17-betaEstradiol and testosterone in sarcopenia: Role of satellite cells

Autores
la Colla, Anabela Belén; Pronsato, Lucía; Milanesi, Lorena Magdalena; Vasconsuelo, Andrea Anahi
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The loss of muscle mass and strength with aging, referred to as sarcopenia, is a prevalent condition among the elderly. Although the molecular mechanisms underlying sarcopenia are unclear, evidence suggests that an age-related acceleration of myocyte loss via apoptosis might be responsible for muscle perfomance decline. Interestingly, sarcopenia has been associated to a deficit of sex hormones which decrease upon aging. The skeletal muscle ability to repair and regenerate itself would not be possible without satellite cells, a subpopulation of cells that remain quiescent throughout life. They are activated in response to stress, enabling them to guide skeletal muscle regeneration. Thus, these cells could be a key factor to overcome sarcopenia. Of importance, satellite cells are 17β-estradiol (E2) and testosterone (T) targets. In this review, we summarize potential mechanisms through which these hormones regulate satellite cells activation during skeletal muscle regeneration in the elderly. The advance in its understanding will help to the development of potential therapeutic agents to alleviate and treat sarcopenia and other related myophaties.
Fil: la Colla, Anabela Belén. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Pronsato, Lucía. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Milanesi, Lorena Magdalena. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Vasconsuelo, Andrea Anahi. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Materia
Satellite Cells
17b-Estradiol
Testosterone
Aging
Sarcopenia
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6336
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/6336
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling 17-betaEstradiol and testosterone in sarcopenia: Role of satellite cellsla Colla, Anabela BelénPronsato, LucíaMilanesi, Lorena MagdalenaVasconsuelo, Andrea AnahiSatellite Cells17b-EstradiolTestosteroneAgingSarcopeniahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The loss of muscle mass and strength with aging, referred to as sarcopenia, is a prevalent condition among the elderly. Although the molecular mechanisms underlying sarcopenia are unclear, evidence suggests that an age-related acceleration of myocyte loss via apoptosis might be responsible for muscle perfomance decline. Interestingly, sarcopenia has been associated to a deficit of sex hormones which decrease upon aging. The skeletal muscle ability to repair and regenerate itself would not be possible without satellite cells, a subpopulation of cells that remain quiescent throughout life. They are activated in response to stress, enabling them to guide skeletal muscle regeneration. Thus, these cells could be a key factor to overcome sarcopenia. Of importance, satellite cells are 17β-estradiol (E2) and testosterone (T) targets. In this review, we summarize potential mechanisms through which these hormones regulate satellite cells activation during skeletal muscle regeneration in the elderly. The advance in its understanding will help to the development of potential therapeutic agents to alleviate and treat sarcopenia and other related myophaties.Fil: la Colla, Anabela Belén. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; ArgentinaFil: Pronsato, Lucía. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; ArgentinaFil: Milanesi, Lorena Magdalena. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; ArgentinaFil: Vasconsuelo, Andrea Anahi. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; ArgentinaElsevier Ireland2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6336la Colla, Anabela Belén; Pronsato, Lucía; Milanesi, Lorena Magdalena; Vasconsuelo, Andrea Anahi; 17-betaEstradiol and testosterone in sarcopenia: Role of satellite cells; Elsevier Ireland; Ageing Research Reviews; 24; Part B; 8-2015; 166-1771568-1637enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.arr.2015.07.011info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/pmid/26247846info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1568163715300131info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:07:36Zoai:ri.conicet.gov.ar:11336/6336instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:07:36.564CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv 17-betaEstradiol and testosterone in sarcopenia: Role of satellite cells
title 17-betaEstradiol and testosterone in sarcopenia: Role of satellite cells
spellingShingle 17-betaEstradiol and testosterone in sarcopenia: Role of satellite cells
