ROS formation and antioxidant status in brain areas of rats exposed to sodium metavanadate

Autores
Cuesta, Santiago; Frances, Daniel Eleazar Antonio; García, Graciela B.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the present work, in vivo ROS formation and the activity of antioxidant enzymes in the hippocampus and the cerebellum of sodium metavanadate (NaVO3) treated rats were studied. Rats were i.p. injected with 3 mg/kg bw/day (V1 group) or with 7.2 mg/kg bw/day of NaVO3 (V2 group) for 5 consecutive days. Results show that after only 5 days of NaVO3 exposure, reactive oxygen species formation and alteration of the oxidative defence system were observed. Vanadium-induced •OH production was detected in cerebellum at the high dose. This result was confirmed by in situ ROS histochemical staining. Neither Cat nor Cu–Zn SOD activities showed changes while GSH/GSSG ratio, in both brain areas, was significantly decreased in NaVO3- treated groups. The present work indicates that the NaVO3 dose and the particular brain area constitution would be critical in the cellular and molecular oxidative mechanism of this element.
Fil: Cuesta, Santiago. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Frances, Daniel Eleazar Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: García, Graciela B.. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina
Materia
Vanadium
Oxidative stress
Neurotoxicity
Antioxidant status
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/281029
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/281029
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling ROS formation and antioxidant status in brain areas of rats exposed to sodium metavanadateCuesta, SantiagoFrances, Daniel Eleazar AntonioGarcía, Graciela B.VanadiumOxidative stressNeurotoxicityAntioxidant statushttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3In the present work, in vivo ROS formation and the activity of antioxidant enzymes in the hippocampus and the cerebellum of sodium metavanadate (NaVO3) treated rats were studied. Rats were i.p. injected with 3 mg/kg bw/day (V1 group) or with 7.2 mg/kg bw/day of NaVO3 (V2 group) for 5 consecutive days. Results show that after only 5 days of NaVO3 exposure, reactive oxygen species formation and alteration of the oxidative defence system were observed. Vanadium-induced •OH production was detected in cerebellum at the high dose. This result was confirmed by in situ ROS histochemical staining. Neither Cat nor Cu–Zn SOD activities showed changes while GSH/GSSG ratio, in both brain areas, was significantly decreased in NaVO3- treated groups. The present work indicates that the NaVO3 dose and the particular brain area constitution would be critical in the cellular and molecular oxidative mechanism of this element.Fil: Cuesta, Santiago. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Frances, Daniel Eleazar Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: García, Graciela B.. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; ArgentinaPergamon-Elsevier Science Ltd2011-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/281029Cuesta, Santiago; Frances, Daniel Eleazar Antonio; García, Graciela B.; ROS formation and antioxidant status in brain areas of rats exposed to sodium metavanadate; Pergamon-Elsevier Science Ltd; Neurotoxicology and Teratology; 33; 2; 4-2011; 297-3020892-0362CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0892036210001947info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ntt.2010.10.010info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:22:29Zoai:ri.conicet.gov.ar:11336/281029instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:22:29.371CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv ROS formation and antioxidant status in brain areas of rats exposed to sodium metavanadate
title ROS formation and antioxidant status in brain areas of rats exposed to sodium metavanadate
spellingShingle ROS formation and antioxidant status in brain areas of rats exposed to sodium metavanadate
Cuesta, Santiago
Vanadium
Oxidative stress
Neurotoxicity
Antioxidant status
title_short ROS formation and antioxidant status in brain areas of rats exposed to sodium metavanadate
title_full ROS formation and antioxidant status in brain areas of rats exposed to sodium metavanadate
title_fullStr ROS formation and antioxidant status in brain areas of rats exposed to sodium metavanadate
title_full_unstemmed ROS formation and antioxidant status in brain areas of rats exposed to sodium metavanadate
title_sort ROS formation and antioxidant status in brain areas of rats exposed to sodium metavanadate
dc.creator.none.fl_str_mv Cuesta, Santiago
Frances, Daniel Eleazar Antonio
García, Graciela B.
author Cuesta, Santiago
author_facet Cuesta, Santiago
Frances, Daniel Eleazar Antonio
García, Graciela B.
author_role author
author2 Frances, Daniel Eleazar Antonio
García, Graciela B.
author2_role author
author
dc.subject.none.fl_str_mv Vanadium
Oxidative stress
Neurotoxicity
Antioxidant status
topic Vanadium
Oxidative stress
Neurotoxicity
Antioxidant status
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In the present work, in vivo ROS formation and the activity of antioxidant enzymes in the hippocampus and the cerebellum of sodium metavanadate (NaVO3) treated rats were studied. Rats were i.p. injected with 3 mg/kg bw/day (V1 group) or with 7.2 mg/kg bw/day of NaVO3 (V2 group) for 5 consecutive days. Results show that after only 5 days of NaVO3 exposure, reactive oxygen species formation and alteration of the oxidative defence system were observed. Vanadium-induced •OH production was detected in cerebellum at the high dose. This result was confirmed by in situ ROS histochemical staining. Neither Cat nor Cu–Zn SOD activities showed changes while GSH/GSSG ratio, in both brain areas, was significantly decreased in NaVO3- treated groups. The present work indicates that the NaVO3 dose and the particular brain area constitution would be critical in the cellular and molecular oxidative mechanism of this element.
Fil: Cuesta, Santiago. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Frances, Daniel Eleazar Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: García, Graciela B.. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina
description In the present work, in vivo ROS formation and the activity of antioxidant enzymes in the hippocampus and the cerebellum of sodium metavanadate (NaVO3) treated rats were studied. Rats were i.p. injected with 3 mg/kg bw/day (V1 group) or with 7.2 mg/kg bw/day of NaVO3 (V2 group) for 5 consecutive days. Results show that after only 5 days of NaVO3 exposure, reactive oxygen species formation and alteration of the oxidative defence system were observed. Vanadium-induced •OH production was detected in cerebellum at the high dose. This result was confirmed by in situ ROS histochemical staining. Neither Cat nor Cu–Zn SOD activities showed changes while GSH/GSSG ratio, in both brain areas, was significantly decreased in NaVO3- treated groups. The present work indicates that the NaVO3 dose and the particular brain area constitution would be critical in the cellular and molecular oxidative mechanism of this element.
publishDate 2011
dc.date.none.fl_str_mv 2011-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/281029
Cuesta, Santiago; Frances, Daniel Eleazar Antonio; García, Graciela B.; ROS formation and antioxidant status in brain areas of rats exposed to sodium metavanadate; Pergamon-Elsevier Science Ltd; Neurotoxicology and Teratology; 33; 2; 4-2011; 297-302
0892-0362
CONICET Digital
CONICET
url http://hdl.handle.net/11336/281029
identifier_str_mv Cuesta, Santiago; Frances, Daniel Eleazar Antonio; García, Graciela B.; ROS formation and antioxidant status in brain areas of rats exposed to sodium metavanadate; Pergamon-Elsevier Science Ltd; Neurotoxicology and Teratology; 33; 2; 4-2011; 297-302
0892-0362
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0892036210001947
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ntt.2010.10.010
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.176822

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