Galectin 8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response

Autores
Sampson, James F.; Hasegawa, Eiichi; Mulki, Lama; Suryawanshi, Amol; Jiang, Shuhong; Chen, Wei Sheng; Rabinovich, Gabriel Adrián; Connor, Kip M.; Panjwani, Noorjahan
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Galectins have emerged as potent immunoregulatory agents that control chronic inflammation through distinct mechanisms. Here, we report that treatment with Galectin-8 (Gal-8), a tandem-repeat member of the galectin family, reduces retinal pathology and prevents photoreceptor cell damage in a murine model of experimental autoimmune uveitis. Gal-8 treatment increased the number of regulatory T cells (Treg) in both the draining lymph node (dLN) and the inflamed retina. Moreover, a greater percentage of Treg cells in the dLN and retina of Gal-8 treated animals expressed the inhibitory coreceptor cytotoxic T lymphocyte antigen (CTLA)-4, the immunosuppressive cytokine IL-10, and the tissue-homing integrin CD103. Treg cells in the retina of Gal-8-treated mice were primarily inducible Treg cells that lack the expression of neuropilin-1. In addition, Gal-8 treatment blunted production of inflammatory cytokines by retinal T helper type (TH) 1 and TH17 cells. The effect of Gal-8 on T cell differentiation and/or function was specific for tissues undergoing an active immune response, as Gal-8 treatment had no effect on T cell populations in the spleen. Given the need for rational therapies for managing human uveitis, Gal-8 emerges as an attractive therapeutic candidate not only for treating retinal autoimmune diseases, but also for other TH1- and TH17-mediated inflammatory disorders
Fil: Sampson, James F.. Tufts University. Sackler School of Graduate Biomedical Sciences; Estados Unidos
Fil: Hasegawa, Eiichi. Harvard Medical School. Massachusetts Eye and Ear Infirmary; Estados Unidos
Fil: Mulki, Lama. Harvard Medical School. Massachusetts Eye and Ear Infirmary; Estados Unidos
Fil: Suryawanshi, Amol. Tufts University School of Medicine. New England Eye Center; Estados Unidos
Fil: Jiang, Shuhong. Tufts University. Human Nutrition Research Center on Aging; Estados Unidos; Argentina
Fil: Chen, Wei Sheng. Tufts University. Human Nutrition Research Center on Aging; Estados Unidos
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Connor, Kip M.. Massachusetts Eye and Ear Infirmary. Harvard Medical School; Estados Unidos
Fil: Panjwani, Noorjahan. Tufts University. Sackler School of Graduate Biomedical Sciences; Estados Unidos
Materia
Galectin 8
Regulatory Cell
Ocular Pathology
Immunosuppressive Agents
Cell Differentiation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8299
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/8299
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Galectin 8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell responseSampson, James F.Hasegawa, EiichiMulki, LamaSuryawanshi, AmolJiang, ShuhongChen, Wei ShengRabinovich, Gabriel AdriánConnor, Kip M.Panjwani, NoorjahanGalectin 8Regulatory CellOcular PathologyImmunosuppressive AgentsCell Differentiationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Galectins have emerged as potent immunoregulatory agents that control chronic inflammation through distinct mechanisms. Here, we report that treatment with Galectin-8 (Gal-8), a tandem-repeat member of the galectin family, reduces retinal pathology and prevents photoreceptor cell damage in a murine model of experimental autoimmune uveitis. Gal-8 treatment increased the number of regulatory T cells (Treg) in both the draining lymph node (dLN) and the inflamed retina. Moreover, a greater percentage of Treg cells in the dLN and retina of Gal-8 treated