Electrochemical determination of ascorbic acid and paracetamol in pharmaceutical formulations using a glassy carbon electrode modified with multi-wall carbon nanotubes dispersed in...

Autores
Dalmasso, Pablo Roberto; Pedano, Maria Laura; Rivas, Gustavo Adolfo
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This work reports on the analytical performance of glassy carbon electrodes (GCE) modified with a dispersion of multi-wall carbon nanotubes (MWCNT) in polyhistidine (Polyhis) (GCE/MWCNT-Polyhis) for the simultaneous determination of ascorbic acid (AA) and paracetamol (PA). The modified electrode exhibited enhanced current responses and lower oxidation overvoltages, demonstrating excellent catalytic activities towards AA and PA oxidation compared to bare GCE. The linear dependence between the anodic peak currents and the square root of scan rates over the range of 0.005-0.300 V/s demonstrate that the electrooxidation of AA and PA occurs under diffusional control. The MWCNT-Polyhis modified GCE displayed a sensitivity of (3.8 ± 0.1) ×104 µA/M (r = 0.998) and a detection limit of 0.76 µM for the selective determination of AA in the presence of 1.00 × 10-4M PA. Conversely, for the direct quantification of PA in the presence of 5.00 ×10-4M AA, the sensitivity and the detection limit were (6.3 ± 0.2) ×105µA/M (r = 0.997) and 32 nM, respectively. The proposed electrochemical sensor was successfully applied for quantifying AA and PA in commercial pharmaceutical formulations without any sample pretreatment.
Fil: Dalmasso, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Pedano, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Materia
Ascorbic acid
Paracetamol
Carbon nanotubes dispersion
Polyhistidine
Glassy Carbon Electrode
Differential pulse voltammetry
Pharmaceutical samples
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/267995
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/267995
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Electrochemical determination of ascorbic acid and paracetamol in pharmaceutical formulations using a glassy carbon electrode modified with multi-wall carbon nanotubes dispersed in polyhistidineDalmasso, Pablo RobertoPedano, Maria LauraRivas, Gustavo AdolfoAscorbic acidParacetamolCarbon nanotubes dispersionPolyhistidineGlassy Carbon ElectrodeDifferential pulse voltammetryPharmaceutical sampleshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1This work reports on the analytical performance of glassy carbon electrodes (GCE) modified with a dispersion of multi-wall carbon nanotubes (MWCNT) in polyhistidine (Polyhis) (GCE/MWCNT-Polyhis) for the simultaneous determination of ascorbic acid (AA) and paracetamol (PA). The modified electrode exhibited enhanced current responses and lower oxidation overvoltages, demonstrating excellent catalytic activities towards AA and PA oxidation compared to bare GCE. The linear dependence between the anodic peak currents and the square root of scan rates over the range of 0.005-0.300 V/s demonstrate that the electrooxidation of AA and PA occurs under diffusional control. The MWCNT-Polyhis modified GCE displayed a sensitivity of (3.8 ± 0.1) ×104 µA/M (r = 0.998) and a detection limit of 0.76 µM for the selective determination of AA in the presence of 1.00 × 10-4M PA. Conversely, for the direct quantification of PA in the presence of 5.00 ×10-4M AA, the sensitivity and the detection limit were (6.3 ± 0.2) ×105µA/M (r = 0.997) and 32 nM, respectively. The proposed electrochemical sensor was successfully applied for quantifying AA and PA in commercial pharmaceutical formulations without any sample pretreatment.Fil: Dalmasso, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Pedano, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaElsevier Science SA2012-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/267995Dalmasso, Pablo Roberto; Pedano, Maria Laura; Rivas, Gustavo Adolfo; Electrochemical determination of ascorbic acid and paracetamol in pharmaceutical formulations using a glassy carbon electrode modified with multi-wall carbon nanotubes dispersed in polyhistidine; Elsevier Science SA; Sensors and Actuators B: Chemical; 173; 10-2012; 732-7360925-4005CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.snb.2012.07.087info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:49:51Zoai:ri.conicet.gov.ar:11336/267995instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:49:51.93CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Electrochemical determination of ascorbic acid and paracetamol in pharmaceutical formulations using a glassy carbon electrode modified with multi-wall carbon nanotubes dispersed in polyhistidine
title Electrochemical determination of ascorbic acid and paracetamol in pharmaceutical formulations using a glassy carbon electrode modified with multi-wall carbon nanotubes dispersed in polyhistidine
spellingShingle Electrochemical determination of ascorbic acid and paracetamol in pharmaceutical formulations using a glassy carbon electrode modified with multi-wall carbon nanotubes dispersed in polyhistidine
Dalmasso, Pablo Roberto
Ascorbic acid
Paracetamol
Carbon nanotubes dispersion
Polyhistidine
Glassy Carbon Electrode
Differential pulse voltammetry
Pharmaceutical samples
title_short Electrochemical determination of ascorbic acid and paracetamol in pharmaceutical formulations using a glassy carbon electrode modified with multi-wall carbon nanotubes dispersed in polyhistidine
