Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks

Autores
Perez Santangelo, Maria Soledad; Schlaen, Rubén Gustavo; Yanovsky, Marcelo Javier
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Circadian clocks, the molecular devices present in almost all eukaryotic and some prokaryotic organisms, phase biological activities to the most appropriate time of day. These devices are synchronized by the daily cycles of light and temperature, and control hundreds of processes, ranging from gene expression to behavior as well as reproductive development. For a long time, these clocks were considered to operate primarily through regulatory feedback loops that act at the transcriptional level. Recent studies, however, conclusively show that circadian rhythms can persist in the absence of transcription, and it is evident that robust and precise circadian oscillations require multiple regulatory mechanisms operating at the co-/post-transcriptional, translational, post-translational and metabolic levels. Furthermore, these different regulatory loops exhibit strong interactions, which contribute to the synchronization of biological rhythms with environmental changes throughout the day and year. Here, we describe recent advances that highlight the role of alternative splicing (AS) in the operation of circadian networks, focusing on molecular and genomic studies conducted in Arabidopsis thaliana. These studies have also enhanced our understanding of the mechanisms that control AS and of the physiological impact of AS.
Fil: Perez Santangelo, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad de Buenos Aires; Argentina
Fil: Schlaen, Rubén Gustavo. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Yanovsky, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Agronomia; Argentina
Materia
Splicing Alternativo
Reloj Biologico
Plantas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/19714
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/19714
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networksPerez Santangelo, Maria SoledadSchlaen, Rubén GustavoYanovsky, Marcelo JavierSplicing AlternativoReloj BiologicoPlantashttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Circadian clocks, the molecular devices present in almost all eukaryotic and some prokaryotic organisms, phase biological activities to the most appropriate time of day. These devices are synchronized by the daily cycles of light and temperature, and control hundreds of processes, ranging from gene expression to behavior as well as reproductive development. For a long time, these clocks were considered to operate primarily through regulatory feedback loops that act at the transcriptional level. Recent studies, however, conclusively show that circadian rhythms can persist in the absence of transcription, and it is evident that robust and precise circadian oscillations require multiple regulatory mechanisms operating at the co-/post-transcriptional, translational, post-translational and metabolic levels. Furthermore, these different regulatory loops exhibit strong interactions, which contribute to the synchronization of biological rhythms with environmental changes throughout the day and year. Here, we describe recent advances that highlight the role of alternative splicing (AS) in the operation of circadian networks, focusing on molecular and genomic studies conducted in Arabidopsis thaliana. These studies have also enhanced our understanding of the mechanisms that control AS and of the physiological impact of AS.Fil: Perez Santangelo, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad de Buenos Aires; ArgentinaFil: Schlaen, Rubén Gustavo. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Yanovsky, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Agronomia; ArgentinaOxford University Press2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/19714Perez Santangelo, Maria Soledad; Schlaen, Rubén Gustavo; Yanovsky, Marcelo Javier; Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks; Oxford University Press; Briefings in Functional Genomics; 12; 1; 1-2013; 13-242041-26492041-2657CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/bfg/article-lookup/doi/10.1093/bfgp/els052info:eu-repo/semantics/altIdentifier/doi/10.1093/bfgp/els052info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:11:38Zoai:ri.conicet.gov.ar:11336/19714instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:11:39.227CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks
title Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks
spellingShingle Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks
Perez Santangelo, Maria Soledad
Splicing Alternativo
Reloj Biologico
Plantas
title_short Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks
title_full Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks
title_fullStr Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks
title_full_unstemmed Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks
title_sort Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks
dc.creator.none.fl_str_mv Perez Santangelo, Maria Soledad
Schlaen, Rubén Gustavo
Yanovsky, Marcelo Javier
author Perez Santangelo, Maria Soledad
author_facet Perez Santangelo, Maria Soledad
Schlaen, Rubén Gustavo
Yanovsky, Marcelo Javier
author_role author
author2 Schlaen, Rubén Gustavo
Yanovsky, Marcelo Javier
author2_role author
author
dc.subject.none.fl_str_mv Splicing Alternativo
Reloj Biologico
Plantas
topic Splicing Alternativo
Reloj Biologico
Plantas
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Circadian clocks, the molecular devices present in almost all eukaryotic and some prokaryotic organisms, phase biological activities to the most appropriate time of day. These devices are synchronized by the daily cycles of light and temperature, and control hundreds of processes, ranging from gene expression to behavior as well as reproductive development. For a long time, these clocks were considered to operate primarily through regulatory feedback loops that act at the transcriptional level. Recent studies, however, conclusively show that circadian rhythms can persist in the absence of transcription, and it is evident that robust and precise circadian oscillations require multiple regulatory mechanisms operating at the co-/post-transcriptional, translational, post-translational and metabolic levels. Furthermore, these different regulatory loops exhibit strong interactions, which contribute to the synchronization of biological rhythms with environmental changes throughout the day and year. Here, we describe recent advances that highlight the role of alternative splicing (AS) in the operation of circadian networks, focusing on molecular and genomic studies conducted in Arabidopsis thaliana. These studies have also enhanced our understanding of the mechanisms that control AS and of the physiological impact of AS.
Fil: Perez Santangelo, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad de Buenos Aires; Argentina
Fil: Schlaen, Rubén Gustavo. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Yanovsky, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Agronomia; Argentina
description Circadian clocks, the molecular devices present in almost all eukaryotic and some prokaryotic organisms, phase biological activities to the most appropriate time of day. These devices are synchronized by the daily cycles of light and temperature, and control hundreds of processes, ranging from gene expression to behavior as well as reproductive development. For a long time, these clocks were considered to operate primarily through regulatory feedback loops that act at the transcriptional level. Recent studies, however, conclusively show that circadian rhythms can persist in the absence of transcription, and it is evident that robust and precise circadian oscillations require multiple regulatory mechanisms operating at the co-/post-transcriptional, translational, post-translational and metabolic levels. Furthermore, these different regulatory loops exhibit strong interactions, which contribute to the synchronization of biological rhythms with environmental changes throughout the day and year. Here, we describe recent advances that highlight the role of alternative splicing (AS) in the operation of circadian networks, focusing on molecular and genomic studies conducted in Arabidopsis thaliana. These studies have also enhanced our understanding of the mechanisms that control AS and of the physiological impact of AS.
publishDate 2013
dc.date.none.fl_str_mv 2013-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/19714
Perez Santangelo, Maria Soledad; Schlaen, Rubén Gustavo; Yanovsky, Marcelo Javier; Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks; Oxford University Press; Briefings in Functional Genomics; 12; 1; 1-2013; 13-24
2041-2649
2041-2657
CONICET Digital
CONICET
url http://hdl.handle.net/11336/19714
identifier_str_mv Perez Santangelo, Maria Soledad; Schlaen, Rubén Gustavo; Yanovsky, Marcelo Javier; Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks; Oxford University Press; Briefings in Functional Genomics; 12; 1; 1-2013; 13-24
2041-2649
2041-2657
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/bfg/article-lookup/doi/10.1093/bfgp/els052
info:eu-repo/semantics/altIdentifier/doi/10.1093/bfgp/els052
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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