Dynamics of circulating follicular helper T cell subsets and follicular regulatory T cells in rheumatoid arthritis patients according to HLA-DRB1 locus

Autores
Ferrero, Paola V.; Onofrio, Luisina Inés; Acosta, Cristina del Valle; Zacca, Estefanía; Ponce, Nicolás Eric; Mussano, Eduardo Daniel Eugenio; Onetti, Laura Beatriz; Cadile, Ignacio I.; Costantino, Alicia B; Werner, Marina Laura; Mas, Luciana A.; Alvarellos, Teresita; Montes, Carolina Lucia; Acosta Rodriguez, Eva Virginia; Gruppi, Adriana
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
B cells, follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells are part of a circuit that may play a role in the development or progression of rheumatoid arthritis (RA). With the aim of providing further insight into this topic, here we evaluated the frequency of different subsets of Tfh and Tfr in untreated and long-term treated RA patients from a cohort of Argentina, and their potential association with particular human leukocyte antigen (HLA) class-II variants and disease activity. We observed that the frequency of total Tfh cells as well as of particular Tfh subsets and Tfr cells were increased in seropositive untreated RA patients. Interestingly, when analyzing paired samples, the frequency of Tfh cells was reduced in synovial fluid compared to peripheral blood, while Tfr cells levels were similar in both biological fluids. After treatment, a decrease in the CCR7loPD1hi Tfh subset and an increase in the frequency of Tfr cells was observed in blood. In comparison to healthy donors, seropositive patients with moderate and high disease activity exhibited higher frequency of Tfh cells while seropositive patients with low disease activity presented higher Tfr cell frequency. Finally, we observed that HLA-DRB1*09 presence correlated with higher frequency of Tfh and Tfr cells, while HLA-DRB1*04 was associated with increased Tfr cell frequency. Together, our results increase our knowledge about the dynamics of Tfh and Tfr cell subsets in RA, showing that this is altered after treatment.
Fil: Ferrero, Paola V.. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Onofrio, Luisina Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Acosta, Cristina del Valle. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Zacca, Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Ponce, Nicolás Eric. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Mussano, Eduardo Daniel Eugenio. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Onetti, Laura Beatriz. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Cadile, Ignacio I.. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Costantino, Alicia B. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Werner, Marina Laura. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Mas, Luciana A.. Hospital Privado Centro Medico de Cordoba; Argentina
Fil: Alvarellos, Teresita. Hospital Privado Centro Medico de Cordoba; Argentina
Fil: Montes, Carolina Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Acosta Rodriguez, Eva Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Gruppi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Materia
DAS28-ESR
DMARDS
HLA-DRB1
RHEUMATOID ARTHRITIS
TFH CELLS
TFR CELLS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/218025
Acceder
id CONICETDig_866fa5f86c4007e93ac8395318871040
oai_identifier_str oai:ri.conicet.gov.ar:11336/218025
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dynamics of circulating follicular helper T cell subsets and follicular regulatory T cells in rheumatoid arthritis patients according to HLA-DRB1 locusFerrero, Paola V.Onofrio, Luisina InésAcosta, Cristina del ValleZacca, EstefaníaPonce, Nicolás EricMussano, Eduardo Daniel EugenioOnetti, Laura BeatrizCadile, Ignacio I.Costantino, Alicia BWerner, Marina LauraMas, Luciana A.Alvarellos, TeresitaMontes, Carolina LuciaAcosta Rodriguez, Eva VirginiaGruppi, AdrianaDAS28-ESRDMARDSHLA-DRB1RHEUMATOID ARTHRITISTFH CELLSTFR CELLShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3B cells, follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells are part of a circuit that may play a role in the development or progression of rheumatoid arthritis (RA). With the aim of providing further insight into this topic, here we evaluated the frequency of different subsets of Tfh and Tfr in untreated and long-term treated RA patients from a cohort of Argentina, and their potential association with particular human leukocyte antigen (HLA) class-II variants and disease activity. We observed that the frequency of total Tfh cells as well as of particular Tfh subsets and Tfr cells were increased in seropositive untreated RA patients. Interestingly, when analyzing paired samples, the frequency of Tfh cells was reduced in synovial fluid compared to peripheral blood, while Tfr cells levels