la Colla, Anabela Belén
Satellite Cells
17b-Estradiol
Testosterone
Aging
Sarcopenia
title_short 17-betaEstradiol and testosterone in sarcopenia: Role of satellite cells
title_full 17-betaEstradiol and testosterone in sarcopenia: Role of satellite cells
title_fullStr 17-betaEstradiol and testosterone in sarcopenia: Role of satellite cells
title_full_unstemmed 17-betaEstradiol and testosterone in sarcopenia: Role of satellite cells
title_sort 17-betaEstradiol and testosterone in sarcopenia: Role of satellite cells
dc.creator.none.fl_str_mv la Colla, Anabela Belén
Pronsato, Lucía
Milanesi, Lorena Magdalena
Vasconsuelo, Andrea Anahi
author la Colla, Anabela Belén
author_facet la Colla, Anabela Belén
Pronsato, Lucía
Milanesi, Lorena Magdalena
Vasconsuelo, Andrea Anahi
author_role author
author2 Pronsato, Lucía
Milanesi, Lorena Magdalena
Vasconsuelo, Andrea Anahi
author2_role author
author
author
dc.subject.none.fl_str_mv Satellite Cells
17b-Estradiol
Testosterone
Aging
Sarcopenia
topic Satellite Cells
17b-Estradiol
Testosterone
Aging
Sarcopenia
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The loss of muscle mass and strength with aging, referred to as sarcopenia, is a prevalent condition among the elderly. Although the molecular mechanisms underlying sarcopenia are unclear, evidence suggests that an age-related acceleration of myocyte loss via apoptosis might be responsible for muscle perfomance decline. Interestingly, sarcopenia has been associated to a deficit of sex hormones which decrease upon aging. The skeletal muscle ability to repair and regenerate itself would not be possible without satellite cells, a subpopulation of cells that remain quiescent throughout life. They are activated in response to stress, enabling them to guide skeletal muscle regeneration. Thus, these cells could be a key factor to overcome sarcopenia. Of importance, satellite cells are 17β-estradiol (E2) and testosterone (T) targets. In this review, we summarize potential mechanisms through which these hormones regulate satellite cells activation during skeletal muscle regeneration in the elderly. The advance in its understanding will help to the development of potential therapeutic agents to alleviate and treat sarcopenia and other related myophaties.
Fil: la Colla, Anabela Belén. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Pronsato, Lucía. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Milanesi, Lorena Magdalena. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Vasconsuelo, Andrea Anahi. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol.conicet - Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
description The loss of muscle mass and strength with aging, referred to as sarcopenia, is a prevalent condition among the elderly. Although the molecular mechanisms underlying sarcopenia are unclear, evidence suggests that an age-related acceleration of myocyte loss via apoptosis might be responsible for muscle perfomance decline. Interestingly, sarcopenia has been associated to a deficit of sex hormones which decrease upon aging. The skeletal muscle ability to repair and regenerate itself would not be possible without satellite cells, a subpopulation of cells that remain quiescent throughout life. They are activated in response to stress, enabling them to guide skeletal muscle regeneration. Thus, these cells could be a key factor to overcome sarcopenia. Of importance, satellite cells are 17β-estradiol (E2) and testosterone (T) targets. In this review, we summarize potential mechanisms through which these hormones regulate satellite cells activation during skeletal muscle regeneration in the elderly. The advance in its understanding will help to the development of potential therapeutic agents to alleviate and treat sarcopenia and other related myophaties.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6336
la Colla, Anabela Belén; Pronsato, Lucía; Milanesi, Lorena Magdalena; Vasconsuelo, Andrea Anahi; 17-betaEstradiol and testosterone in sarcopenia: Role of satellite cells; Elsevier Ireland; Ageing Research Reviews; 24; Part B; 8-2015; 166-177
1568-1637
url http://hdl.handle.net/11336/6336
identifier_str_mv la Colla, Anabela Belén; Pronsato, Lucía; Milanesi, Lorena Magdalena; Vasconsuelo, Andrea Anahi; 17-betaEstradiol and testosterone in sarcopenia: Role of satellite cells; Elsevier Ireland; Ageing Research Reviews; 24; Part B; 8-2015; 166-177
1568-1637
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.arr.2015.07.011
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/pmid/26247846
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1568163715300131
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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