animals expressed the inhibitory coreceptor cytotoxic T lymphocyte antigen (CTLA)-4, the immunosuppressive cytokine IL-10, and the tissue-homing integrin CD103. Treg cells in the retina of Gal-8-treated mice were primarily inducible Treg cells that lack the expression of neuropilin-1. In addition, Gal-8 treatment blunted production of inflammatory cytokines by retinal T helper type (TH) 1 and TH17 cells. The effect of Gal-8 on T cell differentiation and/or function was specific for tissues undergoing an active immune response, as Gal-8 treatment had no effect on T cell populations in the spleen. Given the need for rational therapies for managing human uveitis, Gal-8 emerges as an attractive therapeutic candidate not only for treating retinal autoimmune diseases, but also for other TH1- and TH17-mediated inflammatory disordersFil: Sampson, James F.. Tufts University. Sackler School of Graduate Biomedical Sciences; Estados UnidosFil: Hasegawa, Eiichi. Harvard Medical School. Massachusetts Eye and Ear Infirmary; Estados UnidosFil: Mulki, Lama. Harvard Medical School. Massachusetts Eye and Ear Infirmary; Estados UnidosFil: Suryawanshi, Amol. Tufts University School of Medicine. New England Eye Center; Estados UnidosFil: Jiang, Shuhong. Tufts University. Human Nutrition Research Center on Aging; Estados Unidos; ArgentinaFil: Chen, Wei Sheng. Tufts University. Human Nutrition Research Center on Aging; Estados UnidosFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Connor, Kip M.. Massachusetts Eye and Ear Infirmary. Harvard Medical School; Estados UnidosFil: Panjwani, Noorjahan. Tufts University. Sackler School of Graduate Biomedical Sciences; Estados UnidosPublic Library Of Science2015-06-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8299Sampson, James F.; Hasegawa, Eiichi; Mulki, Lama; Suryawanshi, Amol; Jiang, Shuhong; et al.; Galectin 8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response; Public Library Of Science; Plos One; 10; 6; 30-6-2015; 1-17; e1307721932-62031932-6203enginfo:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130772info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0130772info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488339/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:54:58Zoai:ri.conicet.gov.ar:11336/8299instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:54:58.802CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Galectin 8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response
title Galectin 8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response
spellingShingle Galectin 8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response
Sampson, James F.
Galectin 8
Regulatory Cell
Ocular Pathology
Immunosuppressive Agents
Cell Differentiation
title_short Galectin 8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response
title_full Galectin 8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response
title_fullStr Galectin 8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response
title_full_unstemmed Galectin 8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response
title_sort Galectin 8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response
dc.creator.none.fl_str_mv Sampson, James F.
Hasegawa, Eiichi
Mulki, Lama
Suryawanshi, Amol
Jiang, Shuhong
Chen, Wei Sheng
Rabinovich, Gabriel Adrián
Connor, Kip M.
Panjwani, Noorjahan
author Sampson, James F.
author_facet Sampson, James F.
Hasegawa, Eiichi
Mulki, Lama
Suryawanshi, Amol
Jiang, Shuhong
Chen, Wei Sheng
Rabinovich, Gabriel Adrián
Connor, Kip M.
Panjwani, Noorjahan
author_role author
author2 Hasegawa, Eiichi
Mulki, Lama
Suryawanshi, Amol
Jiang, Shuhong
Chen, Wei Sheng
Rabinovich, Gabriel Adrián
Connor, Kip M.
