Negative association between 25-hydroxy vitamin d and inflammatory markers in rheumatologic diseases

Autores
Brance, María Lorena; Larroudé, María Silvia; Berbotto, Guillermo; Sacnun, Mónica P.; Aeschlimann, Carolina; Palatnik, M.; Chavero, Ignacio; Sánchez, Ariel; Brun, Lucas Ricardo Martín
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective The main purpose of this study was to evaluate serum 25-hydroxyvitamin D (25OHD) levels and its association with in"ammatory markers in patients with rheumatologic diseases (RD). Methods A cross-sectional study in 154 women with RD (rheumatoid arthritis, spondyloarthritis and other connective tissue diseases) and 112 healthy individuals as a control group (CG) was carried out. Results No differences in serum and urine calcium, serum phosphate, and urinary deoxypyridinoline were found. RD group had lower 25OHD and higher PTH compared to CG. RD group had higher C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) compared to CG. The overall mean level of 25OHD (ng/ml) was 26.3±12.0 in the CG and 19.4±6.8 in the RD group (p<0.0001). Moreover, CG had lower percentage of individuals with 25OHD de!ciency compared to RD (29.9% vs 53.2%). The femoral neck BMD was signi!cantly lower in postmenopausal RD women compared to CG. 25OHD levels signi!cantly correlated with ESR and CRP as in"ammatory markers. Age, BMI, presence of RD, and CRP were signi!cantly and negatively associated with 25OHD levels through linear regression analysis. According to univariate logistic regression analysis for 25OHD de!ciency (<20 ng/ml), a signi!cant and negative association with BMI, presence of RD, ESR and CRP were found. Conclusion Patients with RD had lower 25OHD levels than controls and the presence of a RD increases by 2.66 the risk of vitamin D de!ciency. In addition, 25OHD has a negative correlation with ESR and CRP as in"ammatory markers.
Fil: Brance, María Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Reumatología y Enfermedades Óseas; Argentina
Fil: Larroudé, María Silvia. Centro de Diagnostico Rossi; Argentina
Fil: Berbotto, Guillermo. Sanatorio Británico de Rosario; Argentina
Fil: Sacnun, Mónica P.. Hospital Provincial de Rosario; Argentina
Fil: Aeschlimann, Carolina. Hospital Provincial de Rosario; Argentina
Fil: Palatnik, M.. Centro de Reumatologia; Argentina
Fil: Chavero, Ignacio. Reumatología y Enfermedades Óseas; Argentina
Fil: Sánchez, Ariel. Centro de Endocrinología; Argentina
Fil: Brun, Lucas Ricardo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Materia
25-HYDROXYVITAMIN D
RHEUMATOLOGIC DISEASES
INFLAMMATORY MARKERS
C-REACTIVE PROTEIN
ERYTHROCYTE SEDIMENTATION RATE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/164101
Acceder
id CONICETDig_7b4fd9b1a722ac6584a5a2ca864db553
oai_identifier_str oai:ri.conicet.gov.ar:11336/164101
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Negative association between 25-hydroxy vitamin d and inflammatory markers in rheumatologic diseasesAsociación negativa entre 25-Hidroxi vitamina D y los marcadores inflamatorios en enfermedades reumatológicasBrance, María LorenaLarroudé, María SilviaBerbotto, GuillermoSacnun, Mónica P.Aeschlimann, CarolinaPalatnik, M.Chavero, IgnacioSánchez, ArielBrun, Lucas Ricardo Martín25-HYDROXYVITAMIN DRHEUMATOLOGIC DISEASESINFLAMMATORY MARKERSC-REACTIVE PROTEINERYTHROCYTE SEDIMENTATION RATEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective The main purpose of this study was to evaluate serum 25-hydroxyvitamin D (25OHD) levels and its association with in"ammatory markers in patients with rheumatologic diseases (RD). Methods A cross-sectional study in 154 women with RD (rheumatoid arthritis, spondyloarthritis and other connective tissue diseases) and 112 healthy individuals as a control group (CG) was carried out. Results No differences in serum and urine calcium, serum phosphate, and urinary deoxypyridinoline were found. RD group had lower 25OHD and higher PTH compared to CG. RD group had higher C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) compared to CG. The overall mean level of 