Maternal admixture and population structure in Mexican-mestizos based on mtDNA haplogroups

Autores
Martínez Cortés, Gabriela; Salazar Flores, Joel; Haro Guerrero, Javier; Rubi Castellanos, Rodrigo; Velarde Félix, Jesus S.; Muñoz Valle, Jose F.; López Casamichana, Mavil; Carrillo Tapia, Eduardo; Casenco Avila, Luis M.; Bravi, Claudio Marcelo; López Armenta, Mauro; Rangel Villalobos, Hector
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The maternal ancestry (mtDNA) has important applications in different research fields, such as evolution, epidemiology, identification, and human population history. This is particularly interesting in Mestizos, which constitute the main population in Mexico (∼93%) resulting from post-Columbian admixture between Spaniards, Amerindians, and African slaves, principally. Consequently, we conducted minisequencing analysis (SNaPshot) of 11 mitochondrial single-nucleotide polymorphisms in 742 Mestizos of 10 populations from different regions in Mexico. The predominant maternal ancestry was Native American (92.9%), including Haplogroups A, B, C, and D (47, 23.7, 15.9, and 6.2%, respectively). Conversely, European and African ancestries were less frequent (5.3 and 1.9%, respectively). The main characteristics of the maternal lineages observed in Mexican–Mestizos comprised the following: 1) contrasting geographic gradient of Haplogroups A and C; 2) increase of European lineages toward the Northwest; 3) low or absent, but homogeneous, African ancestry throughout the Mexican territory; 4) maternal lineages in Mestizos roughly represent the genetic makeup of the surrounding Amerindian groups, particularly toward the Southeast, but not in the North and West; 5) continuity over time of the geographic distribution of Amerindian lineages in Mayas; and 6) low but significant maternal population structure (FST = 2.8%; P = 0.0000). The average ancestry obtained from uniparental systems (mtDNA and Y-chromosome) in Mexican–Mestizos was correlated with previous ancestry estimates based on autosomal systems (genome-wide single-nucleotide polymorphisms and short tandem repeats). Finally, the comparison of paternal and maternal lineages provided additional information concerning the gender bias admixture, mating patterns, and population structure in Mestizos throughout the Mexican territory. Am J Phys Anthropol.
Fil: Martínez Cortés, Gabriela. Universidad de Guadalajara; México
Fil: Salazar Flores, Joel. Universidad de Guadalajara; México
Fil: Haro Guerrero, Javier. Universidad de Guadalajara; México
Fil: Rubi Castellanos, Rodrigo. Universidad de Guadalajara; México
Fil: Velarde Félix, Jesus S.. Universidad Autonoma de Sinaloa; México
Fil: Muñoz Valle, Jose F.. Universidad de Guadalajara; México
Fil: López Casamichana, Mavil. Universidad Nacional Autónoma de México; México
Fil: Carrillo Tapia, Eduardo. Universidad Nacional Autónoma de México; México
Fil: Casenco Avila, Luis M.. Hospital Regional de Alta Especialidad. Laboratorio de Investigación; México
Fil: Bravi, Claudio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: López Armenta, Mauro. Universidad Nacional Autónoma de México; México
Fil: Rangel Villalobos, Hector. Universidad de Guadalajara; México
Materia
Mtdna Ancestry
Maternal Admixture
Mexican-Mestizo
Mtsnps
Y-Snps
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23928
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/23928
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Maternal admixture and population structure in Mexican-mestizos based on mtDNA haplogroupsMartínez Cortés, GabrielaSalazar Flores, JoelHaro Guerrero, JavierRubi Castellanos, RodrigoVelarde Félix, Jesus S.Muñoz Valle, Jose F.López Casamichana, MavilCarrillo Tapia, EduardoCasenco Avila, Luis M.Bravi, Claudio MarceloLópez Armenta, MauroRangel Villalobos, HectorMtdna AncestryMaternal AdmixtureMexican-MestizoMtsnpsY-Snpshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The maternal ancestry (mtDNA) has important applications in different research fields, such as evolution, epidemiology, identification, and human population history. This is particularly interesting in Mestizos, which constitute the main population in Mexico (∼93%) resulting from post-Columbian admixture between Spaniards, Amerindians, and African slaves, principally. Consequently, we conducted minisequencing analysis (SNaPshot) of 11 mitochondrial single-nucleotide polymorphisms in 742 Mestizos of 10 populations from different regions in Mexico. The predominant maternal ancestry was Native American (92.9%), including Haplogroups A, B, C, and D (47, 23.7, 15.9, and 