Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs

Autores
Mousavi, Seyed T.; Harper, Garry R.; Municoy, Sofia; Ashton, Mark D.; Townsend, David; Alsharif, Ghazi H. K.; Oikonomou, Vasileios K.; Firlak, Melike; Au Yong, Sophie; Murdock, Bethany E.; Akien, Geoffrey R.; Halcovitch, Nathan R.; Baldock, Sara J.; Fazilati, Mohamad; Kolosov, Oleg V.; Robinson, Benjamin J.; Desimone, Martín Federico; Hardy, John G.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Biomaterials capable of controlling the delivery of drugs have the potential to treat a variety of conditions. Herein, the preparation of electrically conductive silk fibroin film-based drug delivery devices is described. Casting aqueous solutions of Bombyx mori silk fibroin, followed by drying and annealing to impart β-sheets to the silk fibroin, assure that the materials are stable for further processing in water; and the silk fibroin films are rendered conductive by generating an interpenetrating network of a copolymer of pyrrole and 3-amino-4-hydroxybenzenesulfonic acid in the silk fibroin matrix (characterized by a variety of techniques including circular dichroism, Fourier-transform infrared spectroscopy, nuclear magnetic resonance, Raman spectroscopy, resistance measurements, scanning electron microscopy-energy dispersive X-ray spectroscopy, thermogravimetric analysis, X-ray diffraction, and X-ray photoelectron spectroscopy). Fibroblasts adhere on the surface of the biomaterials (viability assessed using an (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and visualized using a confocal microscope), and a fluorescently labeled drug (Texas-Red Gentamicin) can be loaded electrochemically and released (µg cm−2 quantities) in response to the application of an electrical stimulus.
Fil: Mousavi, Seyed T.. Lancaster University; Reino Unido
Fil: Harper, Garry R.. Lancaster University; Reino Unido
Fil: Municoy, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Ashton, Mark D.. Lancaster University; Reino Unido
Fil: Townsend, David. Lancaster University; Reino Unido
Fil: Alsharif, Ghazi H. K.. Taibah University; Arabia Saudita
Fil: Oikonomou, Vasileios K.. Lancaster University; Reino Unido
Fil: Firlak, Melike. Gebze Technical University; Turquía
Fil: Au Yong, Sophie. Lancaster University; Reino Unido
Fil: Murdock, Bethany E.. Lancaster University; Reino Unido
Fil: Akien, Geoffrey R.. Lancaster University; Reino Unido
Fil: Halcovitch, Nathan R.. Lancaster University; Reino Unido
Fil: Baldock, Sara J.. Lancaster University; Reino Unido
Fil: Fazilati, Mohamad. Payame Noor University; Irán
Fil: Kolosov, Oleg V.. Lancaster University; Reino Unido
Fil: Robinson, Benjamin J.. Lancaster University; Reino Unido
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Hardy, John G.. Lancaster University; Reino Unido
Materia
BIOMATERIALS
DRUG DELIVERY
ELECTRICAL STIMULATION
SILK FIBROIN
STIMULI-RESPONSIVE MATERIALS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/139889
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/139889
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of DrugsMousavi, Seyed T.Harper, Garry R.Municoy, SofiaAshton, Mark D.Townsend, DavidAlsharif, Ghazi H. K.Oikonomou, Vasileios K.Firlak, MelikeAu Yong, SophieMurdock, Bethany E.Akien, Geoffrey R.Halcovitch, Nathan R.Baldock, Sara J.Fazilati, MohamadKolosov, Oleg V.Robinson, Benjamin J.Desimone, Martín FedericoHardy, John G.BIOMATERIALSDRUG DELIVERYELECTRICAL STIMULATIONSILK FIBROINSTIMULI-RESPONSIVE MATERIALShttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Biomaterials capable of controlling the delivery of drugs have the potential to treat a variety of conditions. Herein, the preparation of electrically conductive silk fibroin film-based drug delivery devices is described. Casting aqueous solutions of Bombyx mori silk fibroin, followed by drying and annealing to impart β-sheets to the silk fibroin, assure that the materials are stable for further processing in water; and the silk fibroin films are rendered conductive by generating an interpenetrating network of a copolymer of