Fatal Sarcocystis cruzi–induced eosinophilic myocarditis in a heifer in Uruguay

Autores
Aráoz, Virginia; da Silva Silveira, Caroline; Moré, Gastón Andrés; Banchero, Georgget; Riet Correa, Franklin; Giannitti, Federico
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Sarcocystis spp. are causative agents of bovine eosinophilic myositis and/or myocarditis, which are chronic subclinical myopathies that are occasionally responsible for condemnation at slaughterhouses. Sarcocystis cruzi is a protozoan parasite of worldwide distribution transmitted by canids, most commonly associated with subclinical infection in cattle. Although S. cruzi infections can rarely lead to fatal systemic disease, fatal cardiac cases with confirmation of the etiologic diagnosis have not been reported, to our knowledge. We describe herein an unusual case of S. cruzi–induced fatal bovine eosinophilic myocarditis. A 22-mo-old, Holstein–Hereford heifer, in a group of 110 cattle on pasture, manifested growth retardation and died in February 2017. Autopsy revealed myriad yellow-green 1–3-mm coalescing foci, surrounded by fibrosis, affecting ~75% of the ventricular myocardium. Pulmonary edema, ascites, and hydrothorax were consistent with chronic congestive heart failure. Histology revealed severe eosinophilic, granulomatous, necrotizing myocarditis, with multinucleate giant cells, fibrosis, and mineralization. Numerous thin-walled protozoan cysts resembling Sarcocystis spp. were present in the necrotic foci and within the sarcoplasm of adjacent cardiomyocytes. PCR and sequencing of the 18S rRNA gene revealed 99.9–100% homology with S. cruzi. Sarcocystosis can be a rare cause of fatal myocarditis in cattle.
Fil: Aráoz, Virginia. Instituto Nacional de Investigación Agropecuaria; Uruguay
Fil: da Silva Silveira, Caroline. Instituto Nacional de Investigación Agropecuaria; Uruguay
Fil: Moré, Gastón Andrés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Banchero, Georgget. Instituto Nacional de Investigación Agropecuaria; Uruguay
Fil: Riet Correa, Franklin. Instituto Nacional de Investigación Agropecuaria; Uruguay
Fil: Giannitti, Federico. Instituto Nacional de Investigación Agropecuaria; Uruguay
Materia
CATTLE
EOSINOPHILIC MYOCARDITIS
FATALITY
SARCOCYSTIS CRUZI
SARCOCYSTOSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/127937
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/127937
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fatal Sarcocystis cruzi–induced eosinophilic myocarditis in a heifer in UruguayAráoz, Virginiada Silva Silveira, CarolineMoré, Gastón AndrésBanchero, GeorggetRiet Correa, FranklinGiannitti, FedericoCATTLEEOSINOPHILIC MYOCARDITISFATALITYSARCOCYSTIS CRUZISARCOCYSTOSIShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Sarcocystis spp. are causative agents of bovine eosinophilic myositis and/or myocarditis, which are chronic subclinical myopathies that are occasionally responsible for condemnation at slaughterhouses. Sarcocystis cruzi is a protozoan parasite of worldwide distribution transmitted by canids, most commonly associated with subclinical infection in cattle. Although S. cruzi infections can rarely lead to fatal systemic disease, fatal cardiac cases with confirmation of the etiologic diagnosis have not been reported, to our knowledge. We describe herein an unusual case of S. cruzi–induced fatal bovine eosinophilic myocarditis. A 22-mo-old, Holstein–Hereford heifer, in a group of 110 cattle on pasture, manifested growth retardation and died in February 2017. Autopsy revealed myriad yellow-green 1–3-mm coalescing foci, surrounded by fibrosis, affecting ~75% of the ventricular myocardium. Pulmonary edema, ascites, and hydrothorax were consistent with chronic congestive heart failure. Histology revealed severe eosinophilic, granulomatous, necrotizing myocarditis, with multinucleate giant cells, fibrosis, and mineralization. Numerous thin-walled protozoan cysts resembling Sarcocystis spp. were present in the necrotic foci and within the sarcoplasm of adjacent cardiomyocytes. PCR and sequencing of the 18S rRNA gene revealed 99.9–100% homology with S. cruzi. Sarcocystosis can be a rare cause of fatal myocarditis in cattle.Fil: Aráoz, Virginia. Instituto