Hypoglycemic activity of Opuntia salagria cladodes in rats
- Autores
- Gili, Valeria; Cabrera, Wilfredo Marcelino; Genta, Susana Beatriz de Fátima; Alonso, Telma Susana; Sanchez, Sara Serafina del V.
- Año de publicación
- 2007
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- An important increase in the medicinal use of plant natural products has been observed in the last few years. Cactus Opuntia has been traditionally used as a valuable health supporting nutrient and its different parts are currently used in folkloric medicine. The number of people with Diabetes mellitus and its associated complications rise on a daily basis. The purpose of this study was to analyze the oral hypoglycemic activity of cladodes of Opuntia salagria, an Argentine autochthonous species, in transiently hyperglycemic and streptozotocin (STZ)-induced diabetic rats. To this end, O. salagria cladodes were collected from the area surrounding Bahía Blanca city, Province of Buenos Aires. After removing the spines, cladodes were sliced and dried at 40ºC in a forced air circulation oven and milled. The flour thus obtained was stored at 4ºC until required. A slimy suspension of O. salagria powder cladode was prepared (2g/ 100ml of water). The animals used were male Wistar rats (250- 300g), which were made diabetic by intraperitoneal injection of STZ (35mg/kg body weight). The animals exhibiting blood glucose levels >350mg/dl were considered diabetic. The main effects of the oral administration of the suspension in doses of 100 or 200 mg/kg body weight are summarized as follows: in transiently hyperglycemic rats (Glucose Tolerance Test) cladode suspension decreased blood glucose levels at both doses, and in STZ-induced diabetic rats, the administration of the suspension for 30 days, produced a significant hypoglycemic effect. These results are indicative of the potential use of O. salagria cladodes to regulate the plasma glucose levels.
Fil: Gili, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Cabrera, Wilfredo Marcelino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina
Fil: Genta, Susana Beatriz de Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina
Fil: Alonso, Telma Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina
Eighth Multidisciplinary Workshop
Buenos Aires
Argentina
Sociedad Argentina de Biología - Materia
-
OPUNTIA
DIABETES
HYPOGLYCEMIC ACTIVITY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/242805
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Hypoglycemic activity of Opuntia salagria cladodes in ratsGili, ValeriaCabrera, Wilfredo MarcelinoGenta, Susana Beatriz de FátimaAlonso, Telma SusanaSanchez, Sara Serafina del V.OPUNTIADIABETESHYPOGLYCEMIC ACTIVITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1An important increase in the medicinal use of plant natural products has been observed in the last few years. Cactus Opuntia has been traditionally used as a valuable health supporting nutrient and its different parts are currently used in folkloric medicine. The number of people with Diabetes mellitus and its associated complications rise on a daily basis. The purpose of this study was to analyze the oral hypoglycemic activity of cladodes of Opuntia salagria, an Argentine autochthonous species, in transiently hyperglycemic and streptozotocin (STZ)-induced diabetic rats. To this end, O. salagria cladodes were collected from the area surrounding Bahía Blanca city, Province of Buenos Aires. After removing the spines, cladodes were sliced and dried at 40ºC in a forced air circulation oven and milled. The flour thus obtained was stored at 4ºC until required. A slimy suspension of O. salagria powder cladode was prepared (2g/ 100ml of water). The animals used were male Wistar rats (250- 300g), which were made diabetic by intraperitoneal injection of STZ (35mg/kg body weight). The animals exhibiting blood glucose levels >350mg/dl were considered diabetic. The main effects of the oral administration of the suspension in doses of 100 or 200 mg/kg body weight are summarized as follows: in transiently hyperglycemic rats (Glucose Tolerance Test) cladode suspension decreased blood glucose levels at both doses, and in STZ-induced diabetic rats, the administration of the suspension for 30 days, produced a significant hypoglycemic effect. These results are indicative of the potential use of O. salagria cladodes to regulate the plasma glucose levels.Fil: Gili, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Cabrera, Wilfredo Marcelino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; ArgentinaFil: Genta, Susana Beatriz de Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; ArgentinaFil: Alonso, Telma Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; ArgentinaEighth Multidisciplinary WorkshopBuenos AiresArgentinaSociedad Argentina de BiologíaBiocell2007info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/242805Hypoglycemic activity of Opuntia salagria cladodes in rats; Eighth Multidisciplinary Workshop; Buenos Aires; Argentina; 2006; 349-3490327-9545CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.techscience.com/biocell/v31nSuppl.S/38013/pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:26Zoai:ri.conicet.gov.ar:11336/242805instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:26.446CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Hypoglycemic activity of Opuntia salagria cladodes in rats |
title |
Hypoglycemic activity of Opuntia salagria cladodes in rats |
spellingShingle |
Hypoglycemic activity of Opuntia salagria cladodes in rats Gili, Valeria OPUNTIA DIABETES HYPOGLYCEMIC ACTIVITY |
title_short |
Hypoglycemic activity of Opuntia salagria cladodes in rats |
