Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site

Autores
Rodriguez, Fernanda Mariana; Lillington, James E.D.; Steven, Johnson; Timmel, Christiane R.; Lea, Susan M.; Berks, Ben C.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: PhoD family enzymes liberate phosphate from organic compounds. Results: The structure of PhoD reveals an active site with one Fe3! and two Ca2! ions. Conclusion: PhoD represents a new class of phosphatase related to purple acid phosphatases. Significance: The requirement of PhoD for iron ions may limit bacterial phosphate acquisition in low iron environments.
Fil: Rodriguez, Fernanda Mariana. University of Oxford; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Procesos Biotecnológicos y Quimicos Rosario. Universidad Nacional de Rosario. Facultad de Cs.bioquímicas y Farmaceuticas. Instituto de Procesos Biotecnológicos y Quimicos Rosario; Argentina
Fil: Lillington, James E.D.. University of Oxford; Reino Unido
Fil: Steven, Johnson. University of Oxford; Reino Unido
Fil: Timmel, Christiane R.. University of Oxford; Reino Unido
Fil: Lea, Susan M.. University of Oxford; Reino Unido
Fil: Berks, Ben C.. University of Oxford; Reino Unido
Materia
Phod
Phosphodiesterase
Structure
Bacillus Subtilis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/31138

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network_name_str CONICET Digital (CONICET)
spelling Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active SiteRodriguez, Fernanda MarianaLillington, James E.D.Steven, JohnsonTimmel, Christiane R.Lea, Susan M.Berks, Ben C.PhodPhosphodiesteraseStructureBacillus Subtilishttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: PhoD family enzymes liberate phosphate from organic compounds. Results: The structure of PhoD reveals an active site with one Fe3! and two Ca2! ions. Conclusion: PhoD represents a new class of phosphatase related to purple acid phosphatases. Significance: The requirement of PhoD for iron ions may limit bacterial phosphate acquisition in low iron environments.Fil: Rodriguez, Fernanda Mariana. University of Oxford; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Procesos Biotecnológicos y Quimicos Rosario. Universidad Nacional de Rosario. Facultad de Cs.bioquímicas y Farmaceuticas. Instituto de Procesos Biotecnológicos y Quimicos Rosario; ArgentinaFil: Lillington, James E.D.. University of Oxford; Reino UnidoFil: Steven, Johnson. University of Oxford; Reino UnidoFil: Timmel, Christiane R.. University of Oxford; Reino UnidoFil: Lea, Susan M.. University of Oxford; Reino UnidoFil: Berks, Ben C.. University of Oxford; Reino UnidoAmerican Society for Biochemistry and Molecular Biology2014-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/31138Rodriguez, Fernanda Mariana; Lillington, James E.D.; Steven, Johnson; Timmel, Christiane R.; Lea, Susan M.; et al.; Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site; American Society for Biochemistry and Molecular Biology; Journal of Biological Chemistry (online); 289; 11-2014; 30889-308990021-9258CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.jbc.org/content/289/45/30889.full.html#ref-list-1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:17Zoai:ri.conicet.gov.ar:11336/31138instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:17.578CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site
title Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site
spellingShingle Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site
Rodriguez, Fernanda Mariana
Phod
Phosphodiesterase
Structure
Bacillus Subtilis
title_short Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site
title_full Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site
title_fullStr Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site
title_full_unstemmed Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site
title_sort Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site
dc.creator.none.fl_str_mv Rodriguez, Fernanda Mariana
Lillington, James E.D.
Steven, Johnson
Timmel, Christiane R.
Lea, Susan M.
Berks, Ben C.
author Rodriguez, Fernanda Mariana
author_facet Rodriguez, Fernanda Mariana
Lillington, James E.D.
Steven, Johnson
Timmel, Christiane R.
Lea, Susan M.
Berks, Ben C.
author_role author
author2 Lillington, James E.D.
Steven, Johnson
Timmel, Christiane R.
Lea, Susan M.
Berks, Ben C.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Phod
Phosphodiesterase
Structure
Bacillus Subtilis
topic Phod
Phosphodiesterase
Structure
Bacillus Subtilis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Background: PhoD family enzymes liberate phosphate from organic compounds. Results: The structure of PhoD reveals an active site with one Fe3! and two Ca2! ions. Conclusion: PhoD represents a new class of phosphatase related to purple acid phosphatases. Significance: The requirement of PhoD for iron ions may limit bacterial phosphate acquisition in low iron environments.
Fil: Rodriguez, Fernanda Mariana. University of Oxford; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Procesos Biotecnológicos y Quimicos Rosario. Universidad Nacional de Rosario. Facultad de Cs.bioquímicas y Farmaceuticas. Instituto de Procesos Biotecnológicos y Quimicos Rosario; Argentina
Fil: Lillington, James E.D.. University of Oxford; Reino Unido
Fil: Steven, Johnson. University of Oxford; Reino Unido
Fil: Timmel, Christiane R.. University of Oxford; Reino Unido
Fil: Lea, Susan M.. University of Oxford; Reino Unido
Fil: Berks, Ben C.. University of Oxford; Reino Unido
description Background: PhoD family enzymes liberate phosphate from organic compounds. Results: The structure of PhoD reveals an active site with one Fe3! and two Ca2! ions. Conclusion: PhoD represents a new class of phosphatase related to purple acid phosphatases. Significance: The requirement of PhoD for iron ions may limit bacterial phosphate acquisition in low iron environments.
publishDate 2014
dc.date.none.fl_str_mv 2014-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/31138
Rodriguez, Fernanda Mariana; Lillington, James E.D.; Steven, Johnson; Timmel, Christiane R.; Lea, Susan M.; et al.; Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site; American Society for Biochemistry and Molecular Biology; Journal of Biological Chemistry (online); 289; 11-2014; 30889-30899
0021-9258
CONICET Digital
CONICET
url http://hdl.handle.net/11336/31138
identifier_str_mv Rodriguez, Fernanda Mariana; Lillington, James E.D.; Steven, Johnson; Timmel, Christiane R.; Lea, Susan M.; et al.; Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site; American Society for Biochemistry and Molecular Biology; Journal of Biological Chemistry (online); 289; 11-2014; 30889-30899
0021-9258
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.jbc.org/content/289/45/30889.full.html#ref-list-1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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