25OHD (ng/ml) was 26.3±12.0 in the CG and 19.4±6.8 in the RD group (p<0.0001). Moreover, CG had lower percentage of individuals with 25OHD de!ciency compared to RD (29.9% vs 53.2%). The femoral neck BMD was signi!cantly lower in postmenopausal RD women compared to CG. 25OHD levels signi!cantly correlated with ESR and CRP as in"ammatory markers. Age, BMI, presence of RD, and CRP were signi!cantly and negatively associated with 25OHD levels through linear regression analysis. According to univariate logistic regression analysis for 25OHD de!ciency (<20 ng/ml), a signi!cant and negative association with BMI, presence of RD, ESR and CRP were found. Conclusion Patients with RD had lower 25OHD levels than controls and the presence of a RD increases by 2.66 the risk of vitamin D de!ciency. In addition, 25OHD has a negative correlation with ESR and CRP as in"ammatory markers.Fil: Brance, María Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Reumatología y Enfermedades Óseas; ArgentinaFil: Larroudé, María Silvia. Centro de Diagnostico Rossi; ArgentinaFil: Berbotto, Guillermo. Sanatorio Británico de Rosario; ArgentinaFil: Sacnun, Mónica P.. Hospital Provincial de Rosario; ArgentinaFil: Aeschlimann, Carolina. Hospital Provincial de Rosario; ArgentinaFil: Palatnik, M.. Centro de Reumatologia; ArgentinaFil: Chavero, Ignacio. Reumatología y Enfermedades Óseas; ArgentinaFil: Sánchez, Ariel. Centro de Endocrinología; ArgentinaFil: Brun, Lucas Ricardo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; ArgentinaAsociación Argentina de Osteología y Metabolismo Mineral2021-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/164101Brance, María Lorena; Larroudé, María Silvia; Berbotto, Guillermo; Sacnun, Mónica P.; Aeschlimann, Carolina; et al.; Negative association between 25-hydroxy vitamin d and inflammatory markers in rheumatologic diseases; Asociación Argentina de Osteología y Metabolismo Mineral; Actualizaciones en Osteología; 17; 1; 7-2021; 8-171669-89751669-8983CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://osteologia.org.ar/articulo/3160/asociaci-n-negativa-entre-25-hidroxi-vitamina-d-y-los-marcadores-inflamatorios-en-enfermedades-reumatol-gicasinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:45:34Zoai:ri.conicet.gov.ar:11336/164101instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:45:35.264CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Negative association between 25-hydroxy vitamin d and inflammatory markers in rheumatologic diseases
Asociación negativa entre 25-Hidroxi vitamina D y los marcadores inflamatorios en enfermedades reumatológicas
title Negative association between 25-hydroxy vitamin d and inflammatory markers in rheumatologic diseases
spellingShingle Negative association between 25-hydroxy vitamin d and inflammatory markers in rheumatologic diseases
Brance, María Lorena
25-HYDROXYVITAMIN D
RHEUMATOLOGIC DISEASES
INFLAMMATORY MARKERS
C-REACTIVE PROTEIN
ERYTHROCYTE SEDIMENTATION RATE
title_short Negative association between 25-hydroxy vitamin d and inflammatory markers in rheumatologic diseases
title_full Negative association between 25-hydroxy vitamin d and inflammatory markers in rheumatologic diseases
title_fullStr Negative association between 25-hydroxy vitamin d and inflammatory markers in rheumatologic diseases
title_full_unstemmed Negative association between 25-hydroxy vitamin d and inflammatory markers in rheumatologic diseases
title_sort Negative association between 25-hydroxy vitamin d and inflammatory markers in rheumatologic diseases
dc.creator.none.fl_str_mv Brance, María Lorena
Larroudé, María Silvia
Berbotto, Guillermo
Sacnun, Mónica P.
Aeschlimann, Carolina
Palatnik, M.
Chavero, Ignacio
Sánchez, Ariel
Brun, Lucas Ricardo Martín
author Brance, María Lorena
author_facet Brance, María Lorena
Larroudé, María Silvia
Berbotto, Guillermo
Sacnun, Mónica P.
Aeschlimann, Carolina
Palatnik, M.
Chavero, Ignacio
Sánchez, Ariel
Brun, Lucas Ricardo Martín
author_role author
author2 Larroudé, María Silvia
Berbotto, Guillermo
Sacnun, Mónica P.
Aeschlimann, Carolina
Palatnik, M.
