Small Cationic Peptides: Influence of Charge on Their Antimicrobial Activity

Autores
Lopez Cascales, Jose Javier; Zenak, Siham; García de La Torre, José; Lezama, José Osvaldo Guy; Garro, Adriana; Enriz, Ricardo Daniel
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The first stage of the action mechanism of small cationic peptides with antimicrobial activity is ruled by electrostatic interactions between the peptide and the pathogen cell membrane. Thus, an increase in its activity could be expected with an increase in the positive charge on the peptide. By contrast, the opposite behavior has been observed when the charge increases to reach a critical value, beyond which the activity falls. This work studies the perturbation effects in a cell membrane model for two small cationic peptides with similar length and morphology but with different cationic charges. The synthesis and antibacterial activity of the two peptides used in this study are described. The thermodynamic study associated with the insertion of these peptides into the membrane and the perturbing effects on the bilayer structure provide valuable insights into the molecular action mechanism associated with the charge of these small cationic peptides.
Fil: Lopez Cascales, Jose Javier. Universidad Politécnica de Cartagena; España
Fil: Zenak, Siham. Universitédes Sciences et de la Technologie d’Oran; Argelia
Fil: García de La Torre, José. Universidad de Murcia; España
Fil: Lezama, José Osvaldo Guy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Garro, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Materia
MD simulations
cationic peptides
antibacterial agents
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/89006
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Small Cationic Peptides: Influence of Charge on Their Antimicrobial ActivityLopez Cascales, Jose JavierZenak, SihamGarcía de La Torre, JoséLezama, José Osvaldo GuyGarro, AdrianaEnriz, Ricardo DanielMD simulationscationic peptidesantibacterial agentshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The first stage of the action mechanism of small cationic peptides with antimicrobial activity is ruled by electrostatic interactions between the peptide and the pathogen cell membrane. Thus, an increase in its activity could be expected with an increase in the positive charge on the peptide. By contrast, the opposite behavior has been observed when the charge increases to reach a critical value, beyond which the activity falls. This work studies the perturbation effects in a cell membrane model for two small cationic peptides with similar length and morphology but with different cationic charges. The synthesis and antibacterial activity of the two peptides used in this study are described. The thermodynamic study associated with the insertion of these peptides into the membrane and the perturbing effects on the bilayer structure provide valuable insights into the molecular action mechanism associated with the charge of these small cationic peptides.Fil: Lopez Cascales, Jose Javier. Universidad Politécnica de Cartagena; EspañaFil: Zenak, Siham. Universitédes Sciences et de la Technologie d’Oran; ArgeliaFil: García de La Torre, José. Universidad de Murcia; EspañaFil: Lezama, José Osvaldo Guy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Garro, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaAmerican Chemical Society2018-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/89006Lopez Cascales, Jose Javier; Zenak, Siham; García de La Torre, José; Lezama, José Osvaldo Guy; Garro, Adriana; et al.; Small Cationic Peptides: Influence of Charge on Their Antimicrobial Activity; American Chemical Society; ACS Omega; 3; 5; 5-2018; 5390-53982470-1343CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/10.1021/acsomega.8b00293info:eu-repo/semantics/altIdentifier/doi/10.1021/acsomega.8b00293info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130792/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:15:24Zoai:ri.conicet.gov.ar:11336/89006instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:15:24.501CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Small Cationic Peptides: Influence of Charge on Their Antimicrobial Activity
title Small Cationic Peptides: Influence of Charge on Their Antimicrobial Activity
spellingShingle Small Cationic Peptides: Influence of Charge on Their Antimicrobial Activity
Lopez Cascales, Jose Javier
MD simulations
cationic peptides
antibacterial agents
title_short Small Cationic Peptides: Influence of Charge on Their Antimicrobial Activity
title_full Small Cationic Peptides: Influence of Charge on Their Antimicrobial Activity
title_fullStr Small Cationic Peptides: Influence of Charge on Their Antimicrobial Activity
title_full_unstemmed Small Cationic Peptides: Influence of Charge on Their Antimicrobial Activity
title_sort Small Cationic Peptides: Influence of Charge on Their Antimicrobial Activity
dc.creator.none.fl_str_mv Lopez Cascales, Jose Javier
Zenak, Siham
García de La Torre, José
Lezama, José Osvaldo Guy
Garro, Adriana
Enriz, Ricardo Daniel
author Lopez Cascales, Jose Javier
author_facet Lopez Cascales, Jose Javier
Zenak, Siham
García de La Torre, José
Lezama, José Osvaldo Guy
Garro, Adriana
Enriz, Ricardo Daniel
author_role author
author2 Zenak, Siham
García de La Torre, José
Lezama, José Osvaldo Guy
Garro, Adriana
Enriz, Ricardo Daniel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv MD simulations
cationic peptides
antibacterial agents
topic MD simulations
cationic peptides
antibacterial agents
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The first stage of the action mechanism of small cationic peptides with antimicrobial activity is ruled by electrostatic interactions between the peptide and the pathogen cell membrane. Thus, an increase in its activity could be expected with an increase in the positive charge on the peptide. By contrast, the opposite behavior has been observed when the charge increases to reach a critical value, beyond which the activity falls. This work studies the perturbation effects in a cell membrane model for two small cationic peptides with similar length and morphology but with different cationic charges. The synthesis and antibacterial activity of the two peptides used in this study are described. The thermodynamic study associated with the insertion of these peptides into the membrane and the perturbing effects on the bilayer structure provide valuable insights into the molecular action mechanism associated with the charge of these small cationic peptides.
Fil: Lopez Cascales, Jose Javier. Universidad Politécnica de Cartagena; España
Fil: Zenak, Siham. Universitédes Sciences et de la Technologie d’Oran; Argelia
Fil: García de La Torre, José. Universidad de Murcia; España
Fil: Lezama, José Osvaldo Guy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Garro, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
description The first stage of the action mechanism of small cationic peptides with antimicrobial activity is ruled by electrostatic interactions between the peptide and the pathogen cell membrane. Thus, an increase in its activity could be expected with an increase in the positive charge on the peptide. By contrast, the opposite behavior has been observed when the charge increases to reach a critical value, beyond which the activity falls. This work studies the perturbation effects in a cell membrane model for two small cationic peptides with similar length and morphology but with different cationic charges. The synthesis and antibacterial activity of the two peptides used in this study are described. The thermodynamic study associated with the insertion of these peptides into the membrane and the perturbing effects on the bilayer structure provide valuable insights into the molecular action mechanism associated with the charge of these small cationic peptides.
publishDate 2018
dc.date.none.fl_str_mv 2018-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/89006
Lopez Cascales, Jose Javier; Zenak, Siham; García de La Torre, José; Lezama, José Osvaldo Guy; Garro, Adriana; et al.; Small Cationic Peptides: Influence of Charge on Their Antimicrobial Activity; American Chemical Society; ACS Omega; 3; 5; 5-2018; 5390-5398
2470-1343
CONICET Digital
CONICET
url http://hdl.handle.net/11336/89006
identifier_str_mv Lopez Cascales, Jose Javier; Zenak, Siham; García de La Torre, José; Lezama, José Osvaldo Guy; Garro, Adriana; et al.; Small Cationic Peptides: Influence of Charge on Their Antimicrobial Activity; American Chemical Society; ACS Omega; 3; 5; 5-2018; 5390-5398
2470-1343
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/10.1021/acsomega.8b00293
info:eu-repo/semantics/altIdentifier/doi/10.1021/acsomega.8b00293
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130792/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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