Is the metabolism of 25-hydroxyvitamin D(3) age-dependent in dairy cows?

Autores
Wilkens, Mirja; Cohrs, Imke; Lifschitz, Adrian Luis; Fraser, David R.; Olszewski, Katharina; Schoeder, Bernd; Breves, Gerhard
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It has recently been demonstrated that prepartum administered 25-hydroxyvitamin D3 (25-OHD3) is a promising candidate to assist the maintenance of peripartal calcium homeostasis in dairy cows. Since the incidence of peripartal hypocalcemia and the reported beneficial effects of the treatment are both associated with the lactation number, we investigated pharmacokinetic aspects of 25-OHD3 related to the age of dairy cows. The daily oral administration of 3mg 25-OHD3 in rapeseed oil as well as a treatment with 4 and 6mg included in the feed during the last eight to ten days of gestation resulted in linear dosage- and age-dependent increases in plasma 25-OHD3. After parturition the administration was stopped and blood samples were taken to calculate the plasma half-life. Irrespective of the supplemented dosage, cows starting the 2nd lactation showed a significantly longer plasma half-life of 25-OHD3 than cows starting the 3rd or higher lactation. Age-dependent differences in the increase of plasma 25-OHD3 could already be found before parturition when calcium homeostasis was not yet significantly challenged. Additionally, no correlations between plasma half-life of 25-OHD3 and 1,25-dihydroxyvitamin D3, PTH or the bone resorption marker CrossLaps were observed after parturition. Thus we conclude that the influence of the lactation number on the pharmacokinetics of 25-OHD3 is related directly to the age of the cows. This article is part of a Special Issue entitled ´Vitamin D Workshop´.
Fil: Wilkens, Mirja. University of Veterinary Medicine Hannover. Department of Physiology; Alemania
Fil: Cohrs, Imke. University of Veterinary Medicine Hannover. Department of Physiology; Alemania
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires.. Facultad de Ciencias Veterinarias; Argentina
Fil: Fraser, David R.. University of Sydney. Faculty of Veterinary Science; Australia
Fil: Olszewski, Katharina. DSM Nutritional Products; Suiza
Fil: Schoeder, Bernd. University of Veterinary Medicine Hannover. Department of Physiology; Alemania
Fil: Breves, Gerhard. University of Veterinary Medicine Hannover. Department of Physiology; Alemania
Materia
25-Hydroxyvitamin D
Metabolism
Cattle
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/4687
Acceder
id CONICETDig_812a49a072c8719f59da7495ebc3cfb0
oai_identifier_str oai:ri.conicet.gov.ar:11336/4687
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Is the metabolism of 25-hydroxyvitamin D(3) age-dependent in dairy cows?Wilkens, MirjaCohrs, ImkeLifschitz, Adrian LuisFraser, David R.Olszewski, KatharinaSchoeder, BerndBreves, Gerhard25-Hydroxyvitamin DMetabolismCattlehttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4It has recently been demonstrated that prepartum administered 25-hydroxyvitamin D3 (25-OHD3) is a promising candidate to assist the maintenance of peripartal calcium homeostasis in dairy cows. Since the incidence of peripartal hypocalcemia and the reported beneficial effects of the treatment are both associated with the lactation number, we investigated pharmacokinetic aspects of 25-OHD3 related to the age of dairy cows. The daily oral administration of 3mg 25-OHD3 in rapeseed oil as well as a treatment with 4 and 6mg