Chavero, Ignacio
Sánchez, Ariel
Brun, Lucas Ricardo Martín
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv 25-HYDROXYVITAMIN D
RHEUMATOLOGIC DISEASES
INFLAMMATORY MARKERS
C-REACTIVE PROTEIN
ERYTHROCYTE SEDIMENTATION RATE
topic 25-HYDROXYVITAMIN D
RHEUMATOLOGIC DISEASES
INFLAMMATORY MARKERS
C-REACTIVE PROTEIN
ERYTHROCYTE SEDIMENTATION RATE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective The main purpose of this study was to evaluate serum 25-hydroxyvitamin D (25OHD) levels and its association with in"ammatory markers in patients with rheumatologic diseases (RD). Methods A cross-sectional study in 154 women with RD (rheumatoid arthritis, spondyloarthritis and other connective tissue diseases) and 112 healthy individuals as a control group (CG) was carried out. Results No differences in serum and urine calcium, serum phosphate, and urinary deoxypyridinoline were found. RD group had lower 25OHD and higher PTH compared to CG. RD group had higher C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) compared to CG. The overall mean level of 25OHD (ng/ml) was 26.3±12.0 in the CG and 19.4±6.8 in the RD group (p<0.0001). Moreover, CG had lower percentage of individuals with 25OHD de!ciency compared to RD (29.9% vs 53.2%). The femoral neck BMD was signi!cantly lower in postmenopausal RD women compared to CG. 25OHD levels signi!cantly correlated with ESR and CRP as in"ammatory markers. Age, BMI, presence of RD, and CRP were signi!cantly and negatively associated with 25OHD levels through linear regression analysis. According to univariate logistic regression analysis for 25OHD de!ciency (<20 ng/ml), a signi!cant and negative association with BMI, presence of RD, ESR and CRP were found. Conclusion Patients with RD had lower 25OHD levels than controls and the presence of a RD increases by 2.66 the risk of vitamin D de!ciency. In addition, 25OHD has a negative correlation with ESR and CRP as in"ammatory markers.
Fil: Brance, María Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Reumatología y Enfermedades Óseas; Argentina
Fil: Larroudé, María Silvia. Centro de Diagnostico Rossi; Argentina
Fil: Berbotto, Guillermo. Sanatorio Británico de Rosario; Argentina
Fil: Sacnun, Mónica P.. Hospital Provincial de Rosario; Argentina
Fil: Aeschlimann, Carolina. Hospital Provincial de Rosario; Argentina
Fil: Palatnik, M.. Centro de Reumatologia; Argentina
Fil: Chavero, Ignacio. Reumatología y Enfermedades Óseas; Argentina
Fil: Sánchez, Ariel. Centro de Endocrinología; Argentina
Fil: Brun, Lucas Ricardo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
description Objective The main purpose of this study was to evaluate serum 25-hydroxyvitamin D (25OHD) levels and its association with in"ammatory markers in patients with rheumatologic diseases (RD). Methods A cross-sectional study in 154 women with RD (rheumatoid arthritis, spondyloarthritis and other connective tissue diseases) and 112 healthy individuals as a control group (CG) was carried out. Results No differences in serum and urine calcium, serum phosphate, and urinary deoxypyridinoline were found. RD group had lower 25OHD and higher PTH compared to CG. RD group had higher C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) compared to CG. The overall mean level of 25OHD (ng/ml) was 26.3±12.0 in the CG and 19.4±6.8 in the RD group (p<0.0001). Moreover, CG had lower percentage of individuals with 25OHD de!ciency compared to RD (29.9% vs 53.2%). The femoral neck BMD was signi!cantly lower in postmenopausal RD women compared to CG. 25OHD levels signi!cantly correlated with ESR and CRP as in"ammatory markers. Age, BMI, presence of RD, and CRP were signi!cantly and negatively associated with 25OHD levels through linear regression analysis. According to univariate logistic regression analysis for 25OHD de!ciency (<20 ng/ml), a signi!cant and negative association with BMI, presence of RD, ESR and CRP were found. Conclusion Patients with RD had lower 25OHD levels than controls and the presence of a RD increases by 2.66 the risk of vitamin D de!ciency. In addition, 25OHD has a negative correlation with ESR and CRP as in"ammatory markers.
publishDate 2021
dc.date.none.fl_str_mv 2021-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/164101
Brance, María Lorena; Larroudé, María Silvia; Berbotto, Guillermo; Sacnun, Mónica P.; Aeschlimann, Carolina; et al.; Negative association between 25-hydroxy vitamin d and inflammatory markers in rheumatologic diseases; Asociación Argentina de Osteología y Metabolismo Mineral; Actualizaciones en Osteología; 17; 1; 7-2021; 8-17
1669-8975
1669-8983
CONICET Digital
CONICET
url http://hdl.handle.net/11336/164101
identifier_str_mv Brance, María Lorena; Larroudé, María Silvia; Berbotto, Guillermo; Sacnun, Mónica P.; Aeschlimann, Carolina; et al.; Negative association between 25-hydroxy vitamin d and inflammatory markers in rheumatologic diseases; Asociación Argentina de Osteología y Metabolismo Mineral; Actualizaciones en Osteología; 17; 1; 7-2021; 8-17
1669-8975
1669-8983
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://osteologia.org.ar/articulo/3160/asociaci-n-negativa-entre-25-hidroxi-vitamina-d-y-los-marcadores-inflamatorios-en-enfermedades-reumatol-gicas
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Asociación Argentina de Osteología y Metabolismo Mineral
publisher.none.fl_str_mv Asociación Argentina de Osteología y Metabolismo Mineral
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.24909

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