17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior

Autores
Steyn, Frederik J.; Ngo, Shyuan T.; Chen, Vicky Ping; Bailey Downs, Lora C.; Xie, Teresa Y.; Ghadami, Martin; Brimijoin, Stephen; Freeman, Willard M.; Rubinstein, Marcelo; Low, Malcolm J.; Stout, Michael B.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease. We previously reported that 17α-estradiol (17α-E2) administration elicits beneficial effects on metabolism and inflammation in old male mice. These observations were associated with reduced calorie intake. Here, we demonstrate that 17α-E2 acts through pro-opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity. These results confirm that 17α-E2 modulates appetite through selective interactions within hypothalamic anorexigenic pathways. Interestingly, some peripheral markers of metabolic homeostasis were also improved in animals with near complete loss of ARC Pomc transcription. This suggests that 17α-E2 might have central and peripheral actions that can beneficially affect metabolism cooperatively or independently.
Fil: Steyn, Frederik J.. University of Queensland Centre for Clinical Research; Australia. Royal Brisbane & Women’s Hospital; Australia. Wesley Medical Research; Australia
Fil: Ngo, Shyuan T.. University of Queensland Centre for Clinical Research; Australia. Royal Brisbane & Women’s Hospital; Australia. Wesley Medical Research; Australia. University of Queensland; Australia
Fil: Chen, Vicky Ping. Mayo Clinic; Estados Unidos
Fil: Bailey Downs, Lora C.. University of Oklahoma Health Sciences Center; Estados Unidos
Fil: Xie, Teresa Y.. University of Queensland; Australia
Fil: Ghadami, Martin. University of Queensland; Australia
Fil: Brimijoin, Stephen. Mayo Clinic; Estados Unidos
Fil: Freeman, Willard M.. University of Oklahoma Health Sciences Center; Estados Unidos
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. University of Michigan Medical School; Estados Unidos
Fil: Low, Malcolm J.. University of Michigan Medical School; Estados Unidos
Fil: Stout, Michael B.. University of Oklahoma. Health Sciences Center; Estados Unidos
Materia
17a-ESTRADIOL
AGING
FOOD INTAKE
HYPOTHALAMUS
OBESITY
PRO-OPIOMELANOCORTIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79838
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/79838
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behaviorSteyn, Frederik J.Ngo, Shyuan T.Chen, Vicky PingBailey Downs, Lora C.Xie, Teresa Y.Ghadami, MartinBrimijoin, StephenFreeman, Willard M.Rubinstein, MarceloLow, Malcolm J.Stout, Michael B.17a-ESTRADIOLAGINGFOOD INTAKEHYPOTHALAMUSOBESITYPRO-OPIOMELANOCORTINhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease. We previously reported that 17α-estradiol (17α-E2) administration elicits beneficial effects on metabolism and inflammation in old male mice. These observations were associated with reduced calorie intake. Here, we demonstrate that 17α-E2 acts through pro-opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity. These results confirm that 17α-E2 modulates appetite through selective interactions within hypothalamic anorexigenic pathways. Interestingly, some peripheral markers of metabolic homeostasis were also improved in animals with near complete loss of ARC Pomc transcription. This suggests that 17α-E2 might have central and peripheral actions that can beneficially affect metabolism cooperatively or independently.Fil: Steyn, Frederik J.. University of Queensland Centre for Clinical Research; Australia. Royal Brisbane & Women’s Hospital; Australia. Wesley Medical Research; AustraliaFil: Ngo, Shyuan T.. University of Queensland Centre for Clinical Research; Australia. Royal Brisbane & Women’s Hospital; Australia. Wesley Medical Research; Australia. University of Queensland; AustraliaFil: Chen, Vicky Ping. Mayo Clinic; Estados UnidosFil: Bailey Downs, Lora C.. University of Oklahoma Health Sciences Center; Estados UnidosFil: Xie, Teresa Y.. University of Queensland; AustraliaFil: Ghadami, Martin. University of Queensland; AustraliaFil: Brimijoin, Stephen. Mayo Clinic; Estados UnidosFil: Freeman, Willard M.. University of Oklahoma Health Sciences Center; Estados UnidosFil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. University of Michigan Medical School; Estados UnidosFil: Low, Malcolm J.. University of Michigan Medical School; Estados UnidosFil: Stout, Michael B.. University of Oklahoma. Health Sciences Center; Estados UnidosWiley Blackwell Publishing, Inc2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79838Steyn, Frederik J.; Ngo, Shyuan T.; Chen, Vicky Ping; Bailey Downs, Lora C.; Xie, Teresa Y.; et al.; 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior; Wiley Blackwell Publishing, Inc; Aging Cell; 17; 1; 2-2018; 1-61474-9718CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/acel.12703info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770854/info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12703info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:15:40Zoai:ri.conicet.gov.ar:11336/79838instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:15:40.552CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior
title 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior
spellingShingle 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior
Steyn, Frederik J.
