Hypoglycemic activity of Opuntia salagria cladodes in rats

Autores
Gili, Valeria; Cabrera, Wilfredo Marcelino; Genta, Susana Beatriz de Fátima; Alonso, Telma Susana; Sanchez, Sara Serafina del V.
Año de publicación
2007
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
An important increase in the medicinal use of plant natural products has been observed in the last few years. Cactus Opuntia has been traditionally used as a valuable health supporting nutrient and its different parts are currently used in folkloric medicine. The number of people with Diabetes mellitus and its associated complications rise on a daily basis. The purpose of this study was to analyze the oral hypoglycemic activity of cladodes of Opuntia salagria, an Argentine autochthonous species, in transiently hyperglycemic and streptozotocin (STZ)-induced diabetic rats. To this end, O. salagria cladodes were collected from the area surrounding Bahía Blanca city, Province of Buenos Aires. After removing the spines, cladodes were sliced and dried at 40ºC in a forced air circulation oven and milled. The flour thus obtained was stored at 4ºC until required. A slimy suspension of O. salagria powder cladode was prepared (2g/ 100ml of water). The animals used were male Wistar rats (250- 300g), which were made diabetic by intraperitoneal injection of STZ (35mg/kg body weight). The animals exhibiting blood glucose levels >350mg/dl were considered diabetic. The main effects of the oral administration of the suspension in doses of 100 or 200 mg/kg body weight are summarized as follows: in transiently hyperglycemic rats (Glucose Tolerance Test) cladode suspension decreased blood glucose levels at both doses, and in STZ-induced diabetic rats, the administration of the suspension for 30 days, produced a significant hypoglycemic effect. These results are indicative of the potential use of O. salagria cladodes to regulate the plasma glucose levels.
Fil: Gili, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Cabrera, Wilfredo Marcelino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina
Fil: Genta, Susana Beatriz de Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina
Fil: Alonso, Telma Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina
Eighth Multidisciplinary Workshop
Buenos Aires
Argentina
Sociedad Argentina de Biología
Materia
OPUNTIA
DIABETES
HYPOGLYCEMIC ACTIVITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/242805
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/242805
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hypoglycemic activity of Opuntia salagria cladodes in ratsGili, ValeriaCabrera, Wilfredo MarcelinoGenta, Susana Beatriz de FátimaAlonso, Telma SusanaSanchez, Sara Serafina del V.OPUNTIADIABETESHYPOGLYCEMIC ACTIVITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1An important increase in the medicinal use of plant natural products has been observed in the last few years. Cactus Opuntia has been traditionally used as a valuable health supporting nutrient and its different parts are currently used in folkloric medicine. The number of people with Diabetes mellitus and its associated complications rise on a daily basis. The purpose of this study was to analyze the oral hypoglycemic activity of cladodes of Opuntia salagria, an Argentine autochthonous species, in transiently hyperglycemic and streptozotocin (STZ)-induced diabetic rats. To this end, O. salagria cladodes were collected from the area surrounding Bahía Blanca city, Province of Buenos Aires. After removing the spines, cladodes were sliced and dried at 40ºC in a forced air circulation oven and milled. The flour thus obtained was stored at 4ºC until required. A slimy suspension of O. salagria powder cladode was prepared (2g/ 100ml of water). The animals used were male Wistar rats (250- 300g), which were made diabetic by intraperitoneal injection of STZ (35mg/kg body weight). The animals exhibiting blood glucose levels >350mg/dl were considered diabetic. The main effects of the oral administration of the suspension in doses of 100 or 200 mg/kg body weight are summarized as follows: in transiently hyperglycemic rats (Glucose Tolerance Test) cladode suspension decreased blood glucose levels at both doses, and in STZ-induced diabetic rats, the administration of the suspension for 30 days, produced a significant hypoglycemic effect. These results are indicative of the potential use of O. salagria cladodes to regulate the plasma glucose levels.Fil: Gili, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Cabrera, Wilfredo Marcelino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; ArgentinaFil: Genta, Susana Beatriz de Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; ArgentinaFil: Alonso, Telma Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; ArgentinaEighth Multidisciplinary WorkshopBuenos AiresArgentinaSociedad Argentina de BiologíaBiocell2007info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/242805Hypoglycemic activity of Opuntia salagria cladodes in rats; Eighth Multidisciplinary Workshop; Buenos Aires; Argentina; 2006; 349-3490327-9545CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.techscience.com/biocell/v31nSuppl.S/38013/pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:02Zoai:ri.conicet.gov.ar:11336/242805instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:02.419CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hypoglycemic activity of Opuntia salagria cladodes in rats
title Hypoglycemic activity of Opuntia salagria cladodes in rats
spellingShingle Hypoglycemic activity of Opuntia salagria cladodes in rats
Gili, Valeria
OPUNTIA
DIABETES
HYPOGLYCEMIC ACTIVITY
title_short Hypoglycemic activity of Opuntia salagria cladodes in rats
title_full Hypoglycemic activity of Opuntia salagria cladodes in rats
title_fullStr Hypoglycemic activity of Opuntia salagria cladodes in rats
title_full_unstemmed Hypoglycemic activity of Opuntia salagria cladodes in rats
title_sort Hypoglycemic activity of Opuntia salagria cladodes in rats
dc.creator.none.fl_str_mv Gili, Valeria
Cabrera, Wilfredo Marcelino
Genta, Susana Beatriz de Fátima
Alonso, Telma Susana
Sanchez, Sara Serafina del V.
author Gili, Valeria
author_facet Gili, Valeria
Cabrera, Wilfredo Marcelino
Genta, Susana Beatriz de Fátima
Alonso, Telma Susana
Sanchez, Sara Serafina del V.
author_role author
author2 Cabrera, Wilfredo Marcelino
Genta, Susana Beatriz de Fátima
Alonso, Telma Susana
Sanchez, Sara Serafina del V.
author2_role author
author
author
author
dc.subject.none.fl_str_mv OPUNTIA
DIABETES
HYPOGLYCEMIC ACTIVITY
topic OPUNTIA
DIABETES
HYPOGLYCEMIC ACTIVITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv An important increase in the medicinal use of plant natural products has been observed in the last few years. Cactus Opuntia has been traditionally used as a valuable health supporting nutrient and its different parts are currently used in folkloric medicine. The number of people with Diabetes mellitus and its associated complications rise on a daily basis. The purpose of this study was to analyze the oral hypoglycemic activity of cladodes of Opuntia salagria, an Argentine autochthonous species, in transiently hyperglycemic and streptozotocin (STZ)-induced diabetic rats. To this end, O. salagria cladodes were collected from the area surrounding Bahía Blanca city, Province of Buenos Aires. After removing the spines, cladodes were sliced and dried at 40ºC in a forced air circulation oven and milled. The flour thus obtained was stored at 4ºC until required. A slimy suspension of O. salagria powder cladode was prepared (2g/ 100ml of water). The animals used were male Wistar rats (250- 300g), which were made diabetic by intraperitoneal injection of STZ (35mg/kg body weight). The animals exhibiting blood glucose levels >350mg/dl were considered diabetic. The main effects of the oral administration of the suspension in doses of 100 or 200 mg/kg body weight are summarized as follows: in transiently hyperglycemic rats (Glucose Tolerance Test) cladode suspension decreased blood glucose levels at both doses, and in STZ-induced diabetic rats, the administration of the suspension for 30 days, produced a significant hypoglycemic effect. These results are indicative of the potential use of O. salagria cladodes to regulate the plasma glucose levels.
Fil: Gili, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Cabrera, Wilfredo Marcelino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina
Fil: Genta, Susana Beatriz de Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina
Fil: Alonso, Telma Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina
Eighth Multidisciplinary Workshop
Buenos Aires
Argentina
Sociedad Argentina de Biología
description An important increase in the medicinal use of plant natural products has been observed in the last few years. Cactus Opuntia has been traditionally used as a valuable health supporting nutrient and its different parts are currently used in folkloric medicine. The number of people with Diabetes mellitus and its associated complications rise on a daily basis. The purpose of this study was to analyze the oral hypoglycemic activity of cladodes of Opuntia salagria, an Argentine autochthonous species, in transiently hyperglycemic and streptozotocin (STZ)-induced diabetic rats. To this end, O. salagria cladodes were collected from the area surrounding Bahía Blanca city, Province of Buenos Aires. After removing the spines, cladodes were sliced and dried at 40ºC in a forced air circulation oven and milled. The flour thus obtained was stored at 4ºC until required. A slimy suspension of O. salagria powder cladode was prepared (2g/ 100ml of water). The animals used were male Wistar rats (250- 300g), which were made diabetic by intraperitoneal injection of STZ (35mg/kg body weight). The animals exhibiting blood glucose levels >350mg/dl were considered diabetic. The main effects of the oral administration of the suspension in doses of 100 or 200 mg/kg body weight are summarized as follows: in transiently hyperglycemic rats (Glucose Tolerance Test) cladode suspension decreased blood glucose levels at both doses, and in STZ-induced diabetic rats, the administration of the suspension for 30 days, produced a significant hypoglycemic effect. These results are indicative of the potential use of O. salagria cladodes to regulate the plasma glucose levels.
publishDate 2007
dc.date.none.fl_str_mv 2007
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
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Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/242805
Hypoglycemic activity of Opuntia salagria cladodes in rats; Eighth Multidisciplinary Workshop; Buenos Aires; Argentina; 2006; 349-349
0327-9545
CONICET Digital
CONICET
url http://hdl.handle.net/11336/242805
identifier_str_mv Hypoglycemic activity of Opuntia salagria cladodes in rats; Eighth Multidisciplinary Workshop; Buenos Aires; Argentina; 2006; 349-349
0327-9545
CONICET Digital
CONICET
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language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.techscience.com/biocell/v31nSuppl.S/38013/pdf
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