Nacional de Investigación Agropecuaria; UruguayFil: da Silva Silveira, Caroline. Instituto Nacional de Investigación Agropecuaria; UruguayFil: Moré, Gastón Andrés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Banchero, Georgget. Instituto Nacional de Investigación Agropecuaria; UruguayFil: Riet Correa, Franklin. Instituto Nacional de Investigación Agropecuaria; UruguayFil: Giannitti, Federico. Instituto Nacional de Investigación Agropecuaria; UruguayAmerican Association of Veterinary Laboratory Diagnosticians2019-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/127937Aráoz, Virginia; da Silva Silveira, Caroline; Moré, Gastón Andrés; Banchero, Georgget; Riet Correa, Franklin; et al.; Fatal Sarcocystis cruzi–induced eosinophilic myocarditis in a heifer in Uruguay; American Association of Veterinary Laboratory Diagnosticians; Journal of Veterinary Diagnostic Investigation; 31; 4; 7-2019; 656-6601040-6387CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/1040638719856651info:eu-repo/semantics/altIdentifier/doi/10.1177/1040638719856651info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:15:15Zoai:ri.conicet.gov.ar:11336/127937instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:15:15.53CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fatal Sarcocystis cruzi–induced eosinophilic myocarditis in a heifer in Uruguay
title Fatal Sarcocystis cruzi–induced eosinophilic myocarditis in a heifer in Uruguay
spellingShingle Fatal Sarcocystis cruzi–induced eosinophilic myocarditis in a heifer in Uruguay
Aráoz, Virginia
CATTLE
EOSINOPHILIC MYOCARDITIS
FATALITY
SARCOCYSTIS CRUZI
SARCOCYSTOSIS
title_short Fatal Sarcocystis cruzi–induced eosinophilic myocarditis in a heifer in Uruguay
title_full Fatal Sarcocystis cruzi–induced eosinophilic myocarditis in a heifer in Uruguay
title_fullStr Fatal Sarcocystis cruzi–induced eosinophilic myocarditis in a heifer in Uruguay
title_full_unstemmed Fatal Sarcocystis cruzi–induced eosinophilic myocarditis in a heifer in Uruguay
title_sort Fatal Sarcocystis cruzi–induced eosinophilic myocarditis in a heifer in Uruguay
dc.creator.none.fl_str_mv Aráoz, Virginia
da Silva Silveira, Caroline
Moré, Gastón Andrés
Banchero, Georgget
Riet Correa, Franklin
Giannitti, Federico
author Aráoz, Virginia
author_facet Aráoz, Virginia
da Silva Silveira, Caroline
Moré, Gastón Andrés
Banchero, Georgget
Riet Correa, Franklin
Giannitti, Federico
author_role author
author2 da Silva Silveira, Caroline
Moré, Gastón Andrés
Banchero, Georgget
Riet Correa, Franklin
Giannitti, Federico
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CATTLE
EOSINOPHILIC MYOCARDITIS
FATALITY
SARCOCYSTIS CRUZI
SARCOCYSTOSIS
topic CATTLE
EOSINOPHILIC MYOCARDITIS
FATALITY
SARCOCYSTIS CRUZI
SARCOCYSTOSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Sarcocystis spp. are causative agents of bovine eosinophilic myositis and/or myocarditis, which are chronic subclinical myopathies that are occasionally responsible for condemnation at slaughterhouses. Sarcocystis cruzi is a protozoan parasite of worldwide distribution transmitted by canids, most commonly associated with subclinical infection in cattle. Although S. cruzi infections can rarely lead to fatal systemic disease, fatal cardiac cases with confirmation of the etiologic diagnosis have not been reported, to our knowledge. We describe herein an unusual case of S. cruzi–induced fatal bovine eosinophilic myocarditis. A 22-mo-old, Holstein–Hereford heifer, in a group of 110 cattle on pasture, manifested growth retardation and died in February 2017. Autopsy revealed myriad yellow-green 1–3-mm coalescing foci, surrounded by fibrosis, affecting ~75% of the ventricular myocardium. Pulmonary edema, ascites, and hydrothorax were consistent with chronic congestive heart failure. Histology revealed severe eosinophilic, granulomatous, necrotizing myocarditis, with multinucleate giant cells, fibrosis, and mineralization. Numerous thin-walled protozoan cysts resembling Sarcocystis spp. were present in the necrotic foci and within the sarcoplasm of adjacent cardiomyocytes. PCR and sequencing of the 18S rRNA gene revealed 99.9–100% homology with S. cruzi. Sarcocystosis can be a rare cause of fatal myocarditis in cattle.