6.2%, respectively). Conversely, European and African ancestries were less frequent (5.3 and 1.9%, respectively). The main characteristics of the maternal lineages observed in Mexican–Mestizos comprised the following: 1) contrasting geographic gradient of Haplogroups A and C; 2) increase of European lineages toward the Northwest; 3) low or absent, but homogeneous, African ancestry throughout the Mexican territory; 4) maternal lineages in Mestizos roughly represent the genetic makeup of the surrounding Amerindian groups, particularly toward the Southeast, but not in the North and West; 5) continuity over time of the geographic distribution of Amerindian lineages in Mayas; and 6) low but significant maternal population structure (FST = 2.8%; P = 0.0000). The average ancestry obtained from uniparental systems (mtDNA and Y-chromosome) in Mexican–Mestizos was correlated with previous ancestry estimates based on autosomal systems (genome-wide single-nucleotide polymorphisms and short tandem repeats). Finally, the comparison of paternal and maternal lineages provided additional information concerning the gender bias admixture, mating patterns, and population structure in Mestizos throughout the Mexican territory. Am J Phys Anthropol.Fil: Martínez Cortés, Gabriela. Universidad de Guadalajara; MéxicoFil: Salazar Flores, Joel. Universidad de Guadalajara; MéxicoFil: Haro Guerrero, Javier. Universidad de Guadalajara; MéxicoFil: Rubi Castellanos, Rodrigo. Universidad de Guadalajara; MéxicoFil: Velarde Félix, Jesus S.. Universidad Autonoma de Sinaloa; MéxicoFil: Muñoz Valle, Jose F.. Universidad de Guadalajara; MéxicoFil: López Casamichana, Mavil. Universidad Nacional Autónoma de México; MéxicoFil: Carrillo Tapia, Eduardo. Universidad Nacional Autónoma de México; MéxicoFil: Casenco Avila, Luis M.. Hospital Regional de Alta Especialidad. Laboratorio de Investigación; MéxicoFil: Bravi, Claudio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: López Armenta, Mauro. Universidad Nacional Autónoma de México; MéxicoFil: Rangel Villalobos, Hector. Universidad de Guadalajara; MéxicoWiley-liss, Div John Wiley & Sons Inc2013-06-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23928Martínez Cortés, Gabriela; Salazar Flores, Joel; Haro Guerrero, Javier; Rubi Castellanos, Rodrigo; Velarde Félix, Jesus S.; et al.; Maternal admixture and population structure in Mexican-mestizos based on mtDNA haplogroups; Wiley-liss, Div John Wiley & Sons Inc; American Journal Of Physical Anthropology; 151; 4; 11-6-2013; 526-5370002-9483CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ajpa.22293/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1002/ajpa.22293info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:40Zoai:ri.conicet.gov.ar:11336/23928instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:40.718CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Maternal admixture and population structure in Mexican-mestizos based on mtDNA haplogroups
title Maternal admixture and population structure in Mexican-mestizos based on mtDNA haplogroups
spellingShingle Maternal admixture and population structure in Mexican-mestizos based on mtDNA haplogroups
Martínez Cortés, Gabriela
Mtdna Ancestry
Maternal Admixture
Mexican-Mestizo
Mtsnps
Y-Snps
title_short Maternal admixture and population structure in Mexican-mestizos based on mtDNA haplogroups
title_full Maternal admixture and population structure in Mexican-mestizos based on mtDNA haplogroups
title_fullStr Maternal admixture and population structure in Mexican-mestizos based on mtDNA haplogroups
title_full_unstemmed Maternal admixture and population structure in Mexican-mestizos based on mtDNA haplogroups
title_sort Maternal admixture and population structure in Mexican-mestizos based on mtDNA haplogroups
dc.creator.none.fl_str_mv Martínez Cortés, Gabriela
Salazar Flores, Joel
Haro Guerrero, Javier
Rubi Castellanos, Rodrigo
Velarde Félix, Jesus S.
Muñoz Valle, Jose F.
López Casamichana, Mavil
Carrillo Tapia, Eduardo
Casenco Avila, Luis M.
Bravi, Claudio Marcelo
López Armenta, Mauro
Rangel Villalobos, Hector
author Martínez Cortés, Gabriela
author_facet Martínez Cortés, Gabriela
Salazar Flores, Joel
Haro Guerrero, Javier
Rubi Castellanos, Rodrigo
Velarde Félix, Jesus S.
Muñoz Valle, Jose F.
López Casamichana, Mavil
Carrillo Tapia, Eduardo
Casenco Avila, Luis M.
Bravi, Claudio Marcelo
López Armenta, Mauro
Rangel Villalobos, Hector
author_role author
author2 Salazar Flores, Joel
Haro Guerrero, Javier
Rubi Castellanos, Rodrigo
Velarde Félix, Jesus S.
Muñoz Valle, Jose F.
López Casamichana, Mavil
Carrillo Tapia, Eduardo
Casenco Avila, Luis M.
