Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility

Autores
Benedetti, Estefanía; Daniels , R. S.; Pontoriero, Andrea; Russo, M. L.; Avaro, Martin; Czech, Andrea; Campos, Ana; Periolo, Natalia; Gregory, V.; McCauley, J.W.; Baumeister, Elsa
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The activity and circulation of influenza viruses in Argentina was studied during 2012 as part of the Argentinean Surveillance for Influenza and other Respiratory Viruses, in the context of Global Influenza Surveillance. The antigenicity and molecular characteristics of haemagglutinins (HA) of circulating influenza A and B viruses were analysed to assess the emergence of virus variants. Susceptibility to oseltamivir and zanamivir was evaluated by enzymatic assay and results were backed-up by sequencing of the neuraminidase (NA) genes. During the 2012 season, influenza virus circulation in Argentina was detected from weeks 24 to 51. The HA sequences of the studied A(H1N1)pdm09 subtype viruses segregated in a different genetic group compared to those identified during the 2009 pandemic, although they were still closely related antigenically to the vaccine virus A/California/07/2009. The HA sequences of the A(H3N2) viruses analysed fell into the A/Victoria/208/2009 clade, genetic group 3C. A mixed circulation of virus variants belonging to B/Victoria and B/Yamagata lineages was detected, with B/Victoria being dominant. All viruses tested were sensitive to oseltamivir and zanamivir except one. This isolate, an A(H1N1)pdm09 virus possessing the substitution NA-N295S, showed highly reduced inhibition by oseltamivir and reduced inhibition by zanamivir. Virological and epidemiological surveillance remains critical for detection of evolving influenza viruses.
Fil: Benedetti, Estefanía. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina
Fil: Daniels , R. S.. The Francis Crick institute; Reino Unido
Fil: Pontoriero, Andrea. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina
Fil: Russo, M. L.. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina
Fil: Avaro, Martin. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina
Fil: Czech, Andrea. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina
Fil: Campos, Ana. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina
Fil: Periolo, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina
Fil: Gregory, V.. The Francis Crick institute; Reino Unido
Fil: McCauley, J.W.. The Francis Crick institute; Reino Unido
Fil: Baumeister, Elsa. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina
Materia
INFLUENZA
INFLUENZA VACCINES
RESISTANCE TO DRUGS
RESPIRATORY INFECTIONS
SURVEILLANCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/90947

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network_name_str CONICET Digital (CONICET)
spelling Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibilityBenedetti, EstefaníaDaniels , R. S.Pontoriero, AndreaRusso, M. L.Avaro, MartinCzech, AndreaCampos, AnaPeriolo, NataliaGregory, V.McCauley, J.W.Baumeister, ElsaINFLUENZAINFLUENZA VACCINESRESISTANCE TO DRUGSRESPIRATORY INFECTIONSSURVEILLANCEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The activity and circulation of influenza viruses in Argentina was studied during 2012 as part of the Argentinean Surveillance for Influenza and other Respiratory Viruses, in the context of Global Influenza Surveillance. The antigenicity and molecular characteristics of haemagglutinins (HA) of circulating influenza A and B viruses were analysed to assess the emergence of virus variants. Susceptibility to oseltamivir and zanamivir was evaluated by enzymatic assay and results were backed-up by sequencing of the neuraminidase (NA) genes. During the 2012 season, influenza virus circulation in Argentina was detected from weeks 24 to 51. The HA sequences of the studied A(H1N1)pdm09 subtype viruses segregated in a different genetic group compared to those identified during the 2009 pandemic, although they were still closely related antigenically to the vaccine virus A/California/07/2009. The HA sequences of the A(H3N2) viruses analysed fell into the A/Victoria/208/2009 clade, genetic group 3C. A mixed circulation of virus variants belonging to B/Victoria and B/Yamagata lineages was detected, with B/Victoria being dominant. All viruses tested were sensitive to oseltamivir and zanamivir except one. This isolate, an A(H1N1)pdm09 virus possessing the substitution NA-N295S, showed highly reduced inhibition by oseltamivir and reduced inhibition by zanamivir. Virological and epidemiological surveillance remains critical for detection of evolving influenza viruses.Fil: Benedetti, Estefanía. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; ArgentinaFil: Daniels , R. S.. The Francis Crick institute; Reino UnidoFil: Pontoriero, Andrea. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; ArgentinaFil: Russo, M. L.. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; ArgentinaFil: Avaro, Martin. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; ArgentinaFil: Czech, Andrea. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; ArgentinaFil: Campos, Ana. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; ArgentinaFil: Periolo, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; ArgentinaFil: Gregory, V.. The Francis Crick institute; Reino UnidoFil: McCauley, J.W.. The Francis Crick institute; Reino UnidoFil: Baumeister, Elsa. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; ArgentinaCambridge University Press2016-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/90947Benedetti, Estefanía; Daniels , R. S.; Pontoriero, Andrea; Russo, M. L.; Avaro, Martin; et al.; Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility; Cambridge University Press; Epidemiology and Infection; 144; 4; 3-2016; 751-7670950-2688CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/epidemiology-and-infection/article/influenza-virus-surveillance-in-argentina-during-the-2012-season-antigenic-characterization-genetic-analysis-and-antiviral-susceptibility/F2C57B7E3B950B0B530462FEC0EE7069info:eu-repo/semantics/altIdentifier/doi/10.1017/S0950268815001806info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:49Zoai:ri.conicet.gov.ar:11336/90947instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:49.688CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility
title Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility
spellingShingle Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility
Benedetti, Estefanía
INFLUENZA
INFLUENZA VACCINES
RESISTANCE TO DRUGS
RESPIRATORY INFECTIONS
SURVEILLANCE
title_short Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility
title_full Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility
title_fullStr Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility
title_full_unstemmed Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility
title_sort Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility
dc.creator.none.fl_str_mv Benedetti, Estefanía
Daniels , R. S.
