Lactiplantibacillus plantarum as a potential adjuvant and delivery system for the development of sars-cov-2 oral vaccines

Autores
Villena, Julio Cesar; Li, Chang; Vizoso Pinto, María Guadalupe; Sacur, Jacinto Alfredo; Ren, Linzhu; Kitazawa, Haruki
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The most important characteristics regarding the mucosal infection and immune responses against the Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) as well as the current vaccines against coronavirus disease 2019 (COVID-19) in development or use are revised to emphasize the opportunity for lactic acid bacteria (LAB)-based vaccines to offer a valid alternative in the fight against this disease. In addition, this article revises the knowledge on: (a) the cellular and molecular mechanisms involved in the improvement of mucosal antiviral defenses by beneficial Lactiplantibacil-lus plantarum strains, (b) the systems for the expression of heterologous proteins in L. plantarum and (c) the successful expressions of viral antigens in L. plantarum that were capable of inducing protective immune responses in the gut and the respiratory tract after their oral administration. The ability of L. plantarum to express viral antigens, including the spike protein of SARS-CoV-2 and its capacity to differentially modulate the innate and adaptive immune responses in both the intestinal and respiratory mucosa after its oral administration, indicates the potential of this LAB to be used in the development of a mucosal COVID-19 vaccine.
Fil: Villena, Julio Cesar. Tohoku University; Japón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Li, Chang. Chinese Academy of Sciences; República de China
Fil: Vizoso Pinto, María Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina
Fil: Sacur, Jacinto Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina
Fil: Ren, Linzhu. Jilin University; China
Fil: Kitazawa, Haruki. Tohoku University; Japón
Materia
ANTIVIRAL IMMUNITY
COVID-19
IMMUNOBIOTICS
LACTIPLANTIBACILLUS PLANTARUM
MUCOSAL IMMUNITY
RECOMBI-NANT LACTOBACILLI
SARS-COV-2
VACCINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/135608
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/135608
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Lactiplantibacillus plantarum as a potential adjuvant and delivery system for the development of sars-cov-2 oral vaccinesVillena, Julio CesarLi, ChangVizoso Pinto, María GuadalupeSacur, Jacinto AlfredoRen, LinzhuKitazawa, HarukiANTIVIRAL IMMUNITYCOVID-19IMMUNOBIOTICSLACTIPLANTIBACILLUS PLANTARUMMUCOSAL IMMUNITYRECOMBI-NANT LACTOBACILLISARS-COV-2VACCINEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The most important characteristics regarding the mucosal infection and immune responses against the Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) as well as the current vaccines against coronavirus disease 2019 (COVID-19) in development or use are revised to emphasize the opportunity for lactic acid bacteria (LAB)-based vaccines to offer a valid alternative in the fight against this disease. In addition, this article revises the knowledge on: (a) the cellular and molecular mechanisms involved in the improvement of mucosal antiviral defenses by beneficial Lactiplantibacil-lus plantarum strains, (b) the systems for the expression of heterologous proteins in L. plantarum and (c) the successful expressions of viral antigens in L. plantarum that were capable of inducing protective immune responses in the gut and the respiratory tract after their oral administration. The ability of L. plantarum to express viral antigens, including the spike protein of SARS-CoV-2 and its capacity to differentially modulate the innate and adaptive immune responses in both the intestinal and respiratory mucosa after its oral administration, indicates the potential of this LAB to be used in the development of a mucosal COVID-19 vaccine.Fil: Villena, Julio Cesar. Tohoku University; Japón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Li, Chang. Chinese Academy of Sciences; República de ChinaFil: Vizoso Pinto, María Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; ArgentinaFil: Sacur, Jacinto Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; ArgentinaFil: Ren, Linzhu. Jilin University; ChinaFil: Kitazawa, Haruki. Tohoku University; JapónMultidisciplinary Digital Publishing Institute2021-03-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/135608Villena, Julio Cesar; Li, Chang; Vizoso Pinto, María Guadalupe; Sacur, Jacinto Alfredo; Ren, Linzhu; et al.; Lactiplantibacillus plantarum as a potential adjuvant and delivery system for the development of sars-cov-2 oral vaccines; Multidisciplinary Digital Publishing Institute; Microorganisms; 9; 4; 26-3-2021; 1-262076-2607CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-2607/9/4/683info:eu-repo/semantics/altIdentifier/doi/10.3390/microorganisms9040683info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T10:00:57Zoai:ri.conicet.gov.ar:11336/135608instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 10:00:57.505CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Lactiplantibacillus plantarum as a potential adjuvant and delivery system for the development of sars-cov-2 oral vaccines
title Lactiplantibacillus plantarum as a potential adjuvant and delivery system for the development of sars-cov-2 oral vaccines
spellingShingle Lactiplantibacillus plantarum as a potential adjuvant and delivery system for the development of sars-cov-2 oral vaccines
Villena, Julio Cesar
ANTIVIRAL IMMUNITY
COVID-19