Panjwani, Noorjahan
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Galectin 8
Regulatory Cell
Ocular Pathology
Immunosuppressive Agents
Cell Differentiation
topic Galectin 8
Regulatory Cell
Ocular Pathology
Immunosuppressive Agents
Cell Differentiation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Galectins have emerged as potent immunoregulatory agents that control chronic inflammation through distinct mechanisms. Here, we report that treatment with Galectin-8 (Gal-8), a tandem-repeat member of the galectin family, reduces retinal pathology and prevents photoreceptor cell damage in a murine model of experimental autoimmune uveitis. Gal-8 treatment increased the number of regulatory T cells (Treg) in both the draining lymph node (dLN) and the inflamed retina. Moreover, a greater percentage of Treg cells in the dLN and retina of Gal-8 treated animals expressed the inhibitory coreceptor cytotoxic T lymphocyte antigen (CTLA)-4, the immunosuppressive cytokine IL-10, and the tissue-homing integrin CD103. Treg cells in the retina of Gal-8-treated mice were primarily inducible Treg cells that lack the expression of neuropilin-1. In addition, Gal-8 treatment blunted production of inflammatory cytokines by retinal T helper type (TH) 1 and TH17 cells. The effect of Gal-8 on T cell differentiation and/or function was specific for tissues undergoing an active immune response, as Gal-8 treatment had no effect on T cell populations in the spleen. Given the need for rational therapies for managing human uveitis, Gal-8 emerges as an attractive therapeutic candidate not only for treating retinal autoimmune diseases, but also for other TH1- and TH17-mediated inflammatory disorders
Fil: Sampson, James F.. Tufts University. Sackler School of Graduate Biomedical Sciences; Estados Unidos
Fil: Hasegawa, Eiichi. Harvard Medical School. Massachusetts Eye and Ear Infirmary; Estados Unidos
Fil: Mulki, Lama. Harvard Medical School. Massachusetts Eye and Ear Infirmary; Estados Unidos
Fil: Suryawanshi, Amol. Tufts University School of Medicine. New England Eye Center; Estados Unidos
Fil: Jiang, Shuhong. Tufts University. Human Nutrition Research Center on Aging; Estados Unidos; Argentina
Fil: Chen, Wei Sheng. Tufts University. Human Nutrition Research Center on Aging; Estados Unidos
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Connor, Kip M.. Massachusetts Eye and Ear Infirmary. Harvard Medical School; Estados Unidos
Fil: Panjwani, Noorjahan. Tufts University. Sackler School of Graduate Biomedical Sciences; Estados Unidos
description Galectins have emerged as potent immunoregulatory agents that control chronic inflammation through distinct mechanisms. Here, we report that treatment with Galectin-8 (Gal-8), a tandem-repeat member of the galectin family, reduces retinal pathology and prevents photoreceptor cell damage in a murine model of experimental autoimmune uveitis. Gal-8 treatment increased the number of regulatory T cells (Treg) in both the draining lymph node (dLN) and the inflamed retina. Moreover, a greater percentage of Treg cells in the dLN and retina of Gal-8 treated animals expressed the inhibitory coreceptor cytotoxic T lymphocyte antigen (CTLA)-4, the immunosuppressive cytokine IL-10, and the tissue-homing integrin CD103. Treg cells in the retina of Gal-8-treated mice were primarily inducible Treg cells that lack the expression of neuropilin-1. In addition, Gal-8 treatment blunted production of inflammatory cytokines by retinal T helper type (TH) 1 and TH17 cells. The effect of Gal-8 on T cell differentiation and/or function was specific for tissues undergoing an active immune response, as Gal-8 treatment had no effect on T cell populations in the spleen. Given the need for rational therapies for managing human uveitis, Gal-8 emerges as an attractive therapeutic candidate not only for treating retinal autoimmune diseases, but also for other TH1- and TH17-mediated inflammatory disorders
publishDate 2015
dc.date.none.fl_str_mv 2015-06-30
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8299
Sampson, James F.; Hasegawa, Eiichi; Mulki, Lama; Suryawanshi, Amol; Jiang, Shuhong; et al.; Galectin 8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response; Public Library Of Science; Plos One; 10; 6; 30-6-2015; 1-17; e130772
1932-6203
1932-6203
url http://hdl.handle.net/11336/8299
identifier_str_mv Sampson, James F.; Hasegawa, Eiichi; Mulki, Lama; Suryawanshi, Amol; Jiang, Shuhong; et al.; Galectin 8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response; Public Library Of Science; Plos One; 10; 6; 30-6-2015; 1-17; e130772
1932-6203
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130772
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0130772
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488339/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library Of Science
publisher.none.fl_str_mv Public Library Of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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