included in the feed during the last eight to ten days of gestation resulted in linear dosage- and age-dependent increases in plasma 25-OHD3. After parturition the administration was stopped and blood samples were taken to calculate the plasma half-life. Irrespective of the supplemented dosage, cows starting the 2nd lactation showed a significantly longer plasma half-life of 25-OHD3 than cows starting the 3rd or higher lactation. Age-dependent differences in the increase of plasma 25-OHD3 could already be found before parturition when calcium homeostasis was not yet significantly challenged. Additionally, no correlations between plasma half-life of 25-OHD3 and 1,25-dihydroxyvitamin D3, PTH or the bone resorption marker CrossLaps were observed after parturition. Thus we conclude that the influence of the lactation number on the pharmacokinetics of 25-OHD3 is related directly to the age of the cows. This article is part of a Special Issue entitled ´Vitamin D Workshop´.Fil: Wilkens, Mirja. University of Veterinary Medicine Hannover. Department of Physiology; AlemaniaFil: Cohrs, Imke. University of Veterinary Medicine Hannover. Department of Physiology; AlemaniaFil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires.. Facultad de Ciencias Veterinarias; ArgentinaFil: Fraser, David R.. University of Sydney. Faculty of Veterinary Science; AustraliaFil: Olszewski, Katharina. DSM Nutritional Products; SuizaFil: Schoeder, Bernd. University of Veterinary Medicine Hannover. Department of Physiology; AlemaniaFil: Breves, Gerhard. University of Veterinary Medicine Hannover. Department of Physiology; AlemaniaElsevier2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4687Wilkens, Mirja; Cohrs, Imke; Lifschitz, Adrian Luis; Fraser, David R.; Olszewski, Katharina; et al.; Is the metabolism of 25-hydroxyvitamin D(3) age-dependent in dairy cows?; Elsevier; Journal of Steroid Biochemistry and Molecular Biology; 136; 7-2013; 44-460960-0760enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960076012002464info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jsbmb.2012.11.013info:eu-repo/semantics/altIdentifier/issn/0960-0760info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:37:16Zoai:ri.conicet.gov.ar:11336/4687instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:37:16.459CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Is the metabolism of 25-hydroxyvitamin D(3) age-dependent in dairy cows?
title Is the metabolism of 25-hydroxyvitamin D(3) age-dependent in dairy cows?
spellingShingle Is the metabolism of 25-hydroxyvitamin D(3) age-dependent in dairy cows?
Wilkens, Mirja
25-Hydroxyvitamin D
Metabolism
Cattle
title_short Is the metabolism of 25-hydroxyvitamin D(3) age-dependent in dairy cows?
title_full Is the metabolism of 25-hydroxyvitamin D(3) age-dependent in dairy cows?
title_fullStr Is the metabolism of 25-hydroxyvitamin D(3) age-dependent in dairy cows?
title_full_unstemmed Is the metabolism of 25-hydroxyvitamin D(3) age-dependent in dairy cows?
title_sort Is the metabolism of 25-hydroxyvitamin D(3) age-dependent in dairy cows?
dc.creator.none.fl_str_mv Wilkens, Mirja
Cohrs, Imke
Lifschitz, Adrian Luis
Fraser, David R.
Olszewski, Katharina
Schoeder, Bernd
Breves, Gerhard
author Wilkens, Mirja
author_facet Wilkens, Mirja
Cohrs, Imke
Lifschitz, Adrian Luis
Fraser, David R.
Olszewski, Katharina
Schoeder, Bernd
Breves, Gerhard
author_role author
author2 Cohrs, Imke
Lifschitz, Adrian Luis
Fraser, David R.