were similar in both biological fluids. After treatment, a decrease in the CCR7loPD1hi Tfh subset and an increase in the frequency of Tfr cells was observed in blood. In comparison to healthy donors, seropositive patients with moderate and high disease activity exhibited higher frequency of Tfh cells while seropositive patients with low disease activity presented higher Tfr cell frequency. Finally, we observed that HLA-DRB1*09 presence correlated with higher frequency of Tfh and Tfr cells, while HLA-DRB1*04 was associated with increased Tfr cell frequency. Together, our results increase our knowledge about the dynamics of Tfh and Tfr cell subsets in RA, showing that this is altered after treatment.Fil: Ferrero, Paola V.. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Onofrio, Luisina Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Acosta, Cristina del Valle. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Zacca, Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Ponce, Nicolás Eric. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Mussano, Eduardo Daniel Eugenio. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Onetti, Laura Beatriz. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Cadile, Ignacio I.. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Costantino, Alicia B. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Werner, Marina Laura. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Mas, Luciana A.. Hospital Privado Centro Medico de Cordoba; ArgentinaFil: Alvarellos, Teresita. Hospital Privado Centro Medico de Cordoba; ArgentinaFil: Montes, Carolina Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Acosta Rodriguez, Eva Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Gruppi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFrontiers Media2022-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/218025Ferrero, Paola V.; Onofrio, Luisina Inés; Acosta, Cristina del Valle; Zacca, Estefanía; Ponce, Nicolás Eric; et al.; Dynamics of circulating follicular helper T cell subsets and follicular regulatory T cells in rheumatoid arthritis patients according to HLA-DRB1 locus; Frontiers Media; Frontiers in Immunology; 13; 12-2022; 1-151664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2022.1000982info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:16:48Zoai:ri.conicet.gov.ar:11336/218025instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:16:48.723CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dynamics of circulating follicular helper T cell subsets and follicular regulatory T cells in rheumatoid arthritis patients according to HLA-DRB1 locus
title Dynamics of circulating follicular helper T cell subsets and follicular regulatory T cells in rheumatoid arthritis patients according to HLA-DRB1 locus
spellingShingle Dynamics of circulating follicular helper T cell subsets and follicular regulatory T cells in rheumatoid arthritis patients according to HLA-DRB1 locus
Ferrero, Paola V.
DAS28-ESR
DMARDS
HLA-DRB1
RHEUMATOID ARTHRITIS
TFH CELLS
TFR CELLS
title_short Dynamics of circulating follicular helper T cell subsets and follicular regulatory T cells in rheumatoid arthritis patients according to HLA-DRB1 locus
title_full Dynamics of circulating follicular helper T cell subsets and follicular regulatory T cells in rheumatoid arthritis patients according to HLA-DRB1 locus
title_fullStr Dynamics of circulating follicular helper T cell subsets and follicular regulatory T cells in rheumatoid arthritis patients according to HLA-DRB1 locus
title_full_unstemmed Dynamics of circulating follicular helper T cell subsets and follicular regulatory T cells in rheumatoid arthritis patients according to HLA-DRB1 locus
title_sort Dynamics of circulating follicular helper T cell subsets and follicular regulatory T cells in rheumatoid arthritis patients according to HLA-DRB1 locus
dc.creator.none.fl_str_mv Ferrero, Paola V.
Onofrio, Luisina Inés
Acosta, Cristina del Valle
Zacca, Estefanía
Ponce, Nicolás Eric
Mussano, Eduardo Daniel Eugenio
Onetti, Laura Beatriz
Cadile, Ignacio I.
Costantino, Alicia B
Werner, Marina Laura
Mas, Luciana A.
Alvarellos, Teresita
Montes, Carolina Lucia
Acosta Rodriguez, Eva Virginia
Gruppi, Adriana
author Ferrero, Paola V.
author_facet Ferrero, Paola V.
Onofrio, Luisina Inés
Acosta, Cristina del Valle
Zacca, Estefanía
Ponce, Nicolás Eric
Mussano, Eduardo Daniel Eugenio
Onetti, Laura Beatriz
Cadile, Ignacio I.
Costantino, Alicia B
Werner, Marina Laura
Mas, Luciana A.
Alvarellos, Teresita
Montes, Carolina Lucia
Acosta Rodriguez, Eva Virginia
Gruppi, Adriana
author_role author
author2 Onofrio, Luisina Inés
Acosta, Cristina del Valle
Zacca, Estefanía
Ponce, Nicolás Eric
Mussano, Eduardo Daniel Eugenio
Onetti, Laura Beatriz
Cadile, Ignacio I.
Costantino, Alicia B
Werner, Marina Laura
Mas, Luciana A.
