Medicinal cannabis delivery systems: A perspective

Autores
Boldrini, Diego Emmanuel; López, Olivia V.
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In recent years, cannabis derivatives have been proposed for the treatment ofvarious medical conditions, including pain, inflammation, epilepsy, sleep disorders,multiple sclerosis, anorexia, schizophrenia, neurodegenerative diseases, nausea,and cancer. While the benefits of cannabis derivatives, primarily cannabinoids,have been demonstrated and continue to be studied, their use presents variouschallenges associated with their low water solubility, rapid metabolism, erraticand poor bioavailability, and erratic pharmacokinetics, which directly affect theirefficacy. In this context, a great deal of research is being carried out to overcomethese drawbacks by designing delivery systems capable of improving solubility/bioavailability, potency, and efficacy, while addressing the purity and quality issuesrequired by the pharmaceutical industry. This article aims to critically review themajor trends and challenges in designing controlled-release cannabinoid deliverysystems and their potential application in the pharmaceutical industry.
Fil: Boldrini, Diego Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
Fil: López, Olivia V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Química; Argentina
Materia
CANNABIS
CANNABIDIOLS
DRUGS DELIVERY SYSTEMS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/260468
Acceder
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spelling Medicinal cannabis delivery systems: A perspectiveBoldrini, Diego EmmanuelLópez, Olivia V.CANNABISCANNABIDIOLSDRUGS DELIVERY SYSTEMShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In recent years, cannabis derivatives have been proposed for the treatment ofvarious medical conditions, including pain, inflammation, epilepsy, sleep disorders,multiple sclerosis, anorexia, schizophrenia, neurodegenerative diseases, nausea,and cancer. While the benefits of cannabis derivatives, primarily cannabinoids,have been demonstrated and continue to be studied, their use presents variouschallenges associated with their low water solubility, rapid metabolism, erraticand poor bioavailability, and erratic pharmacokinetics, which directly affect theirefficacy. In this context, a great deal of research is being carried out to overcomethese drawbacks by designing delivery systems capable of improving solubility/bioavailability, potency, and efficacy, while addressing the purity and quality issuesrequired by the pharmaceutical industry. This article aims to critically review themajor trends and challenges in designing controlled-release cannabinoid deliverysystems and their potential application in the pharmaceutical industry.Fil: Boldrini, Diego Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; ArgentinaFil: López, Olivia V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Química; ArgentinaAccScience Publishing2024-10-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/260468Boldrini, Diego Emmanuel; López, Olivia V.; Medicinal cannabis delivery systems: A perspective; AccScience Publishing; Innovative Medicines & Omics; 2; 1; 25-10-2024; 50-543060-89103060-8740CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://accscience.com/journal/IMO/0/0/10.36922/imo.4448info:eu-repo/semantics/altIdentifier/doi/10.36922/imo.4448info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:39Zoai:ri.conicet.gov.ar:11336/260468instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:39.769CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Medicinal cannabis delivery systems: A perspective
title Medicinal cannabis delivery systems: A perspective
spellingShingle Medicinal cannabis delivery systems: A perspective
Boldrini, Diego Emmanuel
CANNABIS
CANNABIDIOLS
DRUGS DELIVERY SYSTEMS
title_short Medicinal cannabis delivery systems: A perspective
title_full Medicinal cannabis delivery systems: A perspective
title_fullStr Medicinal cannabis delivery systems: A perspective
title_full_unstemmed Medicinal cannabis delivery systems: A perspective
title_sort Medicinal cannabis delivery systems: A perspective
dc.creator.none.fl_str_mv Boldrini, Diego Emmanuel
López, Olivia V.
author Boldrini, Diego Emmanuel
author_facet Boldrini, Diego Emmanuel
López, Olivia V.
author_role author
author2 López, Olivia V.
author2_role author
dc.subject.none.fl_str_mv CANNABIS
CANNABIDIOLS
DRUGS DELIVERY SYSTEMS
topic CANNABIS
CANNABIDIOLS
DRUGS DELIVERY SYSTEMS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In recent years, cannabis derivatives have been proposed for the treatment ofvarious medical conditions, including pain, inflammation, epilepsy, sleep disorders,multiple sclerosis, anorexia, schizophrenia, neurodegenerative diseases, nausea,and cancer. While the benefits of cannabis derivatives, primarily cannabinoids,have been demonstrated and continue to be studied, their use presents variouschallenges associated with their low water solubility, rapid metabolism, erraticand poor bioavailability, and erratic pharmacokinetics, which directly affect theirefficacy. In this context, a great deal of research is being carried out to overcomethese drawbacks by designing delivery systems capable of improving solubility/bioavailability, potency, and efficacy, while addressing the purity and quality issuesrequired by the pharmaceutical industry. This article aims to critically review themajor trends and challenges in designing controlled-release cannabinoid deliverysystems and their potential application in the pharmaceutical industry.
Fil: Boldrini, Diego Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
Fil: López, Olivia V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Química; Argentina
description In recent years, cannabis derivatives have been proposed for the treatment ofvarious medical conditions, including pain, inflammation, epilepsy, sleep disorders,multiple sclerosis, anorexia, schizophrenia, neurodegenerative diseases, nausea,and cancer. While the benefits of cannabis derivatives, primarily cannabinoids,have been demonstrated and continue to be studied, their use presents variouschallenges associated with their low water solubility, rapid metabolism, erraticand poor bioavailability, and erratic pharmacokinetics, which directly affect theirefficacy. In this context, a great deal of research is being carried out to overcomethese drawbacks by designing delivery systems capable of improving solubility/bioavailability, potency, and efficacy, while addressing the purity and quality issuesrequired by the pharmaceutical industry. This article aims to critically review themajor trends and challenges in designing controlled-release cannabinoid deliverysystems and their potential application in the pharmaceutical industry.
publishDate 2024
dc.date.none.fl_str_mv 2024-10-25
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/260468
Boldrini, Diego Emmanuel; López, Olivia V.; Medicinal cannabis delivery systems: A perspective; AccScience Publishing; Innovative Medicines & Omics; 2; 1; 25-10-2024; 50-54
3060-8910
3060-8740
CONICET Digital
CONICET
url http://hdl.handle.net/11336/260468
identifier_str_mv Boldrini, Diego Emmanuel; López, Olivia V.; Medicinal cannabis delivery systems: A perspective; AccScience Publishing; Innovative Medicines & Omics; 2; 1; 25-10-2024; 50-54
3060-8910
3060-8740
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://accscience.com/journal/IMO/0/0/10.36922/imo.4448
info:eu-repo/semantics/altIdentifier/doi/10.36922/imo.4448
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv AccScience Publishing
publisher.none.fl_str_mv AccScience Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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