Pontoriero, Andrea
Russo, M. L.
Avaro, Martin
Czech, Andrea
Campos, Ana
Periolo, Natalia
Gregory, V.
McCauley, J.W.
Baumeister, Elsa
author Benedetti, Estefanía
author_facet Benedetti, Estefanía
Daniels , R. S.
Pontoriero, Andrea
Russo, M. L.
Avaro, Martin
Czech, Andrea
Campos, Ana
Periolo, Natalia
Gregory, V.
McCauley, J.W.
Baumeister, Elsa
author_role author
author2 Daniels , R. S.
Pontoriero, Andrea
Russo, M. L.
Avaro, Martin
Czech, Andrea
Campos, Ana
Periolo, Natalia
Gregory, V.
McCauley, J.W.
Baumeister, Elsa
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv INFLUENZA
INFLUENZA VACCINES
RESISTANCE TO DRUGS
RESPIRATORY INFECTIONS
SURVEILLANCE
topic INFLUENZA
INFLUENZA VACCINES
RESISTANCE TO DRUGS
RESPIRATORY INFECTIONS
SURVEILLANCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The activity and circulation of influenza viruses in Argentina was studied during 2012 as part of the Argentinean Surveillance for Influenza and other Respiratory Viruses, in the context of Global Influenza Surveillance. The antigenicity and molecular characteristics of haemagglutinins (HA) of circulating influenza A and B viruses were analysed to assess the emergence of virus variants. Susceptibility to oseltamivir and zanamivir was evaluated by enzymatic assay and results were backed-up by sequencing of the neuraminidase (NA) genes. During the 2012 season, influenza virus circulation in Argentina was detected from weeks 24 to 51. The HA sequences of the studied A(H1N1)pdm09 subtype viruses segregated in a different genetic group compared to those identified during the 2009 pandemic, although they were still closely related antigenically to the vaccine virus A/California/07/2009. The HA sequences of the A(H3N2) viruses analysed fell into the A/Victoria/208/2009 clade, genetic group 3C. A mixed circulation of virus variants belonging to B/Victoria and B/Yamagata lineages was detected, with B/Victoria being dominant. All viruses tested were sensitive to oseltamivir and zanamivir except one. This isolate, an A(H1N1)pdm09 virus possessing the substitution NA-N295S, showed highly reduced inhibition by oseltamivir and reduced inhibition by zanamivir. Virological and epidemiological surveillance remains critical for detection of evolving influenza viruses.
Fil: Benedetti, Estefanía. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina
Fil: Daniels , R. S.. The Francis Crick institute; Reino Unido
Fil: Pontoriero, Andrea. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina
Fil: Russo, M. L.. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina
Fil: Avaro, Martin. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina
Fil: Czech, Andrea. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina
Fil: Campos, Ana. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina
Fil: Periolo, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina
Fil: Gregory, V.. The Francis Crick institute; Reino Unido
Fil: McCauley, J.W.. The Francis Crick institute; Reino Unido
Fil: Baumeister, Elsa. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina
description The activity and circulation of influenza viruses in Argentina was studied during 2012 as part of the Argentinean Surveillance for Influenza and other Respiratory Viruses, in the context of Global Influenza Surveillance. The antigenicity and molecular characteristics of haemagglutinins (HA) of circulating influenza A and B viruses were analysed to assess the emergence of virus variants. Susceptibility to oseltamivir and zanamivir was evaluated by enzymatic assay and results were backed-up by sequencing of the neuraminidase (NA) genes. During the 2012 season, influenza virus circulation in Argentina was detected from weeks 24 to 51. The HA sequences of the studied A(H1N1)pdm09 subtype viruses segregated in a different genetic group compared to those identified during the 2009 pandemic, although they were still closely related antigenically to the vaccine virus A/California/07/2009. The HA sequences of the A(H3N2) viruses analysed fell into the A/Victoria/208/2009 clade, genetic group 3C. A mixed circulation of virus variants belonging to B/Victoria and B/Yamagata lineages was detected, with B/Victoria being dominant. All viruses tested were sensitive to oseltamivir and zanamivir except one. This isolate, an A(H1N1)pdm09 virus possessing the substitution NA-N295S, showed highly reduced inhibition by oseltamivir and reduced inhibition by zanamivir. Virological and epidemiological surveillance remains critical for detection of evolving influenza viruses.
publishDate 2016
dc.date.none.fl_str_mv 2016-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/90947
Benedetti, Estefanía; Daniels , R. S.; Pontoriero, Andrea; Russo, M. L.; Avaro, Martin; et al.; Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility; Cambridge University Press; Epidemiology and Infection; 144; 4; 3-2016; 751-767
0950-2688
CONICET Digital
CONICET
url http://hdl.handle.net/11336/90947
identifier_str_mv Benedetti, Estefanía; Daniels , R. S.; Pontoriero, Andrea; Russo, M. L.; Avaro, Martin; et al.; Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility; Cambridge University Press; Epidemiology and Infection; 144; 4; 3-2016; 751-767
0950-2688
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/epidemiology-and-infection/article/influenza-virus-surveillance-in-argentina-during-the-2012-season-antigenic-characterization-genetic-analysis-and-antiviral-susceptibility/F2C57B7E3B950B0B530462FEC0EE7069
info:eu-repo/semantics/altIdentifier/doi/10.1017/S0950268815001806
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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