Zika virus infection in pregnant women in Honduras: study protocol

Autores
Buekens, Pierre; Alger, Jackeline; Althabe, Fernando; Bergel, Eduardo; Berrueta, Amanda Mabel; Bustillo, Carolina; Cafferata, Maria Luisa; Harville, Emily; Rosales, Karla; Wesson, Dawn M.; Zuniga, Concepcion
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Although there is increasing evidence for a relationship between symptomatic Zika virus (ZIKV) maternal infection, and microcephaly, a firm causal relation has yet to be established by epidemiologic studies. Studies also need to be conducted in recently infected settings. Our objectives are to assess the frequency of ZIKV infection during pregnancy in Honduras and the association of microcephaly with ZIKV infection. Methods/Design: We will perform a prospective study enrolling pregnant women at their first antenatal visit and following them up until delivery. At the time of enrollment, women will be interviewed to collect socio-demographic data, data needed to locate them for potential additional follow-up, and data about ZIKV symptoms during pregnancy. We will also collect maternal blood as soon as possible after enrollment. A probable maternal ZIKV infection will be defined as positive for maternal ZIKV IgM. A confirmed maternal ZIKV infection will be defined as positive for ZIKV IgM confirmed by plaque reduction neutralization test. Microcephaly at birth will be defined as an occipito-frontal circumference <2SD for sex and gestational age. Our objective is to enroll 2000 pregnant women. In a first step, we will follow a case cohort design and only analyze blood samples for cases and a sub-cohort of 200 women randomly selected. Blood samples for the entire population will be analyzed at a later stage if funds are available. Discussion: This protocol was designed to be implemented with minimal resources. It allows a cohort to be built, which could be a foundation for future in-depth and follow-up studies.
Fil: Buekens, Pierre. University of Tulane; Estados Unidos
Fil: Alger, Jackeline. Universidad Nacional Autónoma de Honduras; Honduras
Fil: Althabe, Fernando. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bergel, Eduardo. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Berrueta, Amanda Mabel. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Bustillo, Carolina. Hospital Escuela. Departamento de Ginecología y Obstetricia; Honduras
Fil: Cafferata, Maria Luisa. Hospital de Clínicas. Unidad de Investigación Clínica y Epidemiológica Montevideo; Uruguay
Fil: Harville, Emily. University of Tulane; Estados Unidos
Fil: Rosales, Karla. Región Sanitaria Metropolitana Distrito Central de Francisco Morazán; Honduras
Fil: Wesson, Dawn M.. University of Tulane; Estados Unidos
Fil: Zuniga, Concepcion. Hospital Escuela Universitario. Instituto de Enfermedades Infecciosas y Parasitología Antonio Vidal; Honduras
Materia
Honduras
Microcephaly
Pregnancy
Zika Virus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47186
Acceder
id CONICETDig_8544a72140169450471ddbef7e16bcdc
oai_identifier_str oai:ri.conicet.gov.ar:11336/47186
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Zika virus infection in pregnant women in Honduras: study protocolBuekens, PierreAlger, JackelineAlthabe, FernandoBergel, EduardoBerrueta, Amanda MabelBustillo, CarolinaCafferata, Maria LuisaHarville, EmilyRosales, KarlaWesson, Dawn M.Zuniga, ConcepcionHondurasMicrocephalyPregnancyZika Virushttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Although there is increasing evidence for a relationship between symptomatic Zika virus (ZIKV) maternal infection, and microcephaly, a firm causal relation has yet to be established by epidemiologic studies. Studies also need to be conducted in recently infected settings. Our objectives are to assess the frequency of ZIKV infection during pregnancy in Honduras and the association of microcephaly with ZIKV infection. Methods/Design: We will perform a prospective study enrolling pregnant women at their first antenatal visit and following them up