Alvarellos, Teresita
Montes, Carolina Lucia
Acosta Rodriguez, Eva Virginia
Gruppi, Adriana
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DAS28-ESR
DMARDS
HLA-DRB1
RHEUMATOID ARTHRITIS
TFH CELLS
TFR CELLS
topic DAS28-ESR
DMARDS
HLA-DRB1
RHEUMATOID ARTHRITIS
TFH CELLS
TFR CELLS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv B cells, follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells are part of a circuit that may play a role in the development or progression of rheumatoid arthritis (RA). With the aim of providing further insight into this topic, here we evaluated the frequency of different subsets of Tfh and Tfr in untreated and long-term treated RA patients from a cohort of Argentina, and their potential association with particular human leukocyte antigen (HLA) class-II variants and disease activity. We observed that the frequency of total Tfh cells as well as of particular Tfh subsets and Tfr cells were increased in seropositive untreated RA patients. Interestingly, when analyzing paired samples, the frequency of Tfh cells was reduced in synovial fluid compared to peripheral blood, while Tfr cells levels were similar in both biological fluids. After treatment, a decrease in the CCR7loPD1hi Tfh subset and an increase in the frequency of Tfr cells was observed in blood. In comparison to healthy donors, seropositive patients with moderate and high disease activity exhibited higher frequency of Tfh cells while seropositive patients with low disease activity presented higher Tfr cell frequency. Finally, we observed that HLA-DRB1*09 presence correlated with higher frequency of Tfh and Tfr cells, while HLA-DRB1*04 was associated with increased Tfr cell frequency. Together, our results increase our knowledge about the dynamics of Tfh and Tfr cell subsets in RA, showing that this is altered after treatment.
Fil: Ferrero, Paola V.. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Onofrio, Luisina Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Acosta, Cristina del Valle. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Zacca, Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Ponce, Nicolás Eric. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Mussano, Eduardo Daniel Eugenio. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Onetti, Laura Beatriz. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Cadile, Ignacio I.. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Costantino, Alicia B. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Werner, Marina Laura. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Mas, Luciana A.. Hospital Privado Centro Medico de Cordoba; Argentina
Fil: Alvarellos, Teresita. Hospital Privado Centro Medico de Cordoba; Argentina
Fil: Montes, Carolina Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Acosta Rodriguez, Eva Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Gruppi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
description B cells, follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells are part of a circuit that may play a role in the development or progression of rheumatoid arthritis (RA). With the aim of providing further insight into this topic, here we evaluated the frequency of different subsets of Tfh and Tfr in untreated and long-term treated RA patients from a cohort of Argentina, and their potential association with particular human leukocyte antigen (HLA) class-II variants and disease activity. We observed that the frequency of total Tfh cells as well as of particular Tfh subsets and Tfr cells were increased in seropositive untreated RA patients. Interestingly, when analyzing paired samples, the frequency of Tfh cells was reduced in synovial fluid compared to peripheral blood, while Tfr cells levels were similar in both biological fluids. After treatment, a decrease in the CCR7loPD1hi Tfh subset and an increase in the frequency of Tfr cells was observed in blood. In comparison to healthy donors, seropositive patients with moderate and high disease activity exhibited higher frequency of Tfh cells while seropositive patients with low disease activity presented higher Tfr cell frequency. Finally, we observed that HLA-DRB1*09 presence correlated with higher frequency of Tfh and Tfr cells, while HLA-DRB1*04 was associated with increased Tfr cell frequency. Together, our results increase our knowledge about the dynamics of Tfh and Tfr cell subsets in RA, showing that this is altered after treatment.
publishDate 2022
dc.date.none.fl_str_mv 2022-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/218025
Ferrero, Paola V.; Onofrio, Luisina Inés; Acosta, Cristina del Valle; Zacca, Estefanía; Ponce, Nicolás Eric; et al.; Dynamics of circulating follicular helper T cell subsets and follicular regulatory T cells in rheumatoid arthritis patients according to HLA-DRB1 locus; Frontiers Media; Frontiers in Immunology; 13; 12-2022; 1-15
1664-3224
CONICET Digital
CONICET
url http://hdl.handle.net/11336/218025
identifier_str_mv Ferrero, Paola V.; Onofrio, Luisina Inés; Acosta, Cristina del Valle; Zacca, Estefanía; Ponce, Nicolás Eric; et al.; Dynamics of circulating follicular helper T cell subsets and follicular regulatory T cells in rheumatoid arthritis patients according to HLA-DRB1 locus; Frontiers Media; Frontiers in Immunology; 13; 12-2022; 1-15
1664-3224
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2022.1000982
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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