5-lipoxygenase (5-LOX) inhibition by zileuton reduces the amount of neutrophils that reaches the liver during liver regeneration after partial hepatectomy (PH)

Autores: Lorenzetti, Florencia; Vera, Marina Cecilia; Lucci, Alvaro; Comanzo, Carla G.; Ferretti, Anabela; Carrillo, Maria Cristina; Ceballos Mancini, María Paula; Quiroga, Ariel Dario; Alvarez, María de Luján
Año de publicación: 2019
Idioma: inglés
Tipo de recurso: documento de conferencia
Estado: versión publicada
Descripción: 5-LOX is the first and main enzyme that participates in the synthesis of leukotrienes. LTB4 is a leukotriene involved in inflammation and also is a potent chemoattractant of neutrophils. Previous studies from our lab showed that treatment with a 5-LOX inhibitor produces a decrease in hepatic LTB4 content and a reduction in liver proliferation after 70% PH in rats, indicating that LTB4 is necessary for liver regeneration. Additionally, it was reported that liver regeneration was impaired after neutrophils depletion. Objective: To study if the reduction in hepatic LTB4 reduces the levels of polymorphonuclear leukocytes (PMNs) post-PH which could be necessary to trigger liver regeneration at early times after PH. Methods and results: Adult male Wistar rats were subjected to sham surgery or PH (70 % liver removal). Two hours before surgery, animals received a specific inhibitor of 5-LOX, zileuton (Zi) 40 mg/kg BW or the drug vehicle. Liver samples were obtained at 3 and 5h post-PH. We studied by immunohistochemistry and qRT-PCR the myeloperoxidase (MPO) levels (marker of neutrophils) and we found a significant increment in the levels of MPO-positive cells in the hepatectomized animals treated with vehicle (control PH) respect to the sham (+300%*). On the other hand, the animals that received the 5-LOX inhibitor showed a decrease in MPO-positive cells (-62,5%# 5h post-PH) and MPO mRNA levels (-38,48%# 3h post-PH) respect to control PH rats. Also, by immunofluorescence and confocal microscopy we analyzed a specific marker of rat neutrophil leukocytes (using anti-neutrophil antibody LS C348005, LSBio) and we observed a significant reduction in the number of positive cells in PH rats treated with Zi compared with control PH rats at 3h post-PH (-36,6%#) (*p<0,05 vs. sham, # p<0,05 vs. control PH). Conclusion: Inhibition of 5-LOX by zileuton reduces the levels of LTB4 that attract PMNs cells into the liver. This phenomenon can mediate the inhibitory effect of 5-LOX inhibition on liver regeneration post PH.
Fil: Lorenzetti, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Vera, Marina Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Lucci, Alvaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Comanzo, Carla G.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Ferretti, Anabela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Carrillo, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Ceballos Mancini, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Quiroga, Ariel Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Alvarez, María de Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Reunión Anual de la Sociedad Argentina de Fisiología
Rosario
Argentina
Sociedad Argentina de Fisiología
Materia: 5-LOX
ZILEUTON
LIVER
REGENERATION
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/147605

Acceder

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repository_id_str	3498
network_name_str	CONICET Digital (CONICET)
spelling	5-lipoxygenase (5-LOX) inhibition by zileuton reduces the amount of neutrophils that reaches the liver during liver regeneration after partial hepatectomy (PH)Lorenzetti, FlorenciaVera, Marina CeciliaLucci, AlvaroComanzo, Carla G.Ferretti, AnabelaCarrillo, Maria CristinaCeballos Mancini, María PaulaQuiroga, Ariel DarioAlvarez, María de Luján5-LOXZILEUTONLIVERREGENERATIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/35-LOX is the first and main enzyme that participates in the synthesis of leukotrienes. LTB4 is a leukotriene involved in inflammation and also is a potent chemoattractant of neutrophils. Previous studies from our lab showed that treatment with a 5-LOX inhibitor produces a decrease in hepatic LTB4 content and a reduction in liver proliferation after 70% PH in rats, indicating that LTB4 is necessary for liver regeneration. Additionally, it was reported that liver regeneration was impaired after neutrophils depletion. Objective: To study if the reduction in hepatic LTB4 reduces the levels of polymorphonuclear leukocytes (PMNs) post-PH which could be necessary to trigger liver regeneration at early times after PH. Methods and results: Adult male Wistar rats were subjected to sham surgery or PH (70 % liver removal). Two hours before surgery, animals received a specific inhibitor of 5-LOX, zileuton (Zi) 40 mg/kg BW or the drug vehicle. Liver samples were obtained at 3 and 5h post-PH. We studied by immunohistochemistry and qRT-PCR the myeloperoxidase (MPO) levels (marker of neutrophils) and we found a significant increment in the levels of MPO-positive cells in the hepatectomized animals treated with vehicle (control PH) respect to the sham (+300%). On the other hand, the animals that received the 5-LOX inhibitor showed a decrease in MPO-positive cells (-62,5%# 5h post-PH) and MPO mRNA levels (-38,48%# 3h post-PH) respect