17a-ESTRADIOL
AGING
FOOD INTAKE
HYPOTHALAMUS
OBESITY
PRO-OPIOMELANOCORTIN
title_short 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior
title_full 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior
title_fullStr 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior
title_full_unstemmed 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior
title_sort 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior
dc.creator.none.fl_str_mv Steyn, Frederik J.
Ngo, Shyuan T.
Chen, Vicky Ping
Bailey Downs, Lora C.
Xie, Teresa Y.
Ghadami, Martin
Brimijoin, Stephen
Freeman, Willard M.
Rubinstein, Marcelo
Low, Malcolm J.
Stout, Michael B.
author Steyn, Frederik J.
author_facet Steyn, Frederik J.
Ngo, Shyuan T.
Chen, Vicky Ping
Bailey Downs, Lora C.
Xie, Teresa Y.
Ghadami, Martin
Brimijoin, Stephen
Freeman, Willard M.
Rubinstein, Marcelo
Low, Malcolm J.
Stout, Michael B.
author_role author
author2 Ngo, Shyuan T.
Chen, Vicky Ping
Bailey Downs, Lora C.
Xie, Teresa Y.
Ghadami, Martin
Brimijoin, Stephen
Freeman, Willard M.
Rubinstein, Marcelo
Low, Malcolm J.
Stout, Michael B.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv 17a-ESTRADIOL
AGING
FOOD INTAKE
HYPOTHALAMUS
OBESITY
PRO-OPIOMELANOCORTIN
topic 17a-ESTRADIOL
AGING
FOOD INTAKE
HYPOTHALAMUS
OBESITY
PRO-OPIOMELANOCORTIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease. We previously reported that 17α-estradiol (17α-E2) administration elicits beneficial effects on metabolism and inflammation in old male mice. These observations were associated with reduced calorie intake. Here, we demonstrate that 17α-E2 acts through pro-opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity. These results confirm that 17α-E2 modulates appetite through selective interactions within hypothalamic anorexigenic pathways. Interestingly, some peripheral markers of metabolic homeostasis were also improved in animals with near complete loss of ARC Pomc transcription. This suggests that 17α-E2 might have central and peripheral actions that can beneficially affect metabolism cooperatively or independently.
Fil: Steyn, Frederik J.. University of Queensland Centre for Clinical Research; Australia. Royal Brisbane & Women’s Hospital; Australia. Wesley Medical Research; Australia
Fil: Ngo, Shyuan T.. University of Queensland Centre for Clinical Research; Australia. Royal Brisbane & Women’s Hospital; Australia. Wesley Medical Research; Australia. University of Queensland; Australia
Fil: Chen, Vicky Ping. Mayo Clinic; Estados Unidos
Fil: Bailey Downs, Lora C.. University of Oklahoma Health Sciences Center; Estados Unidos
Fil: Xie, Teresa Y.. University of Queensland; Australia
Fil: Ghadami, Martin. University of Queensland; Australia
Fil: Brimijoin, Stephen. Mayo Clinic; Estados Unidos
Fil: Freeman, Willard M.. University of Oklahoma Health Sciences Center; Estados Unidos
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. University of Michigan Medical School; Estados Unidos
Fil: Low, Malcolm J.. University of Michigan Medical School; Estados Unidos
Fil: Stout, Michael B.. University of Oklahoma. Health Sciences Center; Estados Unidos
description Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease. We previously reported that 17α-estradiol (17α-E2) administration elicits beneficial effects on metabolism and inflammation in old male mice. These observations were associated with reduced calorie intake. Here, we demonstrate that 17α-E2 acts through pro-opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity. These results confirm that 17α-E2 modulates appetite through selective interactions within hypothalamic anorexigenic pathways. Interestingly, some peripheral markers of metabolic homeostasis were also improved in animals with near complete loss of ARC Pomc transcription. This suggests that 17α-E2 might have central and peripheral actions that can beneficially affect metabolism cooperatively or independently.
publishDate 2018
dc.date.none.fl_str_mv 2018-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79838
Steyn, Frederik J.; Ngo, Shyuan T.; Chen, Vicky Ping; Bailey Downs, Lora C.; Xie, Teresa Y.; et al.; 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior; Wiley Blackwell Publishing, Inc; Aging Cell; 17; 1; 2-2018; 1-6
1474-9718
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79838
identifier_str_mv Steyn, Frederik J.; Ngo, Shyuan T.; Chen, Vicky Ping; Bailey Downs, Lora C.; Xie, Teresa Y.; et al.; 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior; Wiley Blackwell Publishing, Inc; Aging Cell; 17; 1; 2-2018; 1-6
1474-9718
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/acel.12703
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770854/
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12703
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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