Bravi, Claudio Marcelo
López Armenta, Mauro
Rangel Villalobos, Hector
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mtdna Ancestry
Maternal Admixture
Mexican-Mestizo
Mtsnps
Y-Snps
topic Mtdna Ancestry
Maternal Admixture
Mexican-Mestizo
Mtsnps
Y-Snps
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The maternal ancestry (mtDNA) has important applications in different research fields, such as evolution, epidemiology, identification, and human population history. This is particularly interesting in Mestizos, which constitute the main population in Mexico (∼93%) resulting from post-Columbian admixture between Spaniards, Amerindians, and African slaves, principally. Consequently, we conducted minisequencing analysis (SNaPshot) of 11 mitochondrial single-nucleotide polymorphisms in 742 Mestizos of 10 populations from different regions in Mexico. The predominant maternal ancestry was Native American (92.9%), including Haplogroups A, B, C, and D (47, 23.7, 15.9, and 6.2%, respectively). Conversely, European and African ancestries were less frequent (5.3 and 1.9%, respectively). The main characteristics of the maternal lineages observed in Mexican–Mestizos comprised the following: 1) contrasting geographic gradient of Haplogroups A and C; 2) increase of European lineages toward the Northwest; 3) low or absent, but homogeneous, African ancestry throughout the Mexican territory; 4) maternal lineages in Mestizos roughly represent the genetic makeup of the surrounding Amerindian groups, particularly toward the Southeast, but not in the North and West; 5) continuity over time of the geographic distribution of Amerindian lineages in Mayas; and 6) low but significant maternal population structure (FST = 2.8%; P = 0.0000). The average ancestry obtained from uniparental systems (mtDNA and Y-chromosome) in Mexican–Mestizos was correlated with previous ancestry estimates based on autosomal systems (genome-wide single-nucleotide polymorphisms and short tandem repeats). Finally, the comparison of paternal and maternal lineages provided additional information concerning the gender bias admixture, mating patterns, and population structure in Mestizos throughout the Mexican territory. Am J Phys Anthropol.
Fil: Martínez Cortés, Gabriela. Universidad de Guadalajara; México
Fil: Salazar Flores, Joel. Universidad de Guadalajara; México
Fil: Haro Guerrero, Javier. Universidad de Guadalajara; México
Fil: Rubi Castellanos, Rodrigo. Universidad de Guadalajara; México
Fil: Velarde Félix, Jesus S.. Universidad Autonoma de Sinaloa; México
Fil: Muñoz Valle, Jose F.. Universidad de Guadalajara; México
Fil: López Casamichana, Mavil. Universidad Nacional Autónoma de México; México
Fil: Carrillo Tapia, Eduardo. Universidad Nacional Autónoma de México; México
Fil: Casenco Avila, Luis M.. Hospital Regional de Alta Especialidad. Laboratorio de Investigación; México
Fil: Bravi, Claudio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: López Armenta, Mauro. Universidad Nacional Autónoma de México; México
Fil: Rangel Villalobos, Hector. Universidad de Guadalajara; México
description The maternal ancestry (mtDNA) has important applications in different research fields, such as evolution, epidemiology, identification, and human population history. This is particularly interesting in Mestizos, which constitute the main population in Mexico (∼93%) resulting from post-Columbian admixture between Spaniards, Amerindians, and African slaves, principally. Consequently, we conducted minisequencing analysis (SNaPshot) of 11 mitochondrial single-nucleotide polymorphisms in 742 Mestizos of 10 populations from different regions in Mexico. The predominant maternal ancestry was Native American (92.9%), including Haplogroups A, B, C, and D (47, 23.7, 15.9, and 6.2%, respectively). Conversely, European and African ancestries were less frequent (5.3 and 1.9%, respectively). The main characteristics of the maternal lineages observed in Mexican–Mestizos comprised the following: 1) contrasting geographic gradient of Haplogroups A and C; 2) increase of European lineages toward the Northwest; 3) low or absent, but homogeneous, African ancestry throughout the Mexican territory; 4) maternal lineages in Mestizos roughly represent the genetic makeup of the surrounding Amerindian groups, particularly toward the Southeast, but not in the North and West; 5) continuity over time of the geographic distribution of Amerindian lineages in Mayas; and 6) low but significant maternal population structure (FST = 2.8%; P = 0.0000). The average ancestry obtained from uniparental systems (mtDNA and Y-chromosome) in Mexican–Mestizos was correlated with previous ancestry estimates based on autosomal systems (genome-wide single-nucleotide polymorphisms and short tandem repeats). Finally, the comparison of paternal and maternal lineages provided additional information concerning the gender bias admixture, mating patterns, and population structure in Mestizos throughout the Mexican territory. Am J Phys Anthropol.
publishDate 2013
dc.date.none.fl_str_mv 2013-06-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23928
Martínez Cortés, Gabriela; Salazar Flores, Joel; Haro Guerrero, Javier; Rubi Castellanos, Rodrigo; Velarde Félix, Jesus S.; et al.; Maternal admixture and population structure in Mexican-mestizos based on mtDNA haplogroups; Wiley-liss, Div John Wiley & Sons Inc; American Journal Of Physical Anthropology; 151; 4; 11-6-2013; 526-537
0002-9483
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23928
identifier_str_mv Martínez Cortés, Gabriela; Salazar Flores, Joel; Haro Guerrero, Javier; Rubi Castellanos, Rodrigo; Velarde Félix, Jesus S.; et al.; Maternal admixture and population structure in Mexican-mestizos based on mtDNA haplogroups; Wiley-liss, Div John Wiley & Sons Inc; American Journal Of Physical Anthropology; 151; 4; 11-6-2013; 526-537
0002-9483
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ajpa.22293/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1002/ajpa.22293
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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