Fil: Aráoz, Virginia. Instituto Nacional de Investigación Agropecuaria; Uruguay
Fil: da Silva Silveira, Caroline. Instituto Nacional de Investigación Agropecuaria; Uruguay
Fil: Moré, Gastón Andrés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Banchero, Georgget. Instituto Nacional de Investigación Agropecuaria; Uruguay
Fil: Riet Correa, Franklin. Instituto Nacional de Investigación Agropecuaria; Uruguay
Fil: Giannitti, Federico. Instituto Nacional de Investigación Agropecuaria; Uruguay
description Sarcocystis spp. are causative agents of bovine eosinophilic myositis and/or myocarditis, which are chronic subclinical myopathies that are occasionally responsible for condemnation at slaughterhouses. Sarcocystis cruzi is a protozoan parasite of worldwide distribution transmitted by canids, most commonly associated with subclinical infection in cattle. Although S. cruzi infections can rarely lead to fatal systemic disease, fatal cardiac cases with confirmation of the etiologic diagnosis have not been reported, to our knowledge. We describe herein an unusual case of S. cruzi–induced fatal bovine eosinophilic myocarditis. A 22-mo-old, Holstein–Hereford heifer, in a group of 110 cattle on pasture, manifested growth retardation and died in February 2017. Autopsy revealed myriad yellow-green 1–3-mm coalescing foci, surrounded by fibrosis, affecting ~75% of the ventricular myocardium. Pulmonary edema, ascites, and hydrothorax were consistent with chronic congestive heart failure. Histology revealed severe eosinophilic, granulomatous, necrotizing myocarditis, with multinucleate giant cells, fibrosis, and mineralization. Numerous thin-walled protozoan cysts resembling Sarcocystis spp. were present in the necrotic foci and within the sarcoplasm of adjacent cardiomyocytes. PCR and sequencing of the 18S rRNA gene revealed 99.9–100% homology with S. cruzi. Sarcocystosis can be a rare cause of fatal myocarditis in cattle.
publishDate 2019
dc.date.none.fl_str_mv 2019-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/127937
Aráoz, Virginia; da Silva Silveira, Caroline; Moré, Gastón Andrés; Banchero, Georgget; Riet Correa, Franklin; et al.; Fatal Sarcocystis cruzi–induced eosinophilic myocarditis in a heifer in Uruguay; American Association of Veterinary Laboratory Diagnosticians; Journal of Veterinary Diagnostic Investigation; 31; 4; 7-2019; 656-660
1040-6387
CONICET Digital
CONICET
url http://hdl.handle.net/11336/127937
identifier_str_mv Aráoz, Virginia; da Silva Silveira, Caroline; Moré, Gastón Andrés; Banchero, Georgget; Riet Correa, Franklin; et al.; Fatal Sarcocystis cruzi–induced eosinophilic myocarditis in a heifer in Uruguay; American Association of Veterinary Laboratory Diagnosticians; Journal of Veterinary Diagnostic Investigation; 31; 4; 7-2019; 656-660
1040-6387
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/1040638719856651
info:eu-repo/semantics/altIdentifier/doi/10.1177/1040638719856651
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association of Veterinary Laboratory Diagnosticians
publisher.none.fl_str_mv American Association of Veterinary Laboratory Diagnosticians
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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