pyrrole and 3-amino-4-hydroxybenzenesulfonic acid in the silk fibroin matrix (characterized by a variety of techniques including circular dichroism, Fourier-transform infrared spectroscopy, nuclear magnetic resonance, Raman spectroscopy, resistance measurements, scanning electron microscopy-energy dispersive X-ray spectroscopy, thermogravimetric analysis, X-ray diffraction, and X-ray photoelectron spectroscopy). Fibroblasts adhere on the surface of the biomaterials (viability assessed using an (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and visualized using a confocal microscope), and a fluorescently labeled drug (Texas-Red Gentamicin) can be loaded electrochemically and released (µg cm−2 quantities) in response to the application of an electrical stimulus.Fil: Mousavi, Seyed T.. Lancaster University; Reino UnidoFil: Harper, Garry R.. Lancaster University; Reino UnidoFil: Municoy, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Ashton, Mark D.. Lancaster University; Reino UnidoFil: Townsend, David. Lancaster University; Reino UnidoFil: Alsharif, Ghazi H. K.. Taibah University; Arabia SauditaFil: Oikonomou, Vasileios K.. Lancaster University; Reino UnidoFil: Firlak, Melike. Gebze Technical University; TurquíaFil: Au Yong, Sophie. Lancaster University; Reino UnidoFil: Murdock, Bethany E.. Lancaster University; Reino UnidoFil: Akien, Geoffrey R.. Lancaster University; Reino UnidoFil: Halcovitch, Nathan R.. Lancaster University; Reino UnidoFil: Baldock, Sara J.. Lancaster University; Reino UnidoFil: Fazilati, Mohamad. Payame Noor University; IránFil: Kolosov, Oleg V.. Lancaster University; Reino UnidoFil: Robinson, Benjamin J.. Lancaster University; Reino UnidoFil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Hardy, John G.. Lancaster University; Reino UnidoWiley VCH Verlag2020-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/139889Mousavi, Seyed T.; Harper, Garry R.; Municoy, Sofia; Ashton, Mark D.; Townsend, David; et al.; Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs; Wiley VCH Verlag; Macromolecular Materials and Engineering (print); 305; 6; 5-2020; 1-71438-7492CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/mame.202000130info:eu-repo/semantics/altIdentifier/doi/10.1002/mame.202000130info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:18Zoai:ri.conicet.gov.ar:11336/139889instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:18.658CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs
title Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs
spellingShingle Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs
Mousavi, Seyed T.
BIOMATERIALS
DRUG DELIVERY
ELECTRICAL STIMULATION
SILK FIBROIN
STIMULI-RESPONSIVE MATERIALS
title_short Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs
title_full Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs
title_fullStr Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs
title_full_unstemmed Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs
title_sort Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs
dc.creator.none.fl_str_mv Mousavi, Seyed T.
Harper, Garry R.
Municoy, Sofia
Ashton, Mark D.
Townsend, David
Alsharif, Ghazi H. K.
Oikonomou, Vasileios K.
Firlak, Melike
Au Yong, Sophie
Murdock, Bethany E.
Akien, Geoffrey R.
Halcovitch, Nathan R.
Baldock, Sara J.
Fazilati, Mohamad
Kolosov, Oleg V.
Robinson, Benjamin J.
Desimone, Martín Federico
Hardy, John G.
author Mousavi, Seyed T.
author_facet Mousavi, Seyed T.
Harper, Garry R.
Municoy, Sofia
Ashton, Mark D.
Townsend, David
Alsharif, Ghazi H. K.
Oikonomou, Vasileios K.
Firlak, Melike
Au Yong, Sophie
Murdock, Bethany E.
Akien, Geoffrey R.
Halcovitch, Nathan R.
Baldock, Sara J.
Fazilati, Mohamad
Kolosov, Oleg V.
Robinson, Benjamin J.
Desimone, Martín Federico
Hardy, John G.
author_role author
author2 Harper, Garry R.
Municoy, Sofia
Ashton, Mark D.
Townsend, David
Alsharif, Ghazi H. K.
Oikonomou, Vasileios K.
Firlak, Melike
Au Yong, Sophie
Murdock, Bethany E.
Akien, Geoffrey R.
Halcovitch, Nathan R.
Baldock, Sara J.
Fazilati, Mohamad
Kolosov, Oleg V.
Robinson, Benjamin J.