to control PH rats. Also, by immunofluorescence and confocal microscopy we analyzed a specific marker of rat neutrophil leukocytes (using anti-neutrophil antibody LS C348005, LSBio) and we observed a significant reduction in the number of positive cells in PH rats treated with Zi compared with control PH rats at 3h post-PH (-36,6%#) (p<0,05 vs. sham, # p<0,05 vs. control PH). Conclusion: Inhibition of 5-LOX by zileuton reduces the levels of LTB4 that attract PMNs cells into the liver. This phenomenon can mediate the inhibitory effect of 5-LOX inhibition on liver regeneration post PH.Fil: Lorenzetti, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Vera, Marina Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Lucci, Alvaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Comanzo, Carla G.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Ferretti, Anabela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Carrillo, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Ceballos Mancini, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Quiroga, Ariel Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Alvarez, María de Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaReunión Anual de la Sociedad Argentina de FisiologíaRosarioArgentinaSociedad Argentina de FisiologíaSociedad Argentina de Fisiología2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/1476055-lipoxygenase (5-LOX) inhibition by zileuton reduces the amount of neutrophils that reaches the liver during liver regeneration after partial hepatectomy (PH); Reunión Anual de la Sociedad Argentina de Fisiología; Rosario; Argentina; 2019; 1-31669-5410CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/uploadsarchivos/safis2019.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:07:37Zoai:ri.conicet.gov.ar:11336/147605instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:07:38.074CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	5-lipoxygenase (5-LOX) inhibition by zileuton reduces the amount of neutrophils that reaches the liver during liver regeneration after partial hepatectomy (PH)
title	5-lipoxygenase (5-LOX) inhibition by zileuton reduces the amount of neutrophils that reaches the liver during liver regeneration after partial hepatectomy (PH)
spellingShingle	5-lipoxygenase (5-LOX) inhibition by zileuton reduces the amount of neutrophils that reaches the liver during liver regeneration after partial hepatectomy (PH) Lorenzetti, Florencia 5-LOX ZILEUTON LIVER REGENERATION
title_short	5-lipoxygenase (5-LOX) inhibition by zileuton reduces the amount of neutrophils that reaches the liver during liver regeneration after partial hepatectomy (PH)
title_full	5-lipoxygenase (5-LOX) inhibition by zileuton reduces the amount of neutrophils that reaches the liver during liver regeneration after partial hepatectomy (PH)
title_fullStr	5-lipoxygenase (5-LOX) inhibition by zileuton reduces the amount of neutrophils that reaches the liver during liver regeneration after partial hepatectomy (PH)
title_full_unstemmed	5-lipoxygenase (5-LOX) inhibition by zileuton reduces the amount of neutrophils that reaches the liver during liver regeneration after partial hepatectomy (PH)
title_sort	5-lipoxygenase (5-LOX) inhibition by zileuton reduces the amount of neutrophils that reaches the liver during liver regeneration after partial hepatectomy (PH)
dc.creator.none.fl_str_mv	Lorenzetti, Florencia Vera, Marina Cecilia Lucci, Alvaro Comanzo, Carla G. Ferretti, Anabela Carrillo, Maria Cristina Ceballos Mancini, María Paula Quiroga, Ariel Dario Alvarez, María de Luján
author	Lorenzetti, Florencia
author_facet	Lorenzetti, Florencia Vera, Marina Cecilia Lucci, Alvaro Comanzo, Carla G. Ferretti, Anabela Carrillo, Maria Cristina Ceballos Mancini, María Paula Quiroga, Ariel Dario Alvarez, María de Luján
author_role	author
author2	Vera, Marina Cecilia Lucci, Alvaro Comanzo, Carla G. Ferretti, Anabela Carrillo, Maria Cristina Ceballos Mancini, María Paula Quiroga, Ariel Dario Alvarez, María de Luján
author2_role	author author author author author author author author
dc.subject.none.fl_str_mv	5-LOX ZILEUTON LIVER REGENERATION
topic	5-LOX ZILEUTON LIVER REGENERATION
purl_subject.fl_str_mv	https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv	5-LOX is the first and main enzyme that participates in the synthesis of leukotrienes. LTB4 is a leukotriene involved in inflammation and also is a potent chemoattractant of neutrophils. Previous studies from our lab showed that treatment with a 5-LOX inhibitor produces a decrease in hepatic LTB4 content and a reduction in liver proliferation after 70% PH in rats, indicating that LTB4 is necessary for liver regeneration. Additionally, it was reported that liver regeneration was impaired after neutrophils depletion. Objective: To study if the reduction in hepatic LTB4 reduces the levels of polymorphonuclear leukocytes (PMNs) post-PH which could be necessary to trigger liver regeneration at early times after PH. Methods and results: Adult male Wistar rats were subjected to sham surgery or PH (70 % liver removal). Two hours before surgery, animals received a specific inhibitor of 5-LOX, zileuton (Zi) 40 mg/kg BW or the drug vehicle. Liver samples were obtained at 3 and 5h post-PH. We studied by immunohistochemistry and qRT-PCR the myeloperoxidase (MPO) levels (marker of neutrophils) and we found a significant increment in the levels of MPO-positive cells in the hepatectomized animals treated with vehicle (control PH) respect to the sham (+300%). On the other hand, the animals that received the 5-LOX inhibitor showed a decrease in MPO-positive cells (-62,5%# 5h post-PH) and MPO mRNA levels (-38,48%# 3h post-PH) respect to control PH rats. Also, by immunofluorescence and confocal microscopy we analyzed a specific marker of rat neutrophil leukocytes (using anti-neutrophil antibody LS C348005, LSBio) and we observed a significant reduction in the number of positive cells in PH rats treated with Zi compared with control PH rats at 3h post-PH (-36,6%#) (p<0,05 vs. sham, # p<0,05 vs. control PH). Conclusion: Inhibition of 5-LOX by zileuton reduces the levels of LTB4 that attract PMNs cells into the liver. This phenomenon can mediate the inhibitory effect of 5-LOX inhibition on liver regeneration post PH. Fil: Lorenzetti, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Fil: Vera, Marina Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Fil: Lucci, Alvaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Fil: Comanzo, Carla G.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Fil: Ferretti, Anabela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Fil: Carrillo, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Fil: Ceballos Mancini, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Fil: Quiroga, Ariel Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Fil: Alvarez, María de Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Reunión Anual de la Sociedad Argentina de Fisiología Rosario Argentina Sociedad Argentina de Fisiología
description	5-LOX is the first and main enzyme that participates in the synthesis of leukotrienes. LTB4 is a leukotriene involved in inflammation and also is a potent chemoattractant of neutrophils. Previous studies from our lab showed that treatment with a 5-LOX inhibitor produces a decrease in hepatic LTB4 content and a reduction in liver proliferation after 70% PH in rats, indicating that LTB4 is necessary for liver regeneration. Additionally, it was reported that liver regeneration was impaired after neutrophils depletion. Objective: To study if the reduction in hepatic LTB4 reduces the levels of polymorphonuclear leukocytes (PMNs) post-PH which could be necessary to trigger liver regeneration at early times after PH. Methods and results: Adult male Wistar rats were subjected to sham surgery or PH (70 % liver removal). Two hours before surgery, animals received a specific inhibitor of 5-LOX, zileuton (Zi) 40 mg/kg BW or the drug vehicle. Liver samples were obtained at 3 and 5h post-PH. We studied by immunohistochemistry and qRT-PCR the myeloperoxidase (MPO) levels (marker of neutrophils) and we found a significant increment in the levels of MPO-positive cells in the hepatectomized animals treated with vehicle (control PH) respect to the sham (+300%). On the other hand, the animals that received the 5-LOX inhibitor showed a decrease in MPO-positive cells (-62,5%# 5h post-PH) and MPO mRNA levels (-38,48%# 3h post-PH) respect to control PH rats. Also, by immunofluorescence and confocal microscopy we analyzed a specific marker of rat neutrophil leukocytes (using anti-neutrophil antibody LS C348005, LSBio) and we observed a significant reduction in the number of positive cells in PH rats treated with Zi compared with control PH rats at 3h post-PH (-36,6%#) (p<0,05 vs. sham, # p<0,05 vs. control PH). Conclusion: Inhibition of 5-LOX by zileuton reduces the levels of LTB4 that attract PMNs cells into the liver. This phenomenon can mediate the inhibitory effect of 5-LOX inhibition on liver regeneration post PH.
publishDate	2019
dc.date.none.fl_str_mv	2019
dc.type.none.fl_str_mv	info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Reunión Journal http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia
status_str	publishedVersion
format	conferenceObject
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/147605 5-lipoxygenase (5-LOX) inhibition by zileuton reduces the amount of neutrophils that reaches the liver during liver regeneration after partial hepatectomy (PH); Reunión Anual de la Sociedad Argentina de Fisiología; Rosario; Argentina; 2019; 1-3 1669-5410 CONICET Digital CONICET
url	http://hdl.handle.net/11336/147605
identifier_str_mv	5-lipoxygenase (5-LOX) inhibition by zileuton reduces the amount of neutrophils that reaches the liver during liver regeneration after partial hepatectomy (PH); Reunión Anual de la Sociedad Argentina de Fisiología; Rosario; Argentina; 2019; 1-3 1669-5410 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/uploadsarchivos/safis2019.pdf
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rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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dc.coverage.none.fl_str_mv	Nacional
dc.publisher.none.fl_str_mv	Sociedad Argentina de Fisiología
publisher.none.fl_str_mv	Sociedad Argentina de Fisiología
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5-lipoxygenase (5-LOX) inhibition by zileuton reduces the amount of neutrophils that reaches the liver during liver regeneration after partial hepatectomy (PH)

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