Towards a paradigm shift in the treatment of chronic Chagas disease
- Autores
- Viotti, Rodolfo Jorge; Alarcón de Noya, B.; Araujo Jorge, T.; Grijalva, M. J.; Guhl, F.; López, M. C.; Ramsey, J. M.; Ribeiro, I.; Schijman, Alejandro Gabriel; Sosa Estani, S.; Torrico, F.; Gascon, J.
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Treatment for Chagas disease with currently available medications is recommended universally only for acute cases (all ages) and for children up to 14 years old. The World Health Organization, however, also recommends specific antiparasite treatment for all chronic-phase Trypanosoma cruzi-infected individuals, even though in current medical practice this remains controversial, and most physicians only prescribe palliative treatment for adult Chagas patients with dilated cardiomyopathy. The present opinion, prepared by members of the NHEPACHA network (Nuevas Herramientas para el Diagnóstico y la Evaluación del Paciente con Enfermedad de Chagas/New Tools for the Diagnosis and Evaluation of Chagas Disease Patients), reviews the paradigm shift based on clinical and immunological evidence and argues in favor of antiparasitic treatment for all chronic patients. We review the tools needed to monitor therapeutic efficacy and the potential criteria for evaluation of treatment efficacy beyond parasitological cure. Etiological treatment should now be mandatory for all adult chronic Chagas disease patients.
Fil: Viotti, Rodolfo Jorge. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Peron"; Argentina
Fil: Alarcón de Noya, B.. Universidad Central de Venezuela. Instituto de Medicina Tropical; Venezuela
Fil: Araujo Jorge, T.. Ministerio de Salud de Brasil. Fundacion Oswaldo Cruz; Brasil
Fil: Grijalva, M. J.. Pontificia Universidad Católica del Ecuador. Centro de Investigación de Enfermedades Infecciosas; Ecuador. Ohio University. Tropical Disease Institute; Estados Unidos
Fil: Guhl, F.. Universidad de los Andes. Centro de Investigaciones en Microbiología y Parasitología Tropical; Colombia
Fil: López, M. C.. Consejo Superior de Investigaciones Científicas. Instituto de Parasitología y Biomedicina "Lopez Neyra"; España
Fil: Ramsey, J. M.. Instituto Nacional de Salud Pública. Centro Regional de Investigación en Salud Pública; México
Fil: Ribeiro, I.. Drugs for Neglected Diseases Initiative; Suiza
Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina
Fil: Sosa Estani, S.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina
Fil: Torrico, F.. Universidad Mayor de San Simón; Bolivia
Fil: Gascon, J.. Centro de Investigación en Salud Internacional de Barcelona; España - Materia
-
Chagas disease
Treatment - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/3966
Ver los metadatos del registro completo
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Towards a paradigm shift in the treatment of chronic Chagas diseaseViotti, Rodolfo JorgeAlarcón de Noya, B.Araujo Jorge, T.Grijalva, M. J.Guhl, F.López, M. C.Ramsey, J. M.Ribeiro, I.Schijman, Alejandro GabrielSosa Estani, S.Torrico, F.Gascon, J.Chagas diseaseTreatmenthttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Treatment for Chagas disease with currently available medications is recommended universally only for acute cases (all ages) and for children up to 14 years old. The World Health Organization, however, also recommends specific antiparasite treatment for all chronic-phase Trypanosoma cruzi-infected individuals, even though in current medical practice this remains controversial, and most physicians only prescribe palliative treatment for adult Chagas patients with dilated cardiomyopathy. The present opinion, prepared by members of the NHEPACHA network (Nuevas Herramientas para el Diagnóstico y la Evaluación del Paciente con Enfermedad de Chagas/New Tools for the Diagnosis and Evaluation of Chagas Disease Patients), reviews the paradigm shift based on clinical and immunological evidence and argues in favor of antiparasitic treatment for all chronic patients. We review the tools needed to monitor therapeutic efficacy and the potential criteria for evaluation of treatment efficacy beyond parasitological cure. Etiological treatment should now be mandatory for all adult chronic Chagas disease patients.Fil: Viotti, Rodolfo Jorge. