Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate
- Autores
- Palacios, María Gabriela; Cunnick, Joan E.; Winkler, David W.; Vleck, Carol M.
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Understanding the relationships among immune components in free-living animals is a challenge in ecoimmunology, and it is important not only for selecting the immune assays to be used but also for more knowledgeable interpretation of results. In this study, we investigated the relationships among six immune defense indexes commonly used by ecoimmunologists and measured simultaneously in individual free-living tree swallows. Three main axes of variation in immune function were identified using a principal components analysis, representing variation in T-cell, B-cell, and innate immunity. Measures within each axis tended to be positively correlated among individuals, while measures in different axes were uncorrelated. A trade-off between T-cell function and B-cell function became apparent only when variation among individuals in body condition, age, and general quality was taken into account. Interestingly, the level of natural antibodies, a component of innate immunity, showed the strongest association with components of acquired B-cell function, possibly reflecting a common underlying genetic mechanism, as has been documented in poultry. Our results indicate that despite the complexity of the immune system, important insights can be gained by using the currently available assays but in a more comprehensive approach than has generally been used in the field of ecoimmunology.
Fil: Palacios, María Gabriela. Iowa State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cunnick, Joan E.. Iowa State University; Estados Unidos
Fil: Winkler, David W.. Cornell University; Estados Unidos
Fil: Vleck, Carol M.. Iowa State University; Estados Unidos - Materia
-
Complement
Ecological Immunology
Immunocompetence
Lymphocyte Proliferation
Natural Antibodies
Phytohemagglutinin
Tachycineta Bicolor
Trade-Off - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/24363
Ver los metadatos del registro completo
id |
CONICETDig_8a6442060880fa040b5200657f55aed8 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/24363 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebratePalacios, María GabrielaCunnick, Joan E.Winkler, David W.Vleck, Carol M.ComplementEcological ImmunologyImmunocompetenceLymphocyte ProliferationNatural AntibodiesPhytohemagglutininTachycineta BicolorTrade-Offhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Understanding the relationships among immune components in free-living animals is a challenge in ecoimmunology, and it is important not only for selecting the immune assays to be used but also for more knowledgeable interpretation of results. In this study, we investigated the relationships among six immune defense indexes commonly used by ecoimmunologists and measured simultaneously in individual free-living tree swallows. Three main axes of variation in immune function were identified using a principal components analysis, representing variation in T-cell, B-cell, and innate immunity. Measures within each axis tended to be positively correlated among individuals, while measures in different axes were uncorrelated. A trade-off between T-cell function and B-cell function became apparent only when variation among individuals in body condition, age, and general quality was taken into account. Interestingly, the level of natural antibodies, a component of innate immunity, showed the strongest association with components of acquired B-cell function, possibly reflecting a common underlying genetic mechanism, as has been documented in poultry. Our results indicate that despite the complexity of the immune system, important insights can be gained by using the currently available assays but in a more comprehensive approach than has generally been used in the field of ecoimmunology.Fil: Palacios, María Gabriela. Iowa State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cunnick, Joan E.. Iowa State University; Estados UnidosFil: Winkler, David W.. Cornell University; Estados UnidosFil: Vleck, Carol M.. Iowa State University; Estados UnidosUniversity of Chicago Press2011-12-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24363Palacios, María Gabriela; Cunnick, Joan E.; Winkler, David W.; Vleck, Carol M.; Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate; University of Chicago Press; Physiological and Biochemical Zoology; 85; 1; 12-12-2011; 1-101522-2152CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.journals.uchicago.edu/doi/10.1086/663311info:eu-repo/semantics/altIdentifier/doi/10.1086/663311info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:20Zoai:ri.conicet.gov.ar:11336/24363instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:20.583CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate |
title |
Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate |
spellingShingle |
Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate Palacios, María Gabriela Complement Ecological Immunology Immunocompetence Lymphocyte Proliferation Natural Antibodies Phytohemagglutinin Tachycineta Bicolor Trade-Off |
title_short |
Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate |
title_full |
Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate |
title_fullStr |
Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate |
title_full_unstemmed |
Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate |
title_sort |
Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate |
dc.creator.none.fl_str_mv |
Palacios, María Gabriela Cunnick, Joan E. Winkler, David W. Vleck, Carol M. |
author |
Palacios, María Gabriela |
author_facet |
Palacios, María Gabriela Cunnick, Joan E. Winkler, David W. Vleck, Carol M. |
author_role |
author |
author2 |
Cunnick, Joan E. Winkler, David W. Vleck, Carol M. |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Complement Ecological Immunology Immunocompetence Lymphocyte Proliferation Natural Antibodies Phytohemagglutinin Tachycineta Bicolor Trade-Off |
topic |
Complement Ecological Immunology Immunocompetence Lymphocyte Proliferation Natural Antibodies Phytohemagglutinin Tachycineta Bicolor Trade-Off |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Understanding the relationships among immune components in free-living animals is a challenge in ecoimmunology, and it is important not only for selecting the immune assays to be used but also for more knowledgeable interpretation of results. In this study, we investigated the relationships among six immune defense indexes commonly used by ecoimmunologists and measured simultaneously in individual free-living tree swallows. Three main axes of variation in immune function were identified using a principal components analysis, representing variation in T-cell, B-cell, and innate immunity. Measures within each axis tended to be positively correlated among individuals, while measures in different axes were uncorrelated. A trade-off between T-cell function and B-cell function became apparent only when variation among individuals in body condition, age, and general quality was taken into account. Interestingly, the level of natural antibodies, a component of innate immunity, showed the strongest association with components of acquired B-cell function, possibly reflecting a common underlying genetic mechanism, as has been documented in poultry. Our results indicate that despite the complexity of the immune system, important insights can be gained by using the currently available assays but in a more comprehensive approach than has generally been used in the field of ecoimmunology. Fil: Palacios, María Gabriela. Iowa State University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Cunnick, Joan E.. Iowa State University; Estados Unidos Fil: Winkler, David W.. Cornell University; Estados Unidos Fil: Vleck, Carol M.. Iowa State University; Estados Unidos |
description |
Understanding the relationships among immune components in free-living animals is a challenge in ecoimmunology, and it is important not only for selecting the immune assays to be used but also for more knowledgeable interpretation of results. In this study, we investigated the relationships among six immune defense indexes commonly used by ecoimmunologists and measured simultaneously in individual free-living tree swallows. Three main axes of variation in immune function were identified using a principal components analysis, representing variation in T-cell, B-cell, and innate immunity. Measures within each axis tended to be positively correlated among individuals, while measures in different axes were uncorrelated. A trade-off between T-cell function and B-cell function became apparent only when variation among individuals in body condition, age, and general quality was taken into account. Interestingly, the level of natural antibodies, a component of innate immunity, showed the strongest association with components of acquired B-cell function, possibly reflecting a common underlying genetic mechanism, as has been documented in poultry. Our results indicate that despite the complexity of the immune system, important insights can be gained by using the currently available assays but in a more comprehensive approach than has generally been used in the field of ecoimmunology. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/24363 Palacios, María Gabriela; Cunnick, Joan E.; Winkler, David W.; Vleck, Carol M.; Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate; University of Chicago Press; Physiological and Biochemical Zoology; 85; 1; 12-12-2011; 1-10 1522-2152 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/24363 |
identifier_str_mv |
Palacios, María Gabriela; Cunnick, Joan E.; Winkler, David W.; Vleck, Carol M.; Interrelations among immune defense indexes reflect major components of the immune system in a free-living vertebrate; University of Chicago Press; Physiological and Biochemical Zoology; 85; 1; 12-12-2011; 1-10 1522-2152 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.journals.uchicago.edu/doi/10.1086/663311 info:eu-repo/semantics/altIdentifier/doi/10.1086/663311 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
University of Chicago Press |
publisher.none.fl_str_mv |
University of Chicago Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614480654237696 |
score |
13.070432 |