Desimone, Martín Federico
Hardy, John G.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BIOMATERIALS
DRUG DELIVERY
ELECTRICAL STIMULATION
SILK FIBROIN
STIMULI-RESPONSIVE MATERIALS
topic BIOMATERIALS
DRUG DELIVERY
ELECTRICAL STIMULATION
SILK FIBROIN
STIMULI-RESPONSIVE MATERIALS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Biomaterials capable of controlling the delivery of drugs have the potential to treat a variety of conditions. Herein, the preparation of electrically conductive silk fibroin film-based drug delivery devices is described. Casting aqueous solutions of Bombyx mori silk fibroin, followed by drying and annealing to impart β-sheets to the silk fibroin, assure that the materials are stable for further processing in water; and the silk fibroin films are rendered conductive by generating an interpenetrating network of a copolymer of pyrrole and 3-amino-4-hydroxybenzenesulfonic acid in the silk fibroin matrix (characterized by a variety of techniques including circular dichroism, Fourier-transform infrared spectroscopy, nuclear magnetic resonance, Raman spectroscopy, resistance measurements, scanning electron microscopy-energy dispersive X-ray spectroscopy, thermogravimetric analysis, X-ray diffraction, and X-ray photoelectron spectroscopy). Fibroblasts adhere on the surface of the biomaterials (viability assessed using an (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and visualized using a confocal microscope), and a fluorescently labeled drug (Texas-Red Gentamicin) can be loaded electrochemically and released (µg cm−2 quantities) in response to the application of an electrical stimulus.
Fil: Mousavi, Seyed T.. Lancaster University; Reino Unido
Fil: Harper, Garry R.. Lancaster University; Reino Unido
Fil: Municoy, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Ashton, Mark D.. Lancaster University; Reino Unido
Fil: Townsend, David. Lancaster University; Reino Unido
Fil: Alsharif, Ghazi H. K.. Taibah University; Arabia Saudita
Fil: Oikonomou, Vasileios K.. Lancaster University; Reino Unido
Fil: Firlak, Melike. Gebze Technical University; Turquía
Fil: Au Yong, Sophie. Lancaster University; Reino Unido
Fil: Murdock, Bethany E.. Lancaster University; Reino Unido
Fil: Akien, Geoffrey R.. Lancaster University; Reino Unido
Fil: Halcovitch, Nathan R.. Lancaster University; Reino Unido
Fil: Baldock, Sara J.. Lancaster University; Reino Unido
Fil: Fazilati, Mohamad. Payame Noor University; Irán
Fil: Kolosov, Oleg V.. Lancaster University; Reino Unido
Fil: Robinson, Benjamin J.. Lancaster University; Reino Unido
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Hardy, John G.. Lancaster University; Reino Unido
description Biomaterials capable of controlling the delivery of drugs have the potential to treat a variety of conditions. Herein, the preparation of electrically conductive silk fibroin film-based drug delivery devices is described. Casting aqueous solutions of Bombyx mori silk fibroin, followed by drying and annealing to impart β-sheets to the silk fibroin, assure that the materials are stable for further processing in water; and the silk fibroin films are rendered conductive by generating an interpenetrating network of a copolymer of pyrrole and 3-amino-4-hydroxybenzenesulfonic acid in the silk fibroin matrix (characterized by a variety of techniques including circular dichroism, Fourier-transform infrared spectroscopy, nuclear magnetic resonance, Raman spectroscopy, resistance measurements, scanning electron microscopy-energy dispersive X-ray spectroscopy, thermogravimetric analysis, X-ray diffraction, and X-ray photoelectron spectroscopy). Fibroblasts adhere on the surface of the biomaterials (viability assessed using an (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and visualized using a confocal microscope), and a fluorescently labeled drug (Texas-Red Gentamicin) can be loaded electrochemically and released (µg cm−2 quantities) in response to the application of an electrical stimulus.
publishDate 2020
dc.date.none.fl_str_mv 2020-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/139889
Mousavi, Seyed T.; Harper, Garry R.; Municoy, Sofia; Ashton, Mark D.; Townsend, David; et al.; Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs; Wiley VCH Verlag; Macromolecular Materials and Engineering (print); 305; 6; 5-2020; 1-7
1438-7492
CONICET Digital
CONICET
url http://hdl.handle.net/11336/139889
identifier_str_mv Mousavi, Seyed T.; Harper, Garry R.; Municoy, Sofia; Ashton, Mark D.; Townsend, David; et al.; Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs; Wiley VCH Verlag; Macromolecular Materials and Engineering (print); 305; 6; 5-2020; 1-7
1438-7492
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/mame.202000130
info:eu-repo/semantics/altIdentifier/doi/10.1002/mame.202000130
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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