Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy

Autores
Mamone, Leandro Ariel; Saenz, Daniel Alberto; Vallecorsa, Pablo Daniel; Batlle, Alcira Maria del C.; Di Venosa, Gabriela Mariana; Casas, Adriana Gabriela
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization. The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaea argentina against PDT under several treatments and employing different PSs. C. argentina exhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line. The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40 μg/mL onwards and at least after 3 h exposure of the cells. C. argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity.
Fil: Mamone, Leandro Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Fil: Saenz, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Fil: Vallecorsa, Pablo Daniel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Fil: Batlle, Alcira Maria del C.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Fil: Di Venosa, Gabriela Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Fil: Casas, Adriana Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Materia
PHOTODYNAMIC THERAPY
PHOTOPROTECTION
COLLAEA ARGENTINA
ARGENTINEAN PLANTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7787
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/7787
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic TherapyMamone, Leandro ArielSaenz, Daniel AlbertoVallecorsa, Pablo DanielBatlle, Alcira Maria del C.Di Venosa, Gabriela MarianaCasas, Adriana GabrielaPHOTODYNAMIC THERAPYPHOTOPROTECTIONCOLLAEA ARGENTINAARGENTINEAN PLANTShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization. The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaea argentina against PDT under several treatments and employing different PSs. C. argentina exhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line. The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40 μg/mL onwards and at least after 3 h exposure of the cells. C. argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity.Fil: Mamone, Leandro Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; ArgentinaFil: Saenz, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; ArgentinaFil: Vallecorsa, Pablo Daniel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; ArgentinaFil: Batlle, Alcira Maria del C.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; ArgentinaFil: Di Venosa, Gabriela Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; ArgentinaFil: Casas, Adriana Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; ArgentinaHindawi Publishing Corporation2014-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7787Mamone, Leandro Ariel; Saenz, Daniel Alberto; Vallecorsa, Pablo Daniel; Batlle, Alcira Maria del C.; Di Venosa, Gabriela Mariana; et al.; Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy; Hindawi Publishing Corporation; International Journal Of Photoenergy; 2014; 2-2014; 1-81110-662Xenginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ijp/2014/436463/info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/436463info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:00:51Zoai:ri.conicet.gov.ar:11336/7787instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:00:51.777CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy
title Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy
spellingShingle Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy
Mamone, Leandro Ariel
PHOTODYNAMIC THERAPY
PHOTOPROTECTION
COLLAEA ARGENTINA
ARGENTINEAN PLANTS
title_short Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy
title_full Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy
title_fullStr Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy
title_full_unstemmed Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy
title_sort Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy
dc.creator.none.fl_str_mv Mamone, Leandro Ariel
Saenz, Daniel Alberto
Vallecorsa, Pablo Daniel
Batlle, Alcira Maria del C.
Di Venosa, Gabriela Mariana
Casas, Adriana Gabriela
author Mamone, Leandro Ariel
author_facet Mamone, Leandro Ariel
Saenz, Daniel Alberto
Vallecorsa, Pablo Daniel
Batlle, Alcira Maria del C.
Di Venosa, Gabriela Mariana
Casas, Adriana Gabriela
author_role author
author2 Saenz, Daniel Alberto
Vallecorsa, Pablo Daniel
Batlle, Alcira Maria del C.
Di Venosa, Gabriela Mariana
Casas, Adriana Gabriela
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv PHOTODYNAMIC THERAPY
PHOTOPROTECTION
COLLAEA ARGENTINA
ARGENTINEAN PLANTS
topic PHOTODYNAMIC THERAPY
PHOTOPROTECTION
COLLAEA ARGENTINA
ARGENTINEAN PLANTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization. The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaea argentina against PDT under several treatments and employing different PSs. C. argentina exhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line. The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40 μg/mL onwards and at least after 3 h exposure of the cells. C. argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity.
Fil: Mamone, Leandro Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Fil: Saenz, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Fil: Vallecorsa, Pablo Daniel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Fil: Batlle, Alcira Maria del C.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Fil: Di Venosa, Gabriela Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
Fil: Casas, Adriana Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina
description Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization. The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaea argentina against PDT under several treatments and employing different PSs. C. argentina exhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line. The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40 μg/mL onwards and at least after 3 h exposure of the cells. C. argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity.
publishDate 2014
dc.date.none.fl_str_mv 2014-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7787
Mamone, Leandro Ariel; Saenz, Daniel Alberto; Vallecorsa, Pablo Daniel; Batlle, Alcira Maria del C.; Di Venosa, Gabriela Mariana; et al.; Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy; Hindawi Publishing Corporation; International Journal Of Photoenergy; 2014; 2-2014; 1-8
1110-662X
url http://hdl.handle.net/11336/7787
identifier_str_mv Mamone, Leandro Ariel; Saenz, Daniel Alberto; Vallecorsa, Pablo Daniel; Batlle, Alcira Maria del C.; Di Venosa, Gabriela Mariana; et al.; Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy; Hindawi Publishing Corporation; International Journal Of Photoenergy; 2014; 2-2014; 1-8
1110-662X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ijp/2014/436463/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/436463
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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