Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations

Autores
Auad, Jordana; Cerutti, Julieta; Cooper, Laura Gabriela; Camussone, Cecilia María; Lozano, Natalia A.; Crespo, Francisco M.; Lozano, Alejandro
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis with a high prevalence in small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for the improvement of vaccine efficacy. No commercial vaccines are available in Argentina. The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine- specific antibodies from the goat to the offspring through colostrum. Twenty three pregnant goats were vaccinated. The animals were randomly allocated to three groups: control, aluminum hydroxide Al(OH)3 adjuvant and a new cage-like particle adjuvant (ISPA). Antibodies (IgG) against this antigen were measured by ELISA. A robust humoral immune response was detected in vaccinated animals, with production of specific IgG, without finding significant differences between the vaccines formulated with different adjuvants. High levels of specific antibodies were detected in colostrum samples from both immunized groups, which were passively transfered from goats to offprings. No adverse local reactions in the vaccines injection sites were detected.
Fil: Auad, Jordana. Universidad Católica de Córdoba; Argentina
Fil: Cerutti, Julieta. Universidad Católica de Córdoba; Argentina
Fil: Cooper, Laura Gabriela. Universidad Católica de Córdoba; Argentina
Fil: Camussone, Cecilia María. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Lozano, Natalia A.. Universidad Católica de Córdoba; Argentina
Fil: Crespo, Francisco M.. Establecimiento Los Talas. Potrero de Garay, Córdoba; Argentina
Fil: Lozano, Alejandro. Universidad Católica de Córdoba; Argentina
Materia
ISPA adjuvant
Immunoglobulin G
Colostrum
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/92456
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulationsAuad, JordanaCerutti, JulietaCooper, Laura GabrielaCamussone, Cecilia MaríaLozano, Natalia A.Crespo, Francisco M.Lozano, AlejandroISPA adjuvantImmunoglobulin GColostrumhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis with a high prevalence in small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for the improvement of vaccine efficacy. No commercial vaccines are available in Argentina. The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine- specific antibodies from the goat to the offspring through colostrum. Twenty three pregnant goats were vaccinated. The animals were randomly allocated to three groups: control, aluminum hydroxide Al(OH)3 adjuvant and a new cage-like particle adjuvant (ISPA). Antibodies (IgG) against this antigen were measured by ELISA. A robust humoral immune response was detected in vaccinated animals, with production of specific IgG, without finding significant differences between the vaccines formulated with different adjuvants. High levels of specific antibodies were detected in colostrum samples from both immunized groups, which were passively transfered from goats to offprings. No adverse local reactions in the vaccines injection sites were detected.Fil: Auad, Jordana. Universidad Católica de Córdoba; ArgentinaFil: Cerutti, Julieta. Universidad Católica de Córdoba; ArgentinaFil: Cooper, Laura Gabriela. Universidad Católica de Córdoba; ArgentinaFil: Camussone, Cecilia María. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Lozano, Natalia A.. Universidad Católica de Córdoba; ArgentinaFil: Crespo, Francisco M.. Establecimiento Los Talas. Potrero de Garay, Córdoba; ArgentinaFil: Lozano, Alejandro. Universidad Católica de Córdoba; ArgentinaUniversidad Austral de Chile2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/92456Auad, Jordana; Cerutti, Julieta; Cooper, Laura Gabriela; Camussone, Cecilia María; Lozano, Natalia A.; et al.; Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations; Universidad Austral de Chile; Austral Journal of Veterinary Sciences; 50; 1-2018; 101-1050719-8000CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://revistas.uach.cl/index.php/australjvs/article/view/2961info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:55Zoai:ri.conicet.gov.ar:11336/92456instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:56.046CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
title Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
spellingShingle Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
Auad, Jordana
ISPA adjuvant
Immunoglobulin G
Colostrum
title_short Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
title_full Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
title_fullStr Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
title_full_unstemmed Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
title_sort Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
dc.creator.none.fl_str_mv Auad, Jordana
Cerutti, Julieta
Cooper, Laura Gabriela
Camussone, Cecilia María
Lozano, Natalia A.
Crespo, Francisco M.
Lozano, Alejandro
author Auad, Jordana
author_facet Auad, Jordana
Cerutti, Julieta
Cooper, Laura Gabriela
Camussone, Cecilia María
Lozano, Natalia A.
Crespo, Francisco M.
Lozano, Alejandro
author_role author
author2 Cerutti, Julieta
Cooper, Laura Gabriela
Camussone, Cecilia María
Lozano, Natalia A.
Crespo, Francisco M.
Lozano, Alejandro
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ISPA adjuvant
Immunoglobulin G
Colostrum
topic ISPA adjuvant
Immunoglobulin G
Colostrum
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis with a high prevalence in small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for the improvement of vaccine efficacy. No commercial vaccines are available in Argentina. The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine- specific antibodies from the goat to the offspring through colostrum. Twenty three pregnant goats were vaccinated. The animals were randomly allocated to three groups: control, aluminum hydroxide Al(OH)3 adjuvant and a new cage-like particle adjuvant (ISPA). Antibodies (IgG) against this antigen were measured by ELISA. A robust humoral immune response was detected in vaccinated animals, with production of specific IgG, without finding significant differences between the vaccines formulated with different adjuvants. High levels of specific antibodies were detected in colostrum samples from both immunized groups, which were passively transfered from goats to offprings. No adverse local reactions in the vaccines injection sites were detected.
Fil: Auad, Jordana. Universidad Católica de Córdoba; Argentina
Fil: Cerutti, Julieta. Universidad Católica de Córdoba; Argentina
Fil: Cooper, Laura Gabriela. Universidad Católica de Córdoba; Argentina
Fil: Camussone, Cecilia María. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Lozano, Natalia A.. Universidad Católica de Córdoba; Argentina
Fil: Crespo, Francisco M.. Establecimiento Los Talas. Potrero de Garay, Córdoba; Argentina
Fil: Lozano, Alejandro. Universidad Católica de Córdoba; Argentina
description Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis with a high prevalence in small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for the improvement of vaccine efficacy. No commercial vaccines are available in Argentina. The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine- specific antibodies from the goat to the offspring through colostrum. Twenty three pregnant goats were vaccinated. The animals were randomly allocated to three groups: control, aluminum hydroxide Al(OH)3 adjuvant and a new cage-like particle adjuvant (ISPA). Antibodies (IgG) against this antigen were measured by ELISA. A robust humoral immune response was detected in vaccinated animals, with production of specific IgG, without finding significant differences between the vaccines formulated with different adjuvants. High levels of specific antibodies were detected in colostrum samples from both immunized groups, which were passively transfered from goats to offprings. No adverse local reactions in the vaccines injection sites were detected.
publishDate 2018
dc.date.none.fl_str_mv 2018-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/92456
Auad, Jordana; Cerutti, Julieta; Cooper, Laura Gabriela; Camussone, Cecilia María; Lozano, Natalia A.; et al.; Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations; Universidad Austral de Chile; Austral Journal of Veterinary Sciences; 50; 1-2018; 101-105
0719-8000
CONICET Digital
CONICET
url http://hdl.handle.net/11336/92456
identifier_str_mv Auad, Jordana; Cerutti, Julieta; Cooper, Laura Gabriela; Camussone, Cecilia María; Lozano, Natalia A.; et al.; Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations; Universidad Austral de Chile; Austral Journal of Veterinary Sciences; 50; 1-2018; 101-105
0719-8000
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://revistas.uach.cl/index.php/australjvs/article/view/2961
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidad Austral de Chile
publisher.none.fl_str_mv Universidad Austral de Chile
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268891194064896
score 13.13397

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