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Peron"; ArgentinaFil: Alarcón de Noya, B.. Universidad Central de Venezuela. Instituto de Medicina Tropical; VenezuelaFil: Araujo Jorge, T.. Ministerio de Salud de Brasil. Fundacion Oswaldo Cruz; BrasilFil: Grijalva, M. J.. Pontificia Universidad Católica del Ecuador. Centro de Investigación de Enfermedades Infecciosas; Ecuador. Ohio University. Tropical Disease Institute; Estados UnidosFil: Guhl, F.. Universidad de los Andes. Centro de Investigaciones en Microbiología y Parasitología Tropical; ColombiaFil: López, M. C.. Consejo Superior de Investigaciones Científicas. Instituto de Parasitología y Biomedicina "Lopez Neyra"; EspañaFil: Ramsey, J. M.. Instituto Nacional de Salud Pública. Centro Regional de Investigación en Salud Pública; MéxicoFil: Ribeiro, I.. Drugs for Neglected Diseases Initiative; SuizaFil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; ArgentinaFil: Sosa Estani, S.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; ArgentinaFil: Torrico, F.. Universidad Mayor de San Simón; BoliviaFil: Gascon, J.. Centro de Investigación en Salud Internacional de Barcelona; EspañaAmerican Society for Microbiology2014-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/3966Viotti, Rodolfo Jorge; Alarcón de Noya, B.; Araujo Jorge, T.; Grijalva, M. J.; Guhl, F.; et al.; Towards a paradigm shift in the treatment of chronic Chagas disease; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 58; 2; 2-2014; 635-6390066-4804enginfo:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/58/2/635.fullinfo:eu-repo/semantics/altIdentifier/doi/doi:10.1128/AAC.01662-13info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910900/info:eu-repo/semantics/altIdentifier/issn/0066-4804info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:38:26Zoai:ri.conicet.gov.ar:11336/3966instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:38:27.129CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Towards a paradigm shift in the treatment of chronic Chagas disease |
title |
Towards a paradigm shift in the treatment of chronic Chagas disease |
spellingShingle |
Towards a paradigm shift in the treatment of chronic Chagas disease Viotti, Rodolfo Jorge Chagas disease Treatment |
title_short |
Towards a paradigm shift in the treatment of chronic Chagas disease |
title_full |
Towards a paradigm shift in the treatment of chronic Chagas disease |
title_fullStr |
Towards a paradigm shift in the treatment of chronic Chagas disease |
title_full_unstemmed |
Towards a paradigm shift in the treatment of chronic Chagas disease |
title_sort |
Towards a paradigm shift in the treatment of chronic Chagas disease |
dc.creator.none.fl_str_mv |
Viotti, Rodolfo Jorge Alarcón de Noya, B. Araujo Jorge, T. Grijalva, M. J. Guhl, F. López, M. C. Ramsey, J. M. Ribeiro, I. Schijman, Alejandro Gabriel Sosa Estani, S. Torrico, F. Gascon, J. |
author |
Viotti, Rodolfo Jorge |
author_facet |
Viotti, Rodolfo Jorge Alarcón de Noya, B. Araujo Jorge, T. Grijalva, M. J. Guhl, F. López, M. C. Ramsey, J. M. Ribeiro, I. Schijman, Alejandro Gabriel Sosa Estani, S. Torrico, F. Gascon, J. |
author_role |
author |
author2 |
Alarcón de Noya, B. Araujo Jorge, T. Grijalva, M. J. Guhl, F. López, M. C. Ramsey, J. M. Ribeiro, I. Schijman, Alejandro Gabriel Sosa Estani, S. Torrico, F. Gascon, J. |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Chagas disease Treatment |
topic |
