Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans

Autores
Herrero, A.; Romanowski, A.; Meelkop, E.; Caldart, C.s.; Schoofs, L.; Golombek, Diego Andres
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The neuropeptide pigment-dispersing factor (PDF) is important for the generation and entrainment of circadian rhythms in the fruitfly Drosophila melanogaster. Recently two pdf homologs, pdf-1 and pdf-2, and a PDF receptor, pdfr-1, have been found in Caenorhabditis elegans and have been implicated in locomotor activity. In this work, we have studied the role of the PDF neuropeptide in the circadian system of C. elegans and found that both pdf-1 and pdf-2 mutants affect the normal locomotor activity outputs. In particular, loss of pdf-1 induced circadian arrhythmicity under both light-dark (LD) and constant dark (DD) conditions. These defects can be rescued by a genomic copy of the pdf-1 locus. Our results indicate that PDF-1 is involved in rhythm generation and in the synchronization to LD cycles, as rhythmic patterns of activity rapidly disappear when pdf-1 mutants are recorded under both entrained and free-running conditions. The role of PDF-2 and the PDF receptors is probably more complex and involves the interaction between the two pdf paralogues found in the nematode.
Fil: Herrero, A.. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Romanowski, A.. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Meelkop, E.. Katholikie Universiteit Leuven; Bélgica
Fil: Caldart, C.s.. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Schoofs, L.. Katholikie Universiteit Leuven; Bélgica
Fil: Golombek, Diego Andres. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Materia
C. Elegans
Circadian
Clock Genes
Locomotor Activity
Nematode
Neuropeptide
Pdf
Pdf-1
Pdf-2
Pigment-Dispersing Factor
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/18044
Acceder
id CONICETDig_88385201dbc91e97f9663337ea9e800c
oai_identifier_str oai:ri.conicet.gov.ar:11336/18044
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegansHerrero, A.Romanowski, A.Meelkop, E.Caldart, C.s.Schoofs, L.Golombek, Diego AndresC. ElegansCircadianClock GenesLocomotor ActivityNematodeNeuropeptidePdfPdf-1Pdf-2Pigment-Dispersing Factorhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The neuropeptide pigment-dispersing factor (PDF) is important for the generation and entrainment of circadian rhythms in the fruitfly Drosophila melanogaster. Recently two pdf homologs, pdf-1 and pdf-2, and a PDF receptor, pdfr-1, have been found in Caenorhabditis elegans and have been implicated in locomotor activity. In this work, we have studied the role of the PDF neuropeptide in the circadian system of C. elegans and found that both pdf-1 and pdf-2 mutants affect the normal locomotor activity outputs. In particular, loss of pdf-1 induced circadian arrhythmicity under both light-dark (LD) and constant dark (DD) conditions. These defects can be rescued by a genomic copy of the pdf-1 locus. Our results indicate that PDF-1 is involved in rhythm generation and in the synchronization to LD cycles, as rhythmic patterns of activity rapidly disappear when pdf-1 mutants are recorded under both entrained and free-running conditions. The role of PDF-2 and the PDF receptors is probably more complex and involves the interaction between the two pdf paralogues found in the nematode.Fil: Herrero, A.. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaFil: Romanowski, A.. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaFil: Meelkop, E.. Katholikie Universiteit Leuven; BélgicaFil: Caldart, C.s.. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaFil: Schoofs, L.. Katholikie Universiteit Leuven; BélgicaFil: Golombek, Diego Andres. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; ArgentinaWiley Blackwell Publishing, Inc2015-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/18044Herrero, A.; Romanowski, A.; Meelkop, E.; Caldart, C.s.; Schoofs, L.; et al.; Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans; Wiley Blackwell Publishing, Inc; Genes, Brain and Behavior; 14; 6; 7-2015; 493-5011601-1848enginfo:eu-repo/semantics/altIdentifier/doi/10.1111/gbb.12231info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/26113231info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:38:35Zoai:ri.conicet.gov.ar:11336/18044instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:38:35.285CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans
title Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans
spellingShingle Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans
Herrero, A.