title_full Electrochemical determination of ascorbic acid and paracetamol in pharmaceutical formulations using a glassy carbon electrode modified with multi-wall carbon nanotubes dispersed in polyhistidine
title_fullStr Electrochemical determination of ascorbic acid and paracetamol in pharmaceutical formulations using a glassy carbon electrode modified with multi-wall carbon nanotubes dispersed in polyhistidine
title_full_unstemmed Electrochemical determination of ascorbic acid and paracetamol in pharmaceutical formulations using a glassy carbon electrode modified with multi-wall carbon nanotubes dispersed in polyhistidine
title_sort Electrochemical determination of ascorbic acid and paracetamol in pharmaceutical formulations using a glassy carbon electrode modified with multi-wall carbon nanotubes dispersed in polyhistidine
dc.creator.none.fl_str_mv Dalmasso, Pablo Roberto
Pedano, Maria Laura
Rivas, Gustavo Adolfo
author Dalmasso, Pablo Roberto
author_facet Dalmasso, Pablo Roberto
Pedano, Maria Laura
Rivas, Gustavo Adolfo
author_role author
author2 Pedano, Maria Laura
Rivas, Gustavo Adolfo
author2_role author
author
dc.subject.none.fl_str_mv Ascorbic acid
Paracetamol
Carbon nanotubes dispersion
Polyhistidine
Glassy Carbon Electrode
Differential pulse voltammetry
Pharmaceutical samples
topic Ascorbic acid
Paracetamol
Carbon nanotubes dispersion
Polyhistidine
Glassy Carbon Electrode
Differential pulse voltammetry
Pharmaceutical samples
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This work reports on the analytical performance of glassy carbon electrodes (GCE) modified with a dispersion of multi-wall carbon nanotubes (MWCNT) in polyhistidine (Polyhis) (GCE/MWCNT-Polyhis) for the simultaneous determination of ascorbic acid (AA) and paracetamol (PA). The modified electrode exhibited enhanced current responses and lower oxidation overvoltages, demonstrating excellent catalytic activities towards AA and PA oxidation compared to bare GCE. The linear dependence between the anodic peak currents and the square root of scan rates over the range of 0.005-0.300 V/s demonstrate that the electrooxidation of AA and PA occurs under diffusional control. The MWCNT-Polyhis modified GCE displayed a sensitivity of (3.8 ± 0.1) ×104 µA/M (r = 0.998) and a detection limit of 0.76 µM for the selective determination of AA in the presence of 1.00 × 10-4M PA. Conversely, for the direct quantification of PA in the presence of 5.00 ×10-4M AA, the sensitivity and the detection limit were (6.3 ± 0.2) ×105µA/M (r = 0.997) and 32 nM, respectively. The proposed electrochemical sensor was successfully applied for quantifying AA and PA in commercial pharmaceutical formulations without any sample pretreatment.
Fil: Dalmasso, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Pedano, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Rivas, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
description This work reports on the analytical performance of glassy carbon electrodes (GCE) modified with a dispersion of multi-wall carbon nanotubes (MWCNT) in polyhistidine (Polyhis) (GCE/MWCNT-Polyhis) for the simultaneous determination of ascorbic acid (AA) and paracetamol (PA). The modified electrode exhibited enhanced current responses and lower oxidation overvoltages, demonstrating excellent catalytic activities towards AA and PA oxidation compared to bare GCE. The linear dependence between the anodic peak currents and the square root of scan rates over the range of 0.005-0.300 V/s demonstrate that the electrooxidation of AA and PA occurs under diffusional control. The MWCNT-Polyhis modified GCE displayed a sensitivity of (3.8 ± 0.1) ×104 µA/M (r = 0.998) and a detection limit of 0.76 µM for the selective determination of AA in the presence of 1.00 × 10-4M PA. Conversely, for the direct quantification of PA in the presence of 5.00 ×10-4M AA, the sensitivity and the detection limit were (6.3 ± 0.2) ×105µA/M (r = 0.997) and 32 nM, respectively. The proposed electrochemical sensor was successfully applied for quantifying AA and PA in commercial pharmaceutical formulations without any sample pretreatment.
publishDate 2012
dc.date.none.fl_str_mv 2012-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/267995
Dalmasso, Pablo Roberto; Pedano, Maria Laura; Rivas, Gustavo Adolfo; Electrochemical determination of ascorbic acid and paracetamol in pharmaceutical formulations using a glassy carbon electrode modified with multi-wall carbon nanotubes dispersed in polyhistidine; Elsevier Science SA; Sensors and Actuators B: Chemical; 173; 10-2012; 732-736
0925-4005
CONICET Digital
CONICET
url http://hdl.handle.net/11336/267995
identifier_str_mv Dalmasso, Pablo Roberto; Pedano, Maria Laura; Rivas, Gustavo Adolfo; Electrochemical determination of ascorbic acid and paracetamol in pharmaceutical formulations using a glassy carbon electrode modified with multi-wall carbon nanotubes dispersed in polyhistidine; Elsevier Science SA; Sensors and Actuators B: Chemical; 173; 10-2012; 732-736
0925-4005
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.snb.2012.07.087
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science SA
publisher.none.fl_str_mv Elsevier Science SA
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083022092238848
score 13.22299

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