Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in Cancer
- Autores
- Pino, María Teresa Luján; Rocca, María Victoria; Acosta, Lucas Hernan; Cabilla, Jimena Paula
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Since the discovery of nitric oxide (NO), a long journey has led us to the present, during which much knowledge has been gained about its pathway members and their roles in physiological and various pathophysiological conditions. Soluble guanylyl cyclase (sGC), the main NO receptor composed of the sGCα1 and sGCβ1 subunits, has been one of the central figures in this narrative. However, the sGCα1 and sGCβ1 subunits remained obscured by the focus on sGC’s enzymatic activity for many years. In this review, we restore the significance of the sGCα1 and sGCβ1 subunits by compiling and analyzing available but previously overlooked information regarding their roles beyond enzymatic activity. We delve into the basics of sGC expression regulation, from its transcriptional regulation to its interaction with proteins, placing particular emphasis on evidence thus far demonstrating the actions of each sGC subunit in different tumor models. Exploring the roles of sGC subunits in cancer offers a valuable opportunity to enhance our understanding of tumor biology and discover new therapeutic avenues.
Fil: Pino, María Teresa Luján. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rocca, María Victoria. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina
Fil: Acosta, Lucas Hernan. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cabilla, Jimena Paula. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
nitric oxide pathway
cell signaling
soluble guanylyl cyclase alpha
soluble guanylyl cyclase beta
cancer - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/245239
Ver los metadatos del registro completo
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Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in CancerPino, María Teresa LujánRocca, María VictoriaAcosta, Lucas HernanCabilla, Jimena Paulanitric oxide pathwaycell signalingsoluble guanylyl cyclase alphasoluble guanylyl cyclase betacancerhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Since the discovery of nitric oxide (NO), a long journey has led us to the present, during which much knowledge has been gained about its pathway members and their roles in physiological and various pathophysiological conditions. Soluble guanylyl cyclase (sGC), the main NO receptor composed of the sGCα1 and sGCβ1 subunits, has been one of the central figures in this narrative. However, the sGCα1 and sGCβ1 subunits remained obscured by the focus on sGC’s enzymatic activity for many years. In this review, we restore the significance of the sGCα1 and sGCβ1 subunits by compiling and analyzing available but previously overlooked information regarding their roles beyond enzymatic activity. We delve into the basics of sGC expression regulation, from its transcriptional regulation to its interaction with proteins, placing particular emphasis on evidence thus far demonstrating the actions of each sGC subunit in different tumor models. Exploring the roles of sGC subunits in cancer offers a valuable opportunity to enhance our understanding of tumor biology and discover new therapeutic avenues.Fil: Pino, María Teresa Luján. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rocca, María Victoria. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; ArgentinaFil: Acosta, Lucas Hernan. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cabilla, Jimena Paula. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMolecular Diversity Preservation International2024-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/245239Pino, María Teresa Luján; Rocca, María Victoria; Acosta, Lucas Hernan; Cabilla, Jimena Paula; Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in Cancer; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 25; 18; 9-2024; 1-251422-0067CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/25/18/10053info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms251810053info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:08:27Zoai:ri.conicet.gov.ar:11336/245239instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:08:28.08CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in Cancer |
| title |
Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in Cancer |
| spellingShingle |
Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in Cancer Pino, María Teresa Luján nitric oxide pathway cell signaling soluble guanylyl cyclase alpha soluble guanylyl cyclase beta cancer |
| title_short |
Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in Cancer |
| title_full |
Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in Cancer |
| title_fullStr |
Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in Cancer |
| title_full_unstemmed |
Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in Cancer |
| title_sort |
Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in Cancer |
| dc.creator.none.fl_str_mv |
Pino, María Teresa Luján Rocca, María Victoria Acosta, Lucas Hernan Cabilla, Jimena Paula |
| author |
Pino, María Teresa Luján |
| author_facet |
Pino, María Teresa Luján Rocca, María Victoria Acosta, Lucas Hernan Cabilla, Jimena Paula |
| author_role |
author |
| author2 |
Rocca, María Victoria Acosta, Lucas Hernan Cabilla, Jimena Paula |
| author2_role |
author author author |
| dc.subject.none.fl_str_mv |
nitric oxide pathway cell signaling soluble guanylyl cyclase alpha soluble guanylyl cyclase beta cancer |
| topic |
nitric oxide pathway cell signaling soluble guanylyl cyclase alpha soluble guanylyl cyclase beta cancer |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Since the discovery of nitric oxide (NO), a long journey has led us to the present, during which much knowledge has been gained about its pathway members and their roles in physiological and various pathophysiological conditions. Soluble guanylyl cyclase (sGC), the main NO receptor composed of the sGCα1 and sGCβ1 subunits, has been one of the central figures in this narrative. However, the sGCα1 and sGCβ1 subunits remained obscured by the focus on sGC’s enzymatic activity for many years. In this review, we restore the significance of the sGCα1 and sGCβ1 subunits by compiling and analyzing available but previously overlooked information regarding their roles beyond enzymatic activity. We delve into the basics of sGC expression regulation, from its transcriptional regulation to its interaction with proteins, placing particular emphasis on evidence thus far demonstrating the actions of each sGC subunit in different tumor models. Exploring the roles of sGC subunits in cancer offers a valuable opportunity to enhance our understanding of tumor biology and discover new therapeutic avenues. Fil: Pino, María Teresa Luján. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Rocca, María Victoria. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina Fil: Acosta, Lucas Hernan. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Cabilla, Jimena Paula. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| description |
Since the discovery of nitric oxide (NO), a long journey has led us to the present, during which much knowledge has been gained about its pathway members and their roles in physiological and various pathophysiological conditions. Soluble guanylyl cyclase (sGC), the main NO receptor composed of the sGCα1 and sGCβ1 subunits, has been one of the central figures in this narrative. However, the sGCα1 and sGCβ1 subunits remained obscured by the focus on sGC’s enzymatic activity for many years. In this review, we restore the significance of the sGCα1 and sGCβ1 subunits by compiling and analyzing available but previously overlooked information regarding their roles beyond enzymatic activity. We delve into the basics of sGC expression regulation, from its transcriptional regulation to its interaction with proteins, placing particular emphasis on evidence thus far demonstrating the actions of each sGC subunit in different tumor models. Exploring the roles of sGC subunits in cancer offers a valuable opportunity to enhance our understanding of tumor biology and discover new therapeutic avenues. |
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2024 |
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2024-09 |
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http://hdl.handle.net/11336/245239 Pino, María Teresa Luján; Rocca, María Victoria; Acosta, Lucas Hernan; Cabilla, Jimena Paula; Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in Cancer; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 25; 18; 9-2024; 1-25 1422-0067 CONICET Digital CONICET |
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Pino, María Teresa Luján; Rocca, María Victoria; Acosta, Lucas Hernan; Cabilla, Jimena Paula; Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in Cancer; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 25; 18; 9-2024; 1-25 1422-0067 CONICET Digital CONICET |
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