Chagas disease Treatment |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Treatment for Chagas disease with currently available medications is recommended universally only for acute cases (all ages) and for children up to 14 years old. The World Health Organization, however, also recommends specific antiparasite treatment for all chronic-phase Trypanosoma cruzi-infected individuals, even though in current medical practice this remains controversial, and most physicians only prescribe palliative treatment for adult Chagas patients with dilated cardiomyopathy. The present opinion, prepared by members of the NHEPACHA network (Nuevas Herramientas para el Diagnóstico y la Evaluación del Paciente con Enfermedad de Chagas/New Tools for the Diagnosis and Evaluation of Chagas Disease Patients), reviews the paradigm shift based on clinical and immunological evidence and argues in favor of antiparasitic treatment for all chronic patients. We review the tools needed to monitor therapeutic efficacy and the potential criteria for evaluation of treatment efficacy beyond parasitological cure. Etiological treatment should now be mandatory for all adult chronic Chagas disease patients. Fil: Viotti, Rodolfo Jorge. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Peron"; Argentina Fil: Alarcón de Noya, B.. Universidad Central de Venezuela. Instituto de Medicina Tropical; Venezuela Fil: Araujo Jorge, T.. Ministerio de Salud de Brasil. Fundacion Oswaldo Cruz; Brasil Fil: Grijalva, M. J.. Pontificia Universidad Católica del Ecuador. Centro de Investigación de Enfermedades Infecciosas; Ecuador. Ohio University. Tropical Disease Institute; Estados Unidos Fil: Guhl, F.. Universidad de los Andes. Centro de Investigaciones en Microbiología y Parasitología Tropical; Colombia Fil: López, M. C.. Consejo Superior de Investigaciones Científicas. Instituto de Parasitología y Biomedicina "Lopez Neyra"; España Fil: Ramsey, J. M.. Instituto Nacional de Salud Pública. Centro Regional de Investigación en Salud Pública; México Fil: Ribeiro, I.. Drugs for Neglected Diseases Initiative; Suiza Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina Fil: Sosa Estani, S.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina Fil: Torrico, F.. Universidad Mayor de San Simón; Bolivia Fil: Gascon, J.. Centro de Investigación en Salud Internacional de Barcelona; España |
description |
Treatment for Chagas disease with currently available medications is recommended universally only for acute cases (all ages) and for children up to 14 years old. The World Health Organization, however, also recommends specific antiparasite treatment for all chronic-phase Trypanosoma cruzi-infected individuals, even though in current medical practice this remains controversial, and most physicians only prescribe palliative treatment for adult Chagas patients with dilated cardiomyopathy. The present opinion, prepared by members of the NHEPACHA network (Nuevas Herramientas para el Diagnóstico y la Evaluación del Paciente con Enfermedad de Chagas/New Tools for the Diagnosis and Evaluation of Chagas Disease Patients), reviews the paradigm shift based on clinical and immunological evidence and argues in favor of antiparasitic treatment for all chronic patients. We review the tools needed to monitor therapeutic efficacy and the potential criteria for evaluation of treatment efficacy beyond parasitological cure. Etiological treatment should now be mandatory for all adult chronic Chagas disease patients. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/3966 Viotti, Rodolfo Jorge; Alarcón de Noya, B.; Araujo Jorge, T.; Grijalva, M. J.; Guhl, F.; et al.; Towards a paradigm shift in the treatment of chronic Chagas disease; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 58; 2; 2-2014; 635-639 0066-4804 |
url |
http://hdl.handle.net/11336/3966 |
identifier_str_mv |
Viotti, Rodolfo Jorge; Alarcón de Noya, B.; Araujo Jorge, T.; Grijalva, M. J.; Guhl, F.; et al.; Towards a paradigm shift in the treatment of chronic Chagas disease; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 58; 2; 2-2014; 635-639 0066-4804 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/58/2/635.full info:eu-repo/semantics/altIdentifier/doi/doi:10.1128/AAC.01662-13 info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910900/ info:eu-repo/semantics/altIdentifier/issn/0066-4804 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Society for Microbiology |
publisher.none.fl_str_mv |
American Society for Microbiology |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |