Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice

Autores
Herrera, Héctor Matías; Salva, Maria Susana; Villena, Julio Cesar; Barbieri, Natalia Paola del Carmen; Alvarez, Gladis Susana
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The effect of Lactobacillus rhamnosus CRL1505 on blood and bone marrow (BM) myeloid cells and their correlation with resistance against Streptococcus pneumoniae infection was evaluated in protein-malnourished mice. Repletion of malnourished mice with supplemental L. rhamnosus improved recovery of BM responsiveness against the infectious challenge through increase in myeloid progenitors and mobilisation of granulocytes. The CRL1505 strain normalised the number of Gr1+ cells and Gr1low/Gr1high cells balance in BM. These changes in BM correlated with improved neutrophils recruitment, higher phagocytic activity and increased resistance against pneumococcal infection in probiotic-treated mice. This research provides strong evidence of the importance of dietary supplementation with probiotic bacteria to reverse alterations in myeloid progenitors in malnourished mice. The present results strongly suggest that the CRL1505 strain could be used in the development of probiotic foods, which would be especially useful for the recovery of immunocompromised hosts.
Fil: Herrera, Héctor Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
Fil: Barbieri, Natalia Paola del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina. Universidad Nacional de Tucumán; Argentina
Materia
Lactobacillus Rhamnosus Crl1505
Myeloid Cells
Malnutrition
Respiratory Immunity
Bone Marrow
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6883
Acceder
id CONICETDig_7f2aa51bbd093c73db05ba5be1458250
oai_identifier_str oai:ri.conicet.gov.ar:11336/6883
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished miceHerrera, Héctor MatíasSalva, Maria SusanaVillena, Julio CesarBarbieri, Natalia Paola del CarmenAlvarez, Gladis SusanaLactobacillus Rhamnosus Crl1505Myeloid CellsMalnutritionRespiratory ImmunityBone Marrowhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The effect of Lactobacillus rhamnosus CRL1505 on blood and bone marrow (BM) myeloid cells and their correlation with resistance against Streptococcus pneumoniae infection was evaluated in protein-malnourished mice. Repletion of malnourished mice with supplemental L. rhamnosus improved recovery of BM responsiveness against the infectious challenge through increase in myeloid progenitors and mobilisation of granulocytes. The CRL1505 strain normalised the number of Gr1+ cells and Gr1low/Gr1high cells balance in BM. These changes in BM correlated with improved neutrophils recruitment, higher phagocytic activity and increased resistance against pneumococcal infection in probiotic-treated mice. This research provides strong evidence of the importance of dietary supplementation with probiotic bacteria to reverse alterations in myeloid progenitors in malnourished mice. The present results strongly suggest that the CRL1505 strain could be used in the development of probiotic foods, which would be especially useful for the recovery of immunocompromised hosts.Fil: Herrera, Héctor Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); ArgentinaFil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); ArgentinaFil: Barbieri, Natalia Paola del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); ArgentinaFil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina. Universidad Nacional de Tucumán; ArgentinaElsevier2013-08-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6883Herrera, Héctor Matías; Salva, Maria Susana; Villena, Julio Cesar; Barbieri, Natalia Paola del Carmen; Alvarez, Gladis Susana; Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice; Elsevier; Journal of Functional Foods; 5; 13-8-2013; 1693-17041756-4646enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2013.07.014info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1756464613001771info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-29T12:39:17Zoai:ri.conicet.gov.ar:11336/6883instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-29 12:39:17.638CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice
title Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice
spellingShingle Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice
Herrera, Héctor Matías
Lactobacillus Rhamnosus Crl1505
Myeloid Cells
Malnutrition
Respiratory Immunity
Bone Marrow
title_short Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice
title_full Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice
title_fullStr Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice
title_full_unstemmed Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice
title_sort Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice
dc.creator.none.fl_str_mv Herrera, Héctor Matías
Salva, Maria Susana
Villena, Julio Cesar
Barbieri, Natalia Paola del Carmen
Alvarez, Gladis Susana
author Herrera, Héctor Matías
author_facet Herrera, Héctor Matías
Salva, Maria Susana
Villena, Julio Cesar
Barbieri, Natalia Paola del Carmen
Alvarez, Gladis Susana
author_role author
author2 Salva, Maria Susana
Villena, Julio Cesar
Barbieri, Natalia Paola del Carmen
Alvarez, Gladis Susana
author2_role author
author
author
author
dc.subject.none.fl_str_mv Lactobacillus Rhamnosus Crl1505
Myeloid Cells
Malnutrition
Respiratory Immunity
Bone Marrow
topic Lactobacillus Rhamnosus Crl1505
Myeloid Cells
Malnutrition
Respiratory Immunity
Bone Marrow
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The effect of Lactobacillus rhamnosus CRL1505 on blood and bone marrow (BM) myeloid cells and their correlation with resistance against Streptococcus pneumoniae infection was evaluated in protein-malnourished mice. Repletion of malnourished mice with supplemental L. rhamnosus improved recovery of BM responsiveness against the infectious challenge through increase in myeloid progenitors and mobilisation of granulocytes. The CRL1505 strain normalised the number of Gr1+ cells and Gr1low/Gr1high cells balance in BM. These changes in BM correlated with improved neutrophils recruitment, higher phagocytic activity and increased resistance against pneumococcal infection in probiotic-treated mice. This research provides strong evidence of the importance of dietary supplementation with probiotic bacteria to reverse alterations in myeloid progenitors in malnourished mice. The present results strongly suggest that the CRL1505 strain could be used in the development of probiotic foods, which would be especially useful for the recovery of immunocompromised hosts.
Fil: Herrera, Héctor Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
Fil: Barbieri, Natalia Paola del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina. Universidad Nacional de Tucumán; Argentina
description The effect of Lactobacillus rhamnosus CRL1505 on blood and bone marrow (BM) myeloid cells and their correlation with resistance against Streptococcus pneumoniae infection was evaluated in protein-malnourished mice. Repletion of malnourished mice with supplemental L. rhamnosus improved recovery of BM responsiveness against the infectious challenge through increase in myeloid progenitors and mobilisation of granulocytes. The CRL1505 strain normalised the number of Gr1+ cells and Gr1low/Gr1high cells balance in BM. These changes in BM correlated with improved neutrophils recruitment, higher phagocytic activity and increased resistance against pneumococcal infection in probiotic-treated mice. This research provides strong evidence of the importance of dietary supplementation with probiotic bacteria to reverse alterations in myeloid progenitors in malnourished mice. The present results strongly suggest that the CRL1505 strain could be used in the development of probiotic foods, which would be especially useful for the recovery of immunocompromised hosts.
publishDate 2013
dc.date.none.fl_str_mv 2013-08-13
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6883
Herrera, Héctor Matías; Salva, Maria Susana; Villena, Julio Cesar; Barbieri, Natalia Paola del Carmen; Alvarez, Gladis Susana; Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice; Elsevier; Journal of Functional Foods; 5; 13-8-2013; 1693-1704
1756-4646
url http://hdl.handle.net/11336/6883
identifier_str_mv Herrera, Héctor Matías; Salva, Maria Susana; Villena, Julio Cesar; Barbieri, Natalia Paola del Carmen; Alvarez, Gladis Susana; Lactobacillus rhamnosus CRL1505 enhances systemic and respiratory innate immune response in immunocompromised malnourished mice; Elsevier; Journal of Functional Foods; 5; 13-8-2013; 1693-1704
1756-4646
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2013.07.014
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1756464613001771
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1847427388837724160
score 13.10058

Publicaciones similares