C. Elegans
Circadian
Clock Genes
Locomotor Activity
Nematode
Neuropeptide
Pdf
Pdf-1
Pdf-2
Pigment-Dispersing Factor
title_short Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans
title_full Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans
title_fullStr Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans
title_full_unstemmed Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans
title_sort Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans
dc.creator.none.fl_str_mv Herrero, A.
Romanowski, A.
Meelkop, E.
Caldart, C.s.
Schoofs, L.
Golombek, Diego Andres
author Herrero, A.
author_facet Herrero, A.
Romanowski, A.
Meelkop, E.
Caldart, C.s.
Schoofs, L.
Golombek, Diego Andres
author_role author
author2 Romanowski, A.
Meelkop, E.
Caldart, C.s.
Schoofs, L.
Golombek, Diego Andres
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv C. Elegans
Circadian
Clock Genes
Locomotor Activity
Nematode
Neuropeptide
Pdf
Pdf-1
Pdf-2
Pigment-Dispersing Factor
topic C. Elegans
Circadian
Clock Genes
Locomotor Activity
Nematode
Neuropeptide
Pdf
Pdf-1
Pdf-2
Pigment-Dispersing Factor
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The neuropeptide pigment-dispersing factor (PDF) is important for the generation and entrainment of circadian rhythms in the fruitfly Drosophila melanogaster. Recently two pdf homologs, pdf-1 and pdf-2, and a PDF receptor, pdfr-1, have been found in Caenorhabditis elegans and have been implicated in locomotor activity. In this work, we have studied the role of the PDF neuropeptide in the circadian system of C. elegans and found that both pdf-1 and pdf-2 mutants affect the normal locomotor activity outputs. In particular, loss of pdf-1 induced circadian arrhythmicity under both light-dark (LD) and constant dark (DD) conditions. These defects can be rescued by a genomic copy of the pdf-1 locus. Our results indicate that PDF-1 is involved in rhythm generation and in the synchronization to LD cycles, as rhythmic patterns of activity rapidly disappear when pdf-1 mutants are recorded under both entrained and free-running conditions. The role of PDF-2 and the PDF receptors is probably more complex and involves the interaction between the two pdf paralogues found in the nematode.
Fil: Herrero, A.. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Romanowski, A.. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Meelkop, E.. Katholikie Universiteit Leuven; Bélgica
Fil: Caldart, C.s.. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
Fil: Schoofs, L.. Katholikie Universiteit Leuven; Bélgica
Fil: Golombek, Diego Andres. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
description The neuropeptide pigment-dispersing factor (PDF) is important for the generation and entrainment of circadian rhythms in the fruitfly Drosophila melanogaster. Recently two pdf homologs, pdf-1 and pdf-2, and a PDF receptor, pdfr-1, have been found in Caenorhabditis elegans and have been implicated in locomotor activity. In this work, we have studied the role of the PDF neuropeptide in the circadian system of C. elegans and found that both pdf-1 and pdf-2 mutants affect the normal locomotor activity outputs. In particular, loss of pdf-1 induced circadian arrhythmicity under both light-dark (LD) and constant dark (DD) conditions. These defects can be rescued by a genomic copy of the pdf-1 locus. Our results indicate that PDF-1 is involved in rhythm generation and in the synchronization to LD cycles, as rhythmic patterns of activity rapidly disappear when pdf-1 mutants are recorded under both entrained and free-running conditions. The role of PDF-2 and the PDF receptors is probably more complex and involves the interaction between the two pdf paralogues found in the nematode.
publishDate 2015
dc.date.none.fl_str_mv 2015-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/18044
Herrero, A.; Romanowski, A.; Meelkop, E.; Caldart, C.s.; Schoofs, L.; et al.; Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans; Wiley Blackwell Publishing, Inc; Genes, Brain and Behavior; 14; 6; 7-2015; 493-501
1601-1848
url http://hdl.handle.net/11336/18044
identifier_str_mv Herrero, A.; Romanowski, A.; Meelkop, E.; Caldart, C.s.; Schoofs, L.; et al.; Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans; Wiley Blackwell Publishing, Inc; Genes, Brain and Behavior; 14; 6; 7-2015; 493-501
1601-1848
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/gbb.12231
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/26113231
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614408799518720
score 13.070432

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