Electrophysiologic study of globus pallidus projections to the thalamic reticular nucleus

Autores
Pazo, Jorge Horacio; Barcelo, Ana Cristina; Bellantonio, Emanuel; Pazo, Valeria; Almarares, Noel
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study was designed to explore the electrophysiological relationships between the globus pallidus (GP), the substantia nigra pars reticulata (SNr) and the thalamic reticular nucleus (TRN) in urethaneanesthetized rats. The neuronal activity of the rostral part of the TRN was recorded by microelectrodes.Single pulse electrical stimulation of the GP and SNr produced inhibition of the spontaneous activity of the majority of TRN neurons. Stimulation of the GP by microinjections of bicuculline (25 ng/300 nl) produced also inhibition of the spontaneous activity of the reticular neurons. This could lead to facilitation of the cerebral cortex, as the reticular nucleus is reciprocally connected to, and inhibits, the thalamic motor nuclei, that in turn excite the motor cortex.
Fil: Pazo, Jorge Horacio. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurofisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Barcelo, Ana Cristina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurofisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Bellantonio, Emanuel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurofisiología; Argentina
Fil: Pazo, Valeria. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurofisiología; Argentina
Fil: Almarares, Noel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurofisiología; Argentina
Materia
Electrical And Chemical Stimulation
Reticular Thalamic Nucleus
Globus Pallidus
Palidoreticular Pathway
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/1920
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Electrophysiologic study of globus pallidus projections to the thalamic reticular nucleusPazo, Jorge HoracioBarcelo, Ana CristinaBellantonio, EmanuelPazo, ValeriaAlmarares, NoelElectrical And Chemical StimulationReticular Thalamic NucleusGlobus PallidusPalidoreticular Pathwayhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3This study was designed to explore the electrophysiological relationships between the globus pallidus (GP), the substantia nigra pars reticulata (SNr) and the thalamic reticular nucleus (TRN) in urethaneanesthetized rats. The neuronal activity of the rostral part of the TRN was recorded by microelectrodes.Single pulse electrical stimulation of the GP and SNr produced inhibition of the spontaneous activity of the majority of TRN neurons. Stimulation of the GP by microinjections of bicuculline (25 ng/300 nl) produced also inhibition of the spontaneous activity of the reticular neurons. This could lead to facilitation of the cerebral cortex, as the reticular nucleus is reciprocally connected to, and inhibits, the thalamic motor nuclei, that in turn excite the motor cortex.Fil: Pazo, Jorge Horacio. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurofisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Barcelo, Ana Cristina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurofisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Bellantonio, Emanuel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurofisiología; ArgentinaFil: Pazo, Valeria. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurofisiología; ArgentinaFil: Almarares, Noel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurofisiología; ArgentinaElsevier2013-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/1920Pazo, Jorge Horacio; Barcelo, Ana Cristina; Bellantonio, Emanuel; Pazo, Valeria; Almarares, Noel; Electrophysiologic study of globus pallidus projections to the thalamic reticular nucleus; Elsevier; Brain Research Bulletin; 94; 5-2013; 82-890361-9230enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0361923013000439info:eu-repo/semantics/altIdentifier/doi/doi:10.1016/j.brainresbull.2013.02.009info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:19Zoai:ri.conicet.gov.ar:11336/1920instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:19.565CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Electrophysiologic study of globus pallidus projections to the thalamic reticular nucleus
title Electrophysiologic study of globus pallidus projections to the thalamic reticular nucleus
spellingShingle Electrophysiologic study of globus pallidus projections to the thalamic reticular nucleus
Pazo, Jorge Horacio
Electrical And Chemical Stimulation
Reticular Thalamic Nucleus
Globus Pallidus
Palidoreticular Pathway
title_short Electrophysiologic study of globus pallidus projections to the thalamic reticular nucleus
title_full Electrophysiologic study of globus pallidus projections to the thalamic reticular nucleus
title_fullStr Electrophysiologic study of globus pallidus projections to the thalamic reticular nucleus
title_full_unstemmed Electrophysiologic study of globus pallidus projections to the thalamic reticular nucleus
title_sort Electrophysiologic study of globus pallidus projections to the thalamic reticular nucleus
dc.creator.none.fl_str_mv Pazo, Jorge Horacio
Barcelo, Ana Cristina
Bellantonio, Emanuel
Pazo, Valeria
Almarares, Noel
author Pazo, Jorge Horacio
author_facet Pazo, Jorge Horacio
Barcelo, Ana Cristina
Bellantonio, Emanuel
Pazo, Valeria
Almarares, Noel
author_role author
author2 Barcelo, Ana Cristina
Bellantonio, Emanuel
Pazo, Valeria
Almarares, Noel
author2_role author
author
author
author
dc.subject.none.fl_str_mv Electrical And Chemical Stimulation
Reticular Thalamic Nucleus
Globus Pallidus
Palidoreticular Pathway
topic Electrical And Chemical Stimulation
Reticular Thalamic Nucleus
Globus Pallidus
Palidoreticular Pathway
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This study was designed to explore the electrophysiological relationships between the globus pallidus (GP), the substantia nigra pars reticulata (SNr) and the thalamic reticular nucleus (TRN) in urethaneanesthetized rats. The neuronal activity of the rostral part of the TRN was recorded by microelectrodes.Single pulse electrical stimulation of the GP and SNr produced inhibition of the spontaneous activity of the majority of TRN neurons. Stimulation of the GP by microinjections of bicuculline (25 ng/300 nl) produced also inhibition of the spontaneous activity of the reticular neurons. This could lead to facilitation of the cerebral cortex, as the reticular nucleus is reciprocally connected to, and inhibits, the thalamic motor nuclei, that in turn excite the motor cortex.
Fil: Pazo, Jorge Horacio. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurofisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Barcelo, Ana Cristina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurofisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Bellantonio, Emanuel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurofisiología; Argentina
Fil: Pazo, Valeria. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurofisiología; Argentina
Fil: Almarares, Noel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Neurofisiología; Argentina
description This study was designed to explore the electrophysiological relationships between the globus pallidus (GP), the substantia nigra pars reticulata (SNr) and the thalamic reticular nucleus (TRN) in urethaneanesthetized rats. The neuronal activity of the rostral part of the TRN was recorded by microelectrodes.Single pulse electrical stimulation of the GP and SNr produced inhibition of the spontaneous activity of the majority of TRN neurons. Stimulation of the GP by microinjections of bicuculline (25 ng/300 nl) produced also inhibition of the spontaneous activity of the reticular neurons. This could lead to facilitation of the cerebral cortex, as the reticular nucleus is reciprocally connected to, and inhibits, the thalamic motor nuclei, that in turn excite the motor cortex.
publishDate 2013
dc.date.none.fl_str_mv 2013-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/1920
Pazo, Jorge Horacio; Barcelo, Ana Cristina; Bellantonio, Emanuel; Pazo, Valeria; Almarares, Noel; Electrophysiologic study of globus pallidus projections to the thalamic reticular nucleus; Elsevier; Brain Research Bulletin; 94; 5-2013; 82-89
0361-9230
url http://hdl.handle.net/11336/1920
identifier_str_mv Pazo, Jorge Horacio; Barcelo, Ana Cristina; Bellantonio, Emanuel; Pazo, Valeria; Almarares, Noel; Electrophysiologic study of globus pallidus projections to the thalamic reticular nucleus; Elsevier; Brain Research Bulletin; 94; 5-2013; 82-89
0361-9230
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0361923013000439
info:eu-repo/semantics/altIdentifier/doi/doi:10.1016/j.brainresbull.2013.02.009
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269088215203840
score 13.13397

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