Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis

Autores
Bilotas, Mariela Andrea; Meresman, Gabriela Fabiana; Stella, Inés; Sueldo, Carlos; Barañao, Rosa Ines
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: To evaluate the effect of aromatase inhibitors on ectopic endometrial growth and on the release of proangiogenic and proinflammatory factors in peritoneal fluid (PF). Design: Prospective experimental study. Setting: Animal research and laboratory facility. Animal(s): Female Balb/c mice 2 months of age. Intervention(s): Mice had surgery performed to induce endometriosis-like lesions. Treatment with anastrozole or letrozole was started on either postoperative day 1 or 28 and continued for 4 weeks. Main Outcome Measure(s): Endometriotic lesions were counted and measured and aromatase expression, cell proliferation, and apoptosis were assessed. Vascular endothelial growth factor (VEGF) and prostaglandin E (PGE) levels were evaluated in the PF. Result(s): Endometriosis-like lesions express aromatase P-450. Treatment with either anastrozole or letrozole did not prevent lesion establishment; however, it significantly decreased the size of the endometriotic lesion. When treatment was initiated on postoperative day 1, letrozole and anastrozole decreased cell proliferation and increased apoptosis. When treatment was started on postoperative day 28, both aromatase inhibitors decreased cell proliferation, but only anastrozole augmented apoptosis levels. In addition, letrozole reduced VEGF and PGE levels in PF. Anastrozole diminished VEGF content but did not cause any significant change in PGE levels. Conclusion(s): These findings support the further investigation of aromatase inhibition as a treatment option for endometriosis. © 2010 American Society for Reproductive Medicine.
Fil: Bilotas, Mariela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Meresman, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Stella, Inés. Hospital Israelita; Argentina
Fil: Sueldo, Carlos. Centro de Estudios en Ginecología y Reproducción; Argentina
Fil: Barañao, Rosa Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Materia
Aromatase Inhibitors
Endometriosis
Pge
Vegf
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/77467
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/77467
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosisBilotas, Mariela AndreaMeresman, Gabriela FabianaStella, InésSueldo, CarlosBarañao, Rosa InesAromatase InhibitorsEndometriosisPgeVegfhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective: To evaluate the effect of aromatase inhibitors on ectopic endometrial growth and on the release of proangiogenic and proinflammatory factors in peritoneal fluid (PF). Design: Prospective experimental study. Setting: Animal research and laboratory facility. Animal(s): Female Balb/c mice 2 months of age. Intervention(s): Mice had surgery performed to induce endometriosis-like lesions. Treatment with anastrozole or letrozole was started on either postoperative day 1 or 28 and continued for 4 weeks. Main Outcome Measure(s): Endometriotic lesions were counted and measured and aromatase expression, cell proliferation, and apoptosis were assessed. Vascular endothelial growth factor (VEGF) and prostaglandin E (PGE) levels were evaluated in the PF. Result(s): Endometriosis-like lesions express aromatase P-450. Treatment with either anastrozole or letrozole did not prevent lesion establishment; however, it significantly decreased the size of the endometriotic lesion. When treatment was initiated on postoperative day 1, letrozole and anastrozole decreased cell proliferation and increased apoptosis. When treatment was started on postoperative day 28, both aromatase inhibitors decreased cell proliferation, but only anastrozole augmented apoptosis levels. In addition, letrozole reduced VEGF and PGE levels in PF. Anastrozole diminished VEGF content but did not cause any significant change in PGE levels. Conclusion(s): These findings support the further investigation of aromatase inhibition as a treatment option for endometriosis. © 2010 American Society for Reproductive Medicine.Fil: Bilotas, Mariela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Meresman, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Stella, Inés. Hospital Israelita; ArgentinaFil: Sueldo, Carlos. Centro de Estudios en Ginecología y Reproducción; ArgentinaFil: Barañao, Rosa Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaElsevier Science Inc2010-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/77467Bilotas, Mariela Andrea; Meresman, Gabriela Fabiana; Stella, Inés; Sueldo, Carlos; Barañao, Rosa Ines; Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis; Elsevier Science Inc; Fertility and Sterility; 93; 8; 5-2010; 2513-25180015-0282CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.fertnstert.2009.08.058info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0015028209035973info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:02:38Zoai:ri.conicet.gov.ar:11336/77467instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:02:38.571CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis
title Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis
spellingShingle Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis
Bilotas, Mariela Andrea
Aromatase Inhibitors
Endometriosis
Pge
Vegf
