Inferring continental ancestry of argentineans from autosomal, y-chromosomal and mitochondrial dna

Autores
Corach, Daniel; Lao, Oscar; Bobillo, Maria Cecilia; Gaag, Kristiaan van Der; Zuniga, Sofia; Vermeulen, Mark; Duijn, Kate van; Goedbloed, Miriam; Vallone, Peter M.; Parson, Walther; Knijff, Peter de; Kayser, Manfred
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We investigated the bio-geographic ancestry of Argentineans, and quantified their genetic admixture, analyzing 246 unrelated male individuals from eight provinces of three Argentinean regions using ancestry-sensitive DNA markers (ASDM) from autosomal, Y and mitochondrial chromosomes. Our results demonstrate that European, Native American and African ancestry components were detectable in the contemporary Argentineans, the amounts depending on the genetic system applied, exhibiting large inter-individual heterogeneity. Argentineans carried a large fraction of European genetic heritage in their Y-chromosomal (94.1%) and autosomal (78.5%) DNA, but their mitochondrial gene pool is mostly of Native American ancestry (53.7%); instead, African heritage was small in all three genetic systems (<4%). Population substructure in Argentina considering the eight sampled provinces was very small based on autosomal (0.92% of total variation was between provincial groups, p = 0.005) and mtDNA (1.77%, p = 0.005) data (none with NRY data), and all three genetic systems revealed no substructure when clustering the provinces into the three geographic regions to which they belong. The complex genetic ancestry picture detected in Argentineans underscores the need to apply ASDM from all three genetic systems to infer geographic origins and genetic admixture. This applies to all worldwide areas where people with different continental ancestry live geographically close together.
Fil: Corach, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lao, Oscar. Erasmus University Medical Center Rotterdam; Países Bajos
Fil: Bobillo, Maria Cecilia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gaag, Kristiaan van Der. Leiden University Medical Center; Países Bajos
Fil: Zuniga, Sofia. Leiden University Medical Center; Países Bajos
Fil: Vermeulen, Mark. Erasmus University Medical Center Rotterdam; Países Bajos
Fil: Duijn, Kate van. Erasmus University Medical Center Rotterdam; Países Bajos
Fil: Goedbloed, Miriam. Erasmus University Medical Center Rotterdam; Países Bajos
Fil: Vallone, Peter M.. National Institute of Standars and Technology. Biochemical Science Division; Estados Unidos
Fil: Parson, Walther. Innsbruck Medical University; Austria
Fil: Knijff, Peter de. Leiden University Medical Center; Países Bajos
Fil: Kayser, Manfred. Erasmus University Medical Center Rotterdam; Países Bajos
Materia
Argentina
Genetic Ancestry
Mtdna
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14301
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/14301
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Inferring continental ancestry of argentineans from autosomal, y-chromosomal and mitochondrial dnaCorach, DanielLao, OscarBobillo, Maria CeciliaGaag, Kristiaan van DerZuniga, SofiaVermeulen, MarkDuijn, Kate vanGoedbloed, MiriamVallone, Peter M.Parson, WaltherKnijff, Peter deKayser, ManfredArgentinaGenetic AncestryMtdnahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We investigated the bio-geographic ancestry of Argentineans, and quantified their genetic admixture, analyzing 246 unrelated male individuals from eight provinces of three Argentinean regions using ancestry-sensitive DNA markers (ASDM) from autosomal, Y and mitochondrial chromosomes. Our results demonstrate that European, Native American and African ancestry components were detectable in the contemporary Argentineans, the amounts depending on the genetic system applied, exhibiting large inter-individual heterogeneity. Argentineans carried a large fraction of European genetic heritage in their Y-chromosomal (94.1%) and autosomal (78.5%) DNA, but