until delivery. At the time of enrollment, women will be interviewed to collect socio-demographic data, data needed to locate them for potential additional follow-up, and data about ZIKV symptoms during pregnancy. We will also collect maternal blood as soon as possible after enrollment. A probable maternal ZIKV infection will be defined as positive for maternal ZIKV IgM. A confirmed maternal ZIKV infection will be defined as positive for ZIKV IgM confirmed by plaque reduction neutralization test. Microcephaly at birth will be defined as an occipito-frontal circumference <2SD for sex and gestational age. Our objective is to enroll 2000 pregnant women. In a first step, we will follow a case cohort design and only analyze blood samples for cases and a sub-cohort of 200 women randomly selected. Blood samples for the entire population will be analyzed at a later stage if funds are available. Discussion: This protocol was designed to be implemented with minimal resources. It allows a cohort to be built, which could be a foundation for future in-depth and follow-up studies.Fil: Buekens, Pierre. University of Tulane; Estados UnidosFil: Alger, Jackeline. Universidad Nacional Autónoma de Honduras; HondurasFil: Althabe, Fernando. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bergel, Eduardo. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Berrueta, Amanda Mabel. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Bustillo, Carolina. Hospital Escuela. Departamento de Ginecología y Obstetricia; HondurasFil: Cafferata, Maria Luisa. Hospital de Clínicas. Unidad de Investigación Clínica y Epidemiológica Montevideo; UruguayFil: Harville, Emily. University of Tulane; Estados UnidosFil: Rosales, Karla. Región Sanitaria Metropolitana Distrito Central de Francisco Morazán; HondurasFil: Wesson, Dawn M.. University of Tulane; Estados UnidosFil: Zuniga, Concepcion. Hospital Escuela Universitario. Instituto de Enfermedades Infecciosas y Parasitología Antonio Vidal; HondurasBioMed Central2016-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47186Buekens, Pierre; Alger, Jackeline; Althabe, Fernando; Bergel, Eduardo; Berrueta, Amanda Mabel; et al.; Zika virus infection in pregnant women in Honduras: study protocol; BioMed Central; Reproductive Health; 13; 7-2016; 1-61742-4755CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1186/s12978-016-0200-6info:eu-repo/semantics/altIdentifier/url/https://reproductive-health-journal.biomedcentral.com/articles/10.1186/s12978-016-0200-6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:11:01Zoai:ri.conicet.gov.ar:11336/47186instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:11:01.987CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Zika virus infection in pregnant women in Honduras: study protocol
title Zika virus infection in pregnant women in Honduras: study protocol
spellingShingle Zika virus infection in pregnant women in Honduras: study protocol
Buekens, Pierre
Honduras
Microcephaly
Pregnancy
Zika Virus
title_short Zika virus infection in pregnant women in Honduras: study protocol
title_full Zika virus infection in pregnant women in Honduras: study protocol
title_fullStr Zika virus infection in pregnant women in Honduras: study protocol
title_full_unstemmed Zika virus infection in pregnant women in Honduras: study protocol
title_sort Zika virus infection in pregnant women in Honduras: study protocol
dc.creator.none.fl_str_mv Buekens, Pierre
Alger, Jackeline
Althabe, Fernando
Bergel, Eduardo
Berrueta, Amanda Mabel
Bustillo, Carolina
Cafferata, Maria Luisa
Harville, Emily
Rosales, Karla
Wesson, Dawn M.
Zuniga, Concepcion
author Buekens, Pierre
author_facet Buekens, Pierre
Alger, Jackeline
Althabe, Fernando
Bergel, Eduardo
Berrueta, Amanda Mabel
Bustillo, Carolina
Cafferata, Maria Luisa
Harville, Emily
Rosales, Karla
Wesson, Dawn M.
Zuniga, Concepcion
author_role author
author2 Alger, Jackeline
Althabe, Fernando
Bergel, Eduardo
Berrueta, Amanda Mabel
Bustillo, Carolina
Cafferata, Maria Luisa
Harville, Emily
Rosales, Karla
Wesson, Dawn M.
