Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells

Autores
Aarntzen, Erik H. J. G.; Srinivas, Mangala; Bonetto, Fernando Jose; Cruz, Luis J.; Verdijk, Pauline; Schreibelt, Gerty; Van de Rakt, Mandy; Lesterhuis, W. Joost; Van Riel, Maichel; Punt, Cornelius J. A.; Adema, Gosse J.; Heerschap, Arend; Figdor, Carl G.; Oyen, Wim J.; de Vries, I. Jolanda M.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Anti-cancer dendritic cell (DC) vaccines require the DC to relocate to lymph nodes (LN) to trigger immune responses. However, these migration rates are typically very poor. Improving the targeting of ex vivo generated DC to LN might increase vaccine efficacy and reduce costs. We investigated DC migration in vivo in humans in different conditions.
Fil: Aarntzen, Erik H. J. G.. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos; Leiden University. Department of Endocrinology; Países Bajos;
Fil: Srinivas, Mangala. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;
Fil: Bonetto, Fernando Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET- Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina;
Fil: Cruz, Luis J.. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos; Leiden University. Department of Endocrinology; Países Bajos;
Fil: Verdijk, Pauline. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos; National Institute for Public Health and the Environment. Departament of Vaccinology; Países Bajos;
Fil: Schreibelt, Gerty. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;
Fil: Van de Rakt, Mandy. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;
Fil: Lesterhuis, W. Joost. Radboud University Nijmegen Medical Centre. Department of Medical Oncology ; Países Bajos;
Fil: Van Riel, Maichel. Radboud Universiteit Nijmegen Medical Centre Department of Nuclear Medicine; Países Bajos;
Fil: Punt, Cornelius J. A.. Academic Medical Centre. Department of Medical Oncology; Países Bajos;
Fil: Adema, Gosse J.. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;
Fil: Heerschap, Arend. Radboud Universiteit Nijmegen. Department of Radiology; Paí­ses Bajos;
Fil: Figdor, Carl G.. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;
Fil: Oyen, Wim J.. Leiden University. Department of Endocrinology; Países Bajos;
Fil: de Vries, I. Jolanda M.. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;
Materia
Dendritic cells
19F magnetic resonance imaging
Migration
Immunotherapy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/2073
Acceder
id CONICETDig_819abac719a0507b4f32fa1e5e2c4c54
oai_identifier_str oai:ri.conicet.gov.ar:11336/2073
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cellsAarntzen, Erik H. J. G.Srinivas, MangalaBonetto, Fernando JoseCruz, Luis J.Verdijk, PaulineSchreibelt, GertyVan de Rakt, MandyLesterhuis, W. JoostVan Riel, MaichelPunt, Cornelius J. A.Adema, Gosse J.Heerschap, ArendFigdor, Carl G.Oyen, Wim J.de Vries, I. Jolanda M.Dendritic cells19F magnetic resonance imagingMigrationImmunotherapyhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Anti-cancer dendritic cell (DC) vaccines require the DC to relocate to lymph nodes (LN) to trigger immune responses. However, these migration rates are typically very poor. Improving the targeting of ex vivo generated DC to LN might increase vaccine efficacy and reduce costs. We investigated DC migration in vivo in humans in different conditions.Fil: Aarntzen, Erik H. J. G.. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos; Leiden University. Department of Endocrinology; Países Bajos;Fil: Srinivas, Mangala. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;Fil: Bonetto, Fernando Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET- Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina;Fil: Cruz, Luis J.. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos; Leiden University. Department of Endocrinology; Países Bajos;Fil: Verdijk, Pauline. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos; National Institute for Public Health and the Environment. Departament of Vaccinology; Países Bajos;Fil: Schreibelt, Gerty. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;Fil: Van de Rakt, Mandy. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;Fil: Lesterhuis, W. Joost. Radboud University Nijmegen Medical Centre. Department of Medical Oncology ; Países Bajos;Fil: Van Riel, Maichel. Radboud Universiteit Nijmegen Medical Centre Department of Nuclear Medicine; Países Bajos;Fil: Punt, Cornelius J. A.. Academic Medical Centre. Department of Medical Oncology; Países Bajos;Fil: Adema, Gosse J.. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;Fil: Heerschap, Arend. Radboud Universiteit Nijmegen. Department of Radiology; Paí­ses Bajos;Fil: Figdor, Carl G.. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;Fil: Oyen, Wim J.. Leiden University. Department of Endocrinology; Países Bajos;Fil: de Vries, I. Jolanda M.. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;American Association for Cancer Research2013-03-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/2073Aarntzen, Erik H. J. G.; Srinivas, Mangala; Bonetto, Fernando Jose; Cruz, Luis J.; Verdijk, Pauline; et al.; Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells; American Association for Cancer Research; Clinical Cancer Research; 19; 15-3-2013; 1525-15331078-0432enginfo:eu-repo/semantics/altIdentifier/doi/doi:10.1158/1078-0432.CCR-12-1879info:eu-repo/semantics/altIdentifier/url/http://clincancerres.aacrjournals.org/content/19/6/1525.longinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:23:33Zoai:ri.conicet.gov.ar:11336/2073instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:23:34.168CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells
title Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells
spellingShingle Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells
Aarntzen, Erik H. J. G.