their mitochondrial gene pool is mostly of Native American ancestry (53.7%); instead, African heritage was small in all three genetic systems (<4%). Population substructure in Argentina considering the eight sampled provinces was very small based on autosomal (0.92% of total variation was between provincial groups, p = 0.005) and mtDNA (1.77%, p = 0.005) data (none with NRY data), and all three genetic systems revealed no substructure when clustering the provinces into the three geographic regions to which they belong. The complex genetic ancestry picture detected in Argentineans underscores the need to apply ASDM from all three genetic systems to infer geographic origins and genetic admixture. This applies to all worldwide areas where people with different continental ancestry live geographically close together.Fil: Corach, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lao, Oscar. Erasmus University Medical Center Rotterdam; Países BajosFil: Bobillo, Maria Cecilia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gaag, Kristiaan van Der. Leiden University Medical Center; Países BajosFil: Zuniga, Sofia. Leiden University Medical Center; Países BajosFil: Vermeulen, Mark. Erasmus University Medical Center Rotterdam; Países BajosFil: Duijn, Kate van. Erasmus University Medical Center Rotterdam; Países BajosFil: Goedbloed, Miriam. Erasmus University Medical Center Rotterdam; Países BajosFil: Vallone, Peter M.. National Institute of Standars and Technology. Biochemical Science Division; Estados UnidosFil: Parson, Walther. Innsbruck Medical University; AustriaFil: Knijff, Peter de. Leiden University Medical Center; Países BajosFil: Kayser, Manfred. Erasmus University Medical Center Rotterdam; Países BajosWiley2010-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14301Corach, Daniel; Lao, Oscar; Bobillo, Maria Cecilia; Gaag, Kristiaan van Der; Zuniga, Sofia; et al.; Inferring continental ancestry of argentineans from autosomal, y-chromosomal and mitochondrial dna; Wiley; Annals Of Human Genetics; 74; 1; 1-2010; 65-760003-48001469-1809enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1469-1809.2009.00556.x/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1469-1809.2009.00556.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:36:56Zoai:ri.conicet.gov.ar:11336/14301instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:36:57.088CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Inferring continental ancestry of argentineans from autosomal, y-chromosomal and mitochondrial dna
title Inferring continental ancestry of argentineans from autosomal, y-chromosomal and mitochondrial dna
spellingShingle Inferring continental ancestry of argentineans from autosomal, y-chromosomal and mitochondrial dna
Corach, Daniel
Argentina
Genetic Ancestry
Mtdna
title_short Inferring continental ancestry of argentineans from autosomal, y-chromosomal and mitochondrial dna
title_full Inferring continental ancestry of argentineans from autosomal, y-chromosomal and mitochondrial dna
title_fullStr Inferring continental ancestry of argentineans from autosomal, y-chromosomal and mitochondrial dna
title_full_unstemmed Inferring continental ancestry of argentineans from autosomal, y-chromosomal and mitochondrial dna
title_sort Inferring continental ancestry of argentineans from autosomal, y-chromosomal and mitochondrial dna
dc.creator.none.fl_str_mv Corach, Daniel
Lao, Oscar
Bobillo, Maria Cecilia
Gaag, Kristiaan van Der
Zuniga, Sofia
Vermeulen, Mark
Duijn, Kate van
Goedbloed, Miriam
Vallone, Peter M.
Parson, Walther
Knijff, Peter de
Kayser, Manfred
author Corach, Daniel
author_facet Corach, Daniel
Lao, Oscar
Bobillo, Maria Cecilia
Gaag, Kristiaan van Der
Zuniga, Sofia
Vermeulen, Mark
Duijn, Kate van
Goedbloed, Miriam
Vallone, Peter M.
Parson, Walther
Knijff, Peter de
Kayser, Manfred
author_role author
author2 Lao, Oscar
Bobillo, Maria Cecilia
Gaag, Kristiaan van Der
Zuniga, Sofia
Vermeulen, Mark
Duijn, Kate van
Goedbloed, Miriam
Vallone, Peter M.
