24363
identifier_str_mv Palacios, María Gabriela; Cunnick, Joan E.; Winkler, David W.; Vleck, Carol M.; Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate; University of Chicago Press; Physiological and Biochemical Zoology; 85; 1; 12-12-2011; 1-10
1522-2152
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.journals.uchicago.edu/doi/10.1086/663311
info:eu-repo/semantics/altIdentifier/doi/10.1086/663311
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv University of Chicago Press
publisher.none.fl_str_mv University of Chicago Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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