Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study

Autores
Berberian, Griselda Virginia; Bologna, Rosa; Pérez, María Guadalupe; Mangano, Andrea María Mercedes; Costa, Marina; Calligaris, Silvana Debora; Morales, Maria Alejandra; Rugilo, Carlos; Ruiz Burga, Elisa; Thorne, Claire
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, microcephaly was defined as congenital (31/40, 77%) and associated with other features (68%) such as seizures, developmental delay, non-progressive chronic encephalopathy, and West Syndrome. It was found manifestations restricted to central nervous system (55%), ocular (8/40, 20%), and acoustic (9/40, 23%) defects, and abnormal neuroimaging findings (31/39, 79%). Non- infectious diseases were the primary cause of isolated microcephaly (21/37, 57%), largely related to genetic diseases (13/21, 62%). Only 3 were children were diagnosed with Congenital Zika infection (3/16, 7.5%)
Fil: Berberian, Griselda Virginia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Bologna, Rosa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Pérez, María Guadalupe. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Mangano, Andrea María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Costa, Marina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Calligaris, Silvana Debora. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Morales, Maria Alejandra. Centro de Salud Doctor Julio Maiztegui ; Municipalidad de Rosario (santa Fe);
Fil: Rugilo, Carlos. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Ruiz Burga, Elisa. University College London; Estados Unidos
Fil: Thorne, Claire. University College London; Estados Unidos
Materia
microcephaly
zika
birth defects
infectious disease
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/239338
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/239338
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Causes of Microcephaly in the Zika Era in Argentina: A Retrospective StudyBerberian, Griselda VirginiaBologna, RosaPérez, María GuadalupeMangano, Andrea María MercedesCosta, MarinaCalligaris, Silvana DeboraMorales, Maria AlejandraRugilo, CarlosRuiz Burga, ElisaThorne, Clairemicrocephalyzikabirth defectsinfectious diseasehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, microcephaly was defined as congenital (31/40, 77%) and associated with other features (68%) such as seizures, developmental delay, non-progressive chronic encephalopathy, and West Syndrome. It was found manifestations restricted to central nervous system (55%), ocular (8/40, 20%), and acoustic (9/40, 23%) defects, and abnormal neuroimaging findings (31/39, 79%). Non- infectious diseases were the primary cause of isolated microcephaly (21/37, 57%), largely related to genetic diseases (13/21, 62%). Only 3 were children were diagnosed with Congenital Zika infection (3/16, 7.5%)Fil: Berberian, Griselda Virginia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Bologna, Rosa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Pérez, María Guadalupe. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Mangano, Andrea María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Costa, Marina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Calligaris, Silvana Debora. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Morales, Maria Alejandra. Centro de Salud Doctor Julio Maiztegui ; Municipalidad de Rosario (santa Fe);Fil: Rugilo, Carlos. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Ruiz Burga, Elisa. University College London; Estados UnidosFil: Thorne, Claire. University College London; Estados UnidosSAGE Publications2021-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/239338Berberian, Griselda Virginia; Bologna, Rosa; Pérez, María Guadalupe; Mangano, Andrea María Mercedes; Costa, Marina; et al.; Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study; SAGE Publications; Global Pediatric Health; 8; 6-2021; 1-72333-794XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1177/2333794X211040968info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:11:55Zoai:ri.conicet.gov.ar:11336/239338instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:11:56.131CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
title Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
spellingShingle Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
Berberian, Griselda Virginia
microcephaly
zika
birth defects
infectious disease
title_short Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
title_full Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
title_fullStr Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
title_full_unstemmed Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
title_sort Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
dc.creator.none.fl_str_mv Berberian, Griselda Virginia
Bologna, Rosa
Pérez, María Guadalupe
Mangano, Andrea María Mercedes
Costa, Marina
Calligaris, Silvana Debora
Morales, Maria Alejandra
Rugilo, Carlos
Ruiz Burga, Elisa
Thorne, Claire
author Berberian, Griselda Virginia
author_facet Berberian, Griselda Virginia
Bologna, Rosa
Pérez, María Guadalupe
Mangano, Andrea María Mercedes
Costa, Marina
Calligaris, Silvana Debora
Morales, Maria Alejandra
Rugilo, Carlos
Ruiz Burga, Elisa
Thorne, Claire
author_role author
author2 Bologna, Rosa
Pérez, María Guadalupe
Mangano, Andrea María Mercedes
Costa, Marina
Calligaris, Silvana Debora
Morales, Maria Alejandra
Rugilo, Carlos
Ruiz Burga, Elisa
Thorne, Claire
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv microcephaly
zika
birth defects
infectious disease
topic microcephaly
zika
birth defects
infectious disease
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, microcephaly was defined as congenital (31/40, 77%) and associated with other features (68%) such as seizures, developmental delay, non-progressive chronic encephalopathy, and West Syndrome. It was found manifestations restricted to central nervous system (55%), ocular (8/40, 20%), and acoustic (9/40, 23%) defects, and abnormal neuroimaging findings (31/39, 79%). Non- infectious diseases were the primary cause of isolated microcephaly (21/37, 57%), largely related to genetic diseases (13/21, 62%). Only 3 were children were diagnosed with Congenital Zika infection (3/16, 7.5%)
Fil: Berberian, Griselda Virginia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Bologna, Rosa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Pérez, María Guadalupe. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Mangano, Andrea María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Costa, Marina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Calligaris, Silvana Debora. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Morales, Maria Alejandra. Centro de Salud Doctor Julio Maiztegui ; Municipalidad de Rosario (santa Fe);
Fil: Rugilo, Carlos. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Ruiz Burga, Elisa. University College London; Estados Unidos
Fil: Thorne, Claire. University College London; Estados Unidos
description There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, microcephaly was defined as congenital (31/40, 77%) and associated with other features (68%) such as seizures, developmental delay, non-progressive chronic encephalopathy, and West Syndrome. It was found manifestations restricted to central nervous system (55%), ocular (8/40, 20%), and acoustic (9/40, 23%) defects, and abnormal neuroimaging findings (31/39, 79%). Non- infectious diseases were the primary cause of isolated microcephaly (21/37, 57%), largely related to genetic diseases (13/21, 62%). Only 3 were children were diagnosed with Congenital Zika infection (3/16, 7.5%)
publishDate 2021
dc.date.none.fl_str_mv 2021-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/239338
Berberian, Griselda Virginia; Bologna, Rosa; Pérez, María Guadalupe; Mangano, Andrea María Mercedes; Costa, Marina; et al.; Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study; SAGE Publications; Global Pediatric Health; 8; 6-2021; 1-7
2333-794X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/239338
identifier_str_mv Berberian, Griselda Virginia; Bologna, Rosa; Pérez, María Guadalupe; Mangano, Andrea María Mercedes; Costa, Marina; et al.; Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study; SAGE Publications; Global Pediatric Health; 8; 6-2021; 1-7
2333-794X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1177/2333794X211040968
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614022128730112
score 13.070432

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