Parson, Walther
Knijff, Peter de
Kayser, Manfred
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Argentina
Genetic Ancestry
Mtdna
topic Argentina
Genetic Ancestry
Mtdna
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We investigated the bio-geographic ancestry of Argentineans, and quantified their genetic admixture, analyzing 246 unrelated male individuals from eight provinces of three Argentinean regions using ancestry-sensitive DNA markers (ASDM) from autosomal, Y and mitochondrial chromosomes. Our results demonstrate that European, Native American and African ancestry components were detectable in the contemporary Argentineans, the amounts depending on the genetic system applied, exhibiting large inter-individual heterogeneity. Argentineans carried a large fraction of European genetic heritage in their Y-chromosomal (94.1%) and autosomal (78.5%) DNA, but their mitochondrial gene pool is mostly of Native American ancestry (53.7%); instead, African heritage was small in all three genetic systems (<4%). Population substructure in Argentina considering the eight sampled provinces was very small based on autosomal (0.92% of total variation was between provincial groups, p = 0.005) and mtDNA (1.77%, p = 0.005) data (none with NRY data), and all three genetic systems revealed no substructure when clustering the provinces into the three geographic regions to which they belong. The complex genetic ancestry picture detected in Argentineans underscores the need to apply ASDM from all three genetic systems to infer geographic origins and genetic admixture. This applies to all worldwide areas where people with different continental ancestry live geographically close together.
Fil: Corach, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lao, Oscar. Erasmus University Medical Center Rotterdam; Países Bajos
Fil: Bobillo, Maria Cecilia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gaag, Kristiaan van Der. Leiden University Medical Center; Países Bajos
Fil: Zuniga, Sofia. Leiden University Medical Center; Países Bajos
Fil: Vermeulen, Mark. Erasmus University Medical Center Rotterdam; Países Bajos
Fil: Duijn, Kate van. Erasmus University Medical Center Rotterdam; Países Bajos
Fil: Goedbloed, Miriam. Erasmus University Medical Center Rotterdam; Países Bajos
Fil: Vallone, Peter M.. National Institute of Standars and Technology. Biochemical Science Division; Estados Unidos
Fil: Parson, Walther. Innsbruck Medical University; Austria
Fil: Knijff, Peter de. Leiden University Medical Center; Países Bajos
Fil: Kayser, Manfred. Erasmus University Medical Center Rotterdam; Países Bajos
description We investigated the bio-geographic ancestry of Argentineans, and quantified their genetic admixture, analyzing 246 unrelated male individuals from eight provinces of three Argentinean regions using ancestry-sensitive DNA markers (ASDM) from autosomal, Y and mitochondrial chromosomes. Our results demonstrate that European, Native American and African ancestry components were detectable in the contemporary Argentineans, the amounts depending on the genetic system applied, exhibiting large inter-individual heterogeneity. Argentineans carried a large fraction of European genetic heritage in their Y-chromosomal (94.1%) and autosomal (78.5%) DNA, but their mitochondrial gene pool is mostly of Native American ancestry (53.7%); instead, African heritage was small in all three genetic systems (<4%). Population substructure in Argentina considering the eight sampled provinces was very small based on autosomal (0.92% of total variation was between provincial groups, p = 0.005) and mtDNA (1.77%, p = 0.005) data (none with NRY data), and all three genetic systems revealed no substructure when clustering the provinces into the three geographic regions to which they belong. The complex genetic ancestry picture detected in Argentineans underscores the need to apply ASDM from all three genetic systems to infer geographic origins and genetic admixture. This applies to all worldwide areas where people with different continental ancestry live geographically close together.
publishDate 2010
dc.date.none.fl_str_mv 2010-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14301
Corach, Daniel; Lao, Oscar; Bobillo, Maria Cecilia; Gaag, Kristiaan van Der; Zuniga, Sofia; et al.; Inferring continental ancestry of argentineans from autosomal, y-chromosomal and mitochondrial dna; Wiley; Annals Of Human Genetics; 74; 1; 1-2010; 65-76
0003-4800
1469-1809
url http://hdl.handle.net/11336/14301
identifier_str_mv Corach, Daniel; Lao, Oscar; Bobillo, Maria Cecilia; Gaag, Kristiaan van Der; Zuniga, Sofia; et al.; Inferring continental ancestry of argentineans from autosomal, y-chromosomal and mitochondrial dna; Wiley; Annals Of Human Genetics; 74; 1; 1-2010; 65-76
0003-4800
1469-1809
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1469-1809.2009.00556.x/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1469-1809.2009.00556.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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