title_full |
Hypoglycemic activity of Opuntia salagria cladodes in rats |
title_fullStr |
Hypoglycemic activity of Opuntia salagria cladodes in rats |
title_full_unstemmed |
Hypoglycemic activity of Opuntia salagria cladodes in rats |
title_sort |
Hypoglycemic activity of Opuntia salagria cladodes in rats |
dc.creator.none.fl_str_mv |
Gili, Valeria Cabrera, Wilfredo Marcelino Genta, Susana Beatriz de Fátima Alonso, Telma Susana Sanchez, Sara Serafina del V. |
author |
Gili, Valeria |
author_facet |
Gili, Valeria Cabrera, Wilfredo Marcelino Genta, Susana Beatriz de Fátima Alonso, Telma Susana Sanchez, Sara Serafina del V. |
author_role |
author |
author2 |
Cabrera, Wilfredo Marcelino Genta, Susana Beatriz de Fátima Alonso, Telma Susana Sanchez, Sara Serafina del V. |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
OPUNTIA DIABETES HYPOGLYCEMIC ACTIVITY |
topic |
OPUNTIA DIABETES HYPOGLYCEMIC ACTIVITY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
An important increase in the medicinal use of plant natural products has been observed in the last few years. Cactus Opuntia has been traditionally used as a valuable health supporting nutrient and its different parts are currently used in folkloric medicine. The number of people with Diabetes mellitus and its associated complications rise on a daily basis. The purpose of this study was to analyze the oral hypoglycemic activity of cladodes of Opuntia salagria, an Argentine autochthonous species, in transiently hyperglycemic and streptozotocin (STZ)-induced diabetic rats. To this end, O. salagria cladodes were collected from the area surrounding Bahía Blanca city, Province of Buenos Aires. After removing the spines, cladodes were sliced and dried at 40ºC in a forced air circulation oven and milled. The flour thus obtained was stored at 4ºC until required. A slimy suspension of O. salagria powder cladode was prepared (2g/ 100ml of water). The animals used were male Wistar rats (250- 300g), which were made diabetic by intraperitoneal injection of STZ (35mg/kg body weight). The animals exhibiting blood glucose levels >350mg/dl were considered diabetic. The main effects of the oral administration of the suspension in doses of 100 or 200 mg/kg body weight are summarized as follows: in transiently hyperglycemic rats (Glucose Tolerance Test) cladode suspension decreased blood glucose levels at both doses, and in STZ-induced diabetic rats, the administration of the suspension for 30 days, produced a significant hypoglycemic effect. These results are indicative of the potential use of O. salagria cladodes to regulate the plasma glucose levels. Fil: Gili, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina Fil: Cabrera, Wilfredo Marcelino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina Fil: Genta, Susana Beatriz de Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina Fil: Alonso, Telma Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina Fil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino | Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas. Grupo de Investigación y Desarrollo del Noroeste Argentino; Argentina Eighth Multidisciplinary Workshop Buenos Aires Argentina Sociedad Argentina de Biología |
description |
An important increase in the medicinal use of plant natural products has been observed in the last few years. Cactus Opuntia has been traditionally used as a valuable health supporting nutrient and its different parts are currently used in folkloric medicine. The number of people with Diabetes mellitus and its associated complications rise on a daily basis. The purpose of this study was to analyze the oral hypoglycemic activity of cladodes of Opuntia salagria, an Argentine autochthonous species, in transiently hyperglycemic and streptozotocin (STZ)-induced diabetic rats. To this end, O. salagria cladodes were collected from the area surrounding Bahía Blanca city, Province of Buenos Aires. After removing the spines, cladodes were sliced and dried at 40ºC in a forced air circulation oven and milled. The flour thus obtained was stored at 4ºC until required. A slimy suspension of O. salagria powder cladode was prepared (2g/ 100ml of water). The animals used were male Wistar rats (250- 300g), which were made diabetic by intraperitoneal injection of STZ (35mg/kg body weight). The animals exhibiting blood glucose levels >350mg/dl were considered diabetic. The main effects of the oral administration of the suspension in doses of 100 or 200 mg/kg body weight are summarized as follows: in transiently hyperglycemic rats (Glucose Tolerance Test) cladode suspension decreased blood glucose levels at both doses, and in STZ-induced diabetic rats, the administration of the suspension for 30 days, produced a significant hypoglycemic effect. These results are indicative of the potential use of O. salagria cladodes to regulate the plasma glucose levels. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Congreso Journal http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
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http://hdl.handle.net/11336/242805 Hypoglycemic activity of Opuntia salagria cladodes in rats; Eighth Multidisciplinary Workshop; Buenos Aires; Argentina; 2006; 349-349 0327-9545 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/242805 |
identifier_str_mv |
Hypoglycemic activity of Opuntia salagria cladodes in rats; Eighth Multidisciplinary Workshop; Buenos Aires; Argentina; 2006; 349-349 0327-9545 CONICET Digital CONICET |
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eng |
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eng |
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