Phenotypical expression of reduced mobility during limb ontogeny in frogs: The knee-joint case

Autores
Ponssa, María Laura; Abdala, Virginia Sara Luz
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Movement is one of the most important epigenetic factors for normal development of the musculoskeletal system, particularly during genesis and joint development. Studies regarding alterations to embryonic mobility, performed on anurans, chickens and mammals, report important phenotypical similarities as a result of the reduction or absence of this stimulus. The precise stage of development at which the stimulus modification generates phenotypic modifications however, is yet to be determined. In this work we explore whether the developmental effects of abnormal mobility can appear at any time during development or whether they begin to express themselves in particular phases of tadpole ontogeny. We conducted five experiments that showed that morphological abnormalities are not visible until Stages 40-42. Morphology in earlier stages remains normal, probably due to the fact that the bones/muscles/tendons have not yet developed and therefore are not affected by immobilization. These results suggest the existence of a specific period of phenotypical expression in which normal limb movement is necessary for the correct development of the joint tissue framework.
Fil: Ponssa, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Tucumán. Unidad Ejecutora Lillo; Argentina
Fil: Abdala, Virginia Sara Luz. Universidad Nacional de Tucuman. Facultad de Ciencias Naturales E Instituto Miguel Lillo. Cátedra de Biología General; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ANURANS
DEVELOPMENT
KNEE-JOINT
PHENOTYPICAL EXPRESSION
REDUCED MOBILITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/56848
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Phenotypical expression of reduced mobility during limb ontogeny in frogs: The knee-joint casePonssa, María LauraAbdala, Virginia Sara LuzANURANSDEVELOPMENTKNEE-JOINTPHENOTYPICAL EXPRESSIONREDUCED MOBILITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Movement is one of the most important epigenetic factors for normal development of the musculoskeletal system, particularly during genesis and joint development. Studies regarding alterations to embryonic mobility, performed on anurans, chickens and mammals, report important phenotypical similarities as a result of the reduction or absence of this stimulus. The precise stage of development at which the stimulus modification generates phenotypic modifications however, is yet to be determined. In this work we explore whether the developmental effects of abnormal mobility can appear at any time during development or whether they begin to express themselves in particular phases of tadpole ontogeny. We conducted five experiments that showed that morphological abnormalities are not visible until Stages 40-42. Morphology in earlier stages remains normal, probably due to the fact that the bones/muscles/tendons have not yet developed and therefore are not affected by immobilization. These results suggest the existence of a specific period of phenotypical expression in which normal limb movement is necessary for the correct development of the joint tissue framework.Fil: Ponssa, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Tucumán. Unidad Ejecutora Lillo; ArgentinaFil: Abdala, Virginia Sara Luz. Universidad Nacional de Tucuman. Facultad de Ciencias Naturales E Instituto Miguel Lillo. Cátedra de Biología General; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaPeerJ Inc.2016-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/56848Ponssa, María Laura; Abdala, Virginia Sara Luz; Phenotypical expression of reduced mobility during limb ontogeny in frogs: The knee-joint case; PeerJ Inc.; PeerJ; 2016; 2; 3-2016; 1-182167-8359CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.7717/peerj.1730info:eu-repo/semantics/altIdentifier/url/https://peerj.com/articles/1730/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:36Zoai:ri.conicet.gov.ar:11336/56848instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:36.582CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Phenotypical expression of reduced mobility during limb ontogeny in frogs: The knee-joint case
title Phenotypical expression of reduced mobility during limb ontogeny in frogs: The knee-joint case
spellingShingle Phenotypical expression of reduced mobility during limb ontogeny in frogs: The knee-joint case
Ponssa, María Laura
ANURANS
DEVELOPMENT
KNEE-JOINT
PHENOTYPICAL EXPRESSION
