Multinuclear absolute magnetic resonance thermometry

Autores
Silletta, Emilia Victoria; Jerschow, Alexej; Madelin, Guillaume; Alon, Leeor
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Non-invasive measurement of absolute temperature is important for proper characterization of various pathologies and for evaluation of thermal dose during interventional procedures. The proton (hydrogen nucleus) magnetic resonance (MR) frequency shift method can be used to map relative temperature changes. However, spatiotemporal variations in the main magnetic field and the lack of local internal frequency reference challenge the determination of absolute temperature. Here, we introduce a multinuclear method for absolute MR thermometry, based on the fact that the hydrogen and sodium nuclei exhibit a unique and distinct characteristic frequency dependence with temperature and with electrolyte concentration. A one-to-one mapping between the precession frequency difference of the two nuclei and absolute temperature is demonstrated. Proof-of-concept experiments were conducted in aqueous solutions with different NaCl concentrations, in agarose gel samples, and in freshly excised ex vivo mouse tissues. One-dimensional chemical shift imaging experiments also demonstrated excellent agreement with infrared measurements.
Fil: Silletta, Emilia Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. University of New York; Estados Unidos
Fil: Jerschow, Alexej. University of New York; Estados Unidos
Fil: Madelin, Guillaume. University of New York; Estados Unidos
Fil: Alon, Leeor. University of New York; Estados Unidos
Materia
Nuclear Magnetic Resonance
Thermometry
Sodium
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/124416
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Multinuclear absolute magnetic resonance thermometrySilletta, Emilia VictoriaJerschow, AlexejMadelin, GuillaumeAlon, LeeorNuclear Magnetic ResonanceThermometrySodiumhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Non-invasive measurement of absolute temperature is important for proper characterization of various pathologies and for evaluation of thermal dose during interventional procedures. The proton (hydrogen nucleus) magnetic resonance (MR) frequency shift method can be used to map relative temperature changes. However, spatiotemporal variations in the main magnetic field and the lack of local internal frequency reference challenge the determination of absolute temperature. Here, we introduce a multinuclear method for absolute MR thermometry, based on the fact that the hydrogen and sodium nuclei exhibit a unique and distinct characteristic frequency dependence with temperature and with electrolyte concentration. A one-to-one mapping between the precession frequency difference of the two nuclei and absolute temperature is demonstrated. Proof-of-concept experiments were conducted in aqueous solutions with different NaCl concentrations, in agarose gel samples, and in freshly excised ex vivo mouse tissues. One-dimensional chemical shift imaging experiments also demonstrated excellent agreement with infrared measurements.Fil: Silletta, Emilia Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. University of New York; Estados UnidosFil: Jerschow, Alexej. University of New York; Estados UnidosFil: Madelin, Guillaume. University of New York; Estados UnidosFil: Alon, Leeor. University of New York; Estados UnidosNature2019-11-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/124416Silletta, Emilia Victoria; Jerschow, Alexej; Madelin, Guillaume; Alon, Leeor; Multinuclear absolute magnetic resonance thermometry; Nature; Communications Physics; 2; 29-11-2019; 1-10; 1522399-3650CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s42005-019-0252-3info:eu-repo/semantics/altIdentifier/doi/10.1038/s42005-019-0252-3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:04Zoai:ri.conicet.gov.ar:11336/124416instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:04.689CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Multinuclear absolute magnetic resonance thermometry
title Multinuclear absolute magnetic resonance thermometry
spellingShingle Multinuclear absolute magnetic resonance thermometry
Silletta, Emilia Victoria
Nuclear Magnetic Resonance
Thermometry
Sodium
title_short Multinuclear absolute magnetic resonance thermometry
title_full Multinuclear absolute magnetic resonance thermometry
title_fullStr Multinuclear absolute magnetic resonance thermometry
title_full_unstemmed Multinuclear absolute magnetic resonance thermometry
title_sort Multinuclear absolute magnetic resonance thermometry
dc.creator.none.fl_str_mv Silletta, Emilia Victoria
Jerschow, Alexej
Madelin, Guillaume
Alon, Leeor
author Silletta, Emilia Victoria
author_facet Silletta, Emilia Victoria
Jerschow, Alexej
Madelin, Guillaume
Alon, Leeor
author_role author
author2 Jerschow, Alexej
Madelin, Guillaume
Alon, Leeor
author2_role author
author
author
dc.subject.none.fl_str_mv Nuclear Magnetic Resonance
Thermometry
Sodium
topic Nuclear Magnetic Resonance
Thermometry
Sodium
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Non-invasive measurement of absolute temperature is important for proper characterization of various pathologies and for evaluation of thermal dose during interventional procedures. The proton (hydrogen nucleus) magnetic resonance (MR) frequency shift method can be used to map relative temperature changes. However, spatiotemporal variations in the main magnetic field and the lack of local internal frequency reference challenge the determination of absolute temperature. Here, we introduce a multinuclear method for absolute MR thermometry, based on the fact that the hydrogen and sodium nuclei exhibit a unique and distinct characteristic frequency dependence with temperature and with electrolyte concentration. A one-to-one mapping between the precession frequency difference of the two nuclei and absolute temperature is demonstrated. Proof-of-concept experiments were conducted in aqueous solutions with different NaCl concentrations, in agarose gel samples, and in freshly excised ex vivo mouse tissues. One-dimensional chemical shift imaging experiments also demonstrated excellent agreement with infrared measurements.
Fil: Silletta, Emilia Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. University of New York; Estados Unidos
Fil: Jerschow, Alexej. University of New York; Estados Unidos
Fil: Madelin, Guillaume. University of New York; Estados Unidos
Fil: Alon, Leeor. University of New York; Estados Unidos
description Non-invasive measurement of absolute temperature is important for proper characterization of various pathologies and for evaluation of thermal dose during interventional procedures. The proton (hydrogen nucleus) magnetic resonance (MR) frequency shift method can be used to map relative temperature changes. However, spatiotemporal variations in the main magnetic field and the lack of local internal frequency reference challenge the determination of absolute temperature. Here, we introduce a multinuclear method for absolute MR thermometry, based on the fact that the hydrogen and sodium nuclei exhibit a unique and distinct characteristic frequency dependence with temperature and with electrolyte concentration. A one-to-one mapping between the precession frequency difference of the two nuclei and absolute temperature is demonstrated. Proof-of-concept experiments were conducted in aqueous solutions with different NaCl concentrations, in agarose gel samples, and in freshly excised ex vivo mouse tissues. One-dimensional chemical shift imaging experiments also demonstrated excellent agreement with infrared measurements.
publishDate 2019
dc.date.none.fl_str_mv 2019-11-29
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/124416
Silletta, Emilia Victoria; Jerschow, Alexej; Madelin, Guillaume; Alon, Leeor; Multinuclear absolute magnetic resonance thermometry; Nature; Communications Physics; 2; 29-11-2019; 1-10; 152
2399-3650
CONICET Digital
CONICET
url http://hdl.handle.net/11336/124416
identifier_str_mv Silletta, Emilia Victoria; Jerschow, Alexej; Madelin, Guillaume; Alon, Leeor; Multinuclear absolute magnetic resonance thermometry; Nature; Communications Physics; 2; 29-11-2019; 1-10; 152
2399-3650
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s42005-019-0252-3
info:eu-repo/semantics/altIdentifier/doi/10.1038/s42005-019-0252-3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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