Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility
- Autores
- Benedetti, Estefanía; Daniels , R. S.; Pontoriero, Andrea; Russo, M. L.; Avaro, Martin; Czech, Andrea; Campos, Ana; Periolo, Natalia; Gregory, V.; McCauley, J.W.; Baumeister, Elsa
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The activity and circulation of influenza viruses in Argentina was studied during 2012 as part of the Argentinean Surveillance for Influenza and other Respiratory Viruses, in the context of Global Influenza Surveillance. The antigenicity and molecular characteristics of haemagglutinins (HA) of circulating influenza A and B viruses were analysed to assess the emergence of virus variants. Susceptibility to oseltamivir and zanamivir was evaluated by enzymatic assay and results were backed-up by sequencing of the neuraminidase (NA) genes. During the 2012 season, influenza virus circulation in Argentina was detected from weeks 24 to 51. The HA sequences of the studied A(H1N1)pdm09 subtype viruses segregated in a different genetic group compared to those identified during the 2009 pandemic, although they were still closely related antigenically to the vaccine virus A/California/07/2009. The HA sequences of the A(H3N2) viruses analysed fell into the A/Victoria/208/2009 clade, genetic group 3C. A mixed circulation of virus variants belonging to B/Victoria and B/Yamagata lineages was detected, with B/Victoria being dominant. All viruses tested were sensitive to oseltamivir and zanamivir except one. This isolate, an A(H1N1)pdm09 virus possessing the substitution NA-N295S, showed highly reduced inhibition by oseltamivir and reduced inhibition by zanamivir. Virological and epidemiological surveillance remains critical for detection of evolving influenza viruses.
Fil: Benedetti, Estefanía. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina
Fil: Daniels , R. S.. The Francis Crick institute; Reino Unido
Fil: Pontoriero, Andrea. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina
Fil: Russo, M. L.. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina
Fil: Avaro, Martin. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina
Fil: Czech, Andrea. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina
Fil: Campos, Ana. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina
Fil: Periolo, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina
Fil: Gregory, V.. The Francis Crick institute; Reino Unido
Fil: McCauley, J.W.. The Francis Crick institute; Reino Unido
Fil: Baumeister, Elsa. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina - Materia
-
INFLUENZA
INFLUENZA VACCINES
RESISTANCE TO DRUGS
RESPIRATORY INFECTIONS
SURVEILLANCE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/90947
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Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibilityBenedetti, EstefaníaDaniels , R. S.Pontoriero, AndreaRusso, M. L.Avaro, MartinCzech, AndreaCampos, AnaPeriolo, NataliaGregory, V.McCauley, J.W.Baumeister, ElsaINFLUENZAINFLUENZA VACCINESRESISTANCE TO DRUGSRESPIRATORY INFECTIONSSURVEILLANCEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The activity and circulation of influenza viruses in Argentina was studied during 2012 as part of the Argentinean Surveillance for Influenza and other Respiratory Viruses, in the context of Global Influenza Surveillance. The antigenicity and molecular characteristics of haemagglutinins (HA) of circulating influenza A and B viruses were analysed to assess the emergence of virus variants. Susceptibility to oseltamivir and zanamivir was evaluated by enzymatic assay and results were backed-up by sequencing of the neuraminidase (NA) genes. During the 2012 season, influenza virus circulation in Argentina was detected from weeks 24 to 51. The HA sequences of the studied A(H1N1)pdm09 subtype viruses segregated in a different genetic group compared to those identified during the 2009 pandemic, although they were still closely related antigenically to the vaccine virus A/California/07/2009. The HA sequences of the A(H3N2) viruses analysed fell into the A/Victoria/208/2009 clade, genetic group 3C. A mixed circulation of virus variants belonging to B/Victoria and B/Yamagata lineages was detected, with B/Victoria being dominant. All viruses tested were sensitive to oseltamivir and zanamivir except one. This isolate, an A(H1N1)pdm09 virus possessing the substitution NA-N295S, showed highly reduced inhibition by oseltamivir and reduced inhibition by zanamivir. Virological and epidemiological surveillance remains critical for detection of evolving influenza viruses.Fil: Benedetti, Estefanía. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; ArgentinaFil: Daniels , R. S.. The Francis Crick institute; Reino UnidoFil: Pontoriero, Andrea. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; ArgentinaFil: Russo, M. L.. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; ArgentinaFil: Avaro, Martin. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; ArgentinaFil: Czech, Andrea. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; ArgentinaFil: Campos, Ana. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; ArgentinaFil: Periolo, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; ArgentinaFil: Gregory, V.. The Francis Crick institute; Reino UnidoFil: McCauley, J.W.. The Francis Crick institute; Reino UnidoFil: Baumeister, Elsa. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; ArgentinaCambridge University Press2016-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/90947Benedetti, Estefanía; Daniels , R. S.; Pontoriero, Andrea; Russo, M. L.; Avaro, Martin; et al.; Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility; Cambridge University Press; Epidemiology and Infection; 144; 4; 3-2016; 751-7670950-2688CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/epidemiology-and-infection/article/influenza-virus-surveillance-in-argentina-during-the-2012-season-antigenic-characterization-genetic-analysis-and-antiviral-susceptibility/F2C57B7E3B950B0B530462FEC0EE7069info:eu-repo/semantics/altIdentifier/doi/10.1017/S0950268815001806info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:49Zoai:ri.conicet.gov.ar:11336/90947instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:49.688CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility |
title |
Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility |
spellingShingle |
Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility Benedetti, Estefanía INFLUENZA INFLUENZA VACCINES RESISTANCE TO DRUGS RESPIRATORY INFECTIONS SURVEILLANCE |
title_short |
Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility |
title_full |
Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility |
title_fullStr |
Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility |
title_full_unstemmed |
Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility |
title_sort |
Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility |
dc.creator.none.fl_str_mv |
Benedetti, Estefanía Daniels , R. S. Pontoriero, Andrea Russo, M. L. Avaro, Martin Czech, Andrea Campos, Ana Periolo, Natalia Gregory, V. McCauley, J.W. Baumeister, Elsa |
author |
Benedetti, Estefanía |
author_facet |
Benedetti, Estefanía Daniels , R. S. Pontoriero, Andrea Russo, M. L. Avaro, Martin Czech, Andrea Campos, Ana Periolo, Natalia Gregory, V. McCauley, J.W. Baumeister, Elsa |
author_role |
author |
author2 |
Daniels , R. S. Pontoriero, Andrea Russo, M. L. Avaro, Martin Czech, Andrea Campos, Ana Periolo, Natalia Gregory, V. McCauley, J.W. Baumeister, Elsa |
author2_role |
author author author author author author author author author author |
dc.subject.none.fl_str_mv |
INFLUENZA INFLUENZA VACCINES RESISTANCE TO DRUGS RESPIRATORY INFECTIONS SURVEILLANCE |
topic |
INFLUENZA INFLUENZA VACCINES RESISTANCE TO DRUGS RESPIRATORY INFECTIONS SURVEILLANCE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The activity and circulation of influenza viruses in Argentina was studied during 2012 as part of the Argentinean Surveillance for Influenza and other Respiratory Viruses, in the context of Global Influenza Surveillance. The antigenicity and molecular characteristics of haemagglutinins (HA) of circulating influenza A and B viruses were analysed to assess the emergence of virus variants. Susceptibility to oseltamivir and zanamivir was evaluated by enzymatic assay and results were backed-up by sequencing of the neuraminidase (NA) genes. During the 2012 season, influenza virus circulation in Argentina was detected from weeks 24 to 51. The HA sequences of the studied A(H1N1)pdm09 subtype viruses segregated in a different genetic group compared to those identified during the 2009 pandemic, although they were still closely related antigenically to the vaccine virus A/California/07/2009. The HA sequences of the A(H3N2) viruses analysed fell into the A/Victoria/208/2009 clade, genetic group 3C. A mixed circulation of virus variants belonging to B/Victoria and B/Yamagata lineages was detected, with B/Victoria being dominant. All viruses tested were sensitive to oseltamivir and zanamivir except one. This isolate, an A(H1N1)pdm09 virus possessing the substitution NA-N295S, showed highly reduced inhibition by oseltamivir and reduced inhibition by zanamivir. Virological and epidemiological surveillance remains critical for detection of evolving influenza viruses. Fil: Benedetti, Estefanía. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina Fil: Daniels , R. S.. The Francis Crick institute; Reino Unido Fil: Pontoriero, Andrea. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina Fil: Russo, M. L.. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina Fil: Avaro, Martin. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina Fil: Czech, Andrea. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina Fil: Campos, Ana. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina. Organizacion Mundial de la Salud; Argentina Fil: Periolo, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina Fil: Gregory, V.. The Francis Crick institute; Reino Unido Fil: McCauley, J.W.. The Francis Crick institute; Reino Unido Fil: Baumeister, Elsa. Organizacion Mundial de la Salud; Argentina. Direccion Nacional de Instituto de Investigacion. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbran". Instituto Nacional de Enfermedades Infecciosas. Departamento de Virologia; Argentina |
description |
The activity and circulation of influenza viruses in Argentina was studied during 2012 as part of the Argentinean Surveillance for Influenza and other Respiratory Viruses, in the context of Global Influenza Surveillance. The antigenicity and molecular characteristics of haemagglutinins (HA) of circulating influenza A and B viruses were analysed to assess the emergence of virus variants. Susceptibility to oseltamivir and zanamivir was evaluated by enzymatic assay and results were backed-up by sequencing of the neuraminidase (NA) genes. During the 2012 season, influenza virus circulation in Argentina was detected from weeks 24 to 51. The HA sequences of the studied A(H1N1)pdm09 subtype viruses segregated in a different genetic group compared to those identified during the 2009 pandemic, although they were still closely related antigenically to the vaccine virus A/California/07/2009. The HA sequences of the A(H3N2) viruses analysed fell into the A/Victoria/208/2009 clade, genetic group 3C. A mixed circulation of virus variants belonging to B/Victoria and B/Yamagata lineages was detected, with B/Victoria being dominant. All viruses tested were sensitive to oseltamivir and zanamivir except one. This isolate, an A(H1N1)pdm09 virus possessing the substitution NA-N295S, showed highly reduced inhibition by oseltamivir and reduced inhibition by zanamivir. Virological and epidemiological surveillance remains critical for detection of evolving influenza viruses. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/90947 Benedetti, Estefanía; Daniels , R. S.; Pontoriero, Andrea; Russo, M. L.; Avaro, Martin; et al.; Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility; Cambridge University Press; Epidemiology and Infection; 144; 4; 3-2016; 751-767 0950-2688 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/90947 |
identifier_str_mv |
Benedetti, Estefanía; Daniels , R. S.; Pontoriero, Andrea; Russo, M. L.; Avaro, Martin; et al.; Influenza virus surveillance in Argentina during the 2012 season: Antigenic characterization, genetic analysis and antiviral susceptibility; Cambridge University Press; Epidemiology and Infection; 144; 4; 3-2016; 751-767 0950-2688 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/epidemiology-and-infection/article/influenza-virus-surveillance-in-argentina-during-the-2012-season-antigenic-characterization-genetic-analysis-and-antiviral-susceptibility/F2C57B7E3B950B0B530462FEC0EE7069 info:eu-repo/semantics/altIdentifier/doi/10.1017/S0950268815001806 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Cambridge University Press |
publisher.none.fl_str_mv |
Cambridge University Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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