Dendritic cells
19F magnetic resonance imaging
Migration
Immunotherapy
title_short Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells
title_full Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells
title_fullStr Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells
title_full_unstemmed Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells
title_sort Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells
dc.creator.none.fl_str_mv Aarntzen, Erik H. J. G.
Srinivas, Mangala
Bonetto, Fernando Jose
Cruz, Luis J.
Verdijk, Pauline
Schreibelt, Gerty
Van de Rakt, Mandy
Lesterhuis, W. Joost
Van Riel, Maichel
Punt, Cornelius J. A.
Adema, Gosse J.
Heerschap, Arend
Figdor, Carl G.
Oyen, Wim J.
de Vries, I. Jolanda M.
author Aarntzen, Erik H. J. G.
author_facet Aarntzen, Erik H. J. G.
Srinivas, Mangala
Bonetto, Fernando Jose
Cruz, Luis J.
Verdijk, Pauline
Schreibelt, Gerty
Van de Rakt, Mandy
Lesterhuis, W. Joost
Van Riel, Maichel
Punt, Cornelius J. A.
Adema, Gosse J.
Heerschap, Arend
Figdor, Carl G.
Oyen, Wim J.
de Vries, I. Jolanda M.
author_role author
author2 Srinivas, Mangala
Bonetto, Fernando Jose
Cruz, Luis J.
Verdijk, Pauline
Schreibelt, Gerty
Van de Rakt, Mandy
Lesterhuis, W. Joost
Van Riel, Maichel
Punt, Cornelius J. A.
Adema, Gosse J.
Heerschap, Arend
Figdor, Carl G.
Oyen, Wim J.
de Vries, I. Jolanda M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Dendritic cells
19F magnetic resonance imaging
Migration
Immunotherapy
topic Dendritic cells
19F magnetic resonance imaging
Migration
Immunotherapy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Anti-cancer dendritic cell (DC) vaccines require the DC to relocate to lymph nodes (LN) to trigger immune responses. However, these migration rates are typically very poor. Improving the targeting of ex vivo generated DC to LN might increase vaccine efficacy and reduce costs. We investigated DC migration in vivo in humans in different conditions.
Fil: Aarntzen, Erik H. J. G.. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos; Leiden University. Department of Endocrinology; Países Bajos;
Fil: Srinivas, Mangala. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;
Fil: Bonetto, Fernando Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET- Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina;
Fil: Cruz, Luis J.. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos; Leiden University. Department of Endocrinology; Países Bajos;
Fil: Verdijk, Pauline. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos; National Institute for Public Health and the Environment. Departament of Vaccinology; Países Bajos;
Fil: Schreibelt, Gerty. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;
Fil: Van de Rakt, Mandy. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;
Fil: Lesterhuis, W. Joost. Radboud University Nijmegen Medical Centre. Department of Medical Oncology ; Países Bajos;
Fil: Van Riel, Maichel. Radboud Universiteit Nijmegen Medical Centre Department of Nuclear Medicine; Países Bajos;
Fil: Punt, Cornelius J. A.. Academic Medical Centre. Department of Medical Oncology; Países Bajos;
Fil: Adema, Gosse J.. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;
Fil: Heerschap, Arend. Radboud Universiteit Nijmegen. Department of Radiology; Paí­ses Bajos;
Fil: Figdor, Carl G.. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;
Fil: Oyen, Wim J.. Leiden University. Department of Endocrinology; Países Bajos;
Fil: de Vries, I. Jolanda M.. Radboud University Nijmegen Medical Centre. Nijmegen Centre for Molecular Life Sciences. Department of Tumor Immunology; Países Bajos;
description Anti-cancer dendritic cell (DC) vaccines require the DC to relocate to lymph nodes (LN) to trigger immune responses. However, these migration rates are typically very poor. Improving the targeting of ex vivo generated DC to LN might increase vaccine efficacy and reduce costs. We investigated DC migration in vivo in humans in different conditions.
publishDate 2013
dc.date.none.fl_str_mv 2013-03-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/2073
Aarntzen, Erik H. J. G.; Srinivas, Mangala; Bonetto, Fernando Jose; Cruz, Luis J.; Verdijk, Pauline; et al.; Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells; American Association for Cancer Research; Clinical Cancer Research; 19; 15-3-2013; 1525-1533
1078-0432
url http://hdl.handle.net/11336/2073
identifier_str_mv Aarntzen, Erik H. J. G.; Srinivas, Mangala; Bonetto, Fernando Jose; Cruz, Luis J.; Verdijk, Pauline; et al.; Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells; American Association for Cancer Research; Clinical Cancer Research; 19; 15-3-2013; 1525-1533
1078-0432
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/doi:10.1158/1078-0432.CCR-12-1879
info:eu-repo/semantics/altIdentifier/url/http://clincancerres.aacrjournals.org/content/19/6/1525.long
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for Cancer Research
publisher.none.fl_str_mv American Association for Cancer Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082647617437696
score 13.22299

Publicaciones similares