Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study
- Autores
- Berberian, Griselda Virginia; Bologna, Rosa; Pérez, María Guadalupe; Mangano, Andrea María Mercedes; Costa, Marina; Calligaris, Silvana Debora; Morales, Maria Alejandra; Rugilo, Carlos; Ruiz Burga, Elisa; Thorne, Claire
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, microcephaly was defined as congenital (31/40, 77%) and associated with other features (68%) such as seizures, developmental delay, non-progressive chronic encephalopathy, and West Syndrome. It was found manifestations restricted to central nervous system (55%), ocular (8/40, 20%), and acoustic (9/40, 23%) defects, and abnormal neuroimaging findings (31/39, 79%). Non- infectious diseases were the primary cause of isolated microcephaly (21/37, 57%), largely related to genetic diseases (13/21, 62%). Only 3 were children were diagnosed with Congenital Zika infection (3/16, 7.5%)
Fil: Berberian, Griselda Virginia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Bologna, Rosa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Pérez, María Guadalupe. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Mangano, Andrea María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Costa, Marina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Calligaris, Silvana Debora. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Morales, Maria Alejandra. Centro de Salud Doctor Julio Maiztegui ; Municipalidad de Rosario (santa Fe);
Fil: Rugilo, Carlos. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Ruiz Burga, Elisa. University College London; Estados Unidos
Fil: Thorne, Claire. University College London; Estados Unidos - Materia
-
microcephaly
zika
birth defects
infectious disease - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/239338
Ver los metadatos del registro completo
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Causes of Microcephaly in the Zika Era in Argentina: A Retrospective StudyBerberian, Griselda VirginiaBologna, RosaPérez, María GuadalupeMangano, Andrea María MercedesCosta, MarinaCalligaris, Silvana DeboraMorales, Maria AlejandraRugilo, CarlosRuiz Burga, ElisaThorne, Clairemicrocephalyzikabirth defectsinfectious diseasehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, microcephaly was defined as congenital (31/40, 77%) and associated with other features (68%) such as seizures, developmental delay, non-progressive chronic encephalopathy, and West Syndrome. It was found manifestations restricted to central nervous system (55%), ocular (8/40, 20%), and acoustic (9/40, 23%) defects, and abnormal neuroimaging findings (31/39, 79%). Non- infectious diseases were the primary cause of isolated microcephaly (21/37, 57%), largely related to genetic diseases (13/21, 62%). Only 3 were children were diagnosed with Congenital Zika infection (3/16, 7.5%)Fil: Berberian, Griselda Virginia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Bologna, Rosa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Pérez, María Guadalupe. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Mangano, Andrea María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Costa, Marina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Calligaris, Silvana Debora. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Morales, Maria Alejandra. Centro de Salud Doctor Julio Maiztegui ; Municipalidad de Rosario (santa Fe);Fil: Rugilo, Carlos. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Ruiz Burga, Elisa. University College London; Estados UnidosFil: Thorne, Claire. University College London; Estados UnidosSAGE Publications2021-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/239338Berberian, Griselda Virginia; Bologna, Rosa; Pérez, María Guadalupe; Mangano, Andrea María Mercedes; Costa, Marina; et al.; Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study; SAGE Publications; Global Pediatric Health; 8; 6-2021; 1-72333-794XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1177/2333794X211040968info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:11:55Zoai:ri.conicet.gov.ar:11336/239338instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:11:56.131CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study |
title |
Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study |
spellingShingle |
Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study Berberian, Griselda Virginia microcephaly zika birth defects infectious disease |
title_short |
Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study |
title_full |
Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study |
title_fullStr |
Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study |
title_full_unstemmed |
Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study |
title_sort |
Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study |
dc.creator.none.fl_str_mv |
Berberian, Griselda Virginia Bologna, Rosa Pérez, María Guadalupe Mangano, Andrea María Mercedes Costa, Marina Calligaris, Silvana Debora Morales, Maria Alejandra Rugilo, Carlos Ruiz Burga, Elisa Thorne, Claire |
author |
Berberian, Griselda Virginia |
author_facet |
Berberian, Griselda Virginia Bologna, Rosa Pérez, María Guadalupe Mangano, Andrea María Mercedes Costa, Marina Calligaris, Silvana Debora Morales, Maria Alejandra Rugilo, Carlos Ruiz Burga, Elisa Thorne, Claire |
author_role |
author |
author2 |
Bologna, Rosa Pérez, María Guadalupe Mangano, Andrea María Mercedes Costa, Marina Calligaris, Silvana Debora Morales, Maria Alejandra Rugilo, Carlos Ruiz Burga, Elisa Thorne, Claire |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
microcephaly zika birth defects infectious disease |
topic |
microcephaly zika birth defects infectious disease |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, microcephaly was defined as congenital (31/40, 77%) and associated with other features (68%) such as seizures, developmental delay, non-progressive chronic encephalopathy, and West Syndrome. It was found manifestations restricted to central nervous system (55%), ocular (8/40, 20%), and acoustic (9/40, 23%) defects, and abnormal neuroimaging findings (31/39, 79%). Non- infectious diseases were the primary cause of isolated microcephaly (21/37, 57%), largely related to genetic diseases (13/21, 62%). Only 3 were children were diagnosed with Congenital Zika infection (3/16, 7.5%) Fil: Berberian, Griselda Virginia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Bologna, Rosa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Pérez, María Guadalupe. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Mangano, Andrea María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Costa, Marina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Calligaris, Silvana Debora. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Morales, Maria Alejandra. Centro de Salud Doctor Julio Maiztegui ; Municipalidad de Rosario (santa Fe); Fil: Rugilo, Carlos. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Ruiz Burga, Elisa. University College London; Estados Unidos Fil: Thorne, Claire. University College London; Estados Unidos |
description |
There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, microcephaly was defined as congenital (31/40, 77%) and associated with other features (68%) such as seizures, developmental delay, non-progressive chronic encephalopathy, and West Syndrome. It was found manifestations restricted to central nervous system (55%), ocular (8/40, 20%), and acoustic (9/40, 23%) defects, and abnormal neuroimaging findings (31/39, 79%). Non- infectious diseases were the primary cause of isolated microcephaly (21/37, 57%), largely related to genetic diseases (13/21, 62%). Only 3 were children were diagnosed with Congenital Zika infection (3/16, 7.5%) |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/239338 Berberian, Griselda Virginia; Bologna, Rosa; Pérez, María Guadalupe; Mangano, Andrea María Mercedes; Costa, Marina; et al.; Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study; SAGE Publications; Global Pediatric Health; 8; 6-2021; 1-7 2333-794X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/239338 |
identifier_str_mv |
Berberian, Griselda Virginia; Bologna, Rosa; Pérez, María Guadalupe; Mangano, Andrea María Mercedes; Costa, Marina; et al.; Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study; SAGE Publications; Global Pediatric Health; 8; 6-2021; 1-7 2333-794X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1177/2333794X211040968 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
SAGE Publications |
publisher.none.fl_str_mv |
SAGE Publications |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614022128730112 |
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13.070432 |