Zuniga, Concepcion
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Honduras
Microcephaly
Pregnancy
Zika Virus
topic Honduras
Microcephaly
Pregnancy
Zika Virus
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Although there is increasing evidence for a relationship between symptomatic Zika virus (ZIKV) maternal infection, and microcephaly, a firm causal relation has yet to be established by epidemiologic studies. Studies also need to be conducted in recently infected settings. Our objectives are to assess the frequency of ZIKV infection during pregnancy in Honduras and the association of microcephaly with ZIKV infection. Methods/Design: We will perform a prospective study enrolling pregnant women at their first antenatal visit and following them up until delivery. At the time of enrollment, women will be interviewed to collect socio-demographic data, data needed to locate them for potential additional follow-up, and data about ZIKV symptoms during pregnancy. We will also collect maternal blood as soon as possible after enrollment. A probable maternal ZIKV infection will be defined as positive for maternal ZIKV IgM. A confirmed maternal ZIKV infection will be defined as positive for ZIKV IgM confirmed by plaque reduction neutralization test. Microcephaly at birth will be defined as an occipito-frontal circumference <2SD for sex and gestational age. Our objective is to enroll 2000 pregnant women. In a first step, we will follow a case cohort design and only analyze blood samples for cases and a sub-cohort of 200 women randomly selected. Blood samples for the entire population will be analyzed at a later stage if funds are available. Discussion: This protocol was designed to be implemented with minimal resources. It allows a cohort to be built, which could be a foundation for future in-depth and follow-up studies.
Fil: Buekens, Pierre. University of Tulane; Estados Unidos
Fil: Alger, Jackeline. Universidad Nacional Autónoma de Honduras; Honduras
Fil: Althabe, Fernando. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bergel, Eduardo. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Berrueta, Amanda Mabel. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Bustillo, Carolina. Hospital Escuela. Departamento de Ginecología y Obstetricia; Honduras
Fil: Cafferata, Maria Luisa. Hospital de Clínicas. Unidad de Investigación Clínica y Epidemiológica Montevideo; Uruguay
Fil: Harville, Emily. University of Tulane; Estados Unidos
Fil: Rosales, Karla. Región Sanitaria Metropolitana Distrito Central de Francisco Morazán; Honduras
Fil: Wesson, Dawn M.. University of Tulane; Estados Unidos
Fil: Zuniga, Concepcion. Hospital Escuela Universitario. Instituto de Enfermedades Infecciosas y Parasitología Antonio Vidal; Honduras
description Background: Although there is increasing evidence for a relationship between symptomatic Zika virus (ZIKV) maternal infection, and microcephaly, a firm causal relation has yet to be established by epidemiologic studies. Studies also need to be conducted in recently infected settings. Our objectives are to assess the frequency of ZIKV infection during pregnancy in Honduras and the association of microcephaly with ZIKV infection. Methods/Design: We will perform a prospective study enrolling pregnant women at their first antenatal visit and following them up until delivery. At the time of enrollment, women will be interviewed to collect socio-demographic data, data needed to locate them for potential additional follow-up, and data about ZIKV symptoms during pregnancy. We will also collect maternal blood as soon as possible after enrollment. A probable maternal ZIKV infection will be defined as positive for maternal ZIKV IgM. A confirmed maternal ZIKV infection will be defined as positive for ZIKV IgM confirmed by plaque reduction neutralization test. Microcephaly at birth will be defined as an occipito-frontal circumference <2SD for sex and gestational age. Our objective is to enroll 2000 pregnant women. In a first step, we will follow a case cohort design and only analyze blood samples for cases and a sub-cohort of 200 women randomly selected. Blood samples for the entire population will be analyzed at a later stage if funds are available. Discussion: This protocol was designed to be implemented with minimal resources. It allows a cohort to be built, which could be a foundation for future in-depth and follow-up studies.
publishDate 2016
dc.date.none.fl_str_mv 2016-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47186
Buekens, Pierre; Alger, Jackeline; Althabe, Fernando; Bergel, Eduardo; Berrueta, Amanda Mabel; et al.; Zika virus infection in pregnant women in Honduras: study protocol; BioMed Central; Reproductive Health; 13; 7-2016; 1-6
1742-4755
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47186
identifier_str_mv Buekens, Pierre; Alger, Jackeline; Althabe, Fernando; Bergel, Eduardo; Berrueta, Amanda Mabel; et al.; Zika virus infection in pregnant women in Honduras: study protocol; BioMed Central; Reproductive Health; 13; 7-2016; 1-6
1742-4755
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1186/s12978-016-0200-6
info:eu-repo/semantics/altIdentifier/url/https://reproductive-health-journal.biomedcentral.com/articles/10.1186/s12978-016-0200-6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980560742383616
score 12.993085

Publicaciones similares