ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from Argentina

Autores
Kalemkerian, Paula Belén; Metz, German Ernesto; Peral Garcia, Pilar; Echeverria, Maria Gabriela; Giovambattista, Guillermo; Diaz, Silvina
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Polymorphisms at Major Histocompatibility Complex (MHC) genes have been associated with resistance/susceptibility to infectious diseases in domestic animals. The aim of this investigation was to evaluate whether polymorphisms of the DRA gene the Equine Lymphocyte Antigen is associated with susceptibility to Equine Arteritis Virus (EAV) infection in horses in Argentina. The equine DRA gene was screened for polymorphisms using Pyrosequencing® Technology which allowed the detection of three ELA-DRA exon 2 alleles. Neither allele frequencies nor genotypic differentiation exhibited any statistically significant (P-values = 0.788 and 0.745) differences between the EAV-infected and no-infected horses. Fisher’s exact test and OR calculations did not show any significant association. As a consequence, no association could be established between the serological condition and ELA-DRA.
Fil: Kalemkerian, Paula Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Genética Veterinaria "Ingeniero Fernando Noel Dulout"; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Metz, German Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina
Fil: Peral Garcia, Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Genética Veterinaria "Ingeniero Fernando Noel Dulout"; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Echeverria, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina
Fil: Giovambattista, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Genética Veterinaria "Ingeniero Fernando Noel Dulout"; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Diaz, Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Genética Veterinaria "Ingeniero Fernando Noel Dulout"; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Materia
Equine Lymphocyte Antigen
Equine Viral Arteritis
Genetic Susceptibility
Polymorphism
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11593
Acceder
id CONICETDig_887f30411dbdeee365c1687b2dbc057c
oai_identifier_str oai:ri.conicet.gov.ar:11336/11593
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from ArgentinaKalemkerian, Paula BelénMetz, German ErnestoPeral Garcia, PilarEcheverria, Maria GabrielaGiovambattista, GuillermoDiaz, SilvinaEquine Lymphocyte AntigenEquine Viral ArteritisGenetic SusceptibilityPolymorphismhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Polymorphisms at Major Histocompatibility Complex (MHC) genes have been associated with resistance/susceptibility to infectious diseases in domestic animals. The aim of this investigation was to evaluate whether polymorphisms of the DRA gene the Equine Lymphocyte Antigen is associated with susceptibility to Equine Arteritis Virus (EAV) infection in horses in Argentina. The equine DRA gene was screened for polymorphisms using Pyrosequencing® Technology which allowed the detection of three ELA-DRA exon 2 alleles. Neither allele frequencies nor genotypic differentiation exhibited any statistically significant (P-values = 0.788 and 0.745) differences between the EAV-infected and no-infected horses. Fisher’s exact test and OR calculations did not show any significant association. As a consequence, no association could be established between the serological condition and ELA-DRA.Fil: Kalemkerian, Paula Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Genética Veterinaria "Ingeniero Fernando Noel Dulout"; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Metz, German Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; ArgentinaFil: Peral Garcia, Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Genética Veterinaria "Ingeniero Fernando Noel Dulout"; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Echeverria, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; ArgentinaFil: Giovambattista, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Genética Veterinaria "Ingeniero Fernando Noel Dulout"; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Diaz, Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Genética Veterinaria "Ingeniero Fernando Noel Dulout"; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaElsevier2012-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11593Kalemkerian, Paula Belén; Metz, German Ernesto; Peral Garcia, Pilar; Echeverria, Maria Gabriela; Giovambattista, Guillermo; et al.; ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from Argentina; Elsevier; Research In Veterinary Science; 93; 3; 12-2012; 1271–12730034-5288enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.rvsc.2012.03.007info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0034528812000872info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:47Zoai:ri.conicet.gov.ar:11336/11593instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:47.955CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from Argentina
title ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from Argentina
spellingShingle ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from Argentina
Kalemkerian, Paula Belén
Equine Lymphocyte Antigen
Equine Viral Arteritis
Genetic Susceptibility
Polymorphism
title_short ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from Argentina
title_full ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from Argentina
title_fullStr ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from Argentina
title_full_unstemmed ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from Argentina
title_sort ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from Argentina
dc.creator.none.fl_str_mv Kalemkerian, Paula Belén
Metz, German Ernesto
Peral Garcia, Pilar
Echeverria, Maria Gabriela
Giovambattista, Guillermo
Diaz, Silvina
author Kalemkerian, Paula Belén
author_facet Kalemkerian, Paula Belén
Metz, German Ernesto
Peral Garcia, Pilar
Echeverria, Maria Gabriela
Giovambattista, Guillermo
Diaz, Silvina
author_role author
author2 Metz, German Ernesto
Peral Garcia, Pilar
Echeverria, Maria Gabriela
Giovambattista, Guillermo
Diaz, Silvina
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Equine Lymphocyte Antigen
Equine Viral Arteritis
Genetic Susceptibility
Polymorphism
topic Equine Lymphocyte Antigen
Equine Viral Arteritis
Genetic Susceptibility
Polymorphism
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Polymorphisms at Major Histocompatibility Complex (MHC) genes have been associated with resistance/susceptibility to infectious diseases in domestic animals. The aim of this investigation was to evaluate whether polymorphisms of the DRA gene the Equine Lymphocyte Antigen is associated with susceptibility to Equine Arteritis Virus (EAV) infection in horses in Argentina. The equine DRA gene was screened for polymorphisms using Pyrosequencing® Technology which allowed the detection of three ELA-DRA exon 2 alleles. Neither allele frequencies nor genotypic differentiation exhibited any statistically significant (P-values = 0.788 and 0.745) differences between the EAV-infected and no-infected horses. Fisher’s exact test and OR calculations did not show any significant association. As a consequence, no association could be established between the serological condition and ELA-DRA.
Fil: Kalemkerian, Paula Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Genética Veterinaria "Ingeniero Fernando Noel Dulout"; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Metz, German Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina
Fil: Peral Garcia, Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Genética Veterinaria "Ingeniero Fernando Noel Dulout"; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Echeverria, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina
Fil: Giovambattista, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Genética Veterinaria "Ingeniero Fernando Noel Dulout"; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Diaz, Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Instituto de Genética Veterinaria "Ingeniero Fernando Noel Dulout"; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
description Polymorphisms at Major Histocompatibility Complex (MHC) genes have been associated with resistance/susceptibility to infectious diseases in domestic animals. The aim of this investigation was to evaluate whether polymorphisms of the DRA gene the Equine Lymphocyte Antigen is associated with susceptibility to Equine Arteritis Virus (EAV) infection in horses in Argentina. The equine DRA gene was screened for polymorphisms using Pyrosequencing® Technology which allowed the detection of three ELA-DRA exon 2 alleles. Neither allele frequencies nor genotypic differentiation exhibited any statistically significant (P-values = 0.788 and 0.745) differences between the EAV-infected and no-infected horses. Fisher’s exact test and OR calculations did not show any significant association. As a consequence, no association could be established between the serological condition and ELA-DRA.
publishDate 2012
dc.date.none.fl_str_mv 2012-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11593
Kalemkerian, Paula Belén; Metz, German Ernesto; Peral Garcia, Pilar; Echeverria, Maria Gabriela; Giovambattista, Guillermo; et al.; ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from Argentina; Elsevier; Research In Veterinary Science; 93; 3; 12-2012; 1271–1273
0034-5288
url http://hdl.handle.net/11336/11593
identifier_str_mv Kalemkerian, Paula Belén; Metz, German Ernesto; Peral Garcia, Pilar; Echeverria, Maria Gabriela; Giovambattista, Guillermo; et al.; ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from Argentina; Elsevier; Research In Veterinary Science; 93; 3; 12-2012; 1271–1273
0034-5288
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rvsc.2012.03.007
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0034528812000872
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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