IMMUNOBIOTICS
LACTIPLANTIBACILLUS PLANTARUM
MUCOSAL IMMUNITY
RECOMBI-NANT LACTOBACILLI
SARS-COV-2
VACCINE
title_short Lactiplantibacillus plantarum as a potential adjuvant and delivery system for the development of sars-cov-2 oral vaccines
title_full Lactiplantibacillus plantarum as a potential adjuvant and delivery system for the development of sars-cov-2 oral vaccines
title_fullStr Lactiplantibacillus plantarum as a potential adjuvant and delivery system for the development of sars-cov-2 oral vaccines
title_full_unstemmed Lactiplantibacillus plantarum as a potential adjuvant and delivery system for the development of sars-cov-2 oral vaccines
title_sort Lactiplantibacillus plantarum as a potential adjuvant and delivery system for the development of sars-cov-2 oral vaccines
dc.creator.none.fl_str_mv Villena, Julio Cesar
Li, Chang
Vizoso Pinto, María Guadalupe
Sacur, Jacinto Alfredo
Ren, Linzhu
Kitazawa, Haruki
author Villena, Julio Cesar
author_facet Villena, Julio Cesar
Li, Chang
Vizoso Pinto, María Guadalupe
Sacur, Jacinto Alfredo
Ren, Linzhu
Kitazawa, Haruki
author_role author
author2 Li, Chang
Vizoso Pinto, María Guadalupe
Sacur, Jacinto Alfredo
Ren, Linzhu
Kitazawa, Haruki
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ANTIVIRAL IMMUNITY
COVID-19
IMMUNOBIOTICS
LACTIPLANTIBACILLUS PLANTARUM
MUCOSAL IMMUNITY
RECOMBI-NANT LACTOBACILLI
SARS-COV-2
VACCINE
topic ANTIVIRAL IMMUNITY
COVID-19
IMMUNOBIOTICS
LACTIPLANTIBACILLUS PLANTARUM
MUCOSAL IMMUNITY
RECOMBI-NANT LACTOBACILLI
SARS-COV-2
VACCINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The most important characteristics regarding the mucosal infection and immune responses against the Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) as well as the current vaccines against coronavirus disease 2019 (COVID-19) in development or use are revised to emphasize the opportunity for lactic acid bacteria (LAB)-based vaccines to offer a valid alternative in the fight against this disease. In addition, this article revises the knowledge on: (a) the cellular and molecular mechanisms involved in the improvement of mucosal antiviral defenses by beneficial Lactiplantibacil-lus plantarum strains, (b) the systems for the expression of heterologous proteins in L. plantarum and (c) the successful expressions of viral antigens in L. plantarum that were capable of inducing protective immune responses in the gut and the respiratory tract after their oral administration. The ability of L. plantarum to express viral antigens, including the spike protein of SARS-CoV-2 and its capacity to differentially modulate the innate and adaptive immune responses in both the intestinal and respiratory mucosa after its oral administration, indicates the potential of this LAB to be used in the development of a mucosal COVID-19 vaccine.
Fil: Villena, Julio Cesar. Tohoku University; Japón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Li, Chang. Chinese Academy of Sciences; República de China
Fil: Vizoso Pinto, María Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina
Fil: Sacur, Jacinto Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina
Fil: Ren, Linzhu. Jilin University; China
Fil: Kitazawa, Haruki. Tohoku University; Japón
description The most important characteristics regarding the mucosal infection and immune responses against the Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) as well as the current vaccines against coronavirus disease 2019 (COVID-19) in development or use are revised to emphasize the opportunity for lactic acid bacteria (LAB)-based vaccines to offer a valid alternative in the fight against this disease. In addition, this article revises the knowledge on: (a) the cellular and molecular mechanisms involved in the improvement of mucosal antiviral defenses by beneficial Lactiplantibacil-lus plantarum strains, (b) the systems for the expression of heterologous proteins in L. plantarum and (c) the successful expressions of viral antigens in L. plantarum that were capable of inducing protective immune responses in the gut and the respiratory tract after their oral administration. The ability of L. plantarum to express viral antigens, including the spike protein of SARS-CoV-2 and its capacity to differentially modulate the innate and adaptive immune responses in both the intestinal and respiratory mucosa after its oral administration, indicates the potential of this LAB to be used in the development of a mucosal COVID-19 vaccine.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-26
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/135608
Villena, Julio Cesar; Li, Chang; Vizoso Pinto, María Guadalupe; Sacur, Jacinto Alfredo; Ren, Linzhu; et al.; Lactiplantibacillus plantarum as a potential adjuvant and delivery system for the development of sars-cov-2 oral vaccines; Multidisciplinary Digital Publishing Institute; Microorganisms; 9; 4; 26-3-2021; 1-26
2076-2607
CONICET Digital
CONICET
url http://hdl.handle.net/11336/135608
identifier_str_mv Villena, Julio Cesar; Li, Chang; Vizoso Pinto, María Guadalupe; Sacur, Jacinto Alfredo; Ren, Linzhu; et al.; Lactiplantibacillus plantarum as a potential adjuvant and delivery system for the development of sars-cov-2 oral vaccines; Multidisciplinary Digital Publishing Institute; Microorganisms; 9; 4; 26-3-2021; 1-26
2076-2607
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-2607/9/4/683
info:eu-repo/semantics/altIdentifier/doi/10.3390/microorganisms9040683
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.087074

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