Liver glucokinase: An overview on the regulatorymechanisms of its activity

Autores
Massa, Maria Laura; Gagliardino, Juan Jose; Francini, Flavio
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or decreasing glucose output and uptake during fasting and feeding. Glucokinase (GCK) is central to this process. Its activity is modulated in a coordinated manner via a complex set of mechanisms: in the postprandial period, the simultaneous rise in glucose and insulin increases GCK activity by enhanced gene expression, changes in cellular location, and interaction with regulatory proteins. Conversely, in the fasting state, the combined decrease in glucose and insulin concentrations and increase in glucagon concentrations, halt GCK activity. Herein we summarize the current knowledge regarding the regulation of hepatic GCK activity.
Fil: Massa, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Endocrinología Experimental y Aplicada (i); Argentina
Fil: Gagliardino, Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Endocrinología Experimental y Aplicada (i); Argentina
Fil: Francini, Flavio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Endocrinología Experimental y Aplicada (i); Argentina
Materia
GLUCOKINASE
GLUCOSE HOMEOSTASIS
LIVER
LIVER GLUCOKINASE ACTIVITY
TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL GLUCOKINASE ACTIVITY REGULATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/95541
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Liver glucokinase: An overview on the regulatorymechanisms of its activityMassa, Maria LauraGagliardino, Juan JoseFrancini, FlavioGLUCOKINASEGLUCOSE HOMEOSTASISLIVERLIVER GLUCOKINASE ACTIVITYTRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL GLUCOKINASE ACTIVITY REGULATIONhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or decreasing glucose output and uptake during fasting and feeding. Glucokinase (GCK) is central to this process. Its activity is modulated in a coordinated manner via a complex set of mechanisms: in the postprandial period, the simultaneous rise in glucose and insulin increases GCK activity by enhanced gene expression, changes in cellular location, and interaction with regulatory proteins. Conversely, in the fasting state, the combined decrease in glucose and insulin concentrations and increase in glucagon concentrations, halt GCK activity. Herein we summarize the current knowledge regarding the regulation of hepatic GCK activity.Fil: Massa, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Endocrinología Experimental y Aplicada (i); ArgentinaFil: Gagliardino, Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Endocrinología Experimental y Aplicada (i); ArgentinaFil: Francini, Flavio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Endocrinología Experimental y Aplicada (i); ArgentinaJohn Wiley & Sons Inc2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/95541Massa, Maria Laura; Gagliardino, Juan Jose; Francini, Flavio; Liver glucokinase: An overview on the regulatorymechanisms of its activity; John Wiley & Sons Inc; IUBMB Life; 63; 1; 1-2011; 1-61521-6543CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.411info:eu-repo/semantics/altIdentifier/doi/10.1002/iub.411info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:45:28Zoai:ri.conicet.gov.ar:11336/95541instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:45:28.44CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Liver glucokinase: An overview on the regulatorymechanisms of its activity
title Liver glucokinase: An overview on the regulatorymechanisms of its activity
spellingShingle Liver glucokinase: An overview on the regulatorymechanisms of its activity
Massa, Maria Laura
GLUCOKINASE
GLUCOSE HOMEOSTASIS
LIVER
LIVER GLUCOKINASE ACTIVITY
TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL GLUCOKINASE ACTIVITY REGULATION
title_short Liver glucokinase: An overview on the regulatorymechanisms of its activity
title_full Liver glucokinase: An overview on the regulatorymechanisms of its activity
title_fullStr Liver glucokinase: An overview on the regulatorymechanisms of its activity
title_full_unstemmed Liver glucokinase: An overview on the regulatorymechanisms of its activity
title_sort Liver glucokinase: An overview on the regulatorymechanisms of its activity
dc.creator.none.fl_str_mv Massa, Maria Laura
Gagliardino, Juan Jose
Francini, Flavio
author Massa, Maria Laura
author_facet Massa, Maria Laura
Gagliardino, Juan Jose
Francini, Flavio
author_role author
author2 Gagliardino, Juan Jose
Francini, Flavio
author2_role author
author
dc.subject.none.fl_str_mv GLUCOKINASE
GLUCOSE HOMEOSTASIS
LIVER
LIVER GLUCOKINASE ACTIVITY
TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL GLUCOKINASE ACTIVITY REGULATION
topic GLUCOKINASE
GLUCOSE HOMEOSTASIS
LIVER
LIVER GLUCOKINASE ACTIVITY
TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL GLUCOKINASE ACTIVITY REGULATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or decreasing glucose output and uptake during fasting and feeding. Glucokinase (GCK) is central to this process. Its activity is modulated in a coordinated manner via a complex set of mechanisms: in the postprandial period, the simultaneous rise in glucose and insulin increases GCK activity by enhanced gene expression, changes in cellular location, and interaction with regulatory proteins. Conversely, in the fasting state, the combined decrease in glucose and insulin concentrations and increase in glucagon concentrations, halt GCK activity. Herein we summarize the current knowledge regarding the regulation of hepatic GCK activity.
Fil: Massa, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Endocrinología Experimental y Aplicada (i); Argentina
Fil: Gagliardino, Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Endocrinología Experimental y Aplicada (i); Argentina
Fil: Francini, Flavio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Endocrinología Experimental y Aplicada (i); Argentina
description Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or decreasing glucose output and uptake during fasting and feeding. Glucokinase (GCK) is central to this process. Its activity is modulated in a coordinated manner via a complex set of mechanisms: in the postprandial period, the simultaneous rise in glucose and insulin increases GCK activity by enhanced gene expression, changes in cellular location, and interaction with regulatory proteins. Conversely, in the fasting state, the combined decrease in glucose and insulin concentrations and increase in glucagon concentrations, halt GCK activity. Herein we summarize the current knowledge regarding the regulation of hepatic GCK activity.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/95541
Massa, Maria Laura; Gagliardino, Juan Jose; Francini, Flavio; Liver glucokinase: An overview on the regulatorymechanisms of its activity; John Wiley & Sons Inc; IUBMB Life; 63; 1; 1-2011; 1-6
1521-6543
CONICET Digital
CONICET
url http://hdl.handle.net/11336/95541
identifier_str_mv Massa, Maria Laura; Gagliardino, Juan Jose; Francini, Flavio; Liver glucokinase: An overview on the regulatorymechanisms of its activity; John Wiley & Sons Inc; IUBMB Life; 63; 1; 1-2011; 1-6
1521-6543
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.411
info:eu-repo/semantics/altIdentifier/doi/10.1002/iub.411
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Inc
publisher.none.fl_str_mv John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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