REDUCED MOBILITY
title_short Phenotypical expression of reduced mobility during limb ontogeny in frogs: The knee-joint case
title_full Phenotypical expression of reduced mobility during limb ontogeny in frogs: The knee-joint case
title_fullStr Phenotypical expression of reduced mobility during limb ontogeny in frogs: The knee-joint case
title_full_unstemmed Phenotypical expression of reduced mobility during limb ontogeny in frogs: The knee-joint case
title_sort Phenotypical expression of reduced mobility during limb ontogeny in frogs: The knee-joint case
dc.creator.none.fl_str_mv Ponssa, María Laura
Abdala, Virginia Sara Luz
author Ponssa, María Laura
author_facet Ponssa, María Laura
Abdala, Virginia Sara Luz
author_role author
author2 Abdala, Virginia Sara Luz
author2_role author
dc.subject.none.fl_str_mv ANURANS
DEVELOPMENT
KNEE-JOINT
PHENOTYPICAL EXPRESSION
REDUCED MOBILITY
topic ANURANS
DEVELOPMENT
KNEE-JOINT
PHENOTYPICAL EXPRESSION
REDUCED MOBILITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Movement is one of the most important epigenetic factors for normal development of the musculoskeletal system, particularly during genesis and joint development. Studies regarding alterations to embryonic mobility, performed on anurans, chickens and mammals, report important phenotypical similarities as a result of the reduction or absence of this stimulus. The precise stage of development at which the stimulus modification generates phenotypic modifications however, is yet to be determined. In this work we explore whether the developmental effects of abnormal mobility can appear at any time during development or whether they begin to express themselves in particular phases of tadpole ontogeny. We conducted five experiments that showed that morphological abnormalities are not visible until Stages 40-42. Morphology in earlier stages remains normal, probably due to the fact that the bones/muscles/tendons have not yet developed and therefore are not affected by immobilization. These results suggest the existence of a specific period of phenotypical expression in which normal limb movement is necessary for the correct development of the joint tissue framework.
Fil: Ponssa, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Tucumán. Unidad Ejecutora Lillo; Argentina
Fil: Abdala, Virginia Sara Luz. Universidad Nacional de Tucuman. Facultad de Ciencias Naturales E Instituto Miguel Lillo. Cátedra de Biología General; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Movement is one of the most important epigenetic factors for normal development of the musculoskeletal system, particularly during genesis and joint development. Studies regarding alterations to embryonic mobility, performed on anurans, chickens and mammals, report important phenotypical similarities as a result of the reduction or absence of this stimulus. The precise stage of development at which the stimulus modification generates phenotypic modifications however, is yet to be determined. In this work we explore whether the developmental effects of abnormal mobility can appear at any time during development or whether they begin to express themselves in particular phases of tadpole ontogeny. We conducted five experiments that showed that morphological abnormalities are not visible until Stages 40-42. Morphology in earlier stages remains normal, probably due to the fact that the bones/muscles/tendons have not yet developed and therefore are not affected by immobilization. These results suggest the existence of a specific period of phenotypical expression in which normal limb movement is necessary for the correct development of the joint tissue framework.
publishDate 2016
dc.date.none.fl_str_mv 2016-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/56848
Ponssa, María Laura; Abdala, Virginia Sara Luz; Phenotypical expression of reduced mobility during limb ontogeny in frogs: The knee-joint case; PeerJ Inc.; PeerJ; 2016; 2; 3-2016; 1-18
2167-8359
CONICET Digital
CONICET
url http://hdl.handle.net/11336/56848
identifier_str_mv Ponssa, María Laura; Abdala, Virginia Sara Luz; Phenotypical expression of reduced mobility during limb ontogeny in frogs: The knee-joint case; PeerJ Inc.; PeerJ; 2016; 2; 3-2016; 1-18
2167-8359
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.7717/peerj.1730
info:eu-repo/semantics/altIdentifier/url/https://peerj.com/articles/1730/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv PeerJ Inc.
publisher.none.fl_str_mv PeerJ Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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