Olszewski, Katharina
Schoeder, Bernd
Breves, Gerhard
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv 25-Hydroxyvitamin D
Metabolism
Cattle
topic 25-Hydroxyvitamin D
Metabolism
Cattle
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv It has recently been demonstrated that prepartum administered 25-hydroxyvitamin D3 (25-OHD3) is a promising candidate to assist the maintenance of peripartal calcium homeostasis in dairy cows. Since the incidence of peripartal hypocalcemia and the reported beneficial effects of the treatment are both associated with the lactation number, we investigated pharmacokinetic aspects of 25-OHD3 related to the age of dairy cows. The daily oral administration of 3mg 25-OHD3 in rapeseed oil as well as a treatment with 4 and 6mg included in the feed during the last eight to ten days of gestation resulted in linear dosage- and age-dependent increases in plasma 25-OHD3. After parturition the administration was stopped and blood samples were taken to calculate the plasma half-life. Irrespective of the supplemented dosage, cows starting the 2nd lactation showed a significantly longer plasma half-life of 25-OHD3 than cows starting the 3rd or higher lactation. Age-dependent differences in the increase of plasma 25-OHD3 could already be found before parturition when calcium homeostasis was not yet significantly challenged. Additionally, no correlations between plasma half-life of 25-OHD3 and 1,25-dihydroxyvitamin D3, PTH or the bone resorption marker CrossLaps were observed after parturition. Thus we conclude that the influence of the lactation number on the pharmacokinetics of 25-OHD3 is related directly to the age of the cows. This article is part of a Special Issue entitled ´Vitamin D Workshop´.
Fil: Wilkens, Mirja. University of Veterinary Medicine Hannover. Department of Physiology; Alemania
Fil: Cohrs, Imke. University of Veterinary Medicine Hannover. Department of Physiology; Alemania
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tandil. Centro de Investigacion Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires.. Facultad de Ciencias Veterinarias; Argentina
Fil: Fraser, David R.. University of Sydney. Faculty of Veterinary Science; Australia
Fil: Olszewski, Katharina. DSM Nutritional Products; Suiza
Fil: Schoeder, Bernd. University of Veterinary Medicine Hannover. Department of Physiology; Alemania
Fil: Breves, Gerhard. University of Veterinary Medicine Hannover. Department of Physiology; Alemania
description It has recently been demonstrated that prepartum administered 25-hydroxyvitamin D3 (25-OHD3) is a promising candidate to assist the maintenance of peripartal calcium homeostasis in dairy cows. Since the incidence of peripartal hypocalcemia and the reported beneficial effects of the treatment are both associated with the lactation number, we investigated pharmacokinetic aspects of 25-OHD3 related to the age of dairy cows. The daily oral administration of 3mg 25-OHD3 in rapeseed oil as well as a treatment with 4 and 6mg included in the feed during the last eight to ten days of gestation resulted in linear dosage- and age-dependent increases in plasma 25-OHD3. After parturition the administration was stopped and blood samples were taken to calculate the plasma half-life. Irrespective of the supplemented dosage, cows starting the 2nd lactation showed a significantly longer plasma half-life of 25-OHD3 than cows starting the 3rd or higher lactation. Age-dependent differences in the increase of plasma 25-OHD3 could already be found before parturition when calcium homeostasis was not yet significantly challenged. Additionally, no correlations between plasma half-life of 25-OHD3 and 1,25-dihydroxyvitamin D3, PTH or the bone resorption marker CrossLaps were observed after parturition. Thus we conclude that the influence of the lactation number on the pharmacokinetics of 25-OHD3 is related directly to the age of the cows. This article is part of a Special Issue entitled ´Vitamin D Workshop´.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/4687
Wilkens, Mirja; Cohrs, Imke; Lifschitz, Adrian Luis; Fraser, David R.; Olszewski, Katharina; et al.; Is the metabolism of 25-hydroxyvitamin D(3) age-dependent in dairy cows?; Elsevier; Journal of Steroid Biochemistry and Molecular Biology; 136; 7-2013; 44-46
0960-0760
url http://hdl.handle.net/11336/4687
identifier_str_mv Wilkens, Mirja; Cohrs, Imke; Lifschitz, Adrian Luis; Fraser, David R.; Olszewski, Katharina; et al.; Is the metabolism of 25-hydroxyvitamin D(3) age-dependent in dairy cows?; Elsevier; Journal of Steroid Biochemistry and Molecular Biology; 136; 7-2013; 44-46
0960-0760
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960076012002464
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jsbmb.2012.11.013
info:eu-repo/semantics/altIdentifier/issn/0960-0760
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614392720654336
score 13.070432

Publicaciones similares