Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy
- Autores
- Mamone, Leandro Ariel; Saenz, Daniel Alberto; Vallecorsa, Pablo Daniel; Batlle, Alcira Maria del C.; Di Venosa, Gabriela Mariana; Casas, Adriana Gabriela
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization. The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaea argentina against PDT under several treatments and employing different PSs. C. argentina exhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line. The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40 μg/mL onwards and at least after 3 h exposure of the cells. C. argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity.
Fil: Mamone, Leandro Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Fil: Saenz, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Fil: Vallecorsa, Pablo Daniel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Fil: Batlle, Alcira Maria del C.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Fil: Di Venosa, Gabriela Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Fil: Casas, Adriana Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina - Materia
-
PHOTODYNAMIC THERAPY
PHOTOPROTECTION
COLLAEA ARGENTINA
ARGENTINEAN PLANTS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/7787
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/7787 |
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CONICET Digital (CONICET) |
spelling |
Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic TherapyMamone, Leandro ArielSaenz, Daniel AlbertoVallecorsa, Pablo DanielBatlle, Alcira Maria del C.Di Venosa, Gabriela MarianaCasas, Adriana GabrielaPHOTODYNAMIC THERAPYPHOTOPROTECTIONCOLLAEA ARGENTINAARGENTINEAN PLANTShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization. The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaea argentina against PDT under several treatments and employing different PSs. C. argentina exhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line. The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40 μg/mL onwards and at least after 3 h exposure of the cells. C. argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity.Fil: Mamone, Leandro Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; ArgentinaFil: Saenz, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; ArgentinaFil: Vallecorsa, Pablo Daniel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; ArgentinaFil: Batlle, Alcira Maria del C.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; ArgentinaFil: Di Venosa, Gabriela Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; ArgentinaFil: Casas, Adriana Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; ArgentinaHindawi Publishing Corporation2014-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7787Mamone, Leandro Ariel; Saenz, Daniel Alberto; Vallecorsa, Pablo Daniel; Batlle, Alcira Maria del C.; Di Venosa, Gabriela Mariana; et al.; Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy; Hindawi Publishing Corporation; International Journal Of Photoenergy; 2014; 2-2014; 1-81110-662Xenginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ijp/2014/436463/info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/436463info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:52Zoai:ri.conicet.gov.ar:11336/7787instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:52.81CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy |
title |
Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy |
spellingShingle |
Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy Mamone, Leandro Ariel PHOTODYNAMIC THERAPY PHOTOPROTECTION COLLAEA ARGENTINA ARGENTINEAN PLANTS |
title_short |
Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy |
title_full |
Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy |
title_fullStr |
Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy |
title_full_unstemmed |
Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy |
title_sort |
Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy |
dc.creator.none.fl_str_mv |
Mamone, Leandro Ariel Saenz, Daniel Alberto Vallecorsa, Pablo Daniel Batlle, Alcira Maria del C. Di Venosa, Gabriela Mariana Casas, Adriana Gabriela |
author |
Mamone, Leandro Ariel |
author_facet |
Mamone, Leandro Ariel Saenz, Daniel Alberto Vallecorsa, Pablo Daniel Batlle, Alcira Maria del C. Di Venosa, Gabriela Mariana Casas, Adriana Gabriela |
author_role |
author |
author2 |
Saenz, Daniel Alberto Vallecorsa, Pablo Daniel Batlle, Alcira Maria del C. Di Venosa, Gabriela Mariana Casas, Adriana Gabriela |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
PHOTODYNAMIC THERAPY PHOTOPROTECTION COLLAEA ARGENTINA ARGENTINEAN PLANTS |
topic |
PHOTODYNAMIC THERAPY PHOTOPROTECTION COLLAEA ARGENTINA ARGENTINEAN PLANTS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization. The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaea argentina against PDT under several treatments and employing different PSs. C. argentina exhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line. The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40 μg/mL onwards and at least after 3 h exposure of the cells. C. argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity. Fil: Mamone, Leandro Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina Fil: Saenz, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina Fil: Vallecorsa, Pablo Daniel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina Fil: Batlle, Alcira Maria del C.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina Fil: Di Venosa, Gabriela Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina Fil: Casas, Adriana Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina |
description |
Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization. The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaea argentina against PDT under several treatments and employing different PSs. C. argentina exhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line. The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40 μg/mL onwards and at least after 3 h exposure of the cells. C. argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/7787 Mamone, Leandro Ariel; Saenz, Daniel Alberto; Vallecorsa, Pablo Daniel; Batlle, Alcira Maria del C.; Di Venosa, Gabriela Mariana; et al.; Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy; Hindawi Publishing Corporation; International Journal Of Photoenergy; 2014; 2-2014; 1-8 1110-662X |
url |
http://hdl.handle.net/11336/7787 |
identifier_str_mv |
Mamone, Leandro Ariel; Saenz, Daniel Alberto; Vallecorsa, Pablo Daniel; Batlle, Alcira Maria del C.; Di Venosa, Gabriela Mariana; et al.; Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy; Hindawi Publishing Corporation; International Journal Of Photoenergy; 2014; 2-2014; 1-8 1110-662X |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ijp/2014/436463/ info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/436463 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613005696827392 |
score |
13.070432 |