title_short Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis
title_full Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis
title_fullStr Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis
title_full_unstemmed Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis
title_sort Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis
dc.creator.none.fl_str_mv Bilotas, Mariela Andrea
Meresman, Gabriela Fabiana
Stella, Inés
Sueldo, Carlos
Barañao, Rosa Ines
author Bilotas, Mariela Andrea
author_facet Bilotas, Mariela Andrea
Meresman, Gabriela Fabiana
Stella, Inés
Sueldo, Carlos
Barañao, Rosa Ines
author_role author
author2 Meresman, Gabriela Fabiana
Stella, Inés
Sueldo, Carlos
Barañao, Rosa Ines
author2_role author
author
author
author
dc.subject.none.fl_str_mv Aromatase Inhibitors
Endometriosis
Pge
Vegf
topic Aromatase Inhibitors
Endometriosis
Pge
Vegf
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: To evaluate the effect of aromatase inhibitors on ectopic endometrial growth and on the release of proangiogenic and proinflammatory factors in peritoneal fluid (PF). Design: Prospective experimental study. Setting: Animal research and laboratory facility. Animal(s): Female Balb/c mice 2 months of age. Intervention(s): Mice had surgery performed to induce endometriosis-like lesions. Treatment with anastrozole or letrozole was started on either postoperative day 1 or 28 and continued for 4 weeks. Main Outcome Measure(s): Endometriotic lesions were counted and measured and aromatase expression, cell proliferation, and apoptosis were assessed. Vascular endothelial growth factor (VEGF) and prostaglandin E (PGE) levels were evaluated in the PF. Result(s): Endometriosis-like lesions express aromatase P-450. Treatment with either anastrozole or letrozole did not prevent lesion establishment; however, it significantly decreased the size of the endometriotic lesion. When treatment was initiated on postoperative day 1, letrozole and anastrozole decreased cell proliferation and increased apoptosis. When treatment was started on postoperative day 28, both aromatase inhibitors decreased cell proliferation, but only anastrozole augmented apoptosis levels. In addition, letrozole reduced VEGF and PGE levels in PF. Anastrozole diminished VEGF content but did not cause any significant change in PGE levels. Conclusion(s): These findings support the further investigation of aromatase inhibition as a treatment option for endometriosis. © 2010 American Society for Reproductive Medicine.
Fil: Bilotas, Mariela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Meresman, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Stella, Inés. Hospital Israelita; Argentina
Fil: Sueldo, Carlos. Centro de Estudios en Ginecología y Reproducción; Argentina
Fil: Barañao, Rosa Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
description Objective: To evaluate the effect of aromatase inhibitors on ectopic endometrial growth and on the release of proangiogenic and proinflammatory factors in peritoneal fluid (PF). Design: Prospective experimental study. Setting: Animal research and laboratory facility. Animal(s): Female Balb/c mice 2 months of age. Intervention(s): Mice had surgery performed to induce endometriosis-like lesions. Treatment with anastrozole or letrozole was started on either postoperative day 1 or 28 and continued for 4 weeks. Main Outcome Measure(s): Endometriotic lesions were counted and measured and aromatase expression, cell proliferation, and apoptosis were assessed. Vascular endothelial growth factor (VEGF) and prostaglandin E (PGE) levels were evaluated in the PF. Result(s): Endometriosis-like lesions express aromatase P-450. Treatment with either anastrozole or letrozole did not prevent lesion establishment; however, it significantly decreased the size of the endometriotic lesion. When treatment was initiated on postoperative day 1, letrozole and anastrozole decreased cell proliferation and increased apoptosis. When treatment was started on postoperative day 28, both aromatase inhibitors decreased cell proliferation, but only anastrozole augmented apoptosis levels. In addition, letrozole reduced VEGF and PGE levels in PF. Anastrozole diminished VEGF content but did not cause any significant change in PGE levels. Conclusion(s): These findings support the further investigation of aromatase inhibition as a treatment option for endometriosis. © 2010 American Society for Reproductive Medicine.
publishDate 2010
dc.date.none.fl_str_mv 2010-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/77467
Bilotas, Mariela Andrea; Meresman, Gabriela Fabiana; Stella, Inés; Sueldo, Carlos; Barañao, Rosa Ines; Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis; Elsevier Science Inc; Fertility and Sterility; 93; 8; 5-2010; 2513-2518
0015-0282
CONICET Digital
CONICET
url http://hdl.handle.net/11336/77467
identifier_str_mv Bilotas, Mariela Andrea; Meresman, Gabriela Fabiana; Stella, Inés; Sueldo, Carlos; Barañao, Rosa Ines; Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis; Elsevier Science Inc; Fertility and Sterility; 93; 8; 5-2010; 2513-2518
0015-0282